Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice

Nitric Oxide - Biology and Chemistry

Volumn 6, Issue 2, 2002, Pages 160-167

  Hinson, Jack A ^a   Bucci, Thomas J ^b   Irwin, Lisa K ^a   Michael, Sherryll L ^a   Mayeux, Philip R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b Natl Ctr for Toxicological Res   (United States)

Author keywords

Acetaminophen; Aminoguanidine; Hepatotoxicity; Nitric oxide; Nitrotyrosine; Peroxynitrite

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOGUANIDINE; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE; PARACETAMOL; PEROXYNITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TYPE; CONTROLLED STUDY; COVALENT BOND; DRUG OVERDOSE; ENDOTHELIUM CELL; ENZYME INHIBITION; KUPFFER CELL; LIPID PEROXIDATION; LIVER TOXICITY; MOUSE; NITRATION; NONHUMAN; PRIORITY JOURNAL; STELLATE CELL; TISSUE SECTION;

EID: 0036330839     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1006/niox.2001.0404     Document Type: Article

References (49)

1. Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen
2. Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species
3. Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: Role of mitochondrial oxidant stress
4. Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse
5. Selective protein covalent binding and target organ toxicity
6. Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity
7. Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: Correspondence of covalent binding with toxicity
8. Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice
9. Oxidative damage and tyrosine nitration from peroxynitrite
10. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
11. Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite
12. Macrophages and inflammatory mediators in tissue injury
13. Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity
14. Acetaminophen-induced hepatotoxicity is associated with early changes in NF-kB and NF-IL6 DNA binding activity
15. Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase
16. Acetaminophen-induced hepatic glycogen depletion and hyperglycemia in mice
17. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione
18. Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice
19. Microsomal lipid peroxidation
20. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
21. Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and L-N6-(1-iminoethyl)lysine
22. L-N6-(1-iminoethyl)lysine: A selective inhibitor of inducible nitric oxide synthase
23. 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo
24. Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice
25. Immunohistochemical methods to detect nitrotyrosine
26. Ferrous ion supported in vivo lipid peroxidation induced by paracetamol - Its relation to hepatotoxicity
27. Role of lipid peroxidation in acetaminophen-induced hepatotoxicity: Comparison with carbon tetrachloride
28. Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia
29. Chronic inhibition of nitric oxide synthase in Heymann nephritis
30. Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: Studies with the inducible nitric oxide synthase inhibitor L-N(6)-(1-Iminoethyl)lysine
31. Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia
32. Effects of a nitric oxide synthase inhibitor in humans with septic shock
33. Alkylation and peroxidation injury from chemically reactive metabolites
34. Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity
35. The reaction of no with superoxide
36. ·: A pulse radiolysis study
37. Kinetics of cytochrome c2+ oxidation by peroxynitrite: Implications for superoxide measurements in nitric oxide-producing biological systems
38. The mechanism of liver microsomal lipid peroxidation
39. Paraquat toxicity: Proposed mechanism of action involving lipid peroxidation
40. Mechanisms of carbon tetrachloride toxicity
41. Kinetic study of the reaction of glutathione peroxidase with peroxynitrite
42. Tissue-specific functions of individual glutathione peroxidases
43. The glutathione peroxidases
44. Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes
45. Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury
46. Role of proinflammatory cytokines in acetaminophen hepatotoxicity
47. Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen
48. Oxidative and reductive metabolism by cytochrome P450 2E1
49. Regulation of nitric oxide synthesis in the liver