Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle

Thrombosis and Haemostasis

Volumn 92, Issue 4, 2004, Pages 797-802

  Thijssen, Henk H ^a   Soute, Berry A ^a   Vervoort, Lily M ^a   Claessens, Jolanda G ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b Anticoagulation Center Maastricht   (Netherlands)

Author keywords

Drug interaction; Oral anticoagulation; Paracetamol; Vitamin K dependent factors

Indexed keywords

ACENOCOUMAROL; AMINO ACID; ANALGESIC AGENT; ANTICOAGULANT AGENT; CARBOXYLASE; DRUG METABOLITE; ENZYME INHIBITOR; GLUTATHIONE; HYDROQUINONE; MENADIONE EPOXIDE; N ACETYL 1,4 BENZOQUINONE IMINE; OXIDOREDUCTASE; PARACETAMOL; VITAMIN K GROUP; WARFARIN;

AGED; ANTICOAGULANT THERAPY; ARTICLE; CASE REPORT; CONCENTRATION RESPONSE; COVALENT BOND; DRUG CHOICE; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; FEMALE; HUMAN; IN VITRO STUDY; PRIORITY JOURNAL;

ACETAMINOPHEN; AGED; BENZOQUINONES; CARBON-CARBON LIGASES; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; HUMANS; IMINES; KINETICS; MIXED FUNCTION OXYGENASES; VITAMIN K; WARFARIN;

EID: 6344230026     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH04-02-0109     Document Type: Article

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