Gene expression profiling of rat livers reveals indicators of potential adverse effects

Toxicological Sciences

Volumn 80, Issue 1, 2004, Pages 193-202

  Heinloth, Alexandra N ^a   Irwin, Richard D ^a   Boorman, Gary A ^a   Nettesheim, Paul ^a   Fannin, Rickie D ^a   Sieber, Stella O ^a   Snell, Michael L ^a   Tucker, Charles J ^a   Li, Leping ^a   Travlos, Gregory S ^a   Vansant, Gordon ^b   Blackshear, Pamela E ^c   Tennant, Raymond W ^a   Cunningham, Michael L ^a   Paules, Richard S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b Althea Technologies   (United States)

^c INTEGRATED LABORATORY SYSTEMS   (United States)

Author keywords

Acetaminophen; Hepatotoxicity; Mitochondrial toxicity; Toxicogenomics

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; PARACETAMOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA MICROARRAY; DOWN REGULATION; DRUG MEGADOSE; ENERGY CONSUMPTION; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; LIVER TOXICITY; MALE; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SINGLE DRUG DOSE; UPREGULATION;

ACETAMINOPHEN; ADENOSINE TRIPHOSPHATE; ADMINISTRATION, ORAL; ANALGESICS, NON-NARCOTIC; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; HEPATITIS, TOXIC; LIVER; MALE; MICROARRAY ANALYSIS; MITOCHONDRIA, LIVER; RATS; RATS, INBRED F344; TOXICITY TESTS;

EID: 3242742968     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh145     Document Type: Article

References (36)

1. Bai, X. C., Deng, F., Liu, A. L,, Zou, Z. P., Wang, Y., Ke, Z. Y., Ji, Q. S., and Luo, S. Q. (2002). Phospholipase C-gammal is required for cell survival in oxidative stress by protein kinase C. Biochem. J. 363, 395-401.
2. Bandara, L. R., Kelly, M. D., Lock, E. A., and Kennedy, S. (2003). A correlation between a proteomic evaluation and conventional measurements in the assessment of renal proximal tubular toxicity. Toxicol. Sci. 73, 195-206.
3. Banerjee, A., Linscheer, W. G., Chiji, H., Murthy, U. K., Cho, C., Nandi, J., and Chan, S. H. (1998). Induction of an ATPase inhibitor protein by propylthiouracil and protection against paracetamol (acetaminophen) hepatotoxicity in the rat. Br. J. Pharmacol. 124, 1041-1047.
4. Bichsel, V. E., Liotta, L.A., and Petricoin, E. F., 3rd (2001). Cancer proteomics: From biomarker discovery to signal pathway profiling. Cancer J. 7, 69-78.
5. Boorman, G. A., and Eustis, S. L. (1986). The pathology working group as a means for assuring pathology quality in toxicological studies. In Managing Conduct and Data Quality of Toxicological Studies, (B. K. Hoover, J. K. Baldwin, A. F. Uelner, C. E. Whitmire, C. L. Davies, and D. W. Bristol., Eds.) Vol. 1, pp. 271-275. Princeton Scientific Publishing, Princeton, NJ.
6. Casella, G., and Berger, R. L. (1994). Estimation with selected binomial information or do you really believe that Winfield, Dave is batting. 471. J. Am. Stat. Assoc. 89, 1080-1090.
7. Chen, Y., Kamat, V., Dougherty, E. R., Bittner, M. L., Meltzer, P. S., and Trent, J. M. (2002). Ratio statistics of gene expression levels and applications to microarray data analysis. Bioinformatics 18, 1207-1215.
8. Council, N. R. (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC.
9. Davies, S. P., Carling, D., Munday, M. R., and Hardie, D. G. (1992). Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets. Eur. J. Biochem. 203, 615-623.
10. Duggan, D. J., Bittner, M., Chen, Y., Meltzer, P., and Trent, J. M. (1999). Expression profiling using cDNA microarrays. Nat. Genet. 21, 10-14.
11. Easom, R. A., and Zammit, V.A. (1984). A cold-clamping technique for the rapid sampling of rat liver for studies on enzymes in separate cell fractions. Suitability for the study of enzymes regulated by reversible phosphorylationdephosphorylation. Biochem. J. 220, 733-8.
12. Echard, B. W., Talpur, N. A., Fan, A. Y., Bagchi, D., and Preuss, H. G. (2001). Hepatoprotective ability of a novel botanical formulation on mild liver injury in rats produced by acute acetaminophen and/or alcohol ingestion. Res. Commun. Mol. Pathol. Pharmacol. 110, 73-85.
13. Eisen, M. B., Spellman, P. T., Brown, P. O., and Botstein, D. (1998). Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. U.S.A. 95, 14863-14868.
14. Farber, E. (1973). ATP and cell integrity. Fed. Proc. 32, 1534-1539.
15. Ford, L. P., Wright, W. E., and Shay, J. W. (2002). A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation. Oncogene 21, 580-583.
16. Haidara, K., Moffatt, P., and Denizeau, F. (1999). Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes. Toxicol. Sci. 49, 297-305.
17. Hamadeh, H. K., Knight, B. L., Haugen, A. C., Sieber, S., Amin, R. P., Bushel, P. R., Stoll, R., Blanchard, K., Jayadev, S., Tennant, R. W., Cunningham, M. L., Afshari, C. A., and Paules, R. S. (2002). Methapyrilene toxicity: Anchorage of pathologic observations to gene expression alterations. Toxicol. Pathol. 30, 470-482.
18. Immenschuh, S., Hinke, V., Katz, N., and Kietzmann, T. (2000). Transcriptional induction of heme oxygenase-1 gene expression by okadaic acid in primary rat hepatocyte cultures. Mol. Pharmacol. 57, 610-618.
19. Jackson, S. P. (2001). Detecting, signalling and repairing DNA double-strand breaks. Biochem. Soc. Trans. 29, 655-661.
20. Johnson, P. H., Walker, R. P., Jones, S. W., Stephens, K., Meurer, J., Zajchowski, D. A., Luke, M. M., Eeckman, F., Tan, Y. P., Wong, L., Parry, G., Morgan, T. K., McCarrick, M. A., and Monforte, J. (2002). Multiplex gene expression analysis for high-throughput drug discovery: Screening and analysis of compounds affecting genes overexpressed in cancer cells. Mol. Can. Ther. 1, 1293-1304.
21. Knight, T. R., Ho, Y. S., Farhood, A., and Jaeschke, H. (2002). Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: Protection by glutathione. J. Pharmacol. Exp. Ther. 303, 468-475.
22. Lee, W. M. (2003). Acute liver failure in the United States. Semin. Liver Dis. 23, 217-226.
23. Lie, J., Liu, Y., Hartley, D., Klaassen, C. D., Shehin-Johnson, S. E., Lucas, A., and Cohen, S. D. (1999) Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity. J. Pharamacol. exp. Ther. 289, 580-586.
24. Martin, F. L., and McLean, A. E. (1998). Comparison of paracetamol-induced hepatotoxicity in the rat in vivo with progression of cell injury in vitro in rat liver slices. Drug Chem. Toxicol. 21, 477-494.
25. Mitchell, J. R., Jollow, D. J., Potter, W. Z., Gillette, J. R., and Brodie, B. B. (1973). Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther. 187, 211-7.
26. Nishino, H., Murakosh, M., Ii, T., Takemura, M., Kuchide, M., Kanazawa, M., Mou, X. Y., Wada, S., Masuda, M., Ohsaka, Y., Yogosawa, S., Satomi, Y., and Jinno, K. (2002). Carotenoids in cancer chemoprevention. Cancer Metastasis Rev. 21, 257-264.
27. Pessayre, D., Wandscheer, J. C., Cobert, B., Level, R., Degott, C., Batt, A. M., Martin, N., and Benhamou, J. P. (1980). Additive effects of inducers and fasting on acetaminophen hepatotoxicity. Biochem. Pharmacol. 29, 2219-2223.
28. Petersen, S., Casellas, R., Reina-San-Martin, B., Chen, H. T., Difilippantonio, M. J., Wilson, P. C., Hanitsch, L., Celeste, A., Muramatsu, M., Pilch, D. R., Redon, C., Ried, T., Bonner, W. M., Honjo, T., Nussenzweig, M. C., and Nussenzweig, A. (2001). AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 414, 660-665.
29. Pumford, N. R., Halmes, N. C., and Hinson, J. A. (1997). Covalent binding of xenobiotics to specific proteins in the liver. Drug Metab. Rev. 29, 39-57.
30. Roberts, J. L., and Morrow, J. D. (2001). Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In Goodman and Gilman's The Pharmacological Basis of Therapeutics (J. G. Hardman, L. F. Limbird, and A. Goodman Gilman, Eds.), pp. 687-731. McGraw-Hill, New York.
31. Ruepp, S. U., Tonge, R. P., Shaw, J., Wallis, N., and Pognan, F. (2002). Genomics and proteomics analysis of acetaminophen toxicity in mouse liver. Toxicol. Sci. 65, 135-150.
32. Schiodt, F. V., Ott, P., Christensen, E., and Bondesen, S. (2002). The value of plasma acetaminophen half-life in antidote-treated acetaminophen over-dosage. Clin. Pharmacol. Ther. 71, 221-225.
33. Strubelt, O., Dost-Kempf, E., Siegers, C. P., Younes, M., Volpel, M., Preuss, U., and Dreckmann, J. G. (1981). The influence of fasting on the susceptibility of mice to hepatotoxic injury. Toxicol. Appl. Pharmacol. 60, 66-77.
34. Tugwood, J. D., Hollins, L. E., and Cockerill, M. J. (2003). Genomics and the search for novel biomarkers in toxicology. Biomarkers 8, 79-92.
35. Wolfinger, R. D., Gibson, G., Wolfinger, E. D., Bennett, L., Hamadeh, H., Bushel, P., Afshari, C., and Paules, R. S. (2001). Assessing gene significance from cDNA microarray expression data via mixed models. J. Comput. Biol. 8, 625-637.
36. Wormser, U., and Calp, D. (1988). Increased levels of hepatic metallothionein in rat and mouse after injection of acetaminophen. Toxicology 53, 323-329.