NCX-701 (NicOx)

Current Opinion in Investigational Drugs

Volumn 5, Issue 7, 2004, Pages 755-759

  Joshi, Girish P ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (NITROXY)BUTANOIC ACID 4 ACETYLAMINOPHENYL ESTER; 4-(NITROXY)BUTANOIC ACID 4-ACETYLAMINOPHENYL ESTER; DRUG DERIVATIVE; NEW DRUG; NITRATE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOAVAILABILITY; CHEMICAL STRUCTURE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DISEASE MODEL; DRUG INDUSTRY; DRUG SCREENING; EVALUATION; HUMAN; METABOLISM; METHODOLOGY; MOUSE; PATENT; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; RAT; SYNTHESIS; UNITED STATES;

ACETAMINOPHEN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; CLINICAL TRIALS, PHASE I; CLINICAL TRIALS, PHASE II; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; DRUG INDUSTRY; DRUGS, INVESTIGATIONAL; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NITRATES; PATENTS; RANDOMIZED CONTROLLED TRIALS; RATS; UNITED STATES;

EID: 5044249940     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (27)

1. 370517 Positive preclinical results for NicOx's NO-paracetamol. NicOx SA PRESS RELEASE 2000 June 12
2. 386959 Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity. Al-Swayeh OA, Futter LE, Clifford RH, Moore PK BR J PHARMACOL 2000 130 7 1453-1456
3. 409462 An NO-derivative of acetaminophen, NCX-701, spares the liver by inhibiting Fas-dependent apoptosis. Fiorucci S, Antonelli E, Mencarelli A, Palazzetti B, Del Soldato P, Antipolis S, Morelli A GASTROENTEROL 2001 120 5 (Suppl 1) Abs 1861
4. 413824 NicOx: Positive phase I clinical results for the first administration into man of NCX 701. NicOx SA PRESS RELEASE 2001 June 27
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8. 480468 NicOx progresses in 2002. NicOx SA PRESS RELEASE 2003 March 03
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10. 493986 NicOx: Successful phase II efficacy results with NCX 701 in acute pain. NicOx SA PRESS RELEASE 2003 June 18
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