Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity

Chemical Research in Toxicology

Volumn 19, Issue 5, 2006, Pages 701-709

  Mutlib, Abdul E ^a   Goosen, Theunis C ^a   Bauman, Jonathan N ^a   Williams, J Andrew ^a   Kulkarni, Shaila ^a   Kostrubsky, Seva ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER; DEUTERIUM; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B15; PARACETAMOL; PARACETAMOL GLUCURONIDE; PHENOBARBITAL; PHENYTOIN; PHOSPHATE; TROMETAMOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETOXIFICATION; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HILL REACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; LIVER MICROSOME; LIVER TOXICITY; MICHAELIS MENTEN KINETICS; NONHUMAN; TOXICOKINETICS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; BIOTRANSFORMATION; CELLS, CULTURED; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; MICROSOMES, LIVER;

EID: 33744500475     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx050317i     Document Type: Article

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