Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxlc doses of acetaminophen using high-performance liquid chromatography with electrochemical detection

Drug Metabolism and Disposition

Volumn 30, Issue 4, 2002, Pages 446-451

  Muldrew, Kenneth L ^a   James, Laura P ^a   Coop, Leslie ^a   McCullough, Sandra S ^a   Hendrickson, Howard P ^a   Hinson, Jack A ^a   Mayeux, Philip R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYSTEINE; PARACETAMOL; TYROSINE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CHILD; CONTROLLED STUDY; COVALENT BOND; DRUG CONJUGATION; DRUG LIVER LEVEL; DRUG OVERDOSE; DRUG PROTEIN BINDING; ELECTROCHEMICAL DETECTION; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER INJURY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SERUM; TIME;

ACETAMINOPHEN; ADOLESCENT; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; ENDOPEPTIDASES; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; PREDICTIVE VALUE OF TESTS; PROTEINS; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TYROSINE;

ANIMALIA;

EID: 0036206777     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.4.446     Document Type: Article

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