Pharmaco-metabonomic phenotyping and personalized drug treatment

Nature

Volumn 440, Issue 7087, 2006, Pages 1073-1077

  Clayton, T Andrew ^a   Lindon, John C ^a   Cloarec, Olivier ^a   Antti, Henrik ^b   Charuel, Claude ^c   Hanton, Gilles ^c   Provost, Jean Pierre ^c   Net, Jean Loïc Le ^c   Baker, David ^c   Walley, Rosalind J ^d   Everett, Jeremy R ^d   Nicholson, Jeremy K ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UMEÅ UNIVERSITY   (Sweden)

^c PFIZER INC   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; DISEASES; GENES; MATHEMATICAL MODELS; METABOLITES; PATIENT TREATMENT;

LIVER DAMAGE; PARACETAMOL; PRE-DOSE PREDICTION; URINARY COMPOSITION;

DRUG THERAPY;

DRUG METABOLITE; PARACETAMOL;

DOSE-RESPONSE RELATIONSHIP; DRUG PRESCRIBING; ENVIRONMENTAL IMPACT; GENETIC VARIATION; GENOTYPE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOMETRICS; CONTROLLED STUDY; DRUG RESPONSE; DRUG URINE LEVEL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; GAS CHROMATOGRAPHY; GENETIC VARIABILITY; HEREDITY; HISTOPATHOLOGY; HUMAN; INTESTINE FLORA; LIQUID CHROMATOGRAPHY; LIVER INJURY; LIVER NECROSIS; MASS SPECTROMETRY; METABOLISM; METABOLITE; METABONOMICS; MULTIVARIATE ANALYSIS; NONHUMAN; NUTRITIONAL STATUS; PHARMACOGENOMICS; PHARMACOMETABONOMIC PHENOTYPING; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; URINARY EXCRETION;

EID: 33646198860     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04648     Document Type: Article

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