Distinct roles of NF-κB p50 in the regulation of acetaminophen- induced inflammatory mediator production and hepatotoxicity

Toxicology and Applied Pharmacology

Volumn 211, Issue 2, 2006, Pages 157-165

  Dambach, Donna M ^a,b   Durham, Stephen K ^a,b   Laskin, Jeffrey D ^c   Laskin, Debra L ^a  

^a RUTGERS UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Inflammation; Liver; N acetylcysteine; TNF ; Transcription factors

Indexed keywords

ACETYLCYSTEINE; AMINOTRANSFERASE; ANTIOXIDANT; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOKINE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 1; PARACETAMOL; PROTEIN P50; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL MODEL; GENE DISRUPTION; GENE TARGETING; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; MEDIATOR RELEASE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS REGULATION; REGULATORY MECHANISM; TRANSGENIC MOUSE; UPREGULATION;

ACETAMINOPHEN; ACETYLCYSTEINE; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; BLOTTING, WESTERN; CHEMOKINE CCL2; CHEMOKINES; GENE EXPRESSION; GLUTATHIONE; HEPATITIS, TOXIC; HUMANS; INFLAMMATION MEDIATORS; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-4; LIVER; MACROPHAGE INFLAMMATORY PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; NECROSIS; NF-KAPPA B P50 SUBUNIT; OXIDATIVE STRESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MUS MUSCULUS;

EID: 32544432347     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2005.06.024     Document Type: Article

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