Estimates of acetaminophen (paracetamol)-associated overdoses in the United States

Pharmacoepidemiology and Drug Safety

Volumn 15, Issue 6, 2006, Pages 398-405

  Nourjah, Parivash ^a   Ahmad, Syed Rizwanuddin ^a   Karwoski, Claudia ^a   Willy, Mary ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Acetaminophen; Deaths; Drug; NEISS; NHAMCS; NHDS; Overdose

Indexed keywords

NON PRESCRIPTION DRUG; OPIATE; PARACETAMOL;

ADOLESCENT; ADULT; AGED; ARTICLE; CAUSE OF DEATH; CHILD; CONTROLLED STUDY; DATA BASE; DRUG INTOXICATION; DRUG OVERDOSE; DRUG SURVEILLANCE PROGRAM; EMERGENCY CARE; FATALITY; FEMALE; FOOD AND DRUG ADMINISTRATION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RISK FACTOR; SUICIDAL IDEATION; SUICIDE; THERAPEUTIC ERROR; UNITED STATES; EMERGENCY HEALTH SERVICE; FACTUAL DATABASE; HOSPITAL; INTOXICATION; MIDDLE AGED; POISON CENTER; STATISTICS;

ACETAMINOPHEN; ADOLESCENT; ADULT; ADVERSE DRUG REACTION REPORTING SYSTEMS; AGED; CHILD; DATABASES, FACTUAL; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITALS; HUMANS; MALE; MIDDLE AGED; OVERDOSE; POISON CONTROL CENTERS; UNITED STATES;

EID: 33745779244     PISSN: 10538569     EISSN: 10991557     Source Type: Journal    
DOI: 10.1002/pds.1191     Document Type: Article

References (22)

1. Lee WM. Acetaminophen and the U.S. Acute Liver Failure Study Group: Lowering the risks of hepatic failure. Hepatology 2004; 40: 6-9.
2. Litovitz TL, Klein-Schwartz W, Rodgers GC, Jr, et al. 2001 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 2002; 20: 391-452.
3. Ostapowicz G, Fontana RJ, Schiodt FV, et al., U.S. Acute Liver Failure Study Group. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002; 137: 947-954.
4. Schiodt FV, Rochling AF, Casey DL, et al. Acetaminophen toxicity in an urban county hospital. N Engl J Med 1997; 337: 1112-1117.
5. Gyamlani GG, Parikh CR. Acetaminophen toxicity: Suicidal versus accidental. Critical Care 2002; 6: 155-159.
6. Bolesta S, Haber SL. Hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors. Ann Pharmacother 2002; 36: 331-333.
7. Kurtovic J, Riordan SM. Paracetamol-induced hepatotoxicity at recommended dosage. J Intern Med 2003; 253: 240-243.
8. Johnston SC, Pelletier LL. Enhanced hepatotoxicity of acetaminophen in alcoholic patient: Two case reports and a review of the literature. Medicine 1997; 70: 1855-1891.
9. Draganov P, Durrence H, Cox C, et al. Alcohol-acetaminophen syndrome: Even moderate social drinkers are at risk. Postgrad Med 2000; 107: 189-195.
10. Zimmerman HJ, Maddrey WC. Acetamninophen (Paracetamol) hepatotoxicity with regular intake of alcohol: Analysis of instances of therapeutic misadventure. Hepatotogy 1995; 22: 767-773.
11. Seeff LB, Cuccherini BA, Zimmerman HJ, et al. Actaminophen hepatotoxicity in alcoholics: A therapeutic misadventure. Ann Intern Med 1986; 104: 399-404.
12. Whitcomb DC, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994; 272: 1845-1850.
13. Pirotte JH. Apparent potentiation by phenobarbital of hepatotoxicity from small doses of acetaminophen. Ann Intern Med 1984; 101: 403.
14. Murphy R, Swartz R, Watkins PB. Severe acetaminophen toxicity in a patient receiving isoniazid. Ann Intern Med 1990; 113: 799-800.
15. National Hospital Ambulatory Medical Care Survey. Available at: ftp://ftp.cdc.gov/-pub/Health_Statistics/NCHS/Datasets/NHAMCS. Accessed February 18, 2005.
16. National Electronic Injury Surveillance System. Available at: http://www.cpsc.gov/cpscpub/pubs/3002.html. Accessed February 18, 2005.
17. National Hospital Discharge Survey Multi-Year Data File 1979-2000. CD-ROM Series 13 no. 20A issued June 2002. Department of Health and Human Services, Centers for Disease Control and Prevention. National Center for Health Statistics.
18. Mortality Data; Multiple Cause-of-Death Public-Use Data Files. Available at: www.cdc.gov/nchs/products/elec∥ods/subject/mortmcd.htm. Accessed at February 18, 2005.
19. Ahmad SR. Adverse drug event monitoring at the FDA: Your report can make a difference. J Gen Intern Med 2003; 18: 57-60.
20. Litovitz TL, Klein-Schwartz W, Dyer KS, et al, 1997 Annual report of the American association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 1998; 16: 443-497.
21. Paulose-Ram R, Hirsch R, Dillon C, Gu Q. Frequent monthly use of selected non-prescription and prescription non-narcotic analgesics among U.S. adults. Pharmacoepidemiologyemiology Drug Saf 2004; DOI:10.1002/ pds.983.
22. Paulose-Ram R, Hirsch R, Dillon C, et al. Prescription and non-prescription analgesic use among the US adult populations: Results from the third National Health and Nutrition Examination Survey (NHANES). Pharmacoepidemiologydemiology Drug Saf 2003; 12: 315-326.