A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway

British Journal of Pharmacology

Volumn 135, Issue 3, 2002, Pages 589-599

  Fiorucci, Stefano ^a   Antonelli, Elisabetta ^a   Mencarelli, Andrea ^a   Palazzetti, Barbara ^a   Alvarez Miller, Lorena ^b   Muscara, Marcelo ^b   Del Soldato, Piero ^c   Sanpaolo, Laura ^a   Wallace, John L ^b   Morelli, Antonio ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF CALGARY   (Canada)

^c NicOx SA   (France)

Author keywords

Acetaminophen; Cytokines; Fas; Fas ligand; Hepatitis B transgenic mice; Nitric oxide

Indexed keywords

ASPARTATE AMINOTRANSFERASE; ENDOTOXIN; FAS ANTIGEN; FAS LIGAND; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NCX 701; NITRIC OXIDE; PARACETAMOL; PARACETAMOL DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHRONIC LIVER DISEASE; DOSE RESPONSE; DRUG METABOLISM; DRUG OVERDOSE; DRUG SAFETY; DRUG STRUCTURE; FEVER; HEPATITIS B VIRUS; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETAMINOPHEN; ANIMALS; BODY TEMPERATURE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FAS LIGAND PROTEIN; LIVER; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; NITRIC OXIDE; NITRIC OXIDE DONORS; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 0036181113     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704500     Document Type: Article

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