Retinoid X Receptor α Regulates Glutathione Homeostasis and Xenobiotic Detoxification Processes in Mouse Liver

Molecular Pharmacology

Volumn 65, Issue 3, 2004, Pages 550-557

  Wu, Yong ^a   Zhang, Xiaoxue ^a   Bardag Gorce, Fawzia ^a   Robel, Rose C V ^a   Aguilo, Jonathan ^a   Chen, Lixin ^b   Zeng, Ying ^b   Hwang, Kelly ^a   French, Samuel W ^a   Lu, Shelly C ^b   Wan, Yu Jui Y ^c  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 3A1; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE MU; PARACETAMOL; RETINOID X RECEPTOR ALPHA; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DNA MICROARRAY; DRUG DETOXIFICATION; DRUG METABOLISM; GENE EXPRESSION; GENE TARGETING; GLUTATHIONE METABOLISM; LIVER CELL; LIVER METABOLISM; LIVER PROTECTION; LIVER TOXICITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL;

ACETAMINOPHEN; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; GLUTATHIONE; HEPATOCYTES; LIVER; METABOLIC DETOXICATION, DRUG; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS; XENOBIOTICS;

EID: 10744223848     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.3.550     Document Type: Article

References (36)

1. Barber T, Borras E, Torres L, Garcia C, Cabezuelo F, lloret A, Pallardo FV, and Vina JR (2000) Vitamin A deficiency causes oxidative damage to liver mitochondria in rats. Free Radic Biol Med 29:1-7.
2. Baxter SW, Thomas EJ, and Campbell IG (2001) GSTM1 null polymorphism and susceptibility to endometriosis and ovarian cancer. Carcinogenesis 22:63-65.
3. Bermano G, Nicol F, Dyer JA, Sunde RA, Bechett GJ, Arthur JR, and Hesketh JE (1995) Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochem J 311:425-430.
4. Bray BJ and Rosengren RJ (2001) Retinol potentiates acetaminophen-induced hepatotoxicity in the mouse: mechanistic studies. Toxicol Appl Pharmacol 173:129-136.
5. Cai Y, Konishi T, Han G, Campwala KH, French SW, and Wan YJ (2000) The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. Eur J Pharm Sci 15:89-96.
6. Cecchi C, Latorraca S, Sorbi S, Iantomasi T, Favilli F, Vincenzini MT, and Liguri G (1999) Glutathione level is altered in lymphoblasts from patients with familial Alzheimer's disease. Neurosci Lett 275:152-154.
7. Chang M and Reddy CC (1991) Active transcription of the selenium-dependent glutathione peroxidase gene in selenium-deficient rats. Biochem Biophys Res Commun 181:1431-1436.
8. Chen JD, Kubalak SW, and Chien KR (1998) Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development 125:1943-1949.
9. Chomczyuski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
10. Edwards MJ, Keller BJ, Kauffman FC, and Thurman RG (1993) The involvement of Kupffer cells in carbon tetrachloride toxicity. Toxicol Appl Pharmacol 119:275-279.
11. Gaitonde MK (1967) A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids. Biochem J 104:627-633.
12. Huang ZZ, Chen CJ, Zeng ZH, Yang HP, Oh J, Chen LX, and Lu SC (2001) Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration. FASEB J 15:19-21.
13. Huang ZZ, Li H, Cai J, Kuhlenkamp J, Kaplowitz N, and Lu SC (1998) Changes in glutathione homeostasis during liver regeneration in the rat. Hepatol 27:147-153.
14. Imai T, Jiang M, Kastner P, Chambon P, and Metzger D (2001) Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity. Proc Natl Acad Sci USA 98:4581-4586.
15. Kastner P, Grondona JM, Mark M, Gansmuller A, LeMeur M, Decimo D, Vonesch JL, Dolle P, and Chambon P (1994) Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell 78:987-1003.
16. Krezel W, Dupe V, Mark M, Dierich A, Kastner P, and Chambon P (1996) RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable. Proc Natl Acad Sci USA 93:9010-9014.
17. Liu J, Sendelbach LE, Parkinson A, and Klaassen CD (2000) Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression. Toxicol 147:167-176.
18. Lu SC (1999) Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J 13:1169-1183.
19. Mangelsdorf DJ and Evans RM (1995) The RXR heterodimers and orphan receptors. Cell 83:841-850.
20. Marc N, Galisteo M, Lagadic-Gossmann D, Fautrel A, Joannard F, Guillouzo A and Corcos L (2000) Regulation of phenobarbital induction of the cytochrome P450 2b9/10 genes in primary mouse hepatocyte culture. Involvement of calcium- and cAMP-dependent pathways. Eur J Biochem 267:963-970.
21. Merad-Boudia M, Nicole A, Santiard-Baron D, Saille C, and Ceballos-Picot I (1998) Mitocondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease. Biochem Pharmacol 56:645-655.
22. Moriarty PM, Reddy CC, and Maquat LE (1998) Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase I by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol Cell Biol 18:2932-2939.
23. Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, and Magnuson MA (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274:305-315.
24. Rahman I and MacNee W (2000) Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 16:534-554.
25. Sinclair J, Jeffery E, Wrighton S, Kostrubsky V, Szakacs J, Wood S, and Sinclair P (1998) Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A. Biochem Pharmacol 55:1557-1565.
26. Smith TJ, Liao A, Wang LD, Yang GY, Starcic S, Philbert MA, and Yang CS (1998) Characterization of xenobiotic-metabolizing enzymes and nitrosamine metabolism in the human esophagus. Carcinogenesis 19:667-672.
27. Snawder JE, Roe AL, Benson RW, and Roberts DW (1994) Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity. Biochem Biophys Res Commun 203:532-539.
28. Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27:502-522.
29. Toyoda H, Himeno S, and Imura N (1990) Regulation of glutathione peroxidase mRNA level by dietary selenium manipulation. Biochim Biophys Acta 1049:213-215.
30. Tuntaterdtum S, Chaudhary IP, Cibull M, Robertson LW, and Blouin RA (1993) Acetaminophen hepatotoxicity: influence of phenobarbital and beta-naphthoflavone treatment in obese and lean Zucker rats. Toxicol Appl Pharmacol 123:219-225.
31. Wan YJ, An D, Cai Y, Repa JJ, Chen THP, Flores M, Postic C, Magnuson MA, Chen J, Chien KR, et al. (2000a) Hepatocyte-specific mutation establishes retinoid X receptor α as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol 20:4436-4444.
32. Wan YJ, Cai Y, Lungo W, Fu P, Locker J, French S, and Sucov HM (2000b) Peroxisome proliferator-activated receptor α-mediated pathways are altered in hepatocyte-specific retinoid X receptor α-deficient mice. J Biol Chem 275:28285-28290.
33. Wan YJ, Han G, Cai Y, Dai T, Konishi T, and Leng AS (2003) Hepatocyte retinoid X receptor-alpha-deficient mice have reduced food intake, increased body weight and improved glucose tolerance. Endocrinol 144:605-611.
34. Yanagimoto T, Itoh S, Sawada M, and Kamataki T (1997) Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1. Arch Biochem Biophys 340:215-218.
35. Zhou T, Evans AA, London WT, Xia X, Zou H, Shen F, and Clapper ML (1997) Glutathione S-transferase expression in hepatitis B virus-associated human hepatocellular carcinogenesis. Cancer Res 57:2749-2753.
36. Zhang J, Huang W, Chua SS, Wei P, and Moore DD (2002) Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science (Wash DC) 298:422-424.