Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: Potential role of tumor necrosis factor-α and interleukin-10

Toxicology and Applied Pharmacology

Volumn 184, Issue 1, 2002, Pages 27-36

  Gardner, Carol R ^a   Laskin, Jeffrey D ^a   Dambach, Donna M ^a   Sacco, Michael ^a   Durham, Stephen K ^b   Bruno, Mary K ^c   Cohen, Steven D ^d   Gordon, Marion K ^a   Gerecke, Donald R ^a   Zhou, Peihong ^a   Laskin, Debra L ^a  

^a RUTGERS UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

^d MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

Acetaminophen; CTGF; IL 10; Liver; Macrophages; Nitric oxide; Peroxynitrite; TNF

Indexed keywords

3 NITROTYROSINE; CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE B; GLUTATHIONE; INTERLEUKIN 10; ISOENZYME; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PARACETAMOL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPLETION; GENE DISRUPTION; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; LIVER NECROSIS; LIVER TOXICITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAINING; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 0036408857     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(02)99474-3     Document Type: Article

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