Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury

Gene Therapy

Volumn 6, Issue 4, 1999, Pages 573-584

  Hogaboam, C M ^a   Simpson, K J ^a   Chensue, S W ^a,b   Steinhauser, M L ^a   Lukacs, N W ^a   Gauldie, J ^c   Strieter, R M ^a   Kunkel, S L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Acetaminophen; Acute liver injury; Adenovirus; Gene therapy; Macrophage inflammatory protein 2

Indexed keywords

ALPHA CHEMOKINE; AMINOTRANSFERASE; CHEMOKINE RECEPTOR; COMPLEMENTARY DNA; MACROPHAGE INFLAMMATORY PROTEIN 2; PARACETAMOL; VIRUS VECTOR;

ADENOVIRUS 5; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; GENE OVEREXPRESSION; GENE THERAPY; LIVER CELL DAMAGE; LIVER INJURY; LIVER PROTECTION; LIVER REGENERATION; LIVER TOXICITY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; VIRUS INFECTION;

ACETAMINOPHEN; ACUTE DISEASE; ADENOVIRIDAE; ANIMALS; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; LIVER; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; MONOKINES; NECROSIS; TRANSFECTION;

ADENOVIRIDAE; ANIMALIA; HUMAN ADENOVIRUS TYPE 5; RODENTIA;

EID: 0032931621     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300858     Document Type: Article

References (50)

1. Yang Y et al. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Therapy 1996; 3: 137-144.
2. Nielsen LL et al. Recombinant E1-deleted adenovirus-mediated gene therapy for cancer: efficacy of studies with p53 tumor suppressor gene and liver histology in tumor xenograft models. Hum Gen Ther 1998; 9: 681-694.
3. Bao JJ, Zhang WW, Kuo MT. Adenovirus delivery of recombinant DNA into transgenic mice bearing hepatocellular carcinomas. Hum Gene Ther 1996; 7: 355-365.
4. Castell JV et al. Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells. Gene Therapy 1997; 4: 455-464.
5. Raper SE, Wilson JM. Gene therapy for human liver disease. Prog Liver Dis 1995; 13: 201-230.
6. Yang Y et al. Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. J Virol 1996; 70: 6370-6377.
7. Kay MA et al. Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver. Proc Natl Acad Sci USA 1997; 94: 4686-4691.
8. Sullivan DE et al. Liver-directed gene transfer in non-human primates. Hum Gene Ther 1997; 8: 1195-1206.
9. Kwan D, Bartle WR, Walker SE. Abnormal serum transaminases following therapeutic doses of acetaminophen in the absence of known risk factors. Dig Dis Sci 1995; 40: 1951-1955.
10. Alison MR, Golding M, Sarraf CE. Liver stem cells: when the going gets tough they get going. Int J Exp Path 1997; 78: 365-381.
11. Kay MA, Fausto N. Liver regeneration: prospects for therapy based on new technologies. Mol Med Today 1997; 3: 108-115.
12. Louis H et al. Hepatoprotective role of interleukin 10 in galactosamine/ lipopolysaccharide mouse liver injury. Gastroenterology 1997; 112: 935-942.
13. Bruccoleri A et al. Induction of early-immediate genes by tumor necrosis factor alpha contribute to liver repair following chemical-induced hepatotoxicity. Hepatology 1997; 25: 133-141.
14. Renic M et al. The effect of interleukin-1 alpha on acetaminophen-induced hepatotoxicity. Cytokine 1993; 5: 192-197.
15. Tiggelman AM et al. Interleukin-6 production by human liver (myo)fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1 beta and TNF alpha. J Hepatol 1995; 23: 295-306.
16. Trautwein C et al. Concanavalin A-induced liver injury triggers hepatocyte proliferation. J Clin Invest 1998; 101: 1960-1969.
17. Strieter RM et al. 'The good, the bad, and the ugly.' The role of chemokines in models of human disease. J Immunol 1996; 156: 3583-3586.
18. Lentsch AB et al. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC (corrected and republished article originally printed in Hepatology 1998; 27: 507-512). Hepatology 1998; 27: 1172-1177.
19. Lentsch AB et al. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC (corrected and republished article originally printed in Hepatology 1998; 27: 507-512). Hepatology 1998; 27: 1172-1177.
20. Bautista AP. Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein-2 production and intercellular adhesion molecule-1 expression in the liver. Hepatology 1997; 25: 335-342.
21. Sprenger H et al. Induction of neutrophil-attracting chemokines in transforming rat hepatic stellate cells. Gastroenterology 1997; 113: 277-285.
22. Takada H et al. Chemotactic factors released from hepatocytes exposed to acetaminophen. Dig Dis Sci 1995; 40: 1831-1836.
23. Foley R et al. Adenoviral gene transfer of macrophage inflammatory protein-2 in rat lung. Am J Pathol 1996; 149: 1395-1403.
24. Bell MD et al. Recombinant human adenovirus with rat MIP-2 gene insertion causes prolonged PMN recruitment to the murine brain. Eur J Neurosci 1996; 8: 1803-1811.
25. Davern TJ, Scharschmidt BF. Gene therapy for liver disease. Dig Dis 1998; 16: 23-37.
26. Farrell GC. Drug-induced hepatic injury. J Gastroenterol Hepatol 1997; 12: S242-S250.
27. Fahey TJD et al. Cytokine production in a model of wound healing: the appearance of MIP-1, MIP-2, cachectin/TNF and IL-1. Cytokine 1990; 2: 92-99.
28. Huard J et al. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Therapy 1995; 2: 107-115.
29. Peeters MJ et al. Adenovirus-mediated hepatic gene transfer in mice: comparison of intravascular and biliary administration. Hum Gene Ther 1996; 7: 1693-1699.
30. Vickers SM et al. In vivo gene transfer to the human biliary tract. Gene Therapy 1996; 3: 825-828.
31. Bernal W et al. Use and outcome of liver transplantation in acetaminophen-induced acute liver failure. Hepatology 1998; 27: 1050-1055.
32. Makin AJ, Williams R. Acetaminophen-induced hepatotoxicity: predisposing factors and treatments. Adv Intern Med 1997; 42: 453-483.
33. Heubi JE, Barbacci MB, Zimmerman HJ. Therapeutic misadventures with acetaminophen: hepatotoxicity after multiple doses in children. J Pediatr 1998; 132: 22-27.
34. Lores Arnaiz S et al. Oxidative stress by acute acetaminophen administration in mouse liver. Free Rad Biol Med 1995; 19: 303-310.
35. Blazka ME et al. Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 1995; 133: 43-52.
36. Whitcomb DC, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994; 272: 1845-1850.
37. Chanda S et al. Stimulated hepatic tissue repair underlies heteroprotection by thioacetamide against acetaminophen-induced lethality. Hepatology 1995; 21: 477-486.
38. Arsura M et al. Nuclear factor-kappaB/Rel blocks transforming growth factor betal-induced apoptosis of murine hepatocyte cell lines. Cell Growth Diff 1997; 8: 1049-1059.
39. Frevert CW et al. Functional characterization of rat chemokine macrophage inflammatory protein-2. Inflammation 1995; 19: 133-142.
40. Cacalano G et al. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 1994; 265: 682-684.
41. Lee J et al. Chemokine binding and activities mediated by the mouse IL-8 receptor. J Immunol 1995; 155: 2158-2164.
42. Kulke R et al. The CXC receptor 2 is overexpressed in psoriatic epidermis. J Invest Dermatol 1998; 110: 90-94.
43. Sanchez X et al. CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2. J Immunol 1998; 160: 906-910.
44. Evanoff H et al. A sensitive ELISA for the detection of human monocyte chemoattractant protein-1 (MCP-1). Immunol Invest 1992; 21: 39-49.
45. Pessayre D et al. Effect of fasting on metabolite-mediated hepatotoxicity in the rat. Gastroenterology 1979; 77: 264-271.
46. Manautou JE et al. Protection by clofibrate against acetaminophen hepatotoxicity in male CD-1 mice is associated with an early increase in biliary concentration of acetaminophen-glutathione adducts. Toxicol Appl Pharmacol 1996; 140: 30-38.
47. Casley WL et al. Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains. Fund Appl Toxicol 1997; 40: 228-237.
48. Colletti LM et al. Chemokine expression during hepatic ischemia/reperfusion-induced lung injury in the rat. The role of epithelial neutrophil activating protein. J Clin Invest 1995; 95: 134-141.
49. Greenberger MJ et al. Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia. J Infect Dis 1996; 173: 159-165.
50. Hogaboam CM et al. Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease. J Clin Invest 1997; 100: 2766-2776.