Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse

Journal of Pharmaceutical and Biomedical Analysis

Volumn 35, Issue 1, 2004, Pages 93-105

  Coen, Muireann ^a   Ruepp, Stefan U ^b,c   Lindon, John C ^a   Nicholson, Jeremy K ^a   Pognan, François ^b   Lenz, Eva M ^b   Wilson, Ian D ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Acetaminophen; Alanine aminotransferase; ALT; Analysis of variance; ANOVA; APAP; Aspartate aminotransferase; AST; Carr Purcell Meiboom Gill; CPMG; EDTA; Ethylenediaminetetraacetic acid; Heteronuclear multiple quantum coherence; HMQC; Magic angle spinning; MAS; NCBI

Indexed keywords

ACETIC ACID; ALANINE; GLUCOSE; GLYCOGEN; LACTIC ACID; LIPID; PARACETAMOL; PYRUVIC ACID;

ANALYTIC METHOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; ENERGY METABOLISM; GENETIC TRANSCRIPTION; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLYCOGEN METABOLISM; GLYCOLYSIS; LACTATE BLOOD LEVEL; LIPID BLOOD LEVEL; LIPID METABOLISM; LIVER; LIVER METABOLISM; LIVER TOXICITY; METABOLISM; METABONOMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C FOS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSCRIPTOMICS;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ASPARTATE AMINOTRANSFERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; INJECTIONS, INTRAPERITONEAL; LIPID METABOLISM; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED STRAINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-FOS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TOXICITY TESTS;

EID: 1642345498     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2003.12.019     Document Type: Article

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