Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants

Toxicology and Applied Pharmacology

Volumn 191, Issue 3, 2003, Pages 211-226

  Limaye, Pallavi B ^a   Apte, Udayan M ^a   Shankar, Kartik ^a   Bucci, Thomas J ^b   Warbritton, Alan ^b   Mehendale, Harihara M ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Acetaminophen; Ca2+; Calpain; CCl4; Death proteins; Inhibitor of calpain; Liver injury progression; N CBZ Val Phe methyl ester

Indexed keywords

CALPAIN; CALPASTATIN; CARBON TETRACHLORIDE; PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD SAMPLING; CELL DEATH; CELL MEMBRANE PERMEABILITY; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE COURSE; ENZYME RELEASE; LETHAL DOSE; LETHALITY; LIVER CELL; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; RAT; SPECIES DIFFERENCE;

EID: 0042733742     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00250-3     Document Type: Conference Paper

References (43)

1. Arora A.S., de Groen P., Emori Y., Gores G.J. A cascade of degradative hydrolase activity contributes to hepatocyte necrosis during anoxia. Am. J. Physiol. 270:1996;G238-G245.
2. Berlett B.S., Stadtman E.R. Protein oxidation in aging, disease, and oxidative stress. J. Biol. Chem. 272:1997;20313-20316.
3. Bessems J.G., Vermeulen N.P. Paracetamol (acetaminophen)-induced toxicity molecular and biochemical mechanisms, analogues and protective approaches . Crit. Rev. Toxicol. 31:2001;55-138.
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
5. Cotran R.S., Kumar V., Collins T. Cellular pathology I Cell Injury and Cell Death . Cotran R.S., Kumar V., Collins T. Robbins Pathologic Basis of Disease. 1999;1-30 Saunders, Philadelphia.
6. Croall D.E., DeMartino G.N. Calcium-activated neutral protease (calpain) system structure, function, and regulation . Physiol. Rev. 71:1991;813-847.
7. Edelstein C.L. Rat renal proximal tubules, hypoxia, ionomycin, and calpain. Methods Mol. Biol. 144:2000;225-232.
8. elSisi A.E., Earnest D.L., Sipes I.G. Vitamin A potentiation of carbon tetrachloride hepatotoxicity enhanced lipid peroxidation without enhanced biotransformation . Toxicol. Appl. Pharmacol. 119:1993;289-294.
9. Farber J.L., Kyle M.E., Coleman J.B. Mechanisms of cell injury by activated oxygen species. Lab. Invest. 62:1990;609-670.
10. Greenwell A., Foley J.F., Maronpot R.R. An enhancement method for immunohistochemical staining of proliferating cell nuclear antigen in archival rodent tissues. Cancer Lett. 59:1991;251-256.
11. Guengerich F.P., Liebler D.C. Enzymatic activation of chemicals to toxic metabolites. Crit. Rev. Toxicol. 14:1985;259-307.
12. Holzbach R.T. Drug-induced liver disease. Primary Care. 8:1981;231-250.
13. Huang Y., Wang K.K. The calpain family and human disease. Trends Mol. Med. 7:2001;355-362.
14. Itturiaga H., Posalaki I., Rubin E. Aggravation of hepatic necrosis by lysosomal injury. Exp. Mol. Pathol. 10:1969;231-239.
15. Itturiaga, H., Vaisman, S., Eugenia, Pino, M.E., Pereda, T., 1971. Lysosomal injury and hepatic necrosis. Effects of triton WR-1339 on liver cells in the rat. Exp. Mol. Pathol. 14, 350-361.
16. Jollow D.J., Mitchell J.R., Potter W.Z., Davis D.C., Gillette J.R., Brodie B.B. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. 187:1973;195-202.
17. Kohli V., Madden J.F., Bentley R.C., Clavien P.A. Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. Gastroenterology. 116:1999;168-178.
18. Koop D.R. Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a. Mol. Pharmacol. 29:1986;399-404.
19. Kreamer B., Staecker J.L., Sawada N., Sattler G.L., Hsia M.T.S., Pitot H.C. Use of low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations. In Vitro Cell Dev. Biol. 22:1986;201-211.
20. Lawson J.A., Farhood A., Hopper R.D., Bajt M.L., Jaeschke H. The hepatic inflammatory response after acetaminophen overdose role of neutrophils . Toxicol. Sci. 54:2000;509-516.
21. Lesca P. Metabolic activation and toxicology - some models of chemical protection against drug toxicity. Toxicol. Eur. Res. 3:1981;161-166.
22. Mehendale H.M. Toxicodynamics of low level toxicant interactions of biological significance inhibition of tissue repair . Toxicology. 105:1995;251-266.
23. 4 by rats pretreated with chlordecone, mirex, or phenobarbital. Toxicol. Appl. Pharmacol. 93:1988;247-256.
24. Miyoshi H., Umeshita K., Sakon M., Imajoh-Ohmi S., Fujitani K., Gotoh M., Oiki E., Kambayashi J., Monden M. Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury. Gastroenterology. 110:1996;1897-1904.
25. Nakamura H., Nemenoff R.A., Gronich J.H., Bonventre J.V. Subcellular characteristics of phospholipase A2 activity in the rat kidney. Enhanced cytosolic, mitochondrial, and microsomal phospholipase A2 enzymatic activity after renal ischemia and reperfusion. J. Clin. Invest. 87:1991;1810-1818.
26. Osada J., Aylagas H., Miro-Obradors M.J., Palacios-Alaiz E. Alterations in lipid characteristics of lysosomes are involved in liver necrosis induced by thioacetamide. Biol. Chem. Hoppe. Seyler. 374:1993;129-132.
27. Parke D.V., Sapota A. Chemical toxicity and reactive oxygen species. Int. J. Occup. Med. Environ. Health. 9:1996;331-340.
28. Rami, A., Agarwal, R., Giovannina, Winckler, J. 2000. mu-Calpain activation, DNA fragmentation, and synergistic effect of caspase and calpain inhibitors in protecting hippcampal neurons from ischemic damage. Brain Res. 866, 299-312.
29. 4 hepatotoxicity a novel dose-response . Toxicology. 118:1997;181-193.
30. Ray S.A., Matzelle D.D., Wilford G.G., Hogan E.L., Banik N.L. Inhibition of calpain-mediated apoptosis by E-64 d-reduced immediate early gene (IEG) expression and reactive astrogliosis in the lesion and penumbra following spinal cord injury in rats. Brain Res. 916:2001;115-126.
31. Saido T.C., Sorimachi H., Suzuki K. Calpain new perspectives in molecular diversity and physiological-pathological involvement . FASEB J. 8:1994;814-822.
32. Schnellmann R.G., Williams S.W. Proteases in renal cell death calpains mediate cell death produced by diverse toxicants . Renal Failure. 20:1998;679-686.
33. Seglen P.O. Preparation of isolated rat liver cells. Methods Cell Biol. 13:1976;29-34.
34. Sindram D., Kohli V., Madden J.F., Clavien P.A. Calpain inhibition prevents sinusoidal endothelial cell apoptosis in the cold ischemic rat liver. Transplantation. 68:1999;136-140.
35. Slater T.F., Greenbaum A.L. Changes in lysosomal enzymes in acute experimental liver injury. Biochem. J. 96:1965;484-491.
36. Snyder J.W. Mechanisms of toxic cell injury. Clin. Lab. Med. 10:1990;311-321.
37. Soni M.G., Mangipudy R.S., Mumtaz M.M., Mehendale H.M. Tissue repair response as a function of dose during trichloroethylene hepatotoxicity. Toxicol. Sci. 42:1998;158-165.
38. Trump B.J., Berezesky I. The reactions of cells to lethal injury; oncosis and necrosis - the role of calcium. Lockshin R.A., Zakeri Z., Tilly J. When Cells Die - A Comprehensive Evaluation of Apoptosis and Programmed Cell Death. 1998;57-96 Wiley-Liss, New York.
39. Wang T., Shankar K., Ronis M.J., Mehendale H.M. Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1. J. Pharmacol. Exp. Ther. 294:2000;473-479.
40. Williams R.T. Detoxification Mechanisms. second ed. 1959;Wiley, New York.
41. Williams R.T. Nutrients in drug detoxification reactions. Hathcock J.N., Coon J. Nutrition and Drug Interrelations. 1978;Academic Press, New York.
42. Wong F.W., Chan W.Y., Lee S.S. Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol. Appl. Pharmacol. 153:1998;109-118.
43. Yuan Y., Dopheide S.M., Ivanidis C., Salem H.H., Jackson S.P. Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin alphaIIb beta3) in von Willebrand factor-induced signal transduction. J. Biol. Chem. 272:1997;21847-21854.