Alkylating DNA damage stimulates a regulated form of necrotic cell death

Genes and Development

Volumn 18, Issue 11, 2004, Pages 1272-1282

  Zong, Wei Xing ^a   Ditsworth, Dara ^a   Bauer, Daniel E ^a   Wang, Zhao Qi ^b   Thompson, Craig B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Alkylating DNA damage; Bak; Bax; Metabolism; Necrosis; p53; PARP

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALKYLATING AGENT; CHLORMETHINE; DNA; ETOPOSIDE; GLUCOSE; METHYLNITRONITROSOGUANIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAK; PROTEIN BAX; PROTEIN P53; RECOMBINANT INTERLEUKIN 3; RNA POLYMERASE; STAUROSPORINE; TRITIUM; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL FRACTIONATION; CELL METABOLISM; CONTROLLED STUDY; DNA ALKYLATION; DNA DAMAGE; GENE EXPRESSION; GLYCOLYSIS; MOUSE; NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL;

ADENOSINE TRIPHOSPHATE; ALKYLATING AGENTS; ANIMALS; BASE SEQUENCE; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELLS, CULTURED; DNA DAMAGE; ENZYME ACTIVATION; FIBROBLASTS; HMGB1 PROTEIN; INFLAMMATION; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; NAD; NECROSIS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 2642536197     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1199904     Document Type: Article

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