Role of CYP1A2 in the hepatotoxicity of acetaminophen: Investigations using Cyp1a2 null mice

Toxicology and Applied Pharmacology

Volumn 153, Issue 1, 1998, Pages 102-108

  Tonge, Robert P ^a,c   Kelly, Edward J ^a   Bruschi, Sam A ^a   Kalhorn, Tom ^a   Eaton, David L ^a   Nebert, Daniel W ^b   Nelson, Sidney D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Acetaminophen; APAP; Cyp1a2; Hepatotoxicity; Knockout mice; Protein adducts

Indexed keywords

BENZOQUINONE; GLUTATHIONE; PARACETAMOL; PHENACETIN O DEETHYLASE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INTOXICATION; FEVER; KNOCKOUT MOUSE; LIVER NECROSIS; LIVER TOXICITY; MALE; MOUSE; NONHUMAN;

ANIMALIA; MURINAE;

EID: 0032210807     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8543     Document Type: Article

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