-
1
-
-
0037059330
-
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
-
Aguirre, V., Werner, E.D., Giraud, J., Lee, Y.H., Shoelson, S.E., White, M.F., Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 277 (2002), 1531–1537.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1531-1537
-
-
Aguirre, V.1
Werner, E.D.2
Giraud, J.3
Lee, Y.H.4
Shoelson, S.E.5
White, M.F.6
-
2
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan, M.C., Hevener, A.L., Greten, F.R., Maeda, S., Li, Z.W., Long, J.M., Wynshaw-Boris, A., Poli, G., Olefsky, J., Karin, M., IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 11 (2005), 191–198.
-
(2005)
Nat. Med.
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
-
3
-
-
84890550163
-
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
-
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J.R., Pfeffer, K., Coffer, P.J., Rudensky, A.Y., Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504 (2013), 451–455.
-
(2013)
Nature
, vol.504
, pp. 451-455
-
-
Arpaia, N.1
Campbell, C.2
Fan, X.3
Dikiy, S.4
van der Veeken, J.5
deRoos, P.6
Liu, H.7
Cross, J.R.8
Pfeffer, K.9
Coffer, P.J.10
Rudensky, A.Y.11
-
4
-
-
84875809756
-
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation
-
Ballak, D.B., Stienstra, R., Hijmans, A., Joosten, L.A., Netea, M.G., Tack, C.J., Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation. Cytokine 62 (2013), 96–103.
-
(2013)
Cytokine
, vol.62
, pp. 96-103
-
-
Ballak, D.B.1
Stienstra, R.2
Hijmans, A.3
Joosten, L.A.4
Netea, M.G.5
Tack, C.J.6
-
5
-
-
0030615201
-
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases
-
Barnes, P.J., Karin, M., Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336 (1997), 1066–1071.
-
(1997)
N. Engl. J. Med.
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
6
-
-
84929087111
-
Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: a double-blinded, randomized, placebo controlled study
-
Bernstein, A.M., Roizen, M.F., Martinez, L., Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: a double-blinded, randomized, placebo controlled study. J. Clin. Lipidol. 8 (2014), 612–617.
-
(2014)
J. Clin. Lipidol.
, vol.8
, pp. 612-617
-
-
Bernstein, A.M.1
Roizen, M.F.2
Martinez, L.3
-
7
-
-
49749156584
-
Insulin antagonists, insulin antibodies and insulin resistance
-
Berson, S.A., Yalow, R.S., Insulin antagonists, insulin antibodies and insulin resistance. Am. J. Med. 25 (1958), 155–159.
-
(1958)
Am. J. Med.
, vol.25
, pp. 155-159
-
-
Berson, S.A.1
Yalow, R.S.2
-
8
-
-
0022371461
-
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
-
Beutler, B., Greenwald, D., Hulmes, J.D., Chang, M., Pan, Y.C., Mathison, J., Ulevitch, R., Cerami, A., Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 316 (1985), 552–554.
-
(1985)
Nature
, vol.316
, pp. 552-554
-
-
Beutler, B.1
Greenwald, D.2
Hulmes, J.D.3
Chang, M.4
Pan, Y.C.5
Mathison, J.6
Ulevitch, R.7
Cerami, A.8
-
9
-
-
84869227969
-
Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways
-
Bhargava, P., Li, C., Stanya, K.J., Jacobi, D., Dai, L., Liu, S., Gangl, M.R., Harn, D.A., Lee, C.H., Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways. Nat. Med. 18 (2012), 1665–1672.
-
(2012)
Nat. Med.
, vol.18
, pp. 1665-1672
-
-
Bhargava, P.1
Li, C.2
Stanya, K.J.3
Jacobi, D.4
Dai, L.5
Liu, S.6
Gangl, M.R.7
Harn, D.A.8
Lee, C.H.9
-
10
-
-
52749091008
-
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals
-
Boden, G., Duan, X., Homko, C., Molina, E.J., Song, W., Perez, O., Cheung, P., Merali, S., Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 57 (2008), 2438–2444.
-
(2008)
Diabetes
, vol.57
, pp. 2438-2444
-
-
Boden, G.1
Duan, X.2
Homko, C.3
Molina, E.J.4
Song, W.5
Perez, O.6
Cheung, P.7
Merali, S.8
-
11
-
-
84964681263
-
p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages
-
Boriushkin, E., Wang, J.J., Li, J., Bhatta, M., Zhang, S.X., p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages. Sci. Rep., 6, 2016, 25013.
-
(2016)
Sci. Rep.
, vol.6
, pp. 25013
-
-
Boriushkin, E.1
Wang, J.J.2
Li, J.3
Bhatta, M.4
Zhang, S.X.5
-
12
-
-
0036345297
-
Neutralization of tumor necrosis factor reverses age-induced impairment of insulin responsiveness in skeletal muscle of Sprague-Dawley rats
-
Borst, S.E., Bagby, G.J., Neutralization of tumor necrosis factor reverses age-induced impairment of insulin responsiveness in skeletal muscle of Sprague-Dawley rats. Metabolism 51 (2002), 1061–1064.
-
(2002)
Metabolism
, vol.51
, pp. 1061-1064
-
-
Borst, S.E.1
Bagby, G.J.2
-
13
-
-
84924969384
-
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
-
Brestoff, J.R., Kim, B.S., Saenz, S.A., Stine, R.R., Monticelli, L.A., Sonnenberg, G.F., Thome, J.J., Farber, D.L., Lutfy, K., Seale, P., Artis, D., Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519 (2015), 242–246.
-
(2015)
Nature
, vol.519
, pp. 242-246
-
-
Brestoff, J.R.1
Kim, B.S.2
Saenz, S.A.3
Stine, R.R.4
Monticelli, L.A.5
Sonnenberg, G.F.6
Thome, J.J.7
Farber, D.L.8
Lutfy, K.9
Seale, P.10
Artis, D.11
-
14
-
-
84954459329
-
Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes
-
Burak, M.F., Inouye, K.E., White, A., Lee, A., Tuncman, G., Calay, E.S., Sekiya, M., Tirosh, A., Eguchi, K., Birrane, G., Lightwood, D., Howells, L., Odede, G., Hailu, H., West, S., Garlish, R., Neale, H., Doyle, C., Moore, A., Hotamisligil, G.S., Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci. Trans. Med, 7, 2015, 319ra205.
-
(2015)
Sci. Trans. Med
, vol.7
, pp. 319ra205
-
-
Burak, M.F.1
Inouye, K.E.2
White, A.3
Lee, A.4
Tuncman, G.5
Calay, E.S.6
Sekiya, M.7
Tirosh, A.8
Eguchi, K.9
Birrane, G.10
Lightwood, D.11
Howells, L.12
Odede, G.13
Hailu, H.14
West, S.15
Garlish, R.16
Neale, H.17
Doyle, C.18
Moore, A.19
Hotamisligil, G.S.20
more..
-
15
-
-
84923647184
-
Inflammation and ER stress regulate branched-chain amino acid uptake and metabolism in adipocytes
-
Burrill, J.S., Long, E.K., Reilly, B., Deng, Y., Armitage, I.M., Scherer, P.E., Bernlohr, D.A., Inflammation and ER stress regulate branched-chain amino acid uptake and metabolism in adipocytes. Mol. Endocrinol. 29 (2015), 411–420.
-
(2015)
Mol. Endocrinol.
, vol.29
, pp. 411-420
-
-
Burrill, J.S.1
Long, E.K.2
Reilly, B.3
Deng, Y.4
Armitage, I.M.5
Scherer, P.E.6
Bernlohr, D.A.7
-
16
-
-
84889249320
-
The TSC-mTOR pathway regulates macrophage polarization
-
Byles, V., Covarrubias, A.J., Ben-Sahra, I., Lamming, D.W., Sabatini, D.M., Manning, B.D., Horng, T., The TSC-mTOR pathway regulates macrophage polarization. Nat. Commun., 4, 2013, 2834.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2834
-
-
Byles, V.1
Covarrubias, A.J.2
Ben-Sahra, I.3
Lamming, D.W.4
Sabatini, D.M.5
Manning, B.D.6
Horng, T.7
-
17
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai, D., Yuan, M., Frantz, D.F., Melendez, P.A., Hansen, L., Lee, J., Shoelson, S.E., Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Med. 11 (2005), 183–190.
-
(2005)
Nat. Med.
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
18
-
-
0035001446
-
Expression of suppressors of cytokine signaling during liver regeneration
-
Campbell, J.S., Prichard, L., Schaper, F., Schmitz, J., Stephenson-Famy, A., Rosenfeld, M.E., Argast, G.M., Heinrich, P.C., Fausto, N., Expression of suppressors of cytokine signaling during liver regeneration. J. Clin. Invest. 107 (2001), 1285–1292.
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 1285-1292
-
-
Campbell, J.S.1
Prichard, L.2
Schaper, F.3
Schmitz, J.4
Stephenson-Famy, A.5
Rosenfeld, M.E.6
Argast, G.M.7
Heinrich, P.C.8
Fausto, N.9
-
19
-
-
51549107903
-
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
-
Cao, H., Gerhold, K., Mayers, J.R., Wiest, M.M., Watkins, S.M., Hotamisligil, G.S., Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134 (2008), 933–944.
-
(2008)
Cell
, vol.134
, pp. 933-944
-
-
Cao, H.1
Gerhold, K.2
Mayers, J.R.3
Wiest, M.M.4
Watkins, S.M.5
Hotamisligil, G.S.6
-
20
-
-
84877292005
-
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production
-
Cao, H., Sekiya, M., Ertunc, M.E., Burak, M.F., Mayers, J.R., White, A., Inouye, K., Rickey, L.M., Ercal, B.C., Furuhashi, M., et al. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab. 17 (2013), 768–778.
-
(2013)
Cell Metab.
, vol.17
, pp. 768-778
-
-
Cao, H.1
Sekiya, M.2
Ertunc, M.E.3
Burak, M.F.4
Mayers, J.R.5
White, A.6
Inouye, K.7
Rickey, L.M.8
Ercal, B.C.9
Furuhashi, M.10
-
21
-
-
84944916392
-
Endoplasmic reticulum stress interacts with inflammation in human diseases
-
Cao, S.S., Luo, K.L., Shi, L., Endoplasmic reticulum stress interacts with inflammation in human diseases. J. Cell. Physiol. 231 (2016), 288–294.
-
(2016)
J. Cell. Physiol.
, vol.231
, pp. 288-294
-
-
Cao, S.S.1
Luo, K.L.2
Shi, L.3
-
22
-
-
0016723594
-
An endotoxin-induced serum factor that causes necrosis of tumors
-
Carswell, E.A., Old, L.J., Kassel, R.L., Green, S., Fiore, N., Williamson, B., An endotoxin-induced serum factor that causes necrosis of tumors. Proc. Natl. Acad. Sci. USA 72 (1975), 3666–3670.
-
(1975)
Proc. Natl. Acad. Sci. USA
, vol.72
, pp. 3666-3670
-
-
Carswell, E.A.1
Old, L.J.2
Kassel, R.L.3
Green, S.4
Fiore, N.5
Williamson, B.6
-
23
-
-
84859505396
-
TNF and EPO: major players in the innate immune response: their discovery
-
Cerami, A., TNF and EPO: major players in the innate immune response: their discovery. Ann. Rheum. Dis. 71:Suppl 2 (2012), i55–i59.
-
(2012)
Ann. Rheum. Dis.
, vol.71
, pp. i55-i59
-
-
Cerami, A.1
-
24
-
-
84862338510
-
Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4
-
Chang, Y.H., Ho, K.T., Lu, S.H., Huang, C.N., Shiau, M.Y., Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4. Int. J. Obes. 36 (2012), 993–998.
-
(2012)
Int. J. Obes.
, vol.36
, pp. 993-998
-
-
Chang, Y.H.1
Ho, K.T.2
Lu, S.H.3
Huang, C.N.4
Shiau, M.Y.5
-
25
-
-
84878831880
-
Posttranscriptional control of T cell effector function by aerobic glycolysis
-
Chang, C.H., Curtis, J.D., Maggi, L.B. Jr., Faubert, B., Villarino, A.V., O'Sullivan, D., Huang, S.C., van der Windt, G.J., Blagih, J., Qiu, J., et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153 (2013), 1239–1251.
-
(2013)
Cell
, vol.153
, pp. 1239-1251
-
-
Chang, C.H.1
Curtis, J.D.2
Maggi, L.B.3
Faubert, B.4
Villarino, A.V.5
O'Sullivan, D.6
Huang, S.C.7
van der Windt, G.J.8
Blagih, J.9
Qiu, J.10
-
26
-
-
84951031205
-
Macrophage and adipocyte IGF1 maintain adipose tissue homeostasis during metabolic stresses
-
Chang, H.R., Kim, H.J., Xu, X., Ferrante, A.W. Jr., Macrophage and adipocyte IGF1 maintain adipose tissue homeostasis during metabolic stresses. Obesity (Silver Spring) 24 (2016), 172–183.
-
(2016)
Obesity (Silver Spring)
, vol.24
, pp. 172-183
-
-
Chang, H.R.1
Kim, H.J.2
Xu, X.3
Ferrante, A.W.4
-
27
-
-
80355133234
-
Macrophage-mediated inflammation in metabolic disease
-
Chawla, A., Nguyen, K.D., Goh, Y.P., Macrophage-mediated inflammation in metabolic disease. Nat. Rev. Immunol. 11 (2011), 738–749.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 738-749
-
-
Chawla, A.1
Nguyen, K.D.2
Goh, Y.P.3
-
28
-
-
84992436129
-
Adipose tissue dendritic cells are independent contributors to obesity-induced inflammation and insulin resistance
-
Cho, K.W., Zamarron, B.F., Muir, L.A., Singer, K., Porsche, C.E., DelProposto, J.B., Geletka, L., Meyer, K.A., O'Rourke, R.W., Lumeng, C.N., Adipose tissue dendritic cells are independent contributors to obesity-induced inflammation and insulin resistance. J. Immunol. 197 (2016), 3650–3661.
-
(2016)
J. Immunol.
, vol.197
, pp. 3650-3661
-
-
Cho, K.W.1
Zamarron, B.F.2
Muir, L.A.3
Singer, K.4
Porsche, C.E.5
DelProposto, J.B.6
Geletka, L.7
Meyer, K.A.8
O'Rourke, R.W.9
Lumeng, C.N.10
-
29
-
-
85017514320
-
A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity
-
Chung, K.J., Chatzigeorgiou, A., Economopoulou, M., Garcia-Martin, R., Alexaki, V.I., Mitroulis, I., Nati, M., Gebler, J., Ziemssen, T., Goelz, S.E., et al. A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat. Immunol. 18 (2017), 654–664.
-
(2017)
Nat. Immunol.
, vol.18
, pp. 654-664
-
-
Chung, K.J.1
Chatzigeorgiou, A.2
Economopoulou, M.3
Garcia-Martin, R.4
Alexaki, V.I.5
Mitroulis, I.6
Nati, M.7
Gebler, J.8
Ziemssen, T.9
Goelz, S.E.10
-
30
-
-
84989846618
-
Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation
-
Çimen, I., Kocatürk, B., Koyuncu, S., Tufanlı, Ö., Onat, U.I., Yıldırım, A.D., Apaydın, O., Demirsoy, Ş., Aykut, Z.G., Nguyen, U.T., et al. Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation. Sci. Transl. Med., 8, 2016, 358ra126.
-
(2016)
Sci. Transl. Med.
, vol.8
, pp. 358ra126
-
-
Çimen, I.1
Kocatürk, B.2
Koyuncu, S.3
Tufanlı, Ö.4
Onat, U.I.5
Yıldırım, A.D.6
Apaydın, O.7
Demirsoy, Ş.8
Aykut, Z.G.9
Nguyen, U.T.10
-
31
-
-
39849107173
-
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver
-
Cintra, D.E., Pauli, J.R., Araújo, E.P., Moraes, J.C., de Souza, C.T., Milanski, M., Morari, J., Gambero, A., Saad, M.J., Velloso, L.A., Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J. Hepatol. 48 (2008), 628–637.
-
(2008)
J. Hepatol.
, vol.48
, pp. 628-637
-
-
Cintra, D.E.1
Pauli, J.R.2
Araújo, E.P.3
Moraes, J.C.4
de Souza, C.T.5
Milanski, M.6
Morari, J.7
Gambero, A.8
Saad, M.J.9
Velloso, L.A.10
-
32
-
-
84892702771
-
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
-
Cohen, P., Levy, J.D., Zhang, Y., Frontini, A., Kolodin, D.P., Svensson, K.J., Lo, J.C., Zeng, X., Ye, L., Khandekar, M.J., et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156 (2014), 304–316.
-
(2014)
Cell
, vol.156
, pp. 304-316
-
-
Cohen, P.1
Levy, J.D.2
Zhang, Y.3
Frontini, A.4
Kolodin, D.P.5
Svensson, K.J.6
Lo, J.C.7
Zeng, X.8
Ye, L.9
Khandekar, M.J.10
-
33
-
-
84866122780
-
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
-
Copps, K.D., White, M.F., Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 55 (2012), 2565–2582.
-
(2012)
Diabetologia
, vol.55
, pp. 2565-2582
-
-
Copps, K.D.1
White, M.F.2
-
34
-
-
0025224239
-
The growth factor-like effects of tumor necrosis factor-alpha. Stimulation of glucose transport activity and induction of glucose transporter and immediate early gene expression in 3T3-L1 preadipocytes
-
Cornelius, P., Marlowe, M., Lee, M.D., Pekala, P.H., The growth factor-like effects of tumor necrosis factor-alpha. Stimulation of glucose transport activity and induction of glucose transporter and immediate early gene expression in 3T3-L1 preadipocytes. J. Biol. Chem. 265 (1990), 20506–20516.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 20506-20516
-
-
Cornelius, P.1
Marlowe, M.2
Lee, M.D.3
Pekala, P.H.4
-
35
-
-
84983627791
-
TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice
-
da Costa, R.M., Neves, K.B., Mestriner, F.L., Louzada-Junior, P., Bruder-Nascimento, T., Tostes, R.C., TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice. Cardiovasc. Diabetol., 15, 2016, 119.
-
(2016)
Cardiovasc. Diabetol.
, vol.15
, pp. 119
-
-
da Costa, R.M.1
Neves, K.B.2
Mestriner, F.L.3
Louzada-Junior, P.4
Bruder-Nascimento, T.5
Tostes, R.C.6
-
36
-
-
84938746413
-
Blocking high-fat diet-induced obesity, insulin resistance and fatty liver by overexpression of Il-13 gene in mice
-
Darkhal, P., Gao, M., Ma, Y., Liu, D., Blocking high-fat diet-induced obesity, insulin resistance and fatty liver by overexpression of Il-13 gene in mice. Int. J. Obes. 39 (2015), 1292–1299.
-
(2015)
Int. J. Obes.
, vol.39
, pp. 1292-1299
-
-
Darkhal, P.1
Gao, M.2
Ma, Y.3
Liu, D.4
-
37
-
-
44449110675
-
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
-
Davis, J.E., Gabler, N.K., Walker-Daniels, J., Spurlock, M.E., Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 16 (2008), 1248–1255.
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 1248-1255
-
-
Davis, J.E.1
Gabler, N.K.2
Walker-Daniels, J.3
Spurlock, M.E.4
-
38
-
-
24944438230
-
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
-
De Souza, C.T., Araujo, E.P., Bordin, S., Ashimine, R., Zollner, R.L., Boschero, A.C., Saad, M.J., Velloso, L.A., Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146 (2005), 4192–4199.
-
(2005)
Endocrinology
, vol.146
, pp. 4192-4199
-
-
De Souza, C.T.1
Araujo, E.P.2
Bordin, S.3
Ashimine, R.4
Zollner, R.L.5
Boschero, A.C.6
Saad, M.J.7
Velloso, L.A.8
-
39
-
-
84875548030
-
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
-
DeFuria, J., Belkina, A.C., Jagannathan-Bogdan, M., Snyder-Cappione, J., Carr, J.D., Nersesova, Y.R., Markham, D., Strissel, K.J., Watkins, A.A., Zhu, M., et al. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc. Natl. Acad. Sci. USA 110 (2013), 5133–5138.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 5133-5138
-
-
DeFuria, J.1
Belkina, A.C.2
Jagannathan-Bogdan, M.3
Snyder-Cappione, J.4
Carr, J.D.5
Nersesova, Y.R.6
Markham, D.7
Strissel, K.J.8
Watkins, A.A.9
Zhu, M.10
-
40
-
-
84901920026
-
Targeting inflammation in the treatment of type 2 diabetes: time to start
-
Donath, M.Y., Targeting inflammation in the treatment of type 2 diabetes: time to start. Nat. Rev. Drug Discov. 13 (2014), 465–476.
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 465-476
-
-
Donath, M.Y.1
-
41
-
-
0021248402
-
Insulin receptors in acute infection: a study of factors conferring insulin resistance
-
Drobny, E.C., Abramson, E.C., Baumann, G., Insulin receptors in acute infection: a study of factors conferring insulin resistance. J. Clin. Endocrinol. Metab. 58 (1984), 710–716.
-
(1984)
J. Clin. Endocrinol. Metab.
, vol.58
, pp. 710-716
-
-
Drobny, E.C.1
Abramson, E.C.2
Baumann, G.3
-
42
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Düvel, K., Yecies, J.L., Menon, S., Raman, P., Lipovsky, A.I., Souza, A.L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 39 (2010), 171–183.
-
(2010)
Mol. Cell
, vol.39
, pp. 171-183
-
-
Düvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.8
Gorski, R.9
Cleaver, S.10
-
43
-
-
77954594076
-
Weitere mitteillungen uber die behandlung des diabetes mellitus mot carbisaure nebst bemerkunger uber die anwendung der salicylsaure bie dieser krankheit
-
Ebstein, W.M.J., Weitere mitteillungen uber die behandlung des diabetes mellitus mot carbisaure nebst bemerkunger uber die anwendung der salicylsaure bie dieser krankheit. Berl. Klin. Wochenschr. 13 (1876), 53–56.
-
(1876)
Berl. Klin. Wochenschr.
, vol.13
, pp. 53-56
-
-
Ebstein, W.M.J.1
-
44
-
-
84859449180
-
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation
-
Eguchi, K., Manabe, I., Oishi-Tanaka, Y., Ohsugi, M., Kono, N., Ogata, F., Yagi, N., Ohto, U., Kimoto, M., Miyake, K., Tobe, K., Arai, H., Kadowaki, T., Nagai, R., Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell. Met. 15 (2012), 518–533.
-
(2012)
Cell. Met.
, vol.15
, pp. 518-533
-
-
Eguchi, K.1
Manabe, I.2
Oishi-Tanaka, Y.3
Ohsugi, M.4
Kono, N.5
Ogata, F.6
Yagi, N.7
Ohto, U.8
Kimoto, M.9
Miyake, K.10
Tobe, K.11
Arai, H.12
Kadowaki, T.13
Nagai, R.14
-
45
-
-
34548431826
-
Increased number of islet-associated macrophages in type 2 diabetes
-
Ehses, J.A., Perren, A., Eppler, E., Ribaux, P., Pospisilik, J.A., Maor-Cahn, R., Gueripel, X., Ellingsgaard, H., Schneider, M.K., Biollaz, G., et al. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 56 (2007), 2356–2370.
-
(2007)
Diabetes
, vol.56
, pp. 2356-2370
-
-
Ehses, J.A.1
Perren, A.2
Eppler, E.3
Ribaux, P.4
Pospisilik, J.A.5
Maor-Cahn, R.6
Gueripel, X.7
Ellingsgaard, H.8
Schneider, M.K.9
Biollaz, G.10
-
46
-
-
84959370450
-
Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells
-
Eisenbarth, S.C., Williams, A., Colegio, O.R., Meng, H., Strowig, T., Rongvaux, A., Henao-Mejia, J., Thaiss, C.A., Joly, S., Gonzalez, D.G., et al. Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature, 530, 2016, 504.
-
(2016)
Nature
, vol.530
, pp. 504
-
-
Eisenbarth, S.C.1
Williams, A.2
Colegio, O.R.3
Meng, H.4
Strowig, T.5
Rongvaux, A.6
Henao-Mejia, J.7
Thaiss, C.A.8
Joly, S.9
Gonzalez, D.G.10
-
47
-
-
71549152580
-
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
-
Erbay, E., Babaev, V.R., Mayers, J.R., Makowski, L., Charles, K.N., Snitow, M.E., Fazio, S., Wiest, M.M., Watkins, S.M., Linton, M.F., Hotamisligil, G.S., Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat. Med. 15 (2009), 1383–1391.
-
(2009)
Nat. Med.
, vol.15
, pp. 1383-1391
-
-
Erbay, E.1
Babaev, V.R.2
Mayers, J.R.3
Makowski, L.4
Charles, K.N.5
Snitow, M.E.6
Fazio, S.7
Wiest, M.M.8
Watkins, S.M.9
Linton, M.F.10
Hotamisligil, G.S.11
-
48
-
-
84896654124
-
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation
-
Everts, B., Amiel, E., Huang, S.C., Smith, A.M., Chang, C.H., Lam, W.Y., Redmann, V., Freitas, T.C., Blagih, J., van der Windt, G.J., et al. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation. Nat. Immunol. 15 (2014), 323–332.
-
(2014)
Nat. Immunol.
, vol.15
, pp. 323-332
-
-
Everts, B.1
Amiel, E.2
Huang, S.C.3
Smith, A.M.4
Chang, C.H.5
Lam, W.Y.6
Redmann, V.7
Freitas, T.C.8
Blagih, J.9
van der Windt, G.J.10
-
49
-
-
0032917633
-
Leptin deficiency enhances sensitivity to endotoxin-induced lethality
-
Faggioni, R., Fantuzzi, G., Gabay, C., Moser, A., Dinarello, C.A., Feingold, K.R., Grunfeld, C., Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am. J. Physiol. 276 (1999), R136–R142.
-
(1999)
Am. J. Physiol.
, vol.276
, pp. R136-R142
-
-
Faggioni, R.1
Fantuzzi, G.2
Gabay, C.3
Moser, A.4
Dinarello, C.A.5
Feingold, K.R.6
Grunfeld, C.7
-
50
-
-
84976323804
-
Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes
-
Fan, R., Toubal, A., Goñi, S., Drareni, K., Huang, Z., Alzaid, F., Ballaire, R., Ancel, P., Liang, N., Damdimopoulos, A., et al. Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. Nat. Med. 22 (2016), 780–791.
-
(2016)
Nat. Med.
, vol.22
, pp. 780-791
-
-
Fan, R.1
Toubal, A.2
Goñi, S.3
Drareni, K.4
Huang, Z.5
Alzaid, F.6
Ballaire, R.7
Ancel, P.8
Liang, N.9
Damdimopoulos, A.10
-
51
-
-
0024516278
-
Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia
-
Feingold, K.R., Soued, M., Staprans, I., Gavin, L.A., Donahue, M.E., Huang, B.J., Moser, A.H., Gulli, R., Grunfeld, C., Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia. J. Clin. Invest. 83 (1989), 1116–1121.
-
(1989)
J. Clin. Invest.
, vol.83
, pp. 1116-1121
-
-
Feingold, K.R.1
Soued, M.2
Staprans, I.3
Gavin, L.A.4
Donahue, M.E.5
Huang, B.J.6
Moser, A.H.7
Gulli, R.8
Grunfeld, C.9
-
52
-
-
0027332738
-
Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates
-
Feinstein, R., Kanety, H., Papa, M.Z., Lunenfeld, B., Karasik, A., Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J. Biol. Chem. 268 (1993), 26055–26058.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 26055-26058
-
-
Feinstein, R.1
Kanety, H.2
Papa, M.Z.3
Lunenfeld, B.4
Karasik, A.5
-
53
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A.B., Benoist, C., Shoelson, S., Mathis, D., Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15 (2009), 930–939.
-
(2009)
Nat. Med.
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
Herrero, L.2
Cipolletta, D.3
Naaz, A.4
Wong, J.5
Nayer, A.6
Lee, J.7
Goldfine, A.B.8
Benoist, C.9
Shoelson, S.10
Mathis, D.11
-
54
-
-
68549130286
-
The role of interleukins in insulin resistance and type 2 diabetes mellitus
-
Fève, B., Bastard, J.P., The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 5 (2009), 305–311.
-
(2009)
Nat. Rev. Endocrinol.
, vol.5
, pp. 305-311
-
-
Fève, B.1
Bastard, J.P.2
-
55
-
-
85017520090
-
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
-
Fischer, K., Ruiz, H.H., Jhun, K., Finan, B., Oberlin, D.J., van der Heide, V., Kalinovich, A.V., Petrovic, N., Wolf, Y., Clemmensen, C., et al. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nat. Med. 23 (2017), 623–630.
-
(2017)
Nat. Med.
, vol.23
, pp. 623-630
-
-
Fischer, K.1
Ruiz, H.H.2
Jhun, K.3
Finan, B.4
Oberlin, D.J.5
van der Heide, V.6
Kalinovich, A.V.7
Petrovic, N.8
Wolf, Y.9
Clemmensen, C.10
-
56
-
-
33645554438
-
Transitory diabetic syndrome associated with meningococcic meningitis
-
Fox, M.J., Kuzma, J.F., Washam, W.T., Transitory diabetic syndrome associated with meningococcic meningitis. Arch. Intern. Med. (Chic.) 79 (1947), 614–621.
-
(1947)
Arch. Intern. Med. (Chic.)
, vol.79
, pp. 614-621
-
-
Fox, M.J.1
Kuzma, J.F.2
Washam, W.T.3
-
57
-
-
84872660747
-
Immunometabolism of AMPK in insulin resistance and atherosclerosis
-
Fullerton, M.D., Steinberg, G.R., Schertzer, J.D., Immunometabolism of AMPK in insulin resistance and atherosclerosis. Mol. Cell. Endocrinol. 366 (2013), 224–234.
-
(2013)
Mol. Cell. Endocrinol.
, vol.366
, pp. 224-234
-
-
Fullerton, M.D.1
Steinberg, G.R.2
Schertzer, J.D.3
-
58
-
-
46749084688
-
Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice
-
Furuhashi, M., Fucho, R., Görgün, C.Z., Tuncman, G., Cao, H., Hotamisligil, G.S., Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J. Clin. Invest. 118 (2008), 2640–2650.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2640-2650
-
-
Furuhashi, M.1
Fucho, R.2
Görgün, C.Z.3
Tuncman, G.4
Cao, H.5
Hotamisligil, G.S.6
-
59
-
-
84890564250
-
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
-
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T.A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504 (2013), 446–450.
-
(2013)
Nature
, vol.504
, pp. 446-450
-
-
Furusawa, Y.1
Obata, Y.2
Fukuda, S.3
Endo, T.A.4
Nakato, G.5
Takahashi, D.6
Nakanishi, Y.7
Uetake, C.8
Kato, K.9
Kato, T.10
-
60
-
-
84961994260
-
Non-canonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion
-
Fuster, J.J., Zuriaga, M.A., Thi-Minh Ngo, D., Farb, M.G., Aprahamian, T., Yamaguchi, T.P., Gokce, N., Walsh, K., Non-canonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes 64 (2015), 1235–1248.
-
(2015)
Diabetes
, vol.64
, pp. 1235-1248
-
-
Fuster, J.J.1
Zuriaga, M.A.2
Thi-Minh Ngo, D.3
Farb, M.G.4
Aprahamian, T.5
Yamaguchi, T.P.6
Gokce, N.7
Walsh, K.8
-
61
-
-
84055190798
-
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
-
Galic, S., Fullerton, M.D., Schertzer, J.D., Sikkema, S., Marcinko, K., Walkley, C.R., Izon, D., Honeyman, J., Chen, Z.P., van Denderen, B.J., et al. Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J. Clin. Invest. 121 (2011), 4903–4915.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4903-4915
-
-
Galic, S.1
Fullerton, M.D.2
Schertzer, J.D.3
Sikkema, S.4
Marcinko, K.5
Walkley, C.R.6
Izon, D.7
Honeyman, J.8
Chen, Z.P.9
van Denderen, B.J.10
-
62
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
-
Gao, Z., Hwang, D., Bataille, F., Lefevre, M., York, D., Quon, M.J., Ye, J., Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J. Biol. Chem. 277 (2002), 48115–48121.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
Hwang, D.2
Bataille, F.3
Lefevre, M.4
York, D.5
Quon, M.J.6
Ye, J.7
-
63
-
-
85029575247
-
Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome
-
eaai7616
-
Ghazarian, M., Revelo, X.S., Nøhr, M.K., Luck, H., Zeng, K., Lei, H., Tsai, S., Schroer, S.A., Park, Y.J., Chng, M.H.Y., Shen, L., D'Angelo, J.A., et al. Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome. Sci. Immunol, 2, 2017, 10.1126/sciimmunol.aai7616 eaai7616.
-
(2017)
Sci. Immunol
, vol.2
-
-
Ghazarian, M.1
Revelo, X.S.2
Nøhr, M.K.3
Luck, H.4
Zeng, K.5
Lei, H.6
Tsai, S.7
Schroer, S.A.8
Park, Y.J.9
Chng, M.H.Y.10
Shen, L.11
D'Angelo, J.A.12
-
64
-
-
84904173553
-
Metabolism of stromal and immune cells in health and disease
-
Ghesquière, B., Wong, B.W., Kuchnio, A., Carmeliet, P., Metabolism of stromal and immune cells in health and disease. Nature 511 (2014), 167–176.
-
(2014)
Nature
, vol.511
, pp. 167-176
-
-
Ghesquière, B.1
Wong, B.W.2
Kuchnio, A.3
Carmeliet, P.4
-
65
-
-
84959320195
-
p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration
-
González-Terán, B., Matesanz, N., Nikolic, I., Verdugo, M.A., Sreeramkumar, V., Hernández-Cosido, L., Mora, A., Crainiciuc, G., Sáiz, M.L., Bernardo, E., et al. p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration. EMBO J. 35 (2016), 536–552.
-
(2016)
EMBO J.
, vol.35
, pp. 536-552
-
-
González-Terán, B.1
Matesanz, N.2
Nikolic, I.3
Verdugo, M.A.4
Sreeramkumar, V.5
Hernández-Cosido, L.6
Mora, A.7
Crainiciuc, G.8
Sáiz, M.L.9
Bernardo, E.10
-
66
-
-
33745095399
-
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
-
Graham, T.E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T.P., Henry, R.R., Wason, C.J., Oberbach, A., Jansson, P.A., Smith, U., Kahn, B.B., Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N. Engl. J. Med. 354 (2006), 2552–2563.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 2552-2563
-
-
Graham, T.E.1
Yang, Q.2
Blüher, M.3
Hammarstedt, A.4
Ciaraldi, T.P.5
Henry, R.R.6
Wason, C.J.7
Oberbach, A.8
Jansson, P.A.9
Smith, U.10
Kahn, B.B.11
-
67
-
-
0032813549
-
Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic mice
-
Green, E.A., Flavell, R.A., Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic mice. Immunol. Rev. 169 (1999), 11–22.
-
(1999)
Immunol. Rev.
, vol.169
, pp. 11-22
-
-
Green, E.A.1
Flavell, R.A.2
-
68
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
-
Griffin, M.E., Marcucci, M.J., Cline, G.W., Bell, K., Barucci, N., Lee, D., Goodyear, L.J., Kraegen, E.W., White, M.F., Shulman, G.I., Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48 (1999), 1270–1274.
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
Bell, K.4
Barucci, N.5
Lee, D.6
Goodyear, L.J.7
Kraegen, E.W.8
White, M.F.9
Shulman, G.I.10
-
69
-
-
0013893516
-
Pathological changes in adipose tissue of obese mice
-
Hausberger, F.X., Pathological changes in adipose tissue of obese mice. Anat. Rec. 154 (1966), 651–660.
-
(1966)
Anat. Rec.
, vol.154
, pp. 651-660
-
-
Hausberger, F.X.1
-
70
-
-
0013844346
-
Studies in obese-hyperglycemic mice
-
Hellman, B., Studies in obese-hyperglycemic mice. Ann. N Y Acad. Sci. 131 (1965), 541–558.
-
(1965)
Ann. N Y Acad. Sci.
, vol.131
, pp. 541-558
-
-
Hellman, B.1
-
71
-
-
0016590392
-
Effect of tumour necrosis factor on cultured human melanoma cells
-
Helson, L., Green, S., Carswell, E., Old, L.J., Effect of tumour necrosis factor on cultured human melanoma cells. Nature 258 (1975), 731–732.
-
(1975)
Nature
, vol.258
, pp. 731-732
-
-
Helson, L.1
Green, S.2
Carswell, E.3
Old, L.J.4
-
72
-
-
84894196760
-
Inflammasomes and metabolic disease
-
Henao-Mejia, J., Elinav, E., Thaiss, C.A., Flavell, R.A., Inflammasomes and metabolic disease. Annu. Rev. Physiol. 76 (2014), 57–78.
-
(2014)
Annu. Rev. Physiol.
, vol.76
, pp. 57-78
-
-
Henao-Mejia, J.1
Elinav, E.2
Thaiss, C.A.3
Flavell, R.A.4
-
73
-
-
84879098248
-
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis
-
Hett, E.C., Slater, L.H., Mark, K.G., Kawate, T., Monks, B.G., Stutz, A., Latz, E., Hung, D.T., Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat. Chem. Biol. 9 (2013), 398–405.
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 398-405
-
-
Hett, E.C.1
Slater, L.H.2
Mark, K.G.3
Kawate, T.4
Monks, B.G.5
Stutz, A.6
Latz, E.7
Hung, D.T.8
-
74
-
-
84911164076
-
A decade of progress in adipose tissue macrophage biology
-
Hill, A.A., Reid Bolus, W., Hasty, A.H., A decade of progress in adipose tissue macrophage biology. Immunol. Rev. 262 (2014), 134–152.
-
(2014)
Immunol. Rev.
, vol.262
, pp. 134-152
-
-
Hill, A.A.1
Reid Bolus, W.2
Hasty, A.H.3
-
75
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C.Z., Uysal, K.T., Maeda, K., Karin, M., Hotamisligil, G.S., A central role for JNK in obesity and insulin resistance. Nature 420 (2002), 333–336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Görgün, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
76
-
-
70350561703
-
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle
-
Hong, E.G., Ko, H.J., Cho, Y.R., Kim, H.J., Ma, Z., Yu, T.Y., Friedline, R.H., Kurt-Jones, E., Finberg, R., Fischer, M.A., et al. Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes 58 (2009), 2525–2535.
-
(2009)
Diabetes
, vol.58
, pp. 2525-2535
-
-
Hong, E.G.1
Ko, H.J.2
Cho, Y.R.3
Kim, H.J.4
Ma, Z.5
Yu, T.Y.6
Friedline, R.H.7
Kurt-Jones, E.8
Finberg, R.9
Fischer, M.A.10
-
77
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil, G.S., Inflammation and metabolic disorders. Nature 444 (2006), 860–867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
78
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil, G.S., Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140 (2010), 900–917.
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
79
-
-
85012115740
-
Inflammation, metaflammation and immunometabolic disorders
-
Hotamisligil, G.S., Inflammation, metaflammation and immunometabolic disorders. Nature 542 (2017), 177–185.
-
(2017)
Nature
, vol.542
, pp. 177-185
-
-
Hotamisligil, G.S.1
-
80
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
-
Hotamisligil, G.S., Shargill, N.S., Spiegelman, B.M., Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (1993), 87–91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
81
-
-
0028362194
-
Tumor necrosis factor alpha inhibits signaling from the insulin receptor
-
Hotamisligil, G.S., Murray, D.L., Choy, L.N., Spiegelman, B.M., Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc. Natl. Acad. Sci. USA 91 (1994), 4854–4858.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4854-4858
-
-
Hotamisligil, G.S.1
Murray, D.L.2
Choy, L.N.3
Spiegelman, B.M.4
-
82
-
-
0028931724
-
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
-
Hotamisligil, G.S., Arner, P., Caro, J.F., Atkinson, R.L., Spiegelman, B.M., Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 95 (1995), 2409–2415.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2409-2415
-
-
Hotamisligil, G.S.1
Arner, P.2
Caro, J.F.3
Atkinson, R.L.4
Spiegelman, B.M.5
-
83
-
-
0030061922
-
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
-
Hotamisligil, G.S., Peraldi, P., Budavari, A., Ellis, R., White, M.F., Spiegelman, B.M., IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271 (1996), 665–668.
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
White, M.F.5
Spiegelman, B.M.6
-
84
-
-
84860200109
-
Association between tumor necrosis factor-α-308G/A polymorphism and obstructive sleep apnea: a meta-analysis
-
Huang, J., Liao, N., Huang, Q.P., Xie, Z.F., Association between tumor necrosis factor-α-308G/A polymorphism and obstructive sleep apnea: a meta-analysis. Genet. Test. Mol. Biomarkers 16 (2012), 246–251.
-
(2012)
Genet. Test. Mol. Biomarkers
, vol.16
, pp. 246-251
-
-
Huang, J.1
Liao, N.2
Huang, Q.P.3
Xie, Z.F.4
-
85
-
-
84862637344
-
Myeloid heme oxygenase-1 haploinsufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration in mice
-
Huang, J.Y., Chiang, M.T., Yet, S.F., Chau, L.Y., Myeloid heme oxygenase-1 haploinsufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration in mice. PLoS ONE, 7, 2012, e38626.
-
(2012)
PLoS ONE
, vol.7
, pp. e38626
-
-
Huang, J.Y.1
Chiang, M.T.2
Yet, S.F.3
Chau, L.Y.4
-
86
-
-
84858285593
-
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
-
Ichimura, A., Hirasawa, A., Poulain-Godefroy, O., Bonnefond, A., Hara, T., Yengo, L., Kimura, I., Leloire, A., Liu, N., Iida, K., et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483 (2012), 350–354.
-
(2012)
Nature
, vol.483
, pp. 350-354
-
-
Ichimura, A.1
Hirasawa, A.2
Poulain-Godefroy, O.3
Bonnefond, A.4
Hara, T.5
Yengo, L.6
Kimura, I.7
Leloire, A.8
Liu, N.9
Iida, K.10
-
87
-
-
85018784717
-
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages
-
Ip, W.K.E., Hoshi, N., Shouval, D.S., Snapper, S., Medzhitov, R., Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science 356 (2017), 513–519.
-
(2017)
Science
, vol.356
, pp. 513-519
-
-
Ip, W.K.E.1
Hoshi, N.2
Shouval, D.S.3
Snapper, S.4
Medzhitov, R.5
-
88
-
-
0025020303
-
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1
-
Jacob, C.O., Aiso, S., Michie, S.A., McDevitt, H.O., Acha-Orbea, H., Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1. Proc. Natl. Acad. Sci. USA 87 (1990), 968–972.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 968-972
-
-
Jacob, C.O.1
Aiso, S.2
Michie, S.A.3
McDevitt, H.O.4
Acha-Orbea, H.5
-
89
-
-
0023739445
-
Effects of nonesterified fatty acid availability on tissue-specific glucose utilization in rats in vivo
-
Jenkins, A.B., Storlien, L.H., Chisholm, D.J., Kraegen, E.W., Effects of nonesterified fatty acid availability on tissue-specific glucose utilization in rats in vivo. J. Clin. Invest. 82 (1988), 293–299.
-
(1988)
J. Clin. Invest.
, vol.82
, pp. 293-299
-
-
Jenkins, A.B.1
Storlien, L.H.2
Chisholm, D.J.3
Kraegen, E.W.4
-
90
-
-
84924935721
-
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
-
Jha, A.K., Huang, S.C., Sergushichev, A., Lampropoulou, V., Ivanova, Y., Loginicheva, E., Chmielewski, K., Stewart, K.M., Ashall, J., Everts, B., et al. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity 42 (2015), 419–430.
-
(2015)
Immunity
, vol.42
, pp. 419-430
-
-
Jha, A.K.1
Huang, S.C.2
Sergushichev, A.3
Lampropoulou, V.4
Ivanova, Y.5
Loginicheva, E.6
Chmielewski, K.7
Stewart, K.M.8
Ashall, J.9
Everts, B.10
-
91
-
-
84859997837
-
Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity
-
Ji, Y., Sun, S., Xu, A., Bhargava, P., Yang, L., Lam, K.S., Gao, B., Lee, C.H., Kersten, S., Qi, L., Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J. Biol. Chem. 287 (2012), 13561–13571.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 13561-13571
-
-
Ji, Y.1
Sun, S.2
Xu, A.3
Bhargava, P.4
Yang, L.5
Lam, K.S.6
Gao, B.7
Lee, C.H.8
Kersten, S.9
Qi, L.10
-
92
-
-
0026517191
-
Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen synthase activity in normal man
-
Johnson, A.B., Argyraki, M., Thow, J.C., Cooper, B.G., Fulcher, G., Taylor, R., Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen synthase activity in normal man. Clin. Sci. 82 (1992), 219–226.
-
(1992)
Clin. Sci.
, vol.82
, pp. 219-226
-
-
Johnson, A.B.1
Argyraki, M.2
Thow, J.C.3
Cooper, B.G.4
Fulcher, G.5
Taylor, R.6
-
93
-
-
79954996869
-
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
-
Jornayvaz, F.R., Birkenfeld, A.L., Jurczak, M.J., Kanda, S., Guigni, B.A., Jiang, D.C., Zhang, D., Lee, H.Y., Samuel, V.T., Shulman, G.I., Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proc. Natl. Acad. Sci. USA 108 (2011), 5748–5752.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 5748-5752
-
-
Jornayvaz, F.R.1
Birkenfeld, A.L.2
Jurczak, M.J.3
Kanda, S.4
Guigni, B.A.5
Jiang, D.C.6
Zhang, D.7
Lee, H.Y.8
Samuel, V.T.9
Shulman, G.I.10
-
94
-
-
0027260317
-
Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity
-
Jullien, D., Tanti, J.F., Heydrick, S.J., Gautier, N., Grémeaux, T., Van Obberghen, E., Le Marchand-Brustel, Y., Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity. J. Biol. Chem. 268 (1993), 15246–15251.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 15246-15251
-
-
Jullien, D.1
Tanti, J.F.2
Heydrick, S.J.3
Gautier, N.4
Grémeaux, T.5
Van Obberghen, E.6
Le Marchand-Brustel, Y.7
-
95
-
-
7044230885
-
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
-
Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T.A., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y., Hori, M., Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat. Med. 10 (2004), 1128–1132.
-
(2004)
Nat. Med.
, vol.10
, pp. 1128-1132
-
-
Kaneto, H.1
Nakatani, Y.2
Miyatsuka, T.3
Kawamori, D.4
Matsuoka, T.A.5
Matsuhisa, M.6
Kajimoto, Y.7
Ichijo, H.8
Yamasaki, Y.9
Hori, M.10
-
96
-
-
0028825748
-
Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1
-
Kanety, H., Feinstein, R., Papa, M.Z., Hemi, R., Karasik, A., Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1. J. Biol. Chem. 270 (1995), 23780–23784.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 23780-23784
-
-
Kanety, H.1
Feinstein, R.2
Papa, M.Z.3
Hemi, R.4
Karasik, A.5
-
97
-
-
0028968879
-
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
-
Kern, P.A., Saghizadeh, M., Ong, J.M., Bosch, R.J., Deem, R., Simsolo, R.B., The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 95 (1995), 2111–2119.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2111-2119
-
-
Kern, P.A.1
Saghizadeh, M.2
Ong, J.M.3
Bosch, R.J.4
Deem, R.5
Simsolo, R.B.6
-
98
-
-
12144290761
-
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo
-
Kim, H.J., Higashimori, T., Park, S.Y., Choi, H., Dong, J., Kim, Y.J., Noh, H.L., Cho, Y.R., Cline, G., Kim, Y.B., Kim, J.K., Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 53 (2004), 1060–1067.
-
(2004)
Diabetes
, vol.53
, pp. 1060-1067
-
-
Kim, H.J.1
Higashimori, T.2
Park, S.Y.3
Choi, H.4
Dong, J.5
Kim, Y.J.6
Noh, H.L.7
Cho, Y.R.8
Cline, G.9
Kim, Y.B.10
Kim, J.K.11
-
99
-
-
8544244084
-
PKC-theta knockout mice are protected from fat-induced insulin resistance
-
Kim, J.K., Fillmore, J.J., Sunshine, M.J., Albrecht, B., Higashimori, T., Kim, D.W., Liu, Z.X., Soos, T.J., Cline, G.W., O'Brien, W.R., et al. PKC-theta knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 114 (2004), 823–827.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 823-827
-
-
Kim, J.K.1
Fillmore, J.J.2
Sunshine, M.J.3
Albrecht, B.4
Higashimori, T.5
Kim, D.W.6
Liu, Z.X.7
Soos, T.J.8
Cline, G.W.9
O'Brien, W.R.10
-
100
-
-
70349484212
-
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
-
Kleinridders, A., Schenten, D., Könner, A.C., Belgardt, B.F., Mauer, J., Okamura, T., Wunderlich, F.T., Medzhitov, R., Brüning, J.C., MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 10 (2009), 249–259.
-
(2009)
Cell Metab.
, vol.10
, pp. 249-259
-
-
Kleinridders, A.1
Schenten, D.2
Könner, A.C.3
Belgardt, B.F.4
Mauer, J.5
Okamura, T.6
Wunderlich, F.T.7
Medzhitov, R.8
Brüning, J.C.9
-
101
-
-
84928407438
-
Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice
-
Kolodin, D., van Panhuys, N., Li, C., Magnuson, A.M., Cipolletta, D., Miller, C.M., Wagers, A., Germain, R.N., Benoist, C., Mathis, D., Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metab. 21 (2015), 543–557.
-
(2015)
Cell Metab.
, vol.21
, pp. 543-557
-
-
Kolodin, D.1
van Panhuys, N.2
Li, C.3
Magnuson, A.M.4
Cipolletta, D.5
Miller, C.M.6
Wagers, A.7
Germain, R.N.8
Benoist, C.9
Mathis, D.10
-
102
-
-
0028167846
-
Inhibition of NF-kappa B by sodium salicylate and aspirin
-
Kopp, E., Ghosh, S., Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265 (1994), 956–959.
-
(1994)
Science
, vol.265
, pp. 956-959
-
-
Kopp, E.1
Ghosh, S.2
-
103
-
-
77957838795
-
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
-
Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J.F., Lei, J., Zechner, R., Ferrante, A.W. Jr., Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J. Clin. Invest. 120 (2010), 3466–3479.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 3466-3479
-
-
Kosteli, A.1
Sugaru, E.2
Haemmerle, G.3
Martin, J.F.4
Lei, J.5
Zechner, R.6
Ferrante, A.W.7
-
104
-
-
84964345900
-
Hypoglycemic agents and potential anti-inflammatory activity
-
Kothari, V., Galdo, J.A., Mathews, S.T., Hypoglycemic agents and potential anti-inflammatory activity. J. Inflamm. Res. 9 (2016), 27–38.
-
(2016)
J. Inflamm. Res.
, vol.9
, pp. 27-38
-
-
Kothari, V.1
Galdo, J.A.2
Mathews, S.T.3
-
105
-
-
84860992385
-
The role of TNF-α in mice with type 1- and 2- diabetes
-
Koulmanda, M., Bhasin, M., Awdeh, Z., Qipo, A., Fan, Z., Hanidziar, D., Putheti, P., Shi, H., Csizuadia, E., Libermann, T.A., Strom, T.B., The role of TNF-α in mice with type 1- and 2- diabetes. PLoS ONE, 7, 2012, e33254.
-
(2012)
PLoS ONE
, vol.7
, pp. e33254
-
-
Koulmanda, M.1
Bhasin, M.2
Awdeh, Z.3
Qipo, A.4
Fan, Z.5
Hanidziar, D.6
Putheti, P.7
Shi, H.8
Csizuadia, E.9
Libermann, T.A.10
Strom, T.B.11
-
106
-
-
84907991703
-
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
-
Kratz, M., Coats, B.R., Hisert, K.B., Hagman, D., Mutskov, V., Peris, E., Schoenfelt, K.Q., Kuzma, J.N., Larson, I., Billing, P.S., et al. Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab. 20 (2014), 614–625.
-
(2014)
Cell Metab.
, vol.20
, pp. 614-625
-
-
Kratz, M.1
Coats, B.R.2
Hisert, K.B.3
Hagman, D.4
Mutskov, V.5
Peris, E.6
Schoenfelt, K.Q.7
Kuzma, J.N.8
Larson, I.9
Billing, P.S.10
-
107
-
-
84915751694
-
Adipocyte-specific IKKβ signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathway
-
Kwon, H., Laurent, S., Tang, Y., Zong, H., Vemulapalli, P., Pessin, J.E., Adipocyte-specific IKKβ signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathway. Cell Rep. 9 (2014), 1574–1583.
-
(2014)
Cell Rep.
, vol.9
, pp. 1574-1583
-
-
Kwon, H.1
Laurent, S.2
Tang, Y.3
Zong, H.4
Vemulapalli, P.5
Pessin, J.E.6
-
108
-
-
84901632923
-
The immunomodulating role of exercise in metabolic disease
-
Lancaster, G.I., Febbraio, M.A., The immunomodulating role of exercise in metabolic disease. Trends Immunol. 35 (2014), 262–269.
-
(2014)
Trends Immunol.
, vol.35
, pp. 262-269
-
-
Lancaster, G.I.1
Febbraio, M.A.2
-
109
-
-
0026549669
-
Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output
-
Lang, C.H., Dobrescu, C., Bagby, G.J., Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 130 (1992), 43–52.
-
(1992)
Endocrinology
, vol.130
, pp. 43-52
-
-
Lang, C.H.1
Dobrescu, C.2
Bagby, G.J.3
-
110
-
-
0141844653
-
Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
-
Lee, J.Y., Ye, J., Gao, Z., Youn, H.S., Lee, W.H., Zhao, L., Sizemore, N., Hwang, D.H., Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J. Biol. Chem. 278 (2003), 37041–37051.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37041-37051
-
-
Lee, J.Y.1
Ye, J.2
Gao, Z.3
Youn, H.S.4
Lee, W.H.5
Zhao, L.6
Sizemore, N.7
Hwang, D.H.8
-
111
-
-
84883467905
-
Identification of an adipogenic niche for adipose tissue remodeling and restoration
-
Lee, Y.H., Petkova, A.P., Granneman, J.G., Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab. 18 (2013), 355–367.
-
(2013)
Cell Metab.
, vol.18
, pp. 355-367
-
-
Lee, Y.H.1
Petkova, A.P.2
Granneman, J.G.3
-
112
-
-
84920940721
-
Activated type 2 innate lymphoid cells regulate beige fat biogenesis
-
Lee, M.W., Odegaard, J.I., Mukundan, L., Qiu, Y., Molofsky, A.B., Nussbaum, J.C., Yun, K., Locksley, R.M., Chawla, A., Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160 (2015), 74–87.
-
(2015)
Cell
, vol.160
, pp. 74-87
-
-
Lee, M.W.1
Odegaard, J.I.2
Mukundan, L.3
Qiu, Y.4
Molofsky, A.B.5
Nussbaum, J.C.6
Yun, K.7
Locksley, R.M.8
Chawla, A.9
-
113
-
-
25844437136
-
Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease
-
Li, Z., Soloski, M.J., Diehl, A.M., Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology 42 (2005), 880–885.
-
(2005)
Hepatology
, vol.42
, pp. 880-885
-
-
Li, Z.1
Soloski, M.J.2
Diehl, A.M.3
-
114
-
-
41149155892
-
Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
-
Li, M., Kim, D.H., Tsenovoy, P.L., Peterson, S.J., Rezzani, R., Rodella, L.F., Aronow, W.S., Ikehara, S., Abraham, N.G., Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes 57 (2008), 1526–1535.
-
(2008)
Diabetes
, vol.57
, pp. 1526-1535
-
-
Li, M.1
Kim, D.H.2
Tsenovoy, P.L.3
Peterson, S.J.4
Rezzani, R.5
Rodella, L.F.6
Aronow, W.S.7
Ikehara, S.8
Abraham, N.G.9
-
115
-
-
84995554134
-
Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance
-
Li, P., Liu, S., Lu, M., Bandyopadhyay, G., Oh, D., Imamura, T., Johnson, A.M., Sears, D., Shen, Z., Cui, B., et al. Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance. Cell 167 (2016), 973–984.
-
(2016)
Cell
, vol.167
, pp. 973-984
-
-
Li, P.1
Liu, S.2
Lu, M.3
Bandyopadhyay, G.4
Oh, D.5
Imamura, T.6
Johnson, A.M.7
Sears, D.8
Shen, Z.9
Cui, B.10
-
116
-
-
44249103964
-
Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance
-
Liang, H., Yin, B., Zhang, H., Zhang, S., Zeng, Q., Wang, J., Jiang, X., Yuan, L., Wang, C.Y., Li, Z., Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance. Endocrinology 149 (2008), 2943–2951.
-
(2008)
Endocrinology
, vol.149
, pp. 2943-2951
-
-
Liang, H.1
Yin, B.2
Zhang, H.3
Zhang, S.4
Zeng, Q.5
Wang, J.6
Jiang, X.7
Yuan, L.8
Wang, C.Y.9
Li, Z.10
-
117
-
-
0028261462
-
Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake
-
Ling, P.R., Bistrian, B.R., Mendez, B., Istfan, N.W., Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism 43 (1994), 279–284.
-
(1994)
Metabolism
, vol.43
, pp. 279-284
-
-
Ling, P.R.1
Bistrian, B.R.2
Mendez, B.3
Istfan, N.W.4
-
118
-
-
84923171580
-
Genetic studies of body mass index yield new insights for obesity biology
-
Locke, A.E., Kahali, B., Berndt, S.I., Justice, A.E., Pers, T.H., Day, F.R., Powell, C., Vedantam, S., Buchkovich, M.L., Yang, J., et al. LifeLines Cohort Study ADIPOGen Consortium AGEN-BMI Working Group CARDIOGRAMplusC4D Consortium CKDGen Consortium GLGC ICBP MAGIC Investigators MuTHER Consortium MIGen Consortium PAGE Consortium ReproGen Consortium GENIE Consortium, International Endogene Consortium. Genetic studies of body mass index yield new insights for obesity biology. Nature 518 (2015), 197–206.
-
(2015)
Nature
, vol.518
, pp. 197-206
-
-
Locke, A.E.1
Kahali, B.2
Berndt, S.I.3
Justice, A.E.4
Pers, T.H.5
Day, F.R.6
Powell, C.7
Vedantam, S.8
Buchkovich, M.L.9
Yang, J.10
-
119
-
-
0031965266
-
Leptin regulates proinflammatory immune responses
-
Loffreda, S., Yang, S.Q., Lin, H.Z., Karp, C.L., Brengman, M.L., Wang, D.J., Klein, A.S., Bulkley, G.B., Bao, C., Noble, P.W., et al. Leptin regulates proinflammatory immune responses. FASEB J. 12 (1998), 57–65.
-
(1998)
FASEB J.
, vol.12
, pp. 57-65
-
-
Loffreda, S.1
Yang, S.Q.2
Lin, H.Z.3
Karp, C.L.4
Brengman, M.L.5
Wang, D.J.6
Klein, A.S.7
Bulkley, G.B.8
Bao, C.9
Noble, P.W.10
-
120
-
-
0011152741
-
Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes
-
Lowenthal, J.W., Ballard, D.W., Böhnlein, E., Greene, W.C., Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes. Proc. Natl. Acad. Sci. USA 86 (1989), 2331–2335.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 2331-2335
-
-
Lowenthal, J.W.1
Ballard, D.W.2
Böhnlein, E.3
Greene, W.C.4
-
121
-
-
84865511926
-
Novel role of PKR in inflammasome activation and HMGB1 release
-
Lu, B., Nakamura, T., Inouye, K., Li, J., Tang, Y., Lundbäck, P., Valdes-Ferrer, S.I., Olofsson, P.S., Kalb, T., Roth, J., Zou, Y., Erlandsson-Harris, H., Yang, H., Ting, J.P., Wang, H., Andersson, U., Antoine, D.J., Chavan, S.S., Hotamisligil, G.S., Tracey, K.J., Novel role of PKR in inflammasome activation and HMGB1 release. Nature 488 (2012), 670–674.
-
(2012)
Nature
, vol.488
, pp. 670-674
-
-
Lu, B.1
Nakamura, T.2
Inouye, K.3
Li, J.4
Tang, Y.5
Lundbäck, P.6
Valdes-Ferrer, S.I.7
Olofsson, P.S.8
Kalb, T.9
Roth, J.10
Zou, Y.11
Erlandsson-Harris, H.12
Yang, H.13
Ting, J.P.14
Wang, H.15
Andersson, U.16
Antoine, D.J.17
Chavan, S.S.18
Hotamisligil, G.S.19
Tracey, K.J.20
more..
-
122
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
Lumeng, C.N., Bodzin, J.L., Saltiel, A.R., Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117 (2007), 175–184.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
123
-
-
33846004396
-
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins
-
Lumeng, C.N., Deyoung, S.M., Saltiel, A.R., Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am. J. Physiol. Endocrinol. Metab. 292 (2007), E166–E174.
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.292
, pp. E166-E174
-
-
Lumeng, C.N.1
Deyoung, S.M.2
Saltiel, A.R.3
-
124
-
-
84901992453
-
Adipose invariant natural killer T cells
-
Lynch, L., Adipose invariant natural killer T cells. Immunology 142 (2014), 337–346.
-
(2014)
Immunology
, vol.142
, pp. 337-346
-
-
Lynch, L.1
-
125
-
-
0036738398
-
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
-
Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller-Jemelka, H.I., Spinas, G.A., Kaiser, N., Halban, P.A., Donath, M.Y., Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest. 110 (2002), 851–860.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 851-860
-
-
Maedler, K.1
Sergeev, P.2
Ris, F.3
Oberholzer, J.4
Joller-Jemelka, H.I.5
Spinas, G.A.6
Kaiser, N.7
Halban, P.A.8
Donath, M.Y.9
-
126
-
-
0021988474
-
Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells
-
Mahoney, J.R. Jr., Beutler, B.A., Le Trang, N., Vine, W., Ikeda, Y., Kawakami, M., Cerami, A., Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells. J. Immunol. 134 (1985), 1673–1675.
-
(1985)
J. Immunol.
, vol.134
, pp. 1673-1675
-
-
Mahoney, J.R.1
Beutler, B.A.2
Le Trang, N.3
Vine, W.4
Ikeda, Y.5
Kawakami, M.6
Cerami, A.7
-
127
-
-
0030661983
-
TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone
-
Miles, P.D., Romeo, O.M., Higo, K., Cohen, A., Rafaat, K., Olefsky, J.M., TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 46 (1997), 1678–1683.
-
(1997)
Diabetes
, vol.46
, pp. 1678-1683
-
-
Miles, P.D.1
Romeo, O.M.2
Higo, K.3
Cohen, A.4
Rafaat, K.5
Olefsky, J.M.6
-
128
-
-
84876746655
-
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
-
Molofsky, A.B., Nussbaum, J.C., Liang, H.E., Van Dyken, S.J., Cheng, L.E., Mohapatra, A., Chawla, A., Locksley, R.M., Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med. 210 (2013), 535–549.
-
(2013)
J. Exp. Med.
, vol.210
, pp. 535-549
-
-
Molofsky, A.B.1
Nussbaum, J.C.2
Liang, H.E.3
Van Dyken, S.J.4
Cheng, L.E.5
Mohapatra, A.6
Chawla, A.7
Locksley, R.M.8
-
129
-
-
84878800136
-
Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice
-
Morris, D.L., Cho, K.W., Delproposto, J.L., Oatmen, K.E., Geletka, L.M., Martinez-Santibanez, G., Singer, K., Lumeng, C.N., Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice. Diabetes 62 (2013), 2762–2772.
-
(2013)
Diabetes
, vol.62
, pp. 2762-2772
-
-
Morris, D.L.1
Cho, K.W.2
Delproposto, J.L.3
Oatmen, K.E.4
Geletka, L.M.5
Martinez-Santibanez, G.6
Singer, K.7
Lumeng, C.N.8
-
130
-
-
84881356321
-
AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration
-
Mounier, R., Théret, M., Arnold, L., Cuvellier, S., Bultot, L., Göransson, O., Sanz, N., Ferry, A., Sakamoto, K., Foretz, M., et al. AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab. 18 (2013), 251–264.
-
(2013)
Cell Metab.
, vol.18
, pp. 251-264
-
-
Mounier, R.1
Théret, M.2
Arnold, L.3
Cuvellier, S.4
Bultot, L.5
Göransson, O.6
Sanz, N.7
Ferry, A.8
Sakamoto, K.9
Foretz, M.10
-
131
-
-
75749108288
-
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
-
Nakamura, T., Furuhashi, M., Cao, H., Tuncman, G., Sonenberg, N., Gorgun, C.Z., Hotamisligil, G.S., Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 140 (2010), 338–348.
-
(2010)
Cell
, vol.140
, pp. 338-348
-
-
Nakamura, T.1
Furuhashi, M.2
Cao, H.3
Tuncman, G.4
Sonenberg, N.5
Gorgun, C.Z.6
Hotamisligil, G.S.7
-
132
-
-
63449111894
-
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
-
Newgard, C.B., An, J., Bain, J.R., Muehlbauer, M.J., Stevens, R.D., Lien, L.F., Haqq, A.M., Shah, S.H., Arlotto, M., Slentz, C.A., et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 9 (2009), 311–326.
-
(2009)
Cell Metab.
, vol.9
, pp. 311-326
-
-
Newgard, C.B.1
An, J.2
Bain, J.R.3
Muehlbauer, M.J.4
Stevens, R.D.5
Lien, L.F.6
Haqq, A.M.7
Shah, S.H.8
Arlotto, M.9
Slentz, C.A.10
-
133
-
-
82555186955
-
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
-
Nguyen, K.D., Qiu, Y., Cui, X., Goh, Y.P., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R.M., Chawla, A., Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480 (2011), 104–108.
-
(2011)
Nature
, vol.480
, pp. 104-108
-
-
Nguyen, K.D.1
Qiu, Y.2
Cui, X.3
Goh, Y.P.4
Mwangi, J.5
David, T.6
Mukundan, L.7
Brombacher, F.8
Locksley, R.M.9
Chawla, A.10
-
134
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15 (2009), 914–920.
-
(2009)
Nat. Med.
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Eto, K.4
Yamashita, H.5
Ohsugi, M.6
Otsu, M.7
Hara, K.8
Ueki, K.9
Sugiura, S.10
-
135
-
-
84887419072
-
Adipose natural regulatory B cells negatively control adipose tissue inflammation
-
Nishimura, S., Manabe, I., Takaki, S., Nagasaki, M., Otsu, M., Yamashita, H., Sugita, J., Yoshimura, K., Eto, K., Komuro, I., et al. Adipose natural regulatory B cells negatively control adipose tissue inflammation. Cell Metab. 18 (2013), 759–766.
-
(2013)
Cell Metab.
, vol.18
, pp. 759-766
-
-
Nishimura, S.1
Manabe, I.2
Takaki, S.3
Nagasaki, M.4
Otsu, M.5
Yamashita, H.6
Sugita, J.7
Yoshimura, K.8
Eto, K.9
Komuro, I.10
-
136
-
-
84872576236
-
Metabolism of inflammation limited by AMPK and pseudo-starvation
-
O'Neill, L.A., Hardie, D.G., Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 493 (2013), 346–355.
-
(2013)
Nature
, vol.493
, pp. 346-355
-
-
O'Neill, L.A.1
Hardie, D.G.2
-
137
-
-
77956165390
-
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
-
Oh, D.Y., Talukdar, S., Bae, E.J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W.J., Watkins, S.M., Olefsky, J.M., GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142 (2010), 687–698.
-
(2010)
Cell
, vol.142
, pp. 687-698
-
-
Oh, D.Y.1
Talukdar, S.2
Bae, E.J.3
Imamura, T.4
Morinaga, H.5
Fan, W.6
Li, P.7
Lu, W.J.8
Watkins, S.M.9
Olefsky, J.M.10
-
138
-
-
0023638415
-
Tumors secreting human TNF/cachectin induce cachexia in mice
-
Oliff, A., Defeo-Jones, D., Boyer, M., Martinez, D., Kiefer, D., Vuocolo, G., Wolfe, A., Socher, S.H., Tumors secreting human TNF/cachectin induce cachexia in mice. Cell 50 (1987), 555–563.
-
(1987)
Cell
, vol.50
, pp. 555-563
-
-
Oliff, A.1
Defeo-Jones, D.2
Boyer, M.3
Martinez, D.4
Kiefer, D.5
Vuocolo, G.6
Wolfe, A.7
Socher, S.H.8
-
139
-
-
85029169452
-
Inhibition of Ikkvarepsilon and TBK1 improves glucose control in a subset of patients with type 2 diabetes
-
Oral, E.A., Reilly, S.M., Gomez, A.V., Meral, R., Butz, L., Ajluni, N., Chenevert, T.L., Korytnaya, E., Neidert, A.H., Hench, R., et al. Inhibition of Ikkvarepsilon and TBK1 improves glucose control in a subset of patients with type 2 diabetes. Cell Metab. 26 (2017), 157–170.e7.
-
(2017)
Cell Metab.
, vol.26
, pp. 157-170.e7
-
-
Oral, E.A.1
Reilly, S.M.2
Gomez, A.V.3
Meral, R.4
Butz, L.5
Ajluni, N.6
Chenevert, T.L.7
Korytnaya, E.8
Neidert, A.H.9
Hench, R.10
-
140
-
-
0342742310
-
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B
-
Osborn, L., Kunkel, S., Nabel, G.J., Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc. Natl. Acad. Sci. USA 86 (1989), 2336–2340.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 2336-2340
-
-
Osborn, L.1
Kunkel, S.2
Nabel, G.J.3
-
141
-
-
77954844177
-
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
-
Ouchi, N., Higuchi, A., Ohashi, K., Oshima, Y., Gokce, N., Shibata, R., Akasaki, Y., Shimono, A., Walsh, K., Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 329 (2010), 454–457.
-
(2010)
Science
, vol.329
, pp. 454-457
-
-
Ouchi, N.1
Higuchi, A.2
Ohashi, K.3
Oshima, Y.4
Gokce, N.5
Shibata, R.6
Akasaki, Y.7
Shimono, A.8
Walsh, K.9
-
142
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan, U., Cao, Q., Yilmaz, E., Lee, A.H., Iwakoshi, N.N., Ozdelen, E., Tuncman, G., Görgün, C., Glimcher, L.H., Hotamisligil, G.S., Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306 (2004), 457–461.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Görgün, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
143
-
-
0018872598
-
Polymorphonuclear (PMN) function after small intestinal shunt operation for morbid obesity
-
Palmblad, J., Hallberg, D., Engstedt, L., Polymorphonuclear (PMN) function after small intestinal shunt operation for morbid obesity. Br. J. Haematol. 44 (1980), 101–108.
-
(1980)
Br. J. Haematol.
, vol.44
, pp. 101-108
-
-
Palmblad, J.1
Hallberg, D.2
Engstedt, L.3
-
144
-
-
84930678793
-
Granulocyte/macrophage colony-stimulating factor-dependent dendritic cells restrain lean adipose tissue expansion
-
Pamir, N., Liu, N.C., Irwin, A., Becker, L., Peng, Y., Ronsein, G.E., Bornfeldt, K.E., Duffield, J.S., Heinecke, J.W., Granulocyte/macrophage colony-stimulating factor-dependent dendritic cells restrain lean adipose tissue expansion. J. Biol. Chem. 290 (2015), 14656–14667.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 14656-14667
-
-
Pamir, N.1
Liu, N.C.2
Irwin, A.3
Becker, L.4
Peng, Y.5
Ronsein, G.E.6
Bornfeldt, K.E.7
Duffield, J.S.8
Heinecke, J.W.9
-
145
-
-
84969780802
-
IKKβ Is Essential for adipocyte survival and adaptive adipose remodeling in obesity
-
Park, S.H., Liu, Z., Sui, Y., Helsley, R.N., Zhu, B., Powell, D.K., Kern, P.A., Zhou, C., IKKβ Is Essential for adipocyte survival and adaptive adipose remodeling in obesity. Diabetes 65 (2016), 1616–1629.
-
(2016)
Diabetes
, vol.65
, pp. 1616-1629
-
-
Park, S.H.1
Liu, Z.2
Sui, Y.3
Helsley, R.N.4
Zhu, B.5
Powell, D.K.6
Kern, P.A.7
Zhou, C.8
-
146
-
-
0020622922
-
Studies of insulin resistance in adipocytes induced by macrophage mediator
-
Pekala, P., Kawakami, M., Vine, W., Lane, M.D., Cerami, A., Studies of insulin resistance in adipocytes induced by macrophage mediator. J. Exp. Med. 157 (1983), 1360–1365.
-
(1983)
J. Exp. Med.
, vol.157
, pp. 1360-1365
-
-
Pekala, P.1
Kawakami, M.2
Vine, W.3
Lane, M.D.4
Cerami, A.5
-
147
-
-
84994613956
-
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
-
Petersen, M.C., Madiraju, A.K., Gassaway, B.M., Marcel, M., Nasiri, A.R., Butrico, G., Marcucci, M.J., Zhang, D., Abulizi, A., Zhang, X.M., et al. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J. Clin. Invest. 126 (2016), 4361–4371.
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 4361-4371
-
-
Petersen, M.C.1
Madiraju, A.K.2
Gassaway, B.M.3
Marcel, M.4
Nasiri, A.R.5
Butrico, G.6
Marcucci, M.J.7
Zhang, D.8
Abulizi, A.9
Zhang, X.M.10
-
148
-
-
25844456730
-
Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation
-
Plomgaard, P., Bouzakri, K., Krogh-Madsen, R., Mittendorfer, B., Zierath, J.R., Pedersen, B.K., Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes 54 (2005), 2939–2945.
-
(2005)
Diabetes
, vol.54
, pp. 2939-2945
-
-
Plomgaard, P.1
Bouzakri, K.2
Krogh-Madsen, R.3
Mittendorfer, B.4
Zierath, J.R.5
Pedersen, B.K.6
-
149
-
-
39049133455
-
Tumor necrosis factor-alpha modulates human in vivo lipolysis
-
Plomgaard, P., Fischer, C.P., Ibfelt, T., Pedersen, B.K., van Hall, G., Tumor necrosis factor-alpha modulates human in vivo lipolysis. J. Clin. Endocrinol. Metab. 93 (2008), 543–549.
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, pp. 543-549
-
-
Plomgaard, P.1
Fischer, C.P.2
Ibfelt, T.3
Pedersen, B.K.4
van Hall, G.5
-
150
-
-
84902094655
-
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
-
Qiu, Y., Nguyen, K.D., Odegaard, J.I., Cui, X., Tian, X., Locksley, R.M., Palmiter, R.D., Chawla, A., Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157 (2014), 1292–1308.
-
(2014)
Cell
, vol.157
, pp. 1292-1308
-
-
Qiu, Y.1
Nguyen, K.D.2
Odegaard, J.I.3
Cui, X.4
Tian, X.5
Locksley, R.M.6
Palmiter, R.D.7
Chawla, A.8
-
151
-
-
73649168830
-
Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinism
-
Rabinowitz, D., Zierler, K.L., Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinism. J. Clin. Invest. 41 (1962), 2173–2181.
-
(1962)
J. Clin. Invest.
, vol.41
, pp. 2173-2181
-
-
Rabinowitz, D.1
Zierler, K.L.2
-
152
-
-
50549202600
-
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
-
Randle, P.J., Garland, P.B., Hales, C.N., Newsholme, E.A., The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 (1963), 785–789.
-
(1963)
Lancet
, vol.1
, pp. 785-789
-
-
Randle, P.J.1
Garland, P.B.2
Hales, C.N.3
Newsholme, E.A.4
-
153
-
-
0013772629
-
Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles
-
Randle, P.J., Newsholme, E.A., Garland, P.B., Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem. J. 93 (1964), 652–665.
-
(1964)
Biochem. J.
, vol.93
, pp. 652-665
-
-
Randle, P.J.1
Newsholme, E.A.2
Garland, P.B.3
-
154
-
-
38149142633
-
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
-
Rausch, M.E., Weisberg, S., Vardhana, P., Tortoriello, D.V., Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int. J. Obes. 32 (2008), 451–463.
-
(2008)
Int. J. Obes.
, vol.32
, pp. 451-463
-
-
Rausch, M.E.1
Weisberg, S.2
Vardhana, P.3
Tortoriello, D.V.4
-
155
-
-
0019480192
-
In vivo skeletal muscle insulin resistance during E coli endotoxin shock in the dog
-
Raymond, R.M., Harkema, J.M., Emerson, T.E. Jr., In vivo skeletal muscle insulin resistance during E coli endotoxin shock in the dog. Circ. Shock 8 (1981), 425–433.
-
(1981)
Circ. Shock
, vol.8
, pp. 425-433
-
-
Raymond, R.M.1
Harkema, J.M.2
Emerson, T.E.3
-
156
-
-
84875179301
-
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
-
Reilly, S.M., Chiang, S.H., Decker, S.J., Chang, L., Uhm, M., Larsen, M.J., Rubin, J.R., Mowers, J., White, N.M., Hochberg, I., et al. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat. Med. 19 (2013), 313–321.
-
(2013)
Nat. Med.
, vol.19
, pp. 313-321
-
-
Reilly, S.M.1
Chiang, S.H.2
Decker, S.J.3
Chang, L.4
Uhm, M.5
Larsen, M.J.6
Rubin, J.R.7
Mowers, J.8
White, N.M.9
Hochberg, I.10
-
157
-
-
0031048067
-
Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2
-
Reinhard, C., Shamoon, B., Shyamala, V., Williams, L.T., Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J. 16 (1997), 1080–1092.
-
(1997)
EMBO J.
, vol.16
, pp. 1080-1092
-
-
Reinhard, C.1
Shamoon, B.2
Shyamala, V.3
Williams, L.T.4
-
158
-
-
78651073627
-
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity
-
Ricardo-Gonzalez, R.R., Red Eagle, A., Odegaard, J.I., Jouihan, H., Morel, C.R., Heredia, J.E., Mukundan, L., Wu, D., Locksley, R.M., Chawla, A., IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc. Natl. Acad. Sci. USA 107 (2010), 22617–22622.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 22617-22622
-
-
Ricardo-Gonzalez, R.R.1
Red Eagle, A.2
Odegaard, J.I.3
Jouihan, H.4
Morel, C.R.5
Heredia, J.E.6
Mukundan, L.7
Wu, D.8
Locksley, R.M.9
Chawla, A.10
-
159
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio, G., Das, M., Mora, A., Zhang, Z., Jun, J.Y., Ko, H.J., Barrett, T., Kim, J.K., Davis, R.J., A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322 (2008), 1539–1543.
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
160
-
-
0030028606
-
The expression of TNF alpha by human muscle. Relationship to insulin resistance
-
Saghizadeh, M., Ong, J.M., Garvey, W.T., Henry, R.R., Kern, P.A., The expression of TNF alpha by human muscle. Relationship to insulin resistance. J. Clin. Invest. 97 (1996), 1111–1116.
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 1111-1116
-
-
Saghizadeh, M.1
Ong, J.M.2
Garvey, W.T.3
Henry, R.R.4
Kern, P.A.5
-
161
-
-
84937635957
-
Antidiabetic agents: potential anti-inflammatory activity beyond glucose control
-
Scheen, A.J., Esser, N., Paquot, N., Antidiabetic agents: potential anti-inflammatory activity beyond glucose control. Diabetes Metab. 41 (2015), 183–194.
-
(2015)
Diabetes Metab.
, vol.41
, pp. 183-194
-
-
Scheen, A.J.1
Esser, N.2
Paquot, N.3
-
162
-
-
84870058819
-
Adaptive immunity in obesity and insulin resistance
-
Sell, H., Habich, C., Eckel, J., Adaptive immunity in obesity and insulin resistance. Nat. Rev. Endocrinol. 8 (2012), 709–716.
-
(2012)
Nat. Rev. Endocrinol.
, vol.8
, pp. 709-716
-
-
Sell, H.1
Habich, C.2
Eckel, J.3
-
163
-
-
84901921079
-
Pro-resolving lipid mediators are leads for resolution physiology
-
Serhan, C.N., Pro-resolving lipid mediators are leads for resolution physiology. Nature 510 (2014), 92–101.
-
(2014)
Nature
, vol.510
, pp. 92-101
-
-
Serhan, C.N.1
-
164
-
-
0037608687
-
Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity
-
Serra, C., Federici, M., Buongiorno, A., Senni, M.I., Morelli, S., Segratella, E., Pascuccio, M., Tiveron, C., Mattei, E., Tatangelo, L., et al. Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity. J. Cell. Physiol. 196 (2003), 89–97.
-
(2003)
J. Cell. Physiol.
, vol.196
, pp. 89-97
-
-
Serra, C.1
Federici, M.2
Buongiorno, A.3
Senni, M.I.4
Morelli, S.5
Segratella, E.6
Pascuccio, M.7
Tiveron, C.8
Mattei, E.9
Tatangelo, L.10
-
165
-
-
85016109011
-
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity
-
Shan, B., Wang, X., Wu, Y., Xu, C., Xia, Z., Dai, J., Shao, M., Zhao, F., He, S., Yang, L., et al. The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nat. Immunol. 18 (2017), 519–529.
-
(2017)
Nat. Immunol.
, vol.18
, pp. 519-529
-
-
Shan, B.1
Wang, X.2
Wu, Y.3
Xu, C.4
Xia, Z.5
Dai, J.6
Shao, M.7
Zhao, F.8
He, S.9
Yang, L.10
-
166
-
-
84923169934
-
New genetic loci link adipose and insulin biology to body fat distribution
-
Shungin, D., Winkler, T.W., Croteau-Chonka, D.C., Ferreira, T., Locke, A.E., Mägi, R., Strawbridge, R.J., Pers, T.H., Fischer, K., Justice, A.E., et al. ADIPOGen Consortium CARDIOGRAMplusC4D Consortium CKDGen Consortium GEFOS Consortium GENIE Consortium GLGC ICBP International Endogene Consortium LifeLines Cohort Study MAGIC Investigators MuTHER Consortium PAGE Consortium, ReproGen Consortium. New genetic loci link adipose and insulin biology to body fat distribution. Nature 518 (2015), 187–196.
-
(2015)
Nature
, vol.518
, pp. 187-196
-
-
Shungin, D.1
Winkler, T.W.2
Croteau-Chonka, D.C.3
Ferreira, T.4
Locke, A.E.5
Mägi, R.6
Strawbridge, R.J.7
Pers, T.H.8
Fischer, K.9
Justice, A.E.10
-
167
-
-
23044439100
-
Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway
-
Silswal, N., Singh, A.K., Aruna, B., Mukhopadhyay, S., Ghosh, S., Ehtesham, N.Z., Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochem. Biophys. Res. Commun. 334 (2005), 1092–1101.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.334
, pp. 1092-1101
-
-
Silswal, N.1
Singh, A.K.2
Aruna, B.3
Mukhopadhyay, S.4
Ghosh, S.5
Ehtesham, N.Z.6
-
168
-
-
84881068658
-
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
-
Smith, P.M., Howitt, M.R., Panikov, N., Michaud, M., Gallini, C.A., Bohlooly-Y, M., Glickman, J.N., Garrett, W.S., The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341 (2013), 569–573.
-
(2013)
Science
, vol.341
, pp. 569-573
-
-
Smith, P.M.1
Howitt, M.R.2
Panikov, N.3
Michaud, M.4
Gallini, C.A.5
Bohlooly-Y, M.6
Glickman, J.N.7
Garrett, W.S.8
-
169
-
-
84885467630
-
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids
-
Snodgrass, R.G., Huang, S., Choi, I.W., Rutledge, J.C., Hwang, D.H., Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. J. Immunol. 191 (2013), 4337–4347.
-
(2013)
J. Immunol.
, vol.191
, pp. 4337-4347
-
-
Snodgrass, R.G.1
Huang, S.2
Choi, I.W.3
Rutledge, J.C.4
Hwang, D.H.5
-
170
-
-
84936892270
-
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
-
Sonnenberg, G.F., Artis, D., Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nat. Med. 21 (2015), 698–708.
-
(2015)
Nat. Med.
, vol.21
, pp. 698-708
-
-
Sonnenberg, G.F.1
Artis, D.2
-
171
-
-
33645059736
-
Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome
-
Sookoian, S.C., González, C., Pirola, C.J., Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome. Obes. Res. 13 (2005), 2122–2131.
-
(2005)
Obes. Res.
, vol.13
, pp. 2122-2131
-
-
Sookoian, S.C.1
González, C.2
Pirola, C.J.3
-
172
-
-
85017306856
-
IGF1 shapes macrophage activation in response to immunometabolic challenge
-
Spadaro, O., Camell, C.D., Bosurgi, L., Nguyen, K.Y., Youm, Y.H., Rothlin, C.V., Dixit, V.D., IGF1 shapes macrophage activation in response to immunometabolic challenge. Cell Rep. 19 (2017), 225–234.
-
(2017)
Cell Rep.
, vol.19
, pp. 225-234
-
-
Spadaro, O.1
Camell, C.D.2
Bosurgi, L.3
Nguyen, K.Y.4
Youm, Y.H.5
Rothlin, C.V.6
Dixit, V.D.7
-
173
-
-
84891863253
-
Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases
-
Spite, M., Clària, J., Serhan, C.N., Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 19 (2014), 21–36.
-
(2014)
Cell Metab.
, vol.19
, pp. 21-36
-
-
Spite, M.1
Clària, J.2
Serhan, C.N.3
-
174
-
-
0024572697
-
Altered control of carbohydrate metabolism in endotoxemia
-
Spitzer, J.J., Bagby, G.J., Meszaros, K., Lang, C.H., Altered control of carbohydrate metabolism in endotoxemia. Prog. Clin. Biol. Res. 286 (1989), 145–165.
-
(1989)
Prog. Clin. Biol. Res.
, vol.286
, pp. 145-165
-
-
Spitzer, J.J.1
Bagby, G.J.2
Meszaros, K.3
Lang, C.H.4
-
175
-
-
84873804024
-
Direct control of hepatic glucose production by interleukin-13 in mice
-
Stanya, K.J., Jacobi, D., Liu, S., Bhargava, P., Dai, L., Gangl, M.R., Inouye, K., Barlow, J.L., Ji, Y., Mizgerd, J.P., et al. Direct control of hepatic glucose production by interleukin-13 in mice. J. Clin. Invest. 123 (2013), 261–271.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 261-271
-
-
Stanya, K.J.1
Jacobi, D.2
Liu, S.3
Bhargava, P.4
Dai, L.5
Gangl, M.R.6
Inouye, K.7
Barlow, J.L.8
Ji, Y.9
Mizgerd, J.P.10
-
176
-
-
0025837140
-
Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha
-
Stephens, J.M., Pekala, P.H., Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J. Biol. Chem. 266 (1991), 21839–21845.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 21839-21845
-
-
Stephens, J.M.1
Pekala, P.H.2
-
177
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S., Lazar, M.A., The hormone resistin links obesity to diabetes. Nature 409 (2001), 307–312.
-
(2001)
Nature
, vol.409
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
Brown, E.J.4
Banerjee, R.R.5
Wright, C.M.6
Patel, H.R.7
Ahima, R.S.8
Lazar, M.A.9
-
178
-
-
78649498271
-
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
-
Stienstra, R., Joosten, L.A., Koenen, T., van Tits, B., van Diepen, J.A., van den Berg, S.A., Rensen, P.C., Voshol, P.J., Fantuzzi, G., Hijmans, A., et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab. 12 (2010), 593–605.
-
(2010)
Cell Metab.
, vol.12
, pp. 593-605
-
-
Stienstra, R.1
Joosten, L.A.2
Koenen, T.3
van Tits, B.4
van Diepen, J.A.5
van den Berg, S.A.6
Rensen, P.C.7
Voshol, P.J.8
Fantuzzi, G.9
Hijmans, A.10
-
179
-
-
80053087484
-
Inflammasome is a central player in the induction of obesity and insulin resistance
-
Stienstra, R., van Diepen, J.A., Tack, C.J., Zaki, M.H., van de Veerdonk, F.L., Perera, D., Neale, G.A., Hooiveld, G.J., Hijmans, A., Vroegrijk, I., et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc. Natl. Acad. Sci. USA 108 (2011), 15324–15329.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 15324-15329
-
-
Stienstra, R.1
van Diepen, J.A.2
Tack, C.J.3
Zaki, M.H.4
van de Veerdonk, F.L.5
Perera, D.6
Neale, G.A.7
Hooiveld, G.J.8
Hijmans, A.9
Vroegrijk, I.10
-
180
-
-
77957108166
-
T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice
-
Strissel, K.J., DeFuria, J., Shaul, M.E., Bennett, G., Greenberg, A.S., Obin, M.S., T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice. Obesity (Silver Spring) 18 (2010), 1918–1925.
-
(2010)
Obesity (Silver Spring)
, vol.18
, pp. 1918-1925
-
-
Strissel, K.J.1
DeFuria, J.2
Shaul, M.E.3
Bennett, G.4
Greenberg, A.S.5
Obin, M.S.6
-
181
-
-
84903691827
-
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
-
Szendroedi, J., Yoshimura, T., Phielix, E., Koliaki, C., Marcucci, M., Zhang, D., Jelenik, T., Müller, J., Herder, C., Nowotny, P., et al. Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proc. Natl. Acad. Sci. USA 111 (2014), 9597–9602.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 9597-9602
-
-
Szendroedi, J.1
Yoshimura, T.2
Phielix, E.3
Koliaki, C.4
Marcucci, M.5
Zhang, D.6
Jelenik, T.7
Müller, J.8
Herder, C.9
Nowotny, P.10
-
182
-
-
84865289995
-
Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family
-
Tack, C.J., Stienstra, R., Joosten, L.A., Netea, M.G., Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family. Immunol. Rev. 249 (2012), 239–252.
-
(2012)
Immunol. Rev.
, vol.249
, pp. 239-252
-
-
Tack, C.J.1
Stienstra, R.2
Joosten, L.A.3
Netea, M.G.4
-
183
-
-
84930711285
-
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance
-
Talbot, N.A., Wheeler-Jones, C.P., Cleasby, M.E., Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance. Mol. Cell. Endocrinol. 393 (2014), 129–142.
-
(2014)
Mol. Cell. Endocrinol.
, vol.393
, pp. 129-142
-
-
Talbot, N.A.1
Wheeler-Jones, C.P.2
Cleasby, M.E.3
-
184
-
-
84868671526
-
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
-
Talukdar, S., Oh, D.Y., Bandyopadhyay, G., Li, D., Xu, J., McNelis, J., Lu, M., Li, P., Yan, Q., Zhu, Y., et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat. Med. 18 (2012), 1407–1412.
-
(2012)
Nat. Med.
, vol.18
, pp. 1407-1412
-
-
Talukdar, S.1
Oh, D.Y.2
Bandyopadhyay, G.3
Li, D.4
Xu, J.5
McNelis, J.6
Lu, M.7
Li, P.8
Yan, Q.9
Zhu, Y.10
-
185
-
-
0027374932
-
Impaired immunity in obesity: suppressed but reversible lymphocyte responsiveness
-
Tanaka, S., Inoue, S., Isoda, F., Waseda, M., Ishihara, M., Yamakawa, T., Sugiyama, A., Takamura, Y., Okuda, K., Impaired immunity in obesity: suppressed but reversible lymphocyte responsiveness. Int. J. Obes. Relat. Metab. Disord. 17 (1993), 631–636.
-
(1993)
Int. J. Obes. Relat. Metab. Disord.
, vol.17
, pp. 631-636
-
-
Tanaka, S.1
Inoue, S.2
Isoda, F.3
Waseda, M.4
Ishihara, M.5
Yamakawa, T.6
Sugiyama, A.7
Takamura, Y.8
Okuda, K.9
-
186
-
-
84876285741
-
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
-
Tannahill, G.M., Curtis, A.M., Adamik, J., Palsson-McDermott, E.M., McGettrick, A.F., Goel, G., Frezza, C., Bernard, N.J., Kelly, B., Foley, N.H., et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 496 (2013), 238–242.
-
(2013)
Nature
, vol.496
, pp. 238-242
-
-
Tannahill, G.M.1
Curtis, A.M.2
Adamik, J.3
Palsson-McDermott, E.M.4
McGettrick, A.F.5
Goel, G.6
Frezza, C.7
Bernard, N.J.8
Kelly, B.9
Foley, N.H.10
-
187
-
-
84940647013
-
Potential site effects and transgene expression discrepancies in mouse lifespan studies
-
Thurmond, D.C., Oh, E., Miller, R.A., Potential site effects and transgene expression discrepancies in mouse lifespan studies. Cell Metab. 22 (2015), 346–347.
-
(2015)
Cell Metab.
, vol.22
, pp. 346-347
-
-
Thurmond, D.C.1
Oh, E.2
Miller, R.A.3
-
188
-
-
84912111827
-
Distinct roles for JNK and IKK activation in agouti-related peptide neurons in the development of obesity and insulin resistance
-
Tsaousidou, E., Paeger, L., Belgardt, B.F., Pal, M., Wunderlich, C.M., Brönneke, H., Collienne, U., Hampel, B., Wunderlich, F.T., Schmidt-Supprian, M., et al. Distinct roles for JNK and IKK activation in agouti-related peptide neurons in the development of obesity and insulin resistance. Cell Rep. 9 (2014), 1495–1506.
-
(2014)
Cell Rep.
, vol.9
, pp. 1495-1506
-
-
Tsaousidou, E.1
Paeger, L.2
Belgardt, B.F.3
Pal, M.4
Wunderlich, C.M.5
Brönneke, H.6
Collienne, U.7
Hampel, B.8
Wunderlich, F.T.9
Schmidt-Supprian, M.10
-
189
-
-
33746101818
-
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
-
Tuncman, G., Hirosumi, J., Solinas, G., Chang, L., Karin, M., Hotamisligil, G.S., Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc. Natl. Acad. Sci. USA 103 (2006), 10741–10746.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 10741-10746
-
-
Tuncman, G.1
Hirosumi, J.2
Solinas, G.3
Chang, L.4
Karin, M.5
Hotamisligil, G.S.6
-
190
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano, F., Wang, X., Bertolotti, A., Zhang, Y., Chung, P., Harding, H.P., Ron, D., Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287 (2000), 664–666.
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Harding, H.P.6
Ron, D.7
-
191
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
-
Uysal, K.T., Wiesbrock, S.M., Marino, M.W., Hotamisligil, G.S., Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389 (1997), 610–614.
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
192
-
-
0026075959
-
Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans
-
Van der Poll, T., Romijn, J.A., Endert, E., Borm, J.J., Büller, H.R., Sauerwein, H.P., Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans. Am. J. Physiol. 261 (1991), E457–E465.
-
(1991)
Am. J. Physiol.
, vol.261
, pp. E457-E465
-
-
Van der Poll, T.1
Romijn, J.A.2
Endert, E.3
Borm, J.J.4
Büller, H.R.5
Sauerwein, H.P.6
-
193
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar, B., Youm, Y.H., Ravussin, A., Galgani, J.E., Stadler, K., Mynatt, R.L., Ravussin, E., Stephens, J.M., Dixit, V.D., The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17 (2011), 179–188.
-
(2011)
Nat. Med.
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
Youm, Y.H.2
Ravussin, A.3
Galgani, J.E.4
Stadler, K.5
Mynatt, R.L.6
Ravussin, E.7
Stephens, J.M.8
Dixit, V.D.9
-
194
-
-
0015237292
-
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
-
Vane, J.R., Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol. 231 (1971), 232–235.
-
(1971)
Nat. New Biol.
, vol.231
, pp. 232-235
-
-
Vane, J.R.1
-
195
-
-
0030864185
-
Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice
-
Ventre, J., Doebber, T., Wu, M., MacNaul, K., Stevens, K., Pasparakis, M., Kollias, G., Moller, D.E., Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice. Diabetes 46 (1997), 1526–1531.
-
(1997)
Diabetes
, vol.46
, pp. 1526-1531
-
-
Ventre, J.1
Doebber, T.2
Wu, M.3
MacNaul, K.4
Stevens, K.5
Pasparakis, M.6
Kollias, G.7
Moller, D.E.8
-
196
-
-
0034104298
-
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
-
Waeber, G., Delplanque, J., Bonny, C., Mooser, V., Steinmann, M., Widmann, C., Maillard, A., Miklossy, J., Dina, C., Hani, E.H., et al. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat. Genet. 24 (2000), 291–295.
-
(2000)
Nat. Genet.
, vol.24
, pp. 291-295
-
-
Waeber, G.1
Delplanque, J.2
Bonny, C.3
Mooser, V.4
Steinmann, M.5
Widmann, C.6
Maillard, A.7
Miklossy, J.8
Dina, C.9
Hani, E.H.10
-
197
-
-
84866562625
-
Metabolic checkpoints in activated T cells
-
Wang, R., Green, D.R., Metabolic checkpoints in activated T cells. Nat. Immunol. 13 (2012), 907–915.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 907-915
-
-
Wang, R.1
Green, D.R.2
-
198
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg, S.P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R.L., Ferrante, A.W. Jr., Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112 (2003), 1796–1808.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante, A.W.6
-
199
-
-
79955038882
-
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
-
Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M.T., Brickey, W.J., Ting, J.P., Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol. 12 (2011), 408–415.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 408-415
-
-
Wen, H.1
Gris, D.2
Lei, Y.3
Jha, S.4
Zhang, L.5
Huang, M.T.6
Brickey, W.J.7
Ting, J.P.8
-
200
-
-
84904044334
-
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
-
Wernstedt Asterholm, I., Tao, C., Morley, T.S., Wang, Q.A., Delgado-Lopez, F., Wang, Z.V., Scherer, P.E., Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 20 (2014), 103–118.
-
(2014)
Cell Metab.
, vol.20
, pp. 103-118
-
-
Wernstedt Asterholm, I.1
Tao, C.2
Morley, T.S.3
Wang, Q.A.4
Delgado-Lopez, F.5
Wang, Z.V.6
Scherer, P.E.7
-
201
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15 (2009), 921–929.
-
(2009)
Nat. Med.
, vol.15
, pp. 921-929
-
-
Winer, S.1
Chan, Y.2
Paltser, G.3
Truong, D.4
Tsui, H.5
Bahrami, J.6
Dorfman, R.7
Wang, Y.8
Zielenski, J.9
Mastronardi, F.10
-
202
-
-
85027938385
-
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
-
Winer, D.A., Winer, S., Shen, L., Wadia, P.P., Yantha, J., Paltser, G., Tsui, H., Wu, P., Davidson, M.G., Alonso, M.N., et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat. Med. 17 (2011), 610–617.
-
(2011)
Nat. Med.
, vol.17
, pp. 610-617
-
-
Winer, D.A.1
Winer, S.2
Shen, L.3
Wadia, P.P.4
Yantha, J.5
Paltser, G.6
Tsui, H.7
Wu, P.8
Davidson, M.G.9
Alonso, M.N.10
-
203
-
-
85018330840
-
Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure
-
Wolf, Y., Boura-Halfon, S., Cortese, N., Haimon, Z., Sar Shalom, H., Kuperman, Y., Kalchenko, V., Brandis, A., David, E., Segal-Hayoun, Y., et al. Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure. Nat. Immunol. 18 (2017), 665–674.
-
(2017)
Nat. Immunol.
, vol.18
, pp. 665-674
-
-
Wolf, Y.1
Boura-Halfon, S.2
Cortese, N.3
Haimon, Z.4
Sar Shalom, H.5
Kuperman, Y.6
Kalchenko, V.7
Brandis, A.8
David, E.9
Segal-Hayoun, Y.10
-
204
-
-
84940656691
-
Food for thought: revisiting the complexity of food intake
-
Woods, S.C., Begg, D.P., Food for thought: revisiting the complexity of food intake. Cell Metab. 22 (2015), 348–351.
-
(2015)
Cell Metab.
, vol.22
, pp. 348-351
-
-
Woods, S.C.1
Begg, D.P.2
-
205
-
-
84992597199
-
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
-
Xie, M., Yu, Y., Kang, R., Zhu, S., Yang, L., Zeng, L., Sun, X., Yang, M., Billiar, T.R., Wang, H., et al. PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation. Nat. Commun., 7, 2016, 13280.
-
(2016)
Nat. Commun.
, vol.7
, pp. 13280
-
-
Xie, M.1
Yu, Y.2
Kang, R.3
Zhu, S.4
Yang, L.5
Zeng, L.6
Sun, X.7
Yang, M.8
Billiar, T.R.9
Wang, H.10
-
206
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu, H., Barnes, G.T., Yang, Q., Tan, G., Yang, D., Chou, C.J., Sole, J., Nichols, A., Ross, J.S., Tartaglia, L.A., Chen, H., Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112 (2003), 1821–1830.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
207
-
-
85006414829
-
Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease
-
Yan, H., Gao, Y., Zhang, Y., Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease. Mol. Med. Rep. 15 (2017), 180–186.
-
(2017)
Mol. Med. Rep.
, vol.15
, pp. 180-186
-
-
Yan, H.1
Gao, Y.2
Zhang, Y.3
-
208
-
-
22944434929
-
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
-
Yang, Q., Graham, T.E., Mody, N., Preitner, F., Peroni, O.D., Zabolotny, J.M., Kotani, K., Quadro, L., Kahn, B.B., Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436 (2005), 356–362.
-
(2005)
Nature
, vol.436
, pp. 356-362
-
-
Yang, Q.1
Graham, T.E.2
Mody, N.3
Preitner, F.4
Peroni, O.D.5
Zabolotny, J.M.6
Kotani, K.7
Quadro, L.8
Kahn, B.B.9
-
209
-
-
77956396699
-
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance
-
Yang, H., Youm, Y.H., Vandanmagsar, B., Ravussin, A., Gimble, J.M., Greenway, F., Stephens, J.M., Mynatt, R.L., Dixit, V.D., Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J. Immunol. 185 (2010), 1836–1845.
-
(2010)
J. Immunol.
, vol.185
, pp. 1836-1845
-
-
Yang, H.1
Youm, Y.H.2
Vandanmagsar, B.3
Ravussin, A.4
Gimble, J.M.5
Greenway, F.6
Stephens, J.M.7
Mynatt, R.L.8
Dixit, V.D.9
-
210
-
-
84940469888
-
METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction
-
Yang, L., Calay, E.S., Fan, J., Arduini, A., Kunz, R.C., Gygi, S.P., Yalcin, A., Fu, S., Hotamisligil, G.S., METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. Science 349 (2015), 500–506.
-
(2015)
Science
, vol.349
, pp. 500-506
-
-
Yang, L.1
Calay, E.S.2
Fan, J.3
Arduini, A.4
Kunz, R.C.5
Gygi, S.P.6
Yalcin, A.7
Fu, S.8
Hotamisligil, G.S.9
-
211
-
-
84916898719
-
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects
-
Yore, M.M., Syed, I., Moraes-Vieira, P.M., Zhang, T., Herman, M.A., Homan, E.A., Patel, R.T., Lee, J., Chen, S., Peroni, O.D., et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 159 (2014), 318–332.
-
(2014)
Cell
, vol.159
, pp. 318-332
-
-
Yore, M.M.1
Syed, I.2
Moraes-Vieira, P.M.3
Zhang, T.4
Herman, M.A.5
Homan, E.A.6
Patel, R.T.7
Lee, J.8
Chen, S.9
Peroni, O.D.10
-
212
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu, C., Chen, Y., Cline, G.W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J.K., Cushman, S.W., Cooney, G.J., et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277 (2002), 50230–50236.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
Zhang, D.4
Zong, H.5
Wang, Y.6
Bergeron, R.7
Kim, J.K.8
Cushman, S.W.9
Cooney, G.J.10
-
213
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.W., Karin, M., Shoelson, S.E., Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293 (2001), 1673–1677.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
214
-
-
47949099916
-
From endoplasmic-reticulum stress to the inflammatory response
-
Zhang, K., Kaufman, R.J., From endoplasmic-reticulum stress to the inflammatory response. Nature 454 (2008), 455–462.
-
(2008)
Nature
, vol.454
, pp. 455-462
-
-
Zhang, K.1
Kaufman, R.J.2
-
215
-
-
52949096557
-
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
-
Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., Cai, D., Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135 (2008), 61–73.
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
Zhang, G.2
Zhang, H.3
Karin, M.4
Bai, H.5
Cai, D.6
-
216
-
-
33344459071
-
Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: involvement of cAMP-PKA and MAPK pathways
-
Zhao, T., Hou, M., Xia, M., Wang, Q., Zhu, H., Xiao, Y., Tang, Z., Ma, J., Ling, W., Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: involvement of cAMP-PKA and MAPK pathways. Cell. Immunol. 238 (2005), 19–30.
-
(2005)
Cell. Immunol.
, vol.238
, pp. 19-30
-
-
Zhao, T.1
Hou, M.2
Xia, M.3
Wang, Q.4
Zhu, H.5
Xiao, Y.6
Tang, Z.7
Ma, J.8
Ling, W.9
-
217
-
-
85022001562
-
Platelet-derived mitochondria display embryonic stem cell markers and improve pancreatic islet β-cell function in humans
-
Zhao, Y., Jiang, Z., Delgado, E., Li, H., Zhou, H., Hu, W., Perez-Basterrechea, M., Janostakova, A., Tan, Q., Wang, J., et al. Platelet-derived mitochondria display embryonic stem cell markers and improve pancreatic islet β-cell function in humans. Stem Cells Transl. Med. 6 (2017), 1684–1697.
-
(2017)
Stem Cells Transl. Med.
, vol.6
, pp. 1684-1697
-
-
Zhao, Y.1
Jiang, Z.2
Delgado, E.3
Li, H.4
Zhou, H.5
Hu, W.6
Perez-Basterrechea, M.7
Janostakova, A.8
Tan, Q.9
Wang, J.10
-
218
-
-
75649096002
-
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
-
Zhou, R., Tardivel, A., Thorens, B., Choi, I., Tschopp, J., Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11 (2010), 136–140.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 136-140
-
-
Zhou, R.1
Tardivel, A.2
Thorens, B.3
Choi, I.4
Tschopp, J.5
|