Inflammasome is a central player in the induction of obesity and insulin resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 37, 2011, Pages 15324-15329

  Stienstra, Rinke ^a,b,c   Van Diepen, Janna A ^d   Tack, Cees J ^a   Zaki, Md Hasan ^c   Van De Veerdonk, Frank L ^a,c   Perera, Deshani ^c   Neale, Geoffrey A ^c   Hooiveld, Guido J ^b   Hijmans, Anneke ^a   Vroegrijk, Irene ^d   Van Den Berg, Sjoerd ^d   Romijn, Johannes ^d   Rensen, Patrick C N ^d   Joosten, Leo A B ^a,c   Netea, Mihai G ^a   Kanneganti, Thirumala Devi ^c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RESISTIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL SIZE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENERGY EXPENDITURE; GENE EXPRESSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MACROPHAGE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; OVERNUTRITION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN FUNCTION;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; CARRIER PROTEINS; CASPASE 1; CELL MOVEMENT; CHOLESTEROL; CYTOSKELETAL PROTEINS; DIETARY FATS; ENERGY METABOLISM; FATTY LIVER; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERINSULINISM; HYPERTROPHY; INFLAMMASOMES; INSULIN RESISTANCE; MACROPHAGES; MALE; MICE; OBESITY; TRIGLYCERIDES;

MUS;

EID: 80053087484     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100255108     Document Type: Article

References (43)

1. Ye Z, Ting JP (2008) NLR, the nucleotide-binding domain leucine-rich repeat containing gene family. Curr Opin Immunol 20(1):3-9.
2. Kanneganti TD, et al. (2006) Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440:233-236.
3. Sutterwala FS, et al. (2006) Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24:317-327.
4. Mariathasan S, et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440:228-232. (Pubitemid 43372102)
5. Duewell P, et al. (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464:1357-1361.
6. Aganna E, et al. (2004) Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis. Genes Immun 5:289-293. (Pubitemid 38961162)
7. Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237-241. (Pubitemid 43372104)
8. Ghayur T, et al. (1997) Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 386:619-623. (Pubitemid 27175429)
9. Kuida K, et al. (1995) Altered cytokine export and apoptosis in mice deficient in interleukin- 1 beta converting enzyme. Science 267:2000-2003.
10. Li P, et al. (1995) Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80:401-411.
11. Dinarello CA (1996) Biologic basis for interleukin-1 in disease. Blood 87:2095-2147.
12. Horwood NJ, et al. (1998) Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor. J Clin Invest 101: 595-603. (Pubitemid 28084243)
13. Olee T, Hashimoto S, Quach J, Lotz M (1999) IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. J Immunol 162: 1096-1100. (Pubitemid 29035439)
14. Hotamisligil GS, Erbay E (2008) Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 8:923-934.
15. Odegaard JI, Chawla A (2008) Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat Clin Pract Endocrinol Metab 4:619-626.
16. Xu H, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830. (Pubitemid 38063705)
17. Weisberg SP, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808. (Pubitemid 38063703)
18. Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72:219-246.
19. Shoelson SE, Herrero L, Naaz A (2007) Obesity, inflammation, and insulin resistance. Gastroenterology 132:2169-2180. (Pubitemid 46693756)
20. Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF (2007) Interleukin- 1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 148:241-251. (Pubitemid 46021456)
21. Netea MG, et al. (2006) Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 12:650-656. (Pubitemid 43865233)
22. Zorrilla EP, et al. (2007) Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc Natl Acad Sci USA 104:11097-11102. (Pubitemid 47175232)
23. Stienstra R, et al. (2010) The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 12:593-605.
24. Vandanmagsar B, et al. (2011) The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 17(2):179-188.
25. Steppan CM, et al. (2001) The hormone resistin links obesity to diabetes. Nature 409: 307-312. (Pubitemid 32151228)
26. Goossens GH (2008) The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol Behav 94:206-218.
27. Kanda H, et al. (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116:1494-1505.
28. Hasegawa M, et al. (2009) Mechanism and repertoire of ASC-mediated gene expression. J Immunol 182:7655-7662.
29. Shaw PJ, et al. (2010) Cutting edge: Critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. J Immunol 184:4610-4614.
30. Ippagunta SK, et al. (2010) Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis. J Biol Chem 285:12454-12462.
31. Shao W, Yeretssian G, Doiron K, Hussain SN, Saleh M (2007) The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J Biol Chem 282:36321-36329.
32. Koenen TB, et al. (2011) Hyperglycemia activates caspase-1 and TXNIP-mediated IL- 1beta transcription in human adipose tissue. Diabetes 60:517-524.
33. Zaki MH, et al. (2010) The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32:379-391.
34. Thomas PG, et al. (2009) The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30: 566-575.
35. Voshol PJ, et al. (2001) In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes 50:2585-2590. (Pubitemid 33642778)
36. Voshol PJ, et al. (2003) Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 144:3456-3462. (Pubitemid 36904422)
37. Dai M, et al. (2005) Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res 33(20):e175.
38. Bolstad BM (2004) Low level analysis of high-density oligonucleotide array data: Background, normalization and summarization. PhD dissertation. (University of California, Berkeley).
39. Smyth GK (2004) Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article 3.
40. SartorMA, et al. (2006) Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments. BMC Bioinformatics 7:538.
41. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100:9440-9445. (Pubitemid 37033947)
42. Subramanian A, et al. (2005) Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102: 15545-15550. (Pubitemid 41528093)
43. Merico D, Isserlin R, Stueker O, Emili A, Bader GD (2010) Enrichment map: A network-based method for gene-set enrichment visualization and interpretation. PLoS ONE 5: e13984.