-
1
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805-820, doi: 10.1016/j.cell.2010.01.022 (2010).
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
2
-
-
77950362382
-
The inflammasomes
-
Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821-832, doi: 10.1016/j.cell.2010.01.040 (2010).
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
3
-
-
84890417847
-
The central role of anti-IL-1 blockade in the treatment of monogenic and multifactorial autoinflammatory diseases
-
Federici, S., Martini, A. & Gattorno, M. The central role of anti-IL-1 blockade in the treatment of monogenic and multifactorial autoinflammatory diseases. Front. Immunol. 4, doi: 10.3389/fimmu.2013.00351 (2013).
-
(2013)
Front. Immunol
, vol.4
-
-
Federici, S.1
Martini, A.2
Gattorno, M.3
-
4
-
-
79955038882
-
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
-
Wen, H. et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol. 12, 408-415, doi: 10.1038/ni.2022 (2011).
-
(2011)
Nat. Immunol
, vol.12
, pp. 408-415
-
-
Wen, H.1
-
5
-
-
84969330331
-
Interleukin-1β in Central Nervous System Injury and Repair
-
Hewett, S. J., Jackman, N. A. & Claycomb, R. J. Interleukin-1β in Central Nervous System Injury and Repair. Eur. J. Neurodegener. Dis. 1, 195-211 (2012).
-
(2012)
Eur. J. Neurodegener. Dis
, vol.1
, pp. 195-211
-
-
Hewett, S.J.1
Jackman, N.A.2
Claycomb, R.J.3
-
6
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
Larsen, C. M. et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 356, 1517-1526, doi: 10.1056/ NEJMoa065213 (2007).
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 1517-1526
-
-
Larsen, C.M.1
-
7
-
-
77649108168
-
Blockade of interleukin 1 in type 1 diabetes mellitus
-
Mandrup-Poulsen, T., Pickersgill, L. & Donath, M. Y. Blockade of interleukin 1 in type 1 diabetes mellitus. Nat. Rev. Endocrinol. 6, 158-166, doi: 10.1038/nrendo.2009.271 (2010).
-
(2010)
Nat. Rev. Endocrinol
, vol.6
, pp. 158-166
-
-
Mandrup-Poulsen, T.1
Pickersgill, L.2
Donath, M.Y.3
-
8
-
-
0031013877
-
The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR
-
Melville, M. W., Hansen, W. J., Freeman, B. C., Welch, W. J. & Katze, M. G. The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR. Proc. Natl. Acad. Sci. USA 94, 97-102 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 97-102
-
-
Melville, M.W.1
Hansen, W.J.2
Freeman, B.C.3
Welch, W.J.4
Katze, M.G.5
-
9
-
-
0030026945
-
The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity
-
Polyak, S. J., Tang, N., Wambach, M., Barber, G. N. & Katze, M. G. The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. J. Biol. Chem. 271, 1702-1707 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 1702-1707
-
-
Polyak, S.J.1
Tang, N.2
Wambach, M.3
Barber, G.N.4
Katze, M.G.5
-
10
-
-
0029855773
-
The 58-kDa cellular inhibitor of the double stranded RNA-dependent protein kinase requires the tetratricopeptide repeat 6 and DnaJ motifs to stimulate protein synthesis in vivo
-
Tang, N. M., Ho, C. Y. & Katze, M. G. The 58-kDa cellular inhibitor of the double stranded RNA-dependent protein kinase requires the tetratricopeptide repeat 6 and DnaJ motifs to stimulate protein synthesis in vivo. J. Biol. Chem. 271, 28660-28666 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 28660-28666
-
-
Tang, N.M.1
Ho, C.Y.2
Katze, M.G.3
-
11
-
-
34548512233
-
The role of p58IPK in protecting the stressed endoplasmic reticulum
-
Rutkowski, D. T. et al. The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol. Biol. Cell. 18, 3681-3691, doi: 10.1091/mbc.E07-03-0272 (2007).
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 3681-3691
-
-
Rutkowski, D.T.1
-
12
-
-
0027418321
-
The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans
-
Samuel, C. E. The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans. J. Biol. Chem. 268, 7603-7606 (1993).
-
(1993)
J. Biol. Chem
, vol.268
, pp. 7603-7606
-
-
Samuel, C.E.1
-
13
-
-
33847236171
-
Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation
-
Takada, Y., Ichikawa, H., Pataer, A., Swisher, S. & Aggarwal, B. B. Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation. Oncogene 26, 1201-1212, doi: 10.1038/sj.onc.1209906 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 1201-1212
-
-
Takada, Y.1
Ichikawa, H.2
Pataer, A.3
Swisher, S.4
Aggarwal, B.B.5
-
14
-
-
0034082457
-
PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex
-
Bonnet, M. C., Weil, R., Dam, E., Hovanessian, A. G. & Meurs, E. F. PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex. Mol. Cell. Biol. 20, 4532-4542 (2000).
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 4532-4542
-
-
Bonnet, M.C.1
Weil, R.2
Dam, E.3
Hovanessian, A.G.4
Meurs, E.F.5
-
15
-
-
0033621619
-
NF-kappaB activation by double-stranded-RNAactivated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase
-
Zamanian-Daryoush, M., Mogensen, T. H., DiDonato, J. A. & Williams, B. R. NF-kappaB activation by double-stranded-RNAactivated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase. Mol. Cell. Biol. 20, 1278-1290 (2000).
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 1278-1290
-
-
Zamanian-Daryoush, M.1
Mogensen, T.H.2
DiDonato, J.A.3
Williams, B.R.4
-
16
-
-
58049190885
-
Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling
-
Zhang, P. & Samuel, C. E. Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling. J. Biol. Chem. 283, 34580-34587, doi: 10.1074/jbc.M807029200 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 34580-34587
-
-
Zhang, P.1
Samuel, C.E.2
-
17
-
-
72849148211
-
Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virus
-
McAllister, C. S. et al. Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virus. J. Virol. 84, 380-386, doi: 10.1128/JVI.02630-08 (2010).
-
(2010)
J. Virol
, vol.84
, pp. 380-386
-
-
McAllister, C.S.1
-
18
-
-
84865511926
-
Novel role of PKR in inflammasome activation and HMGB1 release
-
Lu, B. et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature 488, 670-674, doi: 10.1038/nature11290 (2012).
-
(2012)
Nature
, vol.488
, pp. 670-674
-
-
Lu, B.1
-
19
-
-
84876872146
-
The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages
-
He, Y., Franchi, L. & Núñez, G. The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. Eur. J. Immunol. 43, 1147-1152, doi: 10.1002/eji.201243187 (2013).
-
(2013)
Eur. J. Immunol
, vol.43
, pp. 1147-1152
-
-
He, Y.1
Franchi, L.2
Núñez, G.3
-
20
-
-
0034663942
-
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin
-
Goh, K. C., deVeer, M. J. & Williams, B. R. G. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J. 19, 4292-4297, doi: 10.1093/emboj/19.16.4292 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 4292-4297
-
-
Goh, K.C.1
DeVeer, M.J.2
Williams, B.R.G.3
-
21
-
-
37549052546
-
PKR Regulates TLR2/TLR4-Dependent Signaling in Murine Alveolar Macrophages
-
Cabanski, M. et al. PKR Regulates TLR2/TLR4-Dependent Signaling in Murine Alveolar Macrophages. Am. J. Respir. Cell Mol. Biol. 38, 26-31, doi: 10.1165/rcmb.2007-0010OC (2008).
-
(2008)
Am. J. Respir. Cell Mol. Biol
, vol.38
, pp. 26-31
-
-
Cabanski, M.1
-
22
-
-
33744472990
-
Lipopolysaccharide-mediated signal transduction: Stabilization of TNFalpha mRNA contributes to increased lipopolysaccharide-stimulated TNF-alpha production by Kupffer cells after chronic ethanol feeding
-
Kishore, R., McMullen, M. R., Cocuzzi, E. & Nagy, L. E. Lipopolysaccharide-mediated signal transduction: Stabilization of TNFalpha mRNA contributes to increased lipopolysaccharide-stimulated TNF-alpha production by Kupffer cells after chronic ethanol feeding. Comp. Hepatol. 3 Suppl 1, S31, doi: 10.1186/1476-5926-2-S1-S31 (2004).
-
(2004)
Comp. Hepatol
, vol.3
, pp. S31
-
-
Kishore, R.1
McMullen, M.R.2
Cocuzzi, E.3
Nagy, L.E.4
-
23
-
-
12044259166
-
Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: Evidence for a positive autoregulatory loop
-
Hiscott, J. et al. Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. Mol. Cell. Biol. 13, 6231-6240 (1993).
-
(1993)
Mol. Cell. Biol
, vol.13
, pp. 6231-6240
-
-
Hiscott, J.1
-
24
-
-
0025343895
-
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
-
Libermann, T. A. & Baltimore, D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol. Cell. Biol. 10, 2327-2334 (1990).
-
(1990)
Mol. Cell. Biol
, vol.10
, pp. 2327-2334
-
-
Libermann, T.A.1
Baltimore, D.2
-
25
-
-
84928346009
-
ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells
-
Huang, H., Jing, G., Wang, J., Sheibani, N. & Zhang, S. ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells. J. Inflamm. 12, 31 (2015).
-
(2015)
J. Inflamm
, vol.12
, pp. 31
-
-
Huang, H.1
Jing, G.2
Wang, J.3
Sheibani, N.4
Zhang, S.5
-
26
-
-
84920614410
-
P58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity
-
Roobol, A. et al. p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. Biochem. J. 465, 213-225, doi: 10.1042/BJ20140852 (2015).
-
(2015)
Biochem. J
, vol.465
, pp. 213-225
-
-
Roobol, A.1
-
27
-
-
67249119884
-
P58IPK: A Novel "cIHD" Member of the Host Innate Defense Response against Pathogenic Virus Infection
-
Goodman, A. G. et al. P58IPK: A Novel "CIHD" Member of the Host Innate Defense Response against Pathogenic Virus Infection. PLoS Pathog. 5, e1000438, doi: 10.1371/journal.ppat.1000438 (2009).
-
(2009)
PLoS Pathog
, vol.5
-
-
Goodman, A.G.1
-
28
-
-
75749108288
-
Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
-
Nakamura, T. et al. Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell 140, 338-348, doi: 10.1016/j.cell.2010.01.001 (2010).
-
(2010)
Cell
, vol.140
, pp. 338-348
-
-
Nakamura, T.1
-
29
-
-
84893155439
-
Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice
-
Nakamura, T., Arduini, A., Baccaro, B., Furuhashi, M. & Hotamisligil, G. S. Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice. Diabetes 63, 526-534, doi: 10.2337/db13-1019 (2014).
-
(2014)
Diabetes
, vol.63
, pp. 526-534
-
-
Nakamura, T.1
Arduini, A.2
Baccaro, B.3
Furuhashi, M.4
Hotamisligil, G.S.5
-
30
-
-
1642617628
-
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
-
Hsu, L.-C. et al. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428, 341-345 (2004).
-
(2004)
Nature
, vol.428
, pp. 341-345
-
-
Hsu, L.-C.1
-
31
-
-
84902191775
-
Protein Kinase R and the Inflammasome
-
Yim, H. C. H. & Williams, B. R. G. Protein Kinase R and the Inflammasome. Interferon Cytokine Res. 34, 447-454, doi: 10.1089/ jir.2014.0008 (2014).
-
(2014)
Interferon Cytokine Res
, vol.34
, pp. 447-454
-
-
Yim, H.C.H.1
Williams, B.R.G.2
-
32
-
-
84871445129
-
Macrophage Metalloelastase (MMP-12) Deficiency Mitigates Retinal Inflammation and Pathological Angiogenesis in Ischemic Retinopathy
-
Li, J. et al. Macrophage Metalloelastase (MMP-12) Deficiency Mitigates Retinal Inflammation and Pathological Angiogenesis in Ischemic Retinopathy. PLoS ONE 7, e52699, doi: 10.1371/journal.pone.0052699 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e52699
-
-
Li, J.1
-
33
-
-
58849167699
-
The Isolation and Characterization of Murine Macrophages
-
Zhang, X., Goncalves, R. & Mosser, D. M. The Isolation and Characterization of Murine Macrophages. Curr. Protoc. Immunol, doi: 10.1002/0471142735.im1401s83 (2008).
-
(2008)
Curr. Protoc. Immunol
-
-
Zhang, X.1
Goncalves, R.2
Mosser, D.M.3
-
34
-
-
84923330445
-
Identification of p58IPK as a Novel Neuroprotective Factor for Retinal Neurons
-
Boriushkin, E. et al. Identification of p58IPK as a Novel Neuroprotective Factor for Retinal Neurons. Invest. Ophthalmol. Vis. Sci. 56, 1374-86, doi: 10.1167/iovs.1114-15196 (2015).
-
(2015)
Invest. Ophthalmol. Vis. Sci
, vol.56
, pp. 1374-1386
-
-
Boriushkin, E.1
|