Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation

Cytokine

Volumn 62, Issue 1, 2013, Pages 96-103

  Ballak, Dov B ^a   Stienstra, Rinke ^a   Hijmans, Anneke ^a   Joosten, Leo A B ^a   Netea, Mihai G ^a   Tack, Cees J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adaptive immune system; Adipose tissue; Glucose intolerance; Macrophages; Obesity induced inflammation

Indexed keywords

CD68 ANTIGEN; CXCL1 CHEMOKINE; GLUCOSE; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD68 GENE; CELL POPULATION; CELL PROTECTION; CELL TRANSPORT; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; F4 80 GENE; GENE; GENE EXPRESSION; GLUCOSE INTOLERANCE; INFLAMMATION; MALE; MCP 1 GENE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; T LYMPHOCYTE; WILD TYPE;

ADIPOSE TISSUE; ANIMALS; B-LYMPHOCYTES; BODY WEIGHT; DIET, HIGH-FAT; EPIDIDYMIS; FEEDING BEHAVIOR; GLUCOSE INTOLERANCE; INFLAMMATION; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, INBRED C57BL; MICE, SCID; OBESITY; T-LYMPHOCYTES;

ANIMALIA; MUS;

EID: 84875809756     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2013.02.009     Document Type: Article

References (36)

1. WHO. WHO fact files: ten facts on obesity. Geneva: WHO; 2010.
2. Gregor M.F., Hotamisligil G.S. Inflammatory mechanisms in obesity. Ann Rev Immunol 2011.
3. Nguyen M.T., Favelyukis S., Nguyen A.K., Reichart D., Scott P.A., Jenn A., et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 2007, 282:35279-35292.
4. Olefsky J.M., Glass C.K. Macrophages, inflammation, and insulin resistance. Ann Rev Physiol 2010, 72:219-246.
5. Shoelson S.E., Herrero L., Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007, 132:2169-2180.
6. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808.
7. Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003, 112:1821-1830.
8. Wood I.S., de Heredia F.P., Wang B., Trayhurn P. Cellular hypoxia and adipose tissue dysfunction in obesity. Proc Nutr Soc 2009, 68:370-377.
9. Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
10. Shi H., Kokoeva M.V., Inouye K., Tzameli I., Yin H., Flier J.S. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006, 116:3015-3025.
11. Suganami T., Nishida J., Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arteriosclerosis Thrombosis Vascular Biol 2005, 25:2062-2068.
12. Keophiphath M., Achard V., Henegar C., Rouault C., Clement K., Lacasa D. Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes. Mol Endocrinol 2009, 23:11-24.
13. Odegaard J.I., Chawla A. Alternative macrophage activation and metabolism. Annu Rev Pathol 2011, 6:275-297.
14. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003, 3:23-35.
15. Martinez F.O., Sica A., Mantovani A., Locati M. Macrophage activation and polarization. Front Biosci 2008, 13:453-461.
16. Kosteli A., Sugaru E., Haemmerle G., Martin J.F., Lei J., Zechner R., et al. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest 2010.
17. Liu J., Divoux A., Sun J., Zhang J., Clement K., Glickman J.N., et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 2009, 15:940-945.
18. Wu D., Molofsky A.B., Liang H.E., Ricardo-Gonzalez R.R., Jouihan H.A., Bando J.K., et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 2011, 332:243-247.
19. Ohmura K., Ishimori N., Ohmura Y., Tokuhara S., Nozawa A., Horii S., et al. Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arteriosclerosis Thrombosis Vascular Biol 2010, 30:193-199.
20. Winer D.A., Winer S., Shen L., Wadia P.P., Yantha J., Paltser G., et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 2011, 17:610-617.
21. Winer S., Chan Y., Paltser G., Truong D., Tsui H., Bahrami J., et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 2009, 15:921-929.
22. + effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009, 15:914-920.
23. Goossens G.H., Blaak E.E., Theunissen R., Duijvestijn A.M., Clement K., Tervaert J.W., et al. Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans. Mol Immunol 2012, 50:142-149.
24. Li M.O., Wan Y.Y., Sanjabi S., Robertson A.K., Flavell R.A. Transforming growth factor-beta regulation of immune responses. Ann Rev Immunol 2006, 24:99-146.
25. Duffaut C., Galitzky J., Lafontan M., Bouloumie A. Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun 2009, 384:482-485.
26. Wu H., Ghosh S., Perrard X.D., Feng L., Garcia G.E., Perrard J.L., et al. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 2007, 115:1029-1038.
27. Feuerer M., Herrero L., Cipolletta D., Naaz A., Wong J., Nayer A., et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009, 15:930-939.
28. Zeyda M., Huber J., Prager G., Stulnig T.M. Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients. Obesity 2011, 19:743-748.
29. Duffaut C., Zakaroff-Girard A., Bourlier V., Decaunes P., Maumus M., Chiotasso P., et al. Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators. Arteriosclerosis Thrombosis Vascular Biol 2009, 29:1608-1614.
30. Netea M.G., Demacker P.N., Kullberg B.J., Boerman O.C., Verschueren I., Stalenhoef A.F., et al. Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections. J Clin Invest 1996, 97:1366-1372.
31. Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S. A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell 2009, 136:1056-1072.
32. Fagarasan S., Kawamoto S., Kanagawa O., Suzuki K. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Ann Immunol 2010, 28:243-273.
33. Neels J.G., Badeanlou L., Hester K.D., Samad F. Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis. J Biol Chem 2009, 284:20692-20698.
34. Talukdar S., Oh da Y., Bandyopadhyay G., Li D., Xu J., McNelis J., et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med 2012, 18:1407-1412.
35. Chawla A., Nguyen K.D., Goh Y.P. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol 2011, 11:738-749.
36. Ilan Y., Maron R., Tukpah A.M., Maioli T.U., Murugaiyan G., Yang K., et al. Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc Natl Acad Sci United States of America 2010, 107:9765-9770.