Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis

Nature Chemical Biology

Volumn 9, Issue 6, 2013, Pages 398-405

  Hett, Erik C ^a,b,c,g   Slater, Louise H ^a,b,c   Mark, Kevin G ^a,b,c   Kawate, Tomohiko ^a,b,c   Monks, Brian G ^d,e   Stutz, Andrea ^e   Latz, Eicke ^d,e,f   Hung, Deborah T ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF BONN   (Germany)

^f GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^g PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 DESACETOXY 6,7 DEHYDROGEDUNIN; ADAPTOR PROTEIN; ANTHRAX LETHAL TOXIN; ANTHRAX TOXIN; ASC PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; NIGERICIN; PROTEIN KINASE R; RNA; SMALL INTERFERING RNA; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CHEMICAL GENETICS; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; MACROPHAGE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; PYROPTOSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; BACILLUS ANTHRACIS; CASPASE 1; CATALYTIC DOMAIN; CELL DEATH; CELL LINE; EIF-2 KINASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HSP90 HEAT-SHOCK PROTEINS; HYDROGEN-ION CONCENTRATION; INFLAMMATION; MACROPHAGES; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION;

EID: 84879098248     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1236     Document Type: Article

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