메뉴 건너뛰기




Volumn 366, Issue 2, 2013, Pages 224-234

Immunometabolism of AMPK in insulin resistance and atherosclerosis

Author keywords

Cardiovascular disease; Cytokine; Diabetes; Inflammation; Metabolism; Obesity

Indexed keywords

FATTY ACID; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INFLAMMASOME; INSULIN; INTERLEUKIN 1BETA; LIPID;

EID: 84872660747     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.02.004     Document Type: Review
Times cited : (58)

References (161)
  • 2
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T., Hemo I., Itin A., Pe'er J., Stone J., Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med. 1995, 1:1024-1028.
    • (1995) Nat. Med. , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Pe'er, J.4    Stone, J.5    Keshet, E.6
  • 3
    • 0036658739 scopus 로고    scopus 로고
    • A novel phenotype for an activated macrophage: the type 2 activated macrophage
    • Anderson C.F., Mosser D.M. A novel phenotype for an activated macrophage: the type 2 activated macrophage. J. Leukoc. Biol. 2002, 72:101-106.
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 101-106
    • Anderson, C.F.1    Mosser, D.M.2
  • 5
    • 0015864346 scopus 로고
    • Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol
    • Beg Z.H., Allmann D.W., Gibson D.M. Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol. Biochem. Biophys. Res. Commun. 1973, 54:1362-1369.
    • (1973) Biochem. Biophys. Res. Commun. , vol.54 , pp. 1362-1369
    • Beg, Z.H.1    Allmann, D.W.2    Gibson, D.M.3
  • 6
    • 0015420995 scopus 로고
    • Interrelated changes in host metabolism during generalized infectious illness
    • Beisel W.R. Interrelated changes in host metabolism during generalized infectious illness. Am. J. Clin. Nutr. 1972, 25:1254-1260.
    • (1972) Am. J. Clin. Nutr. , vol.25 , pp. 1254-1260
    • Beisel, W.R.1
  • 7
    • 0016414203 scopus 로고
    • Metabolic response to infection
    • Beisel W.R. Metabolic response to infection. Annu. Rev. Med. 1975, 26:9-20.
    • (1975) Annu. Rev. Med. , vol.26 , pp. 9-20
    • Beisel, W.R.1
  • 9
    • 14344257169 scopus 로고    scopus 로고
    • AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells
    • Cacicedo J.M., Yagihashi N., Keaney J.F., Ruderman N.B., Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem. Biophys. Re.s Commun. 2004, 324:1204-1209.
    • (2004) Biochem. Biophys. Re.s Commun. , vol.324 , pp. 1204-1209
    • Cacicedo, J.M.1    Yagihashi, N.2    Keaney, J.F.3    Ruderman, N.B.4    Ido, Y.5
  • 12
    • 0015918822 scopus 로고
    • Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation
    • Carlson C.A., Kim K.H. Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation. J. Biol. Chem. 1973, 248:378-380.
    • (1973) J. Biol. Chem. , vol.248 , pp. 378-380
    • Carlson, C.A.1    Kim, K.H.2
  • 13
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat. Med. 2003, 9:653-660.
    • (2003) Nat. Med. , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 15
    • 54049138456 scopus 로고    scopus 로고
    • Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression
    • Chandrasekar B., Boylston W.H., Venkatachalam K., Webster N.J., Prabhu S.D., Valente A.J. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J. Biol. Chem. 2008, 283:24889-24898.
    • (2008) J. Biol. Chem. , vol.283 , pp. 24889-24898
    • Chandrasekar, B.1    Boylston, W.H.2    Venkatachalam, K.3    Webster, N.J.4    Prabhu, S.D.5    Valente, A.J.6
  • 16
    • 7244242357 scopus 로고    scopus 로고
    • Chemokines in the pathogenesis of vascular disease
    • Charo I.F., Taubman M.B. Chemokines in the pathogenesis of vascular disease. Circ. Res. 2004, 95:858-866.
    • (2004) Circ. Res. , vol.95 , pp. 858-866
    • Charo, I.F.1    Taubman, M.B.2
  • 17
    • 0036072017 scopus 로고    scopus 로고
    • Regulation of endothelial cell survival and apoptosis during angiogenesis
    • Chavakis E., Dimmeler S. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler. Thromb. Vasc. Biol. 2002, 22:887-893.
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 887-893
    • Chavakis, E.1    Dimmeler, S.2
  • 18
    • 80355133234 scopus 로고    scopus 로고
    • Macrophage-mediated inflammation in metabolic disease
    • Chawla A., Nguyen K.D., Goh Y.P. Macrophage-mediated inflammation in metabolic disease. Nat. Rev. Immunol. 2011, 11:738-749.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 738-749
    • Chawla, A.1    Nguyen, K.D.2    Goh, Y.P.3
  • 19
    • 80054119745 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice
    • Cheang W.S., Wong W.T., Tian X.Y., Yang Q., Lee H.K., He G.W., Yao X., Huang Y. Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. Cardiovasc. Res. 2011, 92:267-275.
    • (2011) Cardiovasc. Res. , vol.92 , pp. 267-275
    • Cheang, W.S.1    Wong, W.T.2    Tian, X.Y.3    Yang, Q.4    Lee, H.K.5    He, G.W.6    Yao, X.7    Huang, Y.8
  • 20
    • 0242581695 scopus 로고    scopus 로고
    • Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    • Chen H., Montagnani M., Funahashi T., Shimomura I., Quon M.J. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J. Biol. Chem. 2003, 278:45021-45026.
    • (2003) J. Biol. Chem. , vol.278 , pp. 45021-45026
    • Chen, H.1    Montagnani, M.2    Funahashi, T.3    Shimomura, I.4    Quon, M.J.5
  • 24
    • 73349127065 scopus 로고    scopus 로고
    • Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
    • Clementi A.H., Gaudy A.M., van Rooijen N., Pierce R.H., Mooney R.A. Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim. Biophys. Acta 2009, 1792:1062-1072.
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 1062-1072
    • Clementi, A.H.1    Gaudy, A.M.2    van Rooijen, N.3    Pierce, R.H.4    Mooney, R.A.5
  • 26
    • 0030873452 scopus 로고    scopus 로고
    • Energy turnover of vascular endothelial cells
    • Culic O., Gruwel M.L., Schrader J. Energy turnover of vascular endothelial cells. Am. J. Physiol. 1997, 273:C205-C213.
    • (1997) Am. J. Physiol. , vol.273
    • Culic, O.1    Gruwel, M.L.2    Schrader, J.3
  • 27
    • 0033547339 scopus 로고    scopus 로고
    • The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells
    • Dagher Z., Ruderman N., Tornheim K., Ido Y. The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 1999, 265:112-115.
    • (1999) Biochem. Biophys. Res. Commun. , vol.265 , pp. 112-115
    • Dagher, Z.1    Ruderman, N.2    Tornheim, K.3    Ido, Y.4
  • 28
    • 0035933369 scopus 로고    scopus 로고
    • Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells
    • Dagher Z., Ruderman N., Tornheim K., Ido Y. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ. Res. 2001, 88:1276-1282.
    • (2001) Circ. Res. , vol.88 , pp. 1276-1282
    • Dagher, Z.1    Ruderman, N.2    Tornheim, K.3    Ido, Y.4
  • 29
    • 0345548705 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion
    • De Souza C.T., Gasparetti A.L., Pereira-da-Silva M., Araujo E.P., Carvalheira J.B., Saad M.J., Boschero A.C., Carneiro E.M., Velloso L.A. Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion. Diabetologia 2003, 46:1522-1531.
    • (2003) Diabetologia , vol.46 , pp. 1522-1531
    • De Souza, C.T.1    Gasparetti, A.L.2    Pereira-da-Silva, M.3    Araujo, E.P.4    Carvalheira, J.B.5    Saad, M.J.6    Boschero, A.C.7    Carneiro, E.M.8    Velloso, L.A.9
  • 30
    • 0020563692 scopus 로고
    • Metabolic properties of freshly isolated bovine endothelial cells
    • Dobrina A., Rossi F. Metabolic properties of freshly isolated bovine endothelial cells. Biochim. Biophys. Acta 1983, 762:295-301.
    • (1983) Biochim. Biophys. Acta , vol.762 , pp. 295-301
    • Dobrina, A.1    Rossi, F.2
  • 31
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath M.Y., Shoelson S.E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 2011, 11:98-107.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 32
    • 77149134285 scopus 로고    scopus 로고
    • Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo
    • Dong Y., Zhang M., Liang B., Xie Z., Zhao Z., Asfa S., Choi H.C., Zou M.H. Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation 2010, 121:792-803.
    • (2010) Circulation , vol.121 , pp. 792-803
    • Dong, Y.1    Zhang, M.2    Liang, B.3    Xie, Z.4    Zhao, Z.5    Asfa, S.6    Choi, H.C.7    Zou, M.H.8
  • 33
    • 77953226963 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo
    • Dong Y., Zhang M., Wang S., Liang B., Zhao Z., Liu C., Wu M., Choi H.C., Lyons T.J., Zou M.H. Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes 2010, 59:1386-1396.
    • (2010) Diabetes , vol.59 , pp. 1386-1396
    • Dong, Y.1    Zhang, M.2    Wang, S.3    Liang, B.4    Zhao, Z.5    Liu, C.6    Wu, M.7    Choi, H.C.8    Lyons, T.J.9    Zou, M.H.10
  • 36
    • 0032772463 scopus 로고    scopus 로고
    • Vascular effects of non-esterified fatty acids: implications for the cardiovascular risk factor cluster
    • Egan B.M., Lu G., Greene E.L. Vascular effects of non-esterified fatty acids: implications for the cardiovascular risk factor cluster. Prostaglandins Leukot. Essent. Fatty Acids 1999, 60:411-420.
    • (1999) Prostaglandins Leukot. Essent. Fatty Acids , vol.60 , pp. 411-420
    • Egan, B.M.1    Lu, G.2    Greene, E.L.3
  • 38
    • 0024996687 scopus 로고
    • Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition
    • el Touny S., Khan W., Hannun Y. Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition. J. Biol. Chem. 1990, 265:16437-16443.
    • (1990) J. Biol. Chem. , vol.265 , pp. 16437-16443
    • el Touny, S.1    Khan, W.2    Hannun, Y.3
  • 39
    • 79959714887 scopus 로고    scopus 로고
    • AMPK and vasculoprotection
    • Ewart M.A., Kennedy S. AMPK and vasculoprotection. Pharmacol. Ther. 2011, 131:242-253.
    • (2011) Pharmacol. Ther. , vol.131 , pp. 242-253
    • Ewart, M.A.1    Kennedy, S.2
  • 40
    • 57549088860 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase
    • Ewart M.A., Kohlhaas C.F., Salt I.P. Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase. Arterioscler. Thromb. Vasc. Biol. 2008, 28:2255-2257.
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 2255-2257
    • Ewart, M.A.1    Kohlhaas, C.F.2    Salt, I.P.3
  • 41
    • 79953210362 scopus 로고    scopus 로고
    • Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis
    • Fernandez-Marcos P.J., Auwerx J. Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis. Am. J. Clin. Nutr. 2011, 93:884S-890S.
    • (2011) Am. J. Clin. Nutr. , vol.93
    • Fernandez-Marcos, P.J.1    Auwerx, J.2
  • 42
    • 68049103917 scopus 로고    scopus 로고
    • Activation and signaling by the AMP-activated protein kinase in endothelial cells
    • Fisslthaler B., Fleming I. Activation and signaling by the AMP-activated protein kinase in endothelial cells. Circ. Res. 2009, 105:114-127.
    • (2009) Circ. Res. , vol.105 , pp. 114-127
    • Fisslthaler, B.1    Fleming, I.2
  • 44
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer L.G., Parbu-Patel A., Carling D. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J. Biol. Chem. 2002, 277:25226-25232.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 45
    • 43049121395 scopus 로고    scopus 로고
    • Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
    • Fulco M., Cen Y., Zhao P., Hoffman E.P., McBurney M.W., Sauve A.A., Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev. Cell. 2008, 14:661-673.
    • (2008) Dev. Cell. , vol.14 , pp. 661-673
    • Fulco, M.1    Cen, Y.2    Zhao, P.3    Hoffman, E.P.4    McBurney, M.W.5    Sauve, A.A.6    Sartorelli, V.7
  • 48
    • 0024516569 scopus 로고
    • Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism
    • Garton A.J., Campbell D.G., Carling D., Hardie D.G., Colbran R.J., Yeaman S.J. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. Eur. J. Biochem. 1989, 179:249-254.
    • (1989) Eur. J. Biochem. , vol.179 , pp. 249-254
    • Garton, A.J.1    Campbell, D.G.2    Carling, D.3    Hardie, D.G.4    Colbran, R.J.5    Yeaman, S.J.6
  • 49
    • 33846240080 scopus 로고    scopus 로고
    • 5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions
    • Gaskin F.S., Kamada K., Yusof M., Korthuis R.J. 5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H326-H332.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292
    • Gaskin, F.S.1    Kamada, K.2    Yusof, M.3    Korthuis, R.J.4
  • 50
    • 78650964142 scopus 로고    scopus 로고
    • Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
    • Gauthier M.S., O'Brien E.L., Bigornia S., Mott M., Cacicedo J.M., Xu X.J., Gokce N., Apovian C., Ruderman N. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem. Biophys. Res. Commun. 2010, 404:382-387.
    • (2010) Biochem. Biophys. Res. Commun. , vol.404 , pp. 382-387
    • Gauthier, M.S.1    O'Brien, E.L.2    Bigornia, S.3    Mott, M.4    Cacicedo, J.M.5    Xu, X.J.6    Gokce, N.7    Apovian, C.8    Ruderman, N.9
  • 51
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3:23-35.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 52
    • 0030582102 scopus 로고    scopus 로고
    • Reactive oxygen species-induced impairment of endothelium-dependent relaxation in rat aortic rings: protection by l-arginine
    • Gumusel B., Tel B.C., Demirdamar R., Sahin-Erdemli I. Reactive oxygen species-induced impairment of endothelium-dependent relaxation in rat aortic rings: protection by l-arginine. Eur. J. Pharmacol. 1996, 306:107-112.
    • (1996) Eur. J. Pharmacol. , vol.306 , pp. 107-112
    • Gumusel, B.1    Tel, B.C.2    Demirdamar, R.3    Sahin-Erdemli, I.4
  • 54
    • 67650032833 scopus 로고    scopus 로고
    • Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta
    • Gusarova G.A., Dada L.A., Kelly A.M., Brodie C., Witters L.A., Chandel N.S., Sznajder J.I. Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta. Mol. Cell. Biol. 2009, 29:3455-3464.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3455-3464
    • Gusarova, G.A.1    Dada, L.A.2    Kelly, A.M.3    Brodie, C.4    Witters, L.A.5    Chandel, N.S.6    Sznajder, J.I.7
  • 55
    • 79951669207 scopus 로고    scopus 로고
    • The immune system in atherosclerosis
    • Hansson G.K., Hermansson A. The immune system in atherosclerosis. Nat. Immunol. 2011, 12:204-212.
    • (2011) Nat. Immunol. , vol.12 , pp. 204-212
    • Hansson, G.K.1    Hermansson, A.2
  • 56
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
    • Hardie D.G. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 2007, 8:774-785.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 57
    • 43549093962 scopus 로고    scopus 로고
    • High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells
    • Hattori Y., Nakano Y., Hattori S., Tomizawa A., Inukai K., Kasai K. High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells. FEBS Lett. 2008, 582:1719-1724.
    • (2008) FEBS Lett. , vol.582 , pp. 1719-1724
    • Hattori, Y.1    Nakano, Y.2    Hattori, S.3    Tomizawa, A.4    Inukai, K.5    Kasai, K.6
  • 58
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley S.A., Boudeau J., Reid J.L., Mustard K.J., Udd L., Makela T.P., Alessi D.R., Hardie D.G. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2003, 2:28.
    • (2003) J. Biol. , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 62
    • 80053554640 scopus 로고    scopus 로고
    • Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
    • Holzer R.G., Park E.J., Li N., Tran H., Chen M., Choi C., Solinas G., Karin M. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 2011, 147:173-184.
    • (2011) Cell , vol.147 , pp. 173-184
    • Holzer, R.G.1    Park, E.J.2    Li, N.3    Tran, H.4    Chen, M.5    Choi, C.6    Solinas, G.7    Karin, M.8
  • 63
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 64
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil G.S., Peraldi P., Budavari A., Ellis R., White M.F., Spiegelman B.M. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996, 271:665-668.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 65
    • 77952741468 scopus 로고    scopus 로고
    • Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway
    • Hou X., Song J., Li X.N., Zhang L., Wang X., Chen L., Shen Y.H. Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway. Biochem. Biophys. Res. Commun. 2010, 396:199-205.
    • (2010) Biochem. Biophys. Res. Commun. , vol.396 , pp. 199-205
    • Hou, X.1    Song, J.2    Li, X.N.3    Zhang, L.4    Wang, X.5    Chen, L.6    Shen, Y.H.7
  • 66
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • Huang W., Metlakunta A., Dedousis N., Zhang P., Sipula I., Dube J.J., Scott D.K., O'Doherty R.M. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes 2010, 59:347-357.
    • (2010) Diabetes , vol.59 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3    Zhang, P.4    Sipula, I.5    Dube, J.J.6    Scott, D.K.7    O'Doherty, R.M.8
  • 67
    • 0023910290 scopus 로고
    • Aspects of fatty acid metabolism in vascular endothelial cells
    • Hulsmann W.C., Dubelaar M.L. Aspects of fatty acid metabolism in vascular endothelial cells. Biochimie 1988, 70:681-686.
    • (1988) Biochimie , vol.70 , pp. 681-686
    • Hulsmann, W.C.1    Dubelaar, M.L.2
  • 71
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    • Jager S., Handschin C., St-Pierre J., Spiegelman B.M. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. USA 2007, 104:12017-12022.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 12017-12022
    • Jager, S.1    Handschin, C.2    St-Pierre, J.3    Spiegelman, B.M.4
  • 74
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    • Kang K., Reilly S.M., Karabacak V., Gangl M.R., Fitzgerald K., Hatano B., Lee C.H. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008, 7:485-495.
    • (2008) Cell Metab. , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3    Gangl, M.R.4    Fitzgerald, K.5    Hatano, B.6    Lee, C.H.7
  • 75
    • 77956829319 scopus 로고    scopus 로고
    • 5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner
    • Kanno Y., Inoue Y., Inouye Y. 5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner. J. Toxicol. Sci. 2010, 35:571-576.
    • (2010) J. Toxicol. Sci. , vol.35 , pp. 571-576
    • Kanno, Y.1    Inoue, Y.2    Inouye, Y.3
  • 77
    • 41549084644 scopus 로고    scopus 로고
    • AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression
    • Kim J.E., Kim Y.W., Lee I.K., Kim J.Y., Kang Y.J., Park S.Y. AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression. J. Pharmacol. Sci. 2008, 106:394-403.
    • (2008) J. Pharmacol. Sci. , vol.106 , pp. 394-403
    • Kim, J.E.1    Kim, Y.W.2    Lee, I.K.3    Kim, J.Y.4    Kang, Y.J.5    Park, S.Y.6
  • 90
    • 77958465082 scopus 로고    scopus 로고
    • Adenosine monophosphate activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein e-deficient mice.
    • Li, D., Wang, D., Wang, Y., Ling, W., Feng, X., Xia, M., 2010a. Adenosine monophosphate activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein e-deficient mice. J. Biol. Chem.
    • (2010) J. Biol. Chem
    • Li, D.1    Wang, D.2    Wang, Y.3    Ling, W.4    Feng, X.5    Xia, M.6
  • 91
    • 77953960882 scopus 로고    scopus 로고
    • Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction
    • Li D., Zhang Y., Ma J., Ling W., Xia M. Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. Arterioscler. Thromb. Vasc. Biol. 2010, 30:1354-1362.
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1354-1362
    • Li, D.1    Zhang, Y.2    Ma, J.3    Ling, W.4    Xia, M.5
  • 93
    • 77952016579 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin
    • Liu C., Liang B., Wang Q., Wu J., Zou M.H. Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin. J. Biol. Chem. 2010, 285:15346-15355.
    • (2010) J. Biol. Chem. , vol.285 , pp. 15346-15355
    • Liu, C.1    Liang, B.2    Wang, Q.3    Wu, J.4    Zou, M.H.5
  • 94
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng C.N., Bodzin J.L., Saltiel A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 2007, 117:175-184.
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 95
    • 58149347227 scopus 로고    scopus 로고
    • Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    • Lumeng C.N., DelProposto J.B., Westcott D.J., Saltiel A.R. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 2008, 57:3239-3246.
    • (2008) Diabetes , vol.57 , pp. 3239-3246
    • Lumeng, C.N.1    DelProposto, J.B.2    Westcott, D.J.3    Saltiel, A.R.4
  • 96
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng C.N., Deyoung S.M., Bodzin J.L., Saltiel A.R. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 2007, 56:16-23.
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 99
    • 79151475165 scopus 로고    scopus 로고
    • Immunometabolism: an emerging frontier
    • Mathis D., Shoelson S.E. Immunometabolism: an emerging frontier. Nat. Rev. Immunol. 2011, 11:81.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 81
    • Mathis, D.1    Shoelson, S.E.2
  • 100
    • 44849141880 scopus 로고    scopus 로고
    • AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function
    • Mayer A., Denanglaire S., Viollet B., Leo O., Andris F. AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function. Eur. J. Immunol. 2008, 38:948-956.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 948-956
    • Mayer, A.1    Denanglaire, S.2    Viollet, B.3    Leo, O.4    Andris, F.5
  • 101
    • 60449117423 scopus 로고    scopus 로고
    • AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues
    • McCarty M.F., Barroso-Aranda J., Contreras F. AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues. Med. Hypotheses 2009, 72:468-470.
    • (2009) Med. Hypotheses , vol.72 , pp. 468-470
    • McCarty, M.F.1    Barroso-Aranda, J.2    Contreras, F.3
  • 102
    • 79959813724 scopus 로고    scopus 로고
    • Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy
    • McLaren J.E., Michael D.R., Ashlin T.G., Ramji D.P. Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy. Prog. Lipid Res. 2011, 50:331-347.
    • (2011) Prog. Lipid Res. , vol.50 , pp. 331-347
    • McLaren, J.E.1    Michael, D.R.2    Ashlin, T.G.3    Ramji, D.P.4
  • 103
    • 77950345093 scopus 로고    scopus 로고
    • Inflammation 2010: new adventures of an old flame
    • Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell 2010, 140:771-776.
    • (2010) Cell , vol.140 , pp. 771-776
    • Medzhitov, R.1
  • 105
    • 33746839790 scopus 로고    scopus 로고
    • Scavenger receptors in atherosclerosis: beyond lipid uptake
    • Moore K.J., Freeman M.W. Scavenger receptors in atherosclerosis: beyond lipid uptake. Arterioscler. Thromb. Vasc. Biol. 2006, 26:1702-1711.
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , pp. 1702-1711
    • Moore, K.J.1    Freeman, M.W.2
  • 106
    • 0041355355 scopus 로고    scopus 로고
    • Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells
    • Morrow V.A., Foufelle F., Connell J.M., Petrie J.R., Gould G.W., Salt I.P. Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J. Biol. Chem. 2003, 278:31629-31639.
    • (2003) J. Biol. Chem. , vol.278 , pp. 31629-31639
    • Morrow, V.A.1    Foufelle, F.2    Connell, J.M.3    Petrie, J.R.4    Gould, G.W.5    Salt, I.P.6
  • 107
    • 0030996001 scopus 로고    scopus 로고
    • Global mortality, disability, and the contribution of risk factors: global burden of disease study
    • Murray C.J., Lopez A.D. Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet 1997, 349:1436-1442.
    • (1997) Lancet , vol.349 , pp. 1436-1442
    • Murray, C.J.1    Lopez, A.D.2
  • 108
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada D., Saunders T.L., Morrison S.J. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010, 468:653-658.
    • (2010) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 114
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky J.M., Glass C.K. Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 2010, 72:219-246.
    • (2010) Annu. Rev. Physiol. , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 115
    • 0026101746 scopus 로고
    • Protein kinase C modulates basal myogenic tone in resistance arteries from the cerebral circulation
    • Osol G., Laher I., Cipolla M. Protein kinase C modulates basal myogenic tone in resistance arteries from the cerebral circulation. Circ. Res. 1991, 68:359-367.
    • (1991) Circ. Res. , vol.68 , pp. 359-367
    • Osol, G.1    Laher, I.2    Cipolla, M.3
  • 120
    • 10544246489 scopus 로고    scopus 로고
    • Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability
    • Rajagopalan S., Meng X.P., Ramasamy S., Harrison D.G., Galis Z.S. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J. Clin. Invest. 1996, 98:2572-2579.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2572-2579
    • Rajagopalan, S.1    Meng, X.P.2    Ramasamy, S.3    Harrison, D.G.4    Galis, Z.S.5
  • 121
    • 77955356552 scopus 로고    scopus 로고
    • Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation
    • Rajamaki K., Lappalainen J., Oorni K., Valimaki E., Matikainen S., Kovanen P.T., Eklund K.K. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One 2010, 5:e11765.
    • (2010) PLoS One , vol.5
    • Rajamaki, K.1    Lappalainen, J.2    Oorni, K.3    Valimaki, E.4    Matikainen, S.5    Kovanen, P.T.6    Eklund, K.K.7
  • 122
    • 70350389389 scopus 로고    scopus 로고
    • Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    • Saberi M., Woods N.B., de Luca C., Schenk S., Lu J.C., Bandyopadhyay G., Verma I.M., Olefsky J.M. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 2009, 10:419-429.
    • (2009) Cell Metab. , vol.10 , pp. 419-429
    • Saberi, M.1    Woods, N.B.2    de Luca, C.3    Schenk, S.4    Lu, J.C.5    Bandyopadhyay, G.6    Verma, I.M.7    Olefsky, J.M.8
  • 123
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag D., Carling D., Stout R.D., Suttles J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J. Immunol. 2008, 181:8633-8641.
    • (2008) J. Immunol. , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 124
    • 50949087166 scopus 로고    scopus 로고
    • Malonyl-CoA, a key signaling molecule in mammalian cells
    • Saggerson D. Malonyl-CoA, a key signaling molecule in mammalian cells. Annu. Rev. Nutr. 2008, 28:253-272.
    • (2008) Annu. Rev. Nutr. , vol.28 , pp. 253-272
    • Saggerson, D.1
  • 128
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • Shoelson S.E., Herrero L., Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007, 132:2169-2180.
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 130
    • 33846457372 scopus 로고    scopus 로고
    • Implications of early structural-functional changes in the endothelium for vascular disease
    • Simionescu M. Implications of early structural-functional changes in the endothelium for vascular disease. Arterioscler. Thromb. Vasc. Biol. 2007, 27:266-274.
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 266-274
    • Simionescu, M.1
  • 132
    • 0029079926 scopus 로고
    • Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
    • Smith J.D., Trogan E., Ginsberg M., Grigaux C., Tian J., Miyata M. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc. Natl. Acad. Sci. USA 1995, 92:8264-8268.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8264-8268
    • Smith, J.D.1    Trogan, E.2    Ginsberg, M.3    Grigaux, C.4    Tian, J.5    Miyata, M.6
  • 134
    • 67650914230 scopus 로고    scopus 로고
    • AMPK in health and disease
    • Steinberg G.R., Kemp B.E. AMPK in health and disease. Physiol. Rev. 2009, 89:1025-1078.
    • (2009) Physiol. Rev. , vol.89 , pp. 1025-1078
    • Steinberg, G.R.1    Kemp, B.E.2
  • 139
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the metabolic syndrome - an allostatic perspective
    • Virtue S., Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome - an allostatic perspective. Biochim. Biophys. Acta 2010, 1801:338-349.
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 140
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O. On respiratory impairment in cancer cells. Science 1956, 124:269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 141
    • 33745214270 scopus 로고    scopus 로고
    • Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes
    • Watt M.J., Steinberg G.R., Chen Z.P., Kemp B.E., Febbraio M.A. Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. J. Physiol. 2006, 574:139-147.
    • (2006) J. Physiol. , vol.574 , pp. 139-147
    • Watt, M.J.1    Steinberg, G.R.2    Chen, Z.P.3    Kemp, B.E.4    Febbraio, M.A.5
  • 143
  • 145
    • 4544334655 scopus 로고    scopus 로고
    • Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes
    • Wolf A.M., Wolf D., Rumpold H., Enrich B., Tilg H. Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem. Biophys. Res. Commun. 2004, 323:630-635.
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 630-635
    • Wolf, A.M.1    Wolf, D.2    Rumpold, H.3    Enrich, B.4    Tilg, H.5
  • 146
    • 66949121471 scopus 로고    scopus 로고
    • AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease
    • Wong A.K., Howie J., Petrie J.R., Lang C.C. AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. Clin. Sci. (Lond.). 2009, 116:607-620.
    • (2009) Clin. Sci. (Lond.). , vol.116 , pp. 607-620
    • Wong, A.K.1    Howie, J.2    Petrie, J.R.3    Lang, C.C.4
  • 150
    • 77957712861 scopus 로고    scopus 로고
    • Low-intensity exercise enhances expression of markers of alternative activation in circulating leukocytes: roles of PPARgamma and Th2 cytokines
    • Yakeu G., Butcher L., Isa S., Webb R., Roberts A.W., Thomas A.W., Backx K., James P.E., Morris K. Low-intensity exercise enhances expression of markers of alternative activation in circulating leukocytes: roles of PPARgamma and Th2 cytokines. Atherosclerosis 2010, 212:668-673.
    • (2010) Atherosclerosis , vol.212 , pp. 668-673
    • Yakeu, G.1    Butcher, L.2    Isa, S.3    Webb, R.4    Roberts, A.W.5    Thomas, A.W.6    Backx, K.7    James, P.E.8    Morris, K.9
  • 152
    • 79955662090 scopus 로고    scopus 로고
    • Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells
    • Yamawaki H., Kuramoto J., Kameshima S., Usui T., Okada M., Hara Y. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Biochem. Biophys. Res. Commun. 2011, 408:339-343.
    • (2011) Biochem. Biophys. Res. Commun. , vol.408 , pp. 339-343
    • Yamawaki, H.1    Kuramoto, J.2    Kameshima, S.3    Usui, T.4    Okada, M.5    Hara, Y.6
  • 153
    • 77953517927 scopus 로고    scopus 로고
    • Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
    • Yang Z., Kahn B.B., Shi H., Xue B.Z. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J. Biol. Chem. 2010, 285:19051-19059.
    • (2010) J. Biol. Chem. , vol.285 , pp. 19051-19059
    • Yang, Z.1    Kahn, B.B.2    Shi, H.3    Xue, B.Z.4
  • 154
    • 0034284038 scopus 로고    scopus 로고
    • Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    • Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., Matsuzawa Y. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000, 96:1723-1732.
    • (2000) Blood , vol.96 , pp. 1723-1732
    • Yokota, T.1    Oritani, K.2    Takahashi, I.3    Ishikawa, J.4    Matsuyama, A.5    Ouchi, N.6    Kihara, S.7    Funahashi, T.8    Tenner, A.J.9    Tomiyama, Y.10    Matsuzawa, Y.11
  • 155
    • 0034731524 scopus 로고    scopus 로고
    • Phosphorylation of p300 at serine 89 by protein kinase C
    • Yuan L.W., Gambee J.E. Phosphorylation of p300 at serine 89 by protein kinase C. J. Biol. Chem. 2000, 275:40946-40951.
    • (2000) J. Biol. Chem. , vol.275 , pp. 40946-40951
    • Yuan, L.W.1    Gambee, J.E.2
  • 156
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z.W., Karin M., Shoelson S.E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001, 293:1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6    Shoelson, S.E.7
  • 158
    • 55549135363 scopus 로고    scopus 로고
    • Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells
    • Zhang J., Xie Z., Dong Y., Wang S., Liu C., Zou M.H. Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells. J. Biol. Chem. 2008, 283:27452-27461.
    • (2008) J. Biol. Chem. , vol.283 , pp. 27452-27461
    • Zhang, J.1    Xie, Z.2    Dong, Y.3    Wang, S.4    Liu, C.5    Zou, M.H.6
  • 159
    • 81755174323 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. Arterioscler. Thromb. Vasc. Biol.
    • Zhang, Y., Qiu, J., Wang, X., Xia, M., 2011. AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. Arterioscler. Thromb. Vasc. Biol.
    • (2011)
    • Zhang, Y.1    Qiu, J.2    Wang, X.3    Xia, M.4
  • 160
    • 0037058977 scopus 로고    scopus 로고
    • AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    • Zong H., Ren J.M., Young L.H., Pypaert M., Mu J., Birnbaum M.J., Shulman G.I. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc. Natl. Acad. Sci. USA 2002, 99:15983-15987.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 15983-15987
    • Zong, H.1    Ren, J.M.2    Young, L.H.3    Pypaert, M.4    Mu, J.5    Birnbaum, M.J.6    Shulman, G.I.7
  • 161
    • 0037031892 scopus 로고    scopus 로고
    • Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase
    • Zou M.H., Hou X.Y., Shi C.M., Nagata D., Walsh K., Cohen R.A. Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. J. Biol. Chem. 2002, 277:32552-32557.
    • (2002) J. Biol. Chem. , vol.277 , pp. 32552-32557
    • Zou, M.H.1    Hou, X.Y.2    Shi, C.M.3    Nagata, D.4    Walsh, K.5    Cohen, R.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.