TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKε supports the anabolic demands of dendritic cell activation

Nature Immunology

Volumn 15, Issue 4, 2014, Pages 323-332

  Everts, Bart ^a   Amiel, Eyal ^b   Huang, Stanley Ching Cheng ^a   Smith, Amber M ^a   Chang, Chih Hao ^a   Lam, Wing Y ^a   Redmann, Veronika ^a   Freitas, Tori C ^c   Blagih, Julianna ^c   Van Der Windt, Gerritje J W ^a   Artyomov, Maxim N ^a   Jones, Russell G ^d   Pearce, Erika L ^a   Pearce, Edward J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VERMONT   (United States)

^c TRUDEAU INSTITUTE   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; I KAPPA B KINASE EPSILON; PHOSPHOTRANSFERASE; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DENDRITIC CELL; ENDOPLASMIC RETICULUM; GLYCOLYSIS; GOLGI STAIN; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; FATTY ACIDS; GLYCOLYSIS; HEXOKINASE; I-KAPPA B KINASE; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS;

EID: 84896654124     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2833     Document Type: Article

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