Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice

Journal of Clinical Investigation

Volumn 118, Issue 7, 2008, Pages 2640-2650

  Furuhashi, Masato ^a   Fucho, Raquel ^a   Görgün, Cem Z ^a   Tuncman, Gürol ^a   Cao, Haiming ^a   Hotamisligil, Gökhan S ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 4; FATTY ACID BINDING PROTEIN 5; INSULIN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL INTERACTION; CONTROLLED STUDY; FATTY ACID BINDING PROTEIN DEFICIENCY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HORMONE ACTION; INFLAMMATION; LIPID METABOLISM; MACROPHAGE; MALE; METABOLIC INHIBITION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; RADIATION CHIMERA; SIGNAL TRANSDUCTION;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BONE MARROW TRANSPLANTATION; CELL COMMUNICATION; CHEMOKINE CCL2; FATTY ACID-BINDING PROTEINS; GLUCOSE; INFLAMMATION; INSULIN; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASM PROTEINS; OBESITY; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 46749084688     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JC134750     Document Type: Article

References (33)

1. Hotamisligil, G.S. 2006. Inflammation and metabolic disorders. Nature. 444:860-867.
2. Xu, H., et al. 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112:1821-1830.
3. Weisberg, S.P., et al. 2003. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112:1796-1808.
4. Wellen, K.E., and Hotamisligil, G.S. 2005. Inflammation, stress, and diabetes. J. Clin. Invest. 115:1111-1119.
5. Cinti, S., et al. 2005. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46:2347-2355.
6. Lesniewski, L.A., et al. 2007. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat. Med. 13:455-462.
7. Solinas, G., et al. 2007. JNK1 in hematopoietic ally derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 6:386-397.
8. Arkan, M.C., et al. 2005. IKK-β links inflammation to obesity-induced insulin resistance. Nat. Med. 11:191-198.
9. Odegaard, J.I., et al. 2007. Macrophage-specific PPARγ controls alternative activation and improves insulin resistance. Nature. 447:1116-1120.
10. Furuhashi, M., and Hotamisligil, G.S. 2008. Fatty acid-binding proteins: role in metabloic diseases and potential as drug targets. Nat Rev. Drug Discov. 7:489-503.
11. Hunt, C.R., Ro, J.H., Dobson, D.E., Min, H.Y., and Spiegelman, B.M. 1986. Adipocyte P2 gene: developmental expression and homology of 5′-flanking sequences among fat cell-specific genes. Proc. Natl. Acad. Sci. U. S. A. 83:3786-3790.
12. Makowski, L., et al. 2001. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat. Med. 7:699-705.
13. Makowski, L., Brittingham, K.C., Reynolds, J.M.,Suttles, J., and Hotamisligil, G.S. 2005. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor γ and IκB kinase activities. J. Biol. Chem. 280:12888-12895.
14. Hotamisligil, G.S., et al. 1996. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science. 274:1377-1379.
15. Uysal, K.T., Scheja, L., Wiesbrock, S.M., Bonner-Weir, S., and Hotamisligil, G.S. 2000. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. 141:3388-3396.
16. Maeda, K., et al. 2003. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes. 52:300-307.
17. Maeda, K., et al. 2005. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 1:107-119.
18. Cao, H., et al. 2006. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes. 55:1915-1922.
19. Boord, J.B., et al. 2004. Combined adipocyte-mac-rophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation. 110:1492-1498.
20. Tuncman, G., et al. 2006. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc. Natl. Acad. Sci. U. S. A. 103:6970-6975.
21. Fu, Y., Luo, N., Lopes-Virella, M.F., and Garvey, W.T. 2002. The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages. Atherosclerosis. 165:259-269.
22. Furuhashi, M., et al. 2007. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature. 447:959-965.
23. Shum, B.O., et al. 2006. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J. Clin. Invest. 116:2183-2192.
24. Scheja, L., et al. 1999. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Diabetes. 48:1987-1994.
25. Coe, N.R., Simpson, M.A., and Bernlohr, D.A. 1999. Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels. J. Lipid Res. 40:967-972.
26. Xu, A., et al. 2006. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin. Chem. 52:405-413.
27. Crossno, J.T., Majka, S.M., Grazia, T., Gill, R.G., and Klemm, D.J. 2006. Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells. J. Clin. Invest. 116:3220-3228.
28. Koh, Y.J., et al. 2007. Bone marrow-derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice. J. Clin. Invest. 117:3684-3695.
29. Clausen, B.E., Burkhardt, C., Reith, W., Renkawitz, R., and Förster, I. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 8:265-277.
30. Kanda, H., et al. 2006. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116:1494-1505.
31. Kamei, N., et al. 2006. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J. Biol. Chem. 281:26602-26614.
32. Weisberg, S.P., et al. 2006. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J. Clin. Invest. 116:115-124.
33. Inouye, K.E., et al. 2007. Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes. 56:2242-2250.