Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization

Immunity

Volumn 42, Issue 3, 2015, Pages 419-430

  Jha, Abhishek K ^a   Huang, Stanley Ching Cheng ^b   Sergushichev, Alexey ^b,c   Lampropoulou, Vicky ^b   Ivanova, Yulia ^b   Loginicheva, Ekaterina ^b   Chmielewski, Karina ^a   Stewart, Kelly M ^a   Ashall, Juliet ^b   Everts, Bart ^b,d   Pearce, Edward J ^b   Driggers, Edward M ^a,e   Artyomov, Maxim N ^b  

^a AGIOS PHARMACEUTICALS   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ITMO UNIVERSITY   (Russian Federation)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e General Metabolics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; ARGININOSUCCINIC ACID; ASPARTATE AMINOTRANSFERASE; CARBON 13; GLUTAMINE; INTERLEUKIN 6; ISOCITRATE DEHYDROGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; N ACETYLGLUCOSAMINE; NITRIC OXIDE; URIDINE DIPHOSPHATE; ASPARTATE AMINOTRANSFERASE ISOENZYME 2; ASPARTIC ACID; CCL22 PROTEIN, MOUSE; MACROPHAGE DERIVED CHEMOKINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ANIMAL CELL; ARTICLE; CATABOLISM; CELL POLARITY; CITRIC ACID CYCLE; CYTOKINE PRODUCTION; ENZYME INHIBITION; FRAGMENTATION REACTION; GLYCOSYLATION; MACROPHAGE; METABOLISM; MITOCHONDRIAL RESPIRATION; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; ANIMAL; CLASSIFICATION; CYTOLOGY; DEFICIENCY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; MITOCHONDRION; SIGNAL TRANSDUCTION;

ANIMALS; ARGININOSUCCINIC ACID; ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL; ASPARTIC ACID; CHEMOKINE CCL22; CITRIC ACID CYCLE; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GLUTAMINE; GLYCOSYLATION; IMMUNITY, INNATE; INTERLEUKIN-6; ISOCITRATE DEHYDROGENASE; MACROPHAGES; METABOLIC NETWORKS AND PATHWAYS; MICE; MITOCHONDRIA; NITRIC OXIDE; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; URIDINE DIPHOSPHATE N-ACETYLGLUCOSAMINE;

EID: 84924935721     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.02.005     Document Type: Article

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