-
1
-
-
66949122854
-
Approaching the asymptote: 20 years later
-
Medzhitov R. 2009. Approaching the asymptote: 20 years later. Immunity 30:766-755
-
(2009)
Immunity
, vol.30
, pp. 766-755
-
-
Medzhitov, R.1
-
2
-
-
47949099098
-
Origin and physiological roles of inflammation
-
Medzhitov R. 2008. Origin and physiological roles of inflammation. Nature 454:428-355
-
(2008)
Nature
, vol.454
, pp. 428-355
-
-
Medzhitov, R.1
-
5
-
-
84858630049
-
A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?
-
Wen H, Ting JP, O'Neill LA. 2012. A role for the NLRP3 inflammasome in metabolic diseases -did Warburg miss inflammation? Nat. Immunol. 13:352-577
-
(2012)
Nat. Immunol.
, vol.13
, pp. 352-577
-
-
Wen, H.1
Ting, J.P.2
O'Neill, L.A.3
-
6
-
-
74549184092
-
The NLRP3 inflammasome: A sensor for metabolic danger?
-
Schroder K, Zhou R, Tschopp J. 2010. The NLRP3 inflammasome: a sensor for metabolic danger? Science 327:296-3000
-
(2010)
Science
, vol.327
, pp. 296-3000
-
-
Schroder, K.1
Zhou, R.2
Tschopp, J.3
-
8
-
-
70249110860
-
Cutting edge:TNF-mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation
-
Franchi L, Eigenbrod T, NunezG. 2009. Cutting edge:TNF-mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J. Immunol. 183:792-966
-
(2009)
J. Immunol.
, vol.183
, pp. 792-966
-
-
Franchi, L.1
Eigenbrod, T.2
Nunez, G.3
-
9
-
-
70249138036
-
Cutting edge: NF-B activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
-
Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, et al. 2009. Cutting edge: NF-B activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183:787-911
-
(2009)
J. Immunol.
, vol.183
, pp. 787-911
-
-
Bauernfeind, F.G.1
Horvath, G.2
Stutz, A.3
Alnemri, E.S.4
Macdonald, K.5
-
10
-
-
79960542894
-
Cutting edge: Reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome
-
Bauernfeind F, Bartok E, Rieger A, Franchi L, Nunez G, Hornung V. 2011. Cutting edge: Reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J. Immunol. 187:613-177
-
(2011)
J. Immunol.
, vol.187
, pp. 613-177
-
-
Bauernfeind, F.1
Bartok, E.2
Rieger, A.3
Franchi, L.4
Nunez, G.5
Hornung, V.6
-
11
-
-
84878237993
-
Activation and regulation of the inflammasomes
-
Latz E, Xiao TS, Stutz A. 2013. Activation and regulation of the inflammasomes. Nat. Rev. Immunol. 13:397-4111
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 397-4111
-
-
Latz, E.1
Xiao, T.S.2
Stutz, A.3
-
13
-
-
84859986329
-
Structures of theHIN domain:DNA complexes reveal ligand binding and activationmechanisms of the AIM2 inflammasome and IFI16 receptor
-
Jin T, Perry A, Jiang J, Smith P, Curry JA, et al. 2012. Structures of theHIN domain:DNA complexes reveal ligand binding and activationmechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 36:561-711
-
(2012)
Immunity
, vol.36
, pp. 561-711
-
-
Jin, T.1
Perry, A.2
Jiang, J.3
Smith, P.4
Curry, J.A.5
-
14
-
-
45549093755
-
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1 β secretion in response to Bacillus anthracis infection and muramyl dipeptide
-
Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, et al. 2008. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1 β secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc. Natl. Acad. Sci. USA 105:7803-88
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 7803-7888
-
-
Hsu, L.C.1
Ali, S.R.2
McGillivray, S.3
Tseng, P.H.4
Mariathasan, S.5
-
15
-
-
38349081519
-
Engagement of NOD2 has a dual effect on proIL-1 βmRNA transcription and secretion of bioactive IL-1 β
-
Ferwerda G, Kramer M, de Jong D, Piccini A, Joosten LA, et al. 2008. Engagement of NOD2 has a dual effect on proIL-1 βmRNA transcription and secretion of bioactive IL-1 β. Eur. J. Immunol. 38:184-911
-
(2008)
Eur. J. Immunol.
, vol.38
, pp. 184-911
-
-
Ferwerda, G.1
Kramer, M.2
De Jong, D.3
Piccini, A.4
Joosten, L.A.5
-
16
-
-
80053379974
-
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
-
Kofoed EM, Vance RE. 2011. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477:592-955
-
(2011)
Nature
, vol.477
, pp. 592-955
-
-
Kofoed, E.M.1
Vance, R.E.2
-
17
-
-
80053349020
-
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
-
Zhao Y, Yang J, Shi J, Gong YN, Lu Q, et al. 2011. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477:596-6000
-
(2011)
Nature
, vol.477
, pp. 596-6000
-
-
Zhao, Y.1
Yang, J.2
Shi, J.3
Gong, Y.N.4
Lu, Q.5
-
18
-
-
77951269392
-
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
-
Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, et al. 2010. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11:395-4022
-
(2010)
Nat. Immunol.
, vol.11
, pp. 395-4022
-
-
Rathinam, V.A.1
Jiang, Z.2
Waggoner, S.N.3
Sharma, S.4
Cole, L.E.5
-
19
-
-
84858796861
-
An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages
-
Khare S,DorfleutnerA,Bryan NB,Yun C, Radian AD, et al. 2012. An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity 36:464-766
-
(2012)
Immunity
, vol.36
, pp. 464-766
-
-
Khare, S.1
Dorfleutner, A.2
Bryan, N.B.3
Yun, C.4
Radian, A.D.5
-
20
-
-
77249118801
-
The inflammasomes: Mechanisms of activation and function
-
Latz E. 2010. The inflammasomes: mechanisms of activation and function. Curr. Opin. Immunol. 22:28-333
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 28-333
-
-
Latz, E.1
-
21
-
-
84856024206
-
Inflammasome activation via intracellular NLRs triggered by bacterial infection
-
Koizumi Y, Toma C, Higa N, Nohara T, Nakasone N, Suzuki T. 2012. Inflammasome activation via intracellular NLRs triggered by bacterial infection. Cell Microbiol. 14:149-544
-
(2012)
Cell Microbiol.
, vol.14
, pp. 149-544
-
-
Koizumi, Y.1
Toma, C.2
Higa, N.3
Nohara, T.4
Nakasone, N.5
Suzuki, T.6
-
22
-
-
77951295418
-
Influenza virus activates inflammasomes via its intracellular M2 ion channel
-
Ichinohe T, Pang IK, Iwasaki A. 2010. Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nat. Immunol. 11:404-100
-
(2010)
Nat. Immunol.
, vol.11
, pp. 404-100
-
-
Ichinohe, T.1
Pang, I.K.2
Iwasaki, A.3
-
23
-
-
84875431649
-
Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection
-
Gomes MT, Campos PC, Oliveira FS, Corsetti PP, Bortoluci KR, et al. 2013. Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection. J. Immunol. 190:3629-388
-
(2013)
J. Immunol.
, vol.190
, pp. 3629-3398
-
-
Gomes, M.T.1
Campos, P.C.2
Oliveira, F.S.3
Corsetti, P.P.4
Bortoluci, K.R.5
-
24
-
-
79959242498
-
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
-
Sander LE, Davis MJ, Boekschoten MV, Amsen D, Dascher CC, et al. 2011. Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature 474:385-899
-
(2011)
Nature
, vol.474
, pp. 385-899
-
-
Sander, L.E.1
Davis, M.J.2
Boekschoten, M.V.3
Amsen, D.4
Dascher, C.C.5
-
25
-
-
73949118676
-
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
-
Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, et al. 2009. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc. Natl. Acad. Sci. USA 106:20388-933
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20388-20933
-
-
Iyer, S.S.1
Pulskens, W.P.2
Sadler, J.J.3
Butter, L.M.4
Teske, G.J.5
-
26
-
-
34249941913
-
Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling
-
Duncan JA, Bergstralh DT, Wang Y, Willingham SB, Ye Z, et al. 2007. Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc. Natl. Acad. Sci. USA 104:8041-466
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 8041-8466
-
-
Duncan, J.A.1
Bergstralh, D.T.2
Wang, Y.3
Willingham, S.B.4
Ye, Z.5
-
27
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, et al. 2006. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440:228-322
-
(2006)
Nature
, vol.440
, pp. 228-322
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
McBride, J.4
O'Rourke, K.5
-
28
-
-
84875908991
-
TRPM2 links oxidative stress to NLRP3 inflammasome activation
-
Zhong Z, Zhai Y, Liang S, Mori Y, Han R, et al. 2013. TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat. Commun. 4:16111
-
(2013)
Nat. Commun.
, vol.4
, pp. 16111
-
-
Zhong, Z.1
Zhai, Y.2
Liang, S.3
Mori, Y.4
Han, R.5
-
29
-
-
84876285741
-
Succinate is an inflammatory signal that induces IL-1 βthrough HIF-1?
-
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, et al. 2013. Succinate is an inflammatory signal that induces IL-1 βthrough HIF-1?. Nature 496:238-422
-
(2013)
Nature
, vol.496
, pp. 238-422
-
-
Tannahill, G.M.1
Curtis, A.M.2
Adamik, J.3
Palsson-Mcdermott, E.M.4
McGettrick, A.F.5
-
30
-
-
79951846190
-
Basic calcium phosphate crystals induce monocyte/macrophage IL-1 βsecretion through the NLRP3 inflammasome in vitro
-
Pazar B, Ea HK, Narayan S, Kolly L, Bagnoud N, et al. 2011. Basic calcium phosphate crystals induce monocyte/macrophage IL-1 βsecretion through the NLRP3 inflammasome in vitro. J. Immunol. 186:2495-5022
-
(2011)
J. Immunol.
, vol.186
, pp. 2495-5022
-
-
Pazar, B.1
Ea, H.K.2
Narayan, S.3
Kolly, L.4
Bagnoud, N.5
-
31
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237-411
-
(2006)
Nature
, vol.440
, pp. 237-411
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
33
-
-
84873827527
-
Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1 βsecretion
-
Mulay SR, Kulkarni OP, Rupanagudi KV, Migliorini A, Darisipudi MN, et al. 2013. Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1 βsecretion. J. Clin. Investig. 123:236-466
-
(2013)
J. Clin. Investig.
, vol.123
, pp. 236-466
-
-
Mulay, S.R.1
Kulkarni, O.P.2
Rupanagudi, K.V.3
Migliorini, A.4
Darisipudi, M.N.5
-
34
-
-
84888332141
-
NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy
-
Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, et al. 2013. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney Int. 84:895-9011
-
(2013)
Kidney Int.
, vol.84
, pp. 895-9011
-
-
Knauf, F.1
Asplin, J.R.2
Granja, I.3
Schmidt, I.M.4
Moeckel, G.W.5
-
35
-
-
80052581043
-
NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy
-
Jin C, Frayssinet P, Pelker R, Cwirka D, Hu B, et al. 2011. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite- associated arthropathy. Proc. Natl. Acad. Sci. USA 108:14867-722
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 14867-14732
-
-
Jin, C.1
Frayssinet, P.2
Pelker, R.3
Cwirka, D.4
Hu, B.5
-
36
-
-
79952137696
-
Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation
-
Denoble AE, Huffman KM, Stabler TV, Kelly SJ, Hershfield MS, et al. 2011. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. Proc. Natl. Acad. Sci. USA 108:2088-933
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 2088-2933
-
-
Denoble, A.E.1
Huffman, K.M.2
Stabler, T.V.3
Kelly, S.J.4
Hershfield, M.S.5
-
37
-
-
82955187609
-
Osteoarthritis: Crystal-gazing into the pathogenesis of osteoarthritis
-
So A, Busso N. 2011. Osteoarthritis: crystal-gazing into the pathogenesis of osteoarthritis. Nat. Rev. Rheumatol. 7:688-899
-
(2011)
Nat. Rev. Rheumatol.
, vol.7
, pp. 688-899
-
-
So, A.1
Busso, N.2
-
38
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
-
Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, et al. 2008. The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat. Immunol. 9:857-655
-
(2008)
Nat. Immunol.
, vol.9
, pp. 857-655
-
-
Halle, A.1
Hornung, V.2
Petzold, G.C.3
Stewart, C.R.4
Monks, B.G.5
-
39
-
-
84873087532
-
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
-
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, et al. 2013. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493:674-788
-
(2013)
Nature
, vol.493
, pp. 674-788
-
-
Heneka, M.T.1
Kummer, M.P.2
Stutz, A.3
Delekate, A.4
Schwartz, S.5
-
40
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, et al. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9:847-566
-
(2008)
Nat. Immunol.
, vol.9
, pp. 847-566
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
Samstad, E.O.4
Kono, H.5
-
41
-
-
47849132947
-
The Nalp3 inflammasome is essential for the development of silicosis
-
Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, et al. 2008. The Nalp3 inflammasome is essential for the development of silicosis. Proc. Natl. Acad. Sci. USA 105:9035-400
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 9035-9400
-
-
Cassel, S.L.1
Eisenbarth, S.C.2
Iyer, S.S.3
Sadler, J.J.4
Colegio, O.R.5
-
42
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. 2008. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320:674-777
-
(2008)
Science
, vol.320
, pp. 674-777
-
-
Dostert, C.1
Petrilli, V.2
Van Bruggen, R.3
Steele, C.4
Mossman, B.T.5
Tschopp, J.6
-
43
-
-
47849087075
-
Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
-
Li H, Willingham SB, Ting JP, Re F. 2008. Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J. Immunol. 181:17-211
-
(2008)
J. Immunol.
, vol.181
, pp. 17-211
-
-
Li, H.1
Willingham, S.B.2
Ting, J.P.3
Re, F.4
-
44
-
-
56149119563
-
Cutting edge:Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
-
Kool M, Petrilli V, DeSmedt T, Rolaz A, Hammad H, et al. 2008. Cutting edge:Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J. Immunol. 181:3755-599
-
(2008)
J. Immunol.
, vol.181
, pp. 3755-3599
-
-
Kool, M.1
Petrilli, V.2
Desmedt, T.3
Rolaz, A.4
Hammad, H.5
-
45
-
-
45749111446
-
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
-
Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. 2008. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453:1122-266
-
(2008)
Nature
, vol.453
, pp. 1122-1266
-
-
Eisenbarth, S.C.1
Colegio, O.R.2
O'Connor, W.3
Sutterwala, F.S.4
Flavell, R.A.5
-
46
-
-
77749245832
-
The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants
-
Spreafico R, Ricciardi-Castagnoli P, Mortellaro A. 2010. The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants. Eur. J. Immunol. 40:638-422
-
(2010)
Eur. J. Immunol.
, vol.40
, pp. 638-422
-
-
Spreafico, R.1
Ricciardi-Castagnoli, P.2
Mortellaro, A.3
-
47
-
-
79953747554
-
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
-
Flach TL, Ng G, Hari A, Desrosiers MD, Zhang P, et al. 2011. Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nat. Med. 17:479-877
-
(2011)
Nat. Med.
, vol.17
, pp. 479-877
-
-
Flach, T.L.1
Ng, G.2
Hari, A.3
Desrosiers, M.D.4
Zhang, P.5
-
48
-
-
84876567161
-
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
-
Misawa T, Takahama M, Kozaki T, Lee H, Zou J, et al. 2013. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat. Immunol. 14:454-600
-
(2013)
Nat. Immunol.
, vol.14
, pp. 454-600
-
-
Misawa, T.1
Takahama, M.2
Kozaki, T.3
Lee, H.4
Zou, J.5
-
49
-
-
84860225554
-
GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals
-
Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, et al. 2012. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science 336:481-855
-
(2012)
Science
, vol.336
, pp. 481-855
-
-
Shenoy, A.R.1
Wellington, D.A.2
Kumar, P.3
Kassa, H.4
Booth, C.J.5
-
50
-
-
84864545087
-
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
-
Dinarello CA, Simon A, van der Meer JW. 2012. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat. Rev. Drug Discov. 11:633-522
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 633-522
-
-
Dinarello, C.A.1
Simon, A.2
Van Der Meer, J.W.3
-
51
-
-
0032923377
-
The secretory route of the leaderless protein interleukin 1 β involves exocytosis of endolysosome-related vesicles
-
Andrei C, Dazzi C, Lotti L, Torrisi MR, Chimini G, Rubartelli A. 1999. The secretory route of the leaderless protein interleukin 1 β involves exocytosis of endolysosome-related vesicles. Mol. Biol. Cell 10:1463-755
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 1463-1755
-
-
Andrei, C.1
Dazzi, C.2
Lotti, L.3
Torrisi, M.R.4
Chimini, G.5
Rubartelli, A.6
-
52
-
-
3042800587
-
Phospholipases C and A2 control lysosome-mediated IL-1 βsecretion: Implications for inflammatory processes
-
Andrei C, Margiocco P, Poggi A, Lotti LV, Torrisi MR, Rubartelli A. 2004. Phospholipases C and A2 control lysosome-mediated IL-1 βsecretion: implications for inflammatory processes. Proc. Natl. Acad. Sci. USA 101:9745-500
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 9745-9510
-
-
Andrei, C.1
Margiocco, P.2
Poggi, A.3
Lotti, L.V.4
Torrisi, M.R.5
Rubartelli, A.6
-
53
-
-
0035655395
-
Rapid secretion of interleukin-1 βby microvesicle shedding
-
MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, Surprenant A. 2001. Rapid secretion of interleukin-1 βby microvesicle shedding. Immunity 15:825-355
-
(2001)
Immunity
, vol.15
, pp. 825-355
-
-
Mackenzie, A.1
Wilson, H.L.2
Kiss-Toth, E.3
Dower, S.K.4
North, R.A.5
Surprenant, A.6
-
54
-
-
47249144272
-
P2X7 receptor differentially couples to distinct release pathways for IL-1 βin mouse macrophage
-
Pelegrin P, Barroso-Gutierrez C, Surprenant A. 2008. P2X7 receptor differentially couples to distinct release pathways for IL-1 βin mouse macrophage. J. Immunol. 180:7147-577
-
(2008)
J. Immunol.
, vol.180
, pp. 7147-7577
-
-
Pelegrin, P.1
Barroso-Gutierrez, C.2
Surprenant, A.3
-
56
-
-
84882280029
-
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
-
Sagulenko V, Thygesen SJ, Sester DP, Idris A, Cridland JA, et al. 2013. AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death Differ. 20:1149-600
-
(2013)
Cell Death Differ.
, vol.20
, pp. 1149-1600
-
-
Sagulenko, V.1
Thygesen, S.J.2
Sester, D.P.3
Idris, A.4
Cridland, J.A.5
-
57
-
-
0026635783
-
Shigella flexneri induces apoptosis in infected macrophages
-
Zychlinsky A, Prevost MC, Sansonetti PJ. 1992. Shigella flexneri induces apoptosis in infected macrophages. Nature 358:167-699
-
(1992)
Nature
, vol.358
, pp. 167-699
-
-
Zychlinsky, A.1
Prevost, M.C.2
Sansonetti, P.J.3
-
58
-
-
0034115859
-
Salmonella enterica serovars Typhimurium and Dublin can lyse macrophages by a mechanism distinct from apoptosis
-
Watson PR, Gautier AV, Paulin SM, Bland AP, Jones PW, Wallis TS. 2000. Salmonella enterica serovars Typhimurium and Dublin can lyse macrophages by a mechanism distinct from apoptosis. Infect. Immun. 68:3744-477
-
(2000)
Infect. Immun.
, vol.68
, pp. 3744-3487
-
-
Watson, P.R.1
Gautier, A.V.2
Paulin, S.M.3
Bland, A.P.4
Jones, P.W.5
Wallis, T.S.6
-
59
-
-
84864240409
-
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
-
Li J, McQuade T, Siemer AB, Napetschnig J,Moriwaki K, et al. 2012. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 150:339-500
-
(2012)
Cell
, vol.150
, pp. 339-500
-
-
Li, J.1
McQuade, T.2
Siemer, A.B.3
Napetschnig, J.4
Moriwaki, K.5
-
60
-
-
34247345833
-
The apoptosome: Signalling platform of cell death
-
Riedl SJ, Salvesen GS. 2007. The apoptosome: signalling platform of cell death. Nat. Rev. Mol. Cell Biol. 8:405-133
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 405-133
-
-
Riedl, S.J.1
Salvesen, G.S.2
-
63
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou R, Yazdi AS, Menu P, Tschopp J. 2011. A role for mitochondria in NLRP3 inflammasome activation. Nature 469:221-255
-
(2011)
Nature
, vol.469
, pp. 221-255
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
65
-
-
84857861919
-
Mechanisms for insulin resistance: Common threads and missing links
-
Samuel VT, Shulman GI. 2012. Mechanisms for insulin resistance: common threads and missing links. Cell 148:852-711
-
(2012)
Cell
, vol.148
, pp. 852-711
-
-
Samuel, V.T.1
Shulman, G.I.2
-
66
-
-
68549130286
-
The role of interleukins in insulin resistance and type 2 diabetes mellitus
-
Feve B, Bastard JP. 2009. The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 5:305-111
-
(2009)
Nat. Rev. Endocrinol.
, vol.5
, pp. 305-111
-
-
Feve, B.1
Bastard, J.P.2
-
67
-
-
33745009509
-
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
-
Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, et al. 2006. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat. Med. 12:650-566
-
(2006)
Nat. Med.
, vol.12
, pp. 650-566
-
-
Netea, M.G.1
Joosten, L.A.2
Lewis, E.3
Jensen, D.R.4
Voshol, P.J.5
-
68
-
-
84975856269
-
Economic costs of diabetes in the US in 2012
-
Am. Diet. Assoc.
-
Am. Diet. Assoc. 2013. Economic costs of diabetes in the US in 2012. Diabetes Care 36:1033-466
-
(2013)
Diabetes Care
, vol.36
, pp. 1033-1466
-
-
-
69
-
-
0029983063
-
Interleukin 1 and tumor necrosis factor in obese alcoholics compared with normal-weight patients
-
Bunout D, Munoz C, Lopez M, de la Maza MP, Schlesinger L, et al. 1996. Interleukin 1 and tumor necrosis factor in obese alcoholics compared with normal-weight patients. Am. J. Clin.Nutr. 63:373-766
-
(1996)
Am. J. Clin.Nutr.
, vol.63
, pp. 373-766
-
-
Bunout, D.1
Munoz, C.2
Lopez, M.3
De La Maza, M.P.4
Schlesinger, L.5
-
70
-
-
0031720795
-
Is type II diabetes mellitus a disease of the innate immune system?
-
Pickup JC, Crook MA. 1998. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41:1241-488
-
(1998)
Diabetologia
, vol.41
, pp. 1241-1488
-
-
Pickup, J.C.1
Crook, M.A.2
-
71
-
-
0033537013
-
Elevated C-reactive protein levels in overweight and obese adults
-
Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. 1999. Elevated C-reactive protein levels in overweight and obese adults. JAMA 282:2131-355
-
(1999)
JAMA
, vol.282
, pp. 2131-2355
-
-
Visser, M.1
Bouter, L.M.2
McQuillan, G.M.3
Wener, M.H.4
Harris, T.B.5
-
72
-
-
0027459878
-
Adipose expression of tumor necrosis factor-: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM. 1993. Adipose expression of tumor necrosis factor-: direct role in obesity-linked insulin resistance. Science 259:87-911
-
(1993)
Science
, vol.259
, pp. 87-911
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
73
-
-
0028931724
-
Increased adipose tissue expression of tumor necrosis factor-in human obesity and insulin resistance
-
Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. 1995. Increased adipose tissue expression of tumor necrosis factor-in human obesity and insulin resistance. J. Clin. Investig. 95:2409-155
-
(1995)
J. Clin. Investig.
, vol.95
, pp. 2409-2165
-
-
Hotamisligil, G.S.1
Arner, P.2
Caro, J.F.3
Atkinson, R.L.4
Spiegelman, B.M.5
-
74
-
-
0028968879
-
The expression of tumor necrosis factor in human adipose tissue
-
Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. 1995. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J. Clin. Investig. 95:2111-199
-
(1995)
Regulation by Obesity, Weight Loss, and Relationship to Lipoprotein Lipase. J. Clin. Investig.
, vol.95
, pp. 2111-2199
-
-
Kern, P.A.1
Saghizadeh, M.2
Ong, J.M.3
Bosch, R.J.4
Deem, R.5
Simsolo, R.B.6
-
75
-
-
0034708832
-
The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307
-
Aguirre V, Uchida T, Yenush L, Davis R,White MF. 2000. The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307. J. Biol. Chem. 275:9047-544
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9047-9544
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis Rwhite, M.F.4
-
76
-
-
0030061922
-
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-and obesity-induced insulin resistance
-
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. 1996. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-and obesity-induced insulin resistance. Science 271:665-688
-
(1996)
Science
, vol.271
, pp. 665-688
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
White, M.F.5
Spiegelman, B.M.6
-
77
-
-
31044456529
-
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
-
Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, et al. 2006. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J. Clin. Investig. 116:115-244
-
(2006)
J. Clin. Investig.
, vol.116
, pp. 115-244
-
-
Weisberg, S.P.1
Hunter, D.2
Huber, R.3
Lemieux, J.4
Slaymaker, S.5
-
78
-
-
33745216724
-
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
-
Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, et al. 2006. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Investig. 116:1494-5055
-
(2006)
J. Clin. Investig.
, vol.116
, pp. 1494-5055
-
-
Kanda, H.1
Tateya, S.2
Tamori, Y.3
Kotani, K.4
Hiasa, K.5
-
79
-
-
78650472774
-
Toll-like receptors: Linking inflammation to metabolism
-
Konner AC, Bruning JC. 2011. Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol. Metab. 22:16-233
-
(2011)
Trends Endocrinol. Metab.
, vol.22
, pp. 16-233
-
-
Konner, A.C.1
Bruning, J.C.2
-
80
-
-
79151478555
-
Type 2 diabetes as an inflammatory disease
-
Donath MY, Shoelson SE. 2011. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 11:98-1077
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 98-1077
-
-
Donath, M.Y.1
Shoelson, S.E.2
-
81
-
-
84874247282
-
Implication of inflammatory signaling pathways in obesityinduced insulin resistance
-
Tanti JF, Ceppo F, Jager J, Berthou F. 2012. Implication of inflammatory signaling pathways in obesityinduced insulin resistance. Front. Endocrinol. 3:1811
-
(2012)
Front. Endocrinol.
, vol.3
, pp. 1811
-
-
Tanti, J.F.1
Ceppo, F.2
Jager, J.3
Berthou, F.4
-
82
-
-
70350389389
-
Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
-
Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, et al. 2009. Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 10:419-299
-
(2009)
Cell Metab.
, vol.10
, pp. 419-299
-
-
Saberi, M.1
Woods, N.B.2
De Luca, C.3
Schenk, S.4
Lu, J.C.5
-
83
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. 2006. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Investig. 116:3015-255
-
(2006)
J. Clin. Investig.
, vol.116
, pp. 3015-3255
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
84
-
-
79751512463
-
TheNLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar B, Youm YH, Ravussin A,Galgani JE, Stadler K, et al. 2011. TheNLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17:179-888
-
(2011)
Nat. Med.
, vol.17
, pp. 179-888
-
-
Vandanmagsar, B.1
Youm, Y.H.2
Ravussin, A.3
Galgani, J.E.4
Stadler, K.5
-
85
-
-
78649498271
-
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
-
Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, et al. 2010. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab. 12:593-6055
-
(2010)
Cell Metab.
, vol.12
, pp. 593-6055
-
-
Stienstra, R.1
Joosten, L.A.2
Koenen, T.3
Van Tits, B.4
Van Diepen, J.A.5
-
86
-
-
79955038882
-
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
-
Wen H, Gris D, Lei Y, Jha S, Zhang L, et al. 2011. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol. 12:408-155
-
(2011)
Nat. Immunol.
, vol.12
, pp. 408-155
-
-
Wen, H.1
Gris, D.2
Lei, Y.3
Jha, S.4
Zhang, L.5
-
87
-
-
33845873659
-
Interleukin-1 β-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression
-
Jager J, Gremeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF. 2007. Interleukin-1 β-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 148:241-511
-
(2007)
Endocrinology
, vol.148
, pp. 241-511
-
-
Jager, J.1
Gremeaux, T.2
Cormont, M.3
Le Marchand-Brustel, Y.4
Tanti, J.F.5
-
88
-
-
69549098032
-
IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabeticGKrat
-
Ehses JA, Lacraz G, Giroix MH, Schmidlin F, Coulaud J, et al. 2009. IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabeticGKrat. Proc.Natl. Acad. Sci. USA106:13998-40033
-
(2009)
Proc.Natl. Acad. Sci. USA106
, pp. 13998-40033
-
-
Ehses, J.A.1
Lacraz, G.2
Giroix, M.H.3
Schmidlin, F.4
Coulaud, J.5
-
89
-
-
56749143801
-
Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance
-
Osborn O, Gram H, Zorrilla EP, Conti B, Bartfai T. 2008. Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med. Wkly. 138:665-733
-
(2008)
Swiss Med. Wkly.
, vol.138
, pp. 665-733
-
-
Osborn, O.1
Gram, H.2
Zorrilla, E.P.3
Conti, B.4
Bartfai, T.5
-
90
-
-
79960920271
-
NLRP3 inflammasomes link inflammation and metabolic disease
-
De Nardo D, Latz E. 2011. NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 32:373-799
-
(2011)
Trends Immunol.
, vol.32
, pp. 373-799
-
-
De Nardo, D.1
Latz, E.2
-
91
-
-
78649498271
-
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
-
Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, et al. 2010. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab. 12:593-6055
-
(2010)
Cell Metab.
, vol.12
, pp. 593-6055
-
-
Stienstra, R.1
Joosten, L.A.2
Koenen, T.3
Van Tits, B.4
Van Diepen, J.A.5
-
93
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
Larsen CM, Faulenbach M, Vaag A, Volund A, Ehses JA, et al. 2007. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 356:1517-266
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 1517-1276
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
Volund, A.4
Ehses, J.A.5
-
94
-
-
84859449180
-
Saturated fatty acid and TLR signaling link βcell dysfunction and islet inflammation
-
Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, et al. 2012. Saturated fatty acid and TLR signaling link βcell dysfunction and islet inflammation. Cell Metab. 15:518-333
-
(2012)
Cell Metab.
, vol.15
, pp. 518-333
-
-
Eguchi, K.1
Manabe, I.2
Oishi-Tanaka, Y.3
Ohsugi, M.4
Kono, N.5
-
95
-
-
0034937707
-
S20G mutation of the amylin gene is associated with type II diabetes in Japanese
-
Study Group of Comprehensive Analysis of Genetic Factors in Diabetes Mellitus
-
Seino S. 2001. S20G mutation of the amylin gene is associated with type II diabetes in Japanese. Study Group of Comprehensive Analysis of Genetic Factors in Diabetes Mellitus. Diabetologia 44:906-99
-
(2001)
Diabetologia
, vol.44
, pp. 906-999
-
-
Seino, S.1
-
96
-
-
77956958947
-
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides amechanism for enhanced IL-1 βin type 2 diabetes
-
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, et al. 2010. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides amechanism for enhanced IL-1 βin type 2 diabetes. Nat. Immunol. 11:897-9044
-
(2010)
Nat. Immunol.
, vol.11
, pp. 897-9044
-
-
Masters, S.L.1
Dunne, A.2
Subramanian, S.L.3
Hull, R.L.4
Tannahill, G.M.5
-
97
-
-
75649096002
-
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
-
Zhou R, Tardivel A, Thorens B,Choi I,Tschopp J. 2010. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11:136-400
-
(2010)
Nat. Immunol.
, vol.11
, pp. 136-400
-
-
Zhou, R.1
Tardivel, A.2
Thorens, B.3
Choi, I.4
Tschopp, J.5
-
98
-
-
72049099294
-
Cardiovascular disease risk factors: Epidemiology and risk assessment
-
Dahlof B. 2010. Cardiovascular disease risk factors: epidemiology and risk assessment. Am. J. Cardiol. 105:A3-99
-
(2010)
Am. J. Cardiol.
, vol.105
-
-
Dahlof, B.1
-
99
-
-
84865060103
-
Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes
-
Lau KK, Wong YK, Chan YH, Yiu KH, Teo KC, et al. 2012. Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes. Cardiovasc. Diabetol. 11:1011
-
(2012)
Cardiovasc. Diabetol.
, vol.11
, pp. 1011
-
-
Lau, K.K.1
Wong, Y.K.2
Chan, Y.H.3
Yiu, K.H.4
Teo, K.C.5
-
100
-
-
79951669207
-
The immune system in atherosclerosis
-
Hansson GK, Hermansson A. 2011. The immune system in atherosclerosis. Nat. Immunol. 12:204-122
-
(2011)
Nat. Immunol.
, vol.12
, pp. 204-122
-
-
Hansson, G.K.1
Hermansson, A.2
-
101
-
-
84862018529
-
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice
-
Ding L, Biswas S, Morton RE, Smith JD, Hay N, et al. 2012. Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice. Cell Metab. 15:861-722
-
(2012)
Cell Metab.
, vol.15
, pp. 861-722
-
-
Ding, L.1
Biswas, S.2
Morton, R.E.3
Smith, J.D.4
Hay, N.5
-
102
-
-
3242710174
-
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein e
-
Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, et al. 2004. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc. Natl. Acad. Sci. USA 101:10679-844
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 10679-10844
-
-
Michelsen, K.S.1
Wong, M.H.2
Shah, P.K.3
Zhang, W.4
Yano, J.5
-
103
-
-
3242728901
-
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
-
Bjorkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, et al. 2004. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat. Med. 10:416-211
-
(2004)
Nat. Med.
, vol.10
, pp. 416-211
-
-
Bjorkbacka, H.1
Kunjathoor, V.V.2
Moore, K.J.3
Koehn, S.4
Ordija, C.M.5
-
104
-
-
34250169823
-
Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
-
Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, et al. 2007. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ. Res. 100:1589-966
-
(2007)
Circ. Res.
, vol.100
, pp. 1589-1966
-
-
Kim, F.1
Pham, M.2
Luttrell, I.3
Bannerman, D.D.4
Tupper, J.5
-
105
-
-
58149476609
-
Impact of macrophage Toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice
-
Coenen KR, Gruen ML, Lee-Young RS, Puglisi MJ, Wasserman DH, Hasty AH. 2009. Impact of macrophage Toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia 52:318-288
-
(2009)
Diabetologia
, vol.52
, pp. 318-288
-
-
Coenen, K.R.1
Gruen, M.L.2
Lee-Young, R.S.3
Puglisi, M.J.4
Wasserman, D.H.5
Hasty, A.H.6
-
106
-
-
85027951898
-
Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice
-
Ding Y, Subramanian S, Montes VN, Goodspeed L, Wang S, et al. 2012. Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 32:1596-6044
-
(2012)
Arterioscler. Thromb. Vasc. Biol.
, vol.32
, pp. 1596-6044
-
-
Ding, Y.1
Subramanian, S.2
Montes, V.N.3
Goodspeed, L.4
Wang, S.5
-
107
-
-
52449106177
-
Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: Proteomic findings
-
Madan M, Amar S. 2008. Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS ONE 3:e32044
-
(2008)
PLoS ONE
, vol.3
-
-
Madan, M.1
Amar, S.2
-
110
-
-
77958532945
-
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress
-
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, et al. 2010. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab. 12:467-822
-
(2010)
Cell Metab.
, vol.12
, pp. 467-822
-
-
Seimon, T.A.1
Nadolski, M.J.2
Liao, X.3
Magallon, J.4
Nguyen, M.5
-
111
-
-
78049250350
-
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
-
West XZ, Malinin NL, Merkulova AA, Tischenko M, Kerr BA, et al. 2010. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature 467:972-766
-
(2010)
Nature
, vol.467
, pp. 972-766
-
-
West, X.Z.1
Malinin, N.L.2
Merkulova, A.A.3
Tischenko, M.4
Kerr, B.A.5
-
112
-
-
77951800951
-
NLRP3inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, et al. 2010.NLRP3inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464:1357-611
-
(2010)
Nature
, vol.464
, pp. 1357-1611
-
-
Duewell, P.1
Kono, H.2
Rayner, K.J.3
Sirois, C.M.4
Vladimer, G.5
-
113
-
-
84858614711
-
Caspase-1 deficiency decreases atherosclerosis in apolipoprotein E-null mice
-
Gage J, Hasu M, Thabet M, Whitman SC. 2012. Caspase-1 deficiency decreases atherosclerosis in apolipoprotein E-null mice. Can. J. Cardiol. 28:222-299
-
(2012)
Can. J. Cardiol.
, vol.28
, pp. 222-299
-
-
Gage, J.1
Hasu, M.2
Thabet, M.3
Whitman, S.C.4
-
114
-
-
84865389353
-
Critical role of caspase-1 in vascular inflammation and development of atherosclerosis inWestern diet-fed apolipoprotein E-deficient mice
-
Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, et al. 2012. Critical role of caspase-1 in vascular inflammation and development of atherosclerosis inWestern diet-fed apolipoprotein E-deficient mice. Biochem. Biophys. Res. Commun. 425:162-688
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.425
, pp. 162-688
-
-
Usui, F.1
Shirasuna, K.2
Kimura, H.3
Tatsumi, K.4
Kawashima, A.5
-
115
-
-
79959999614
-
Atherosclerosis in ApoEdeficient mice progresses independently of the NLRP3 inflammasome
-
Menu P, Pellegrin M, Aubert JF, Bouzourene K, Tardivel A, et al. 2011. Atherosclerosis in ApoEdeficient mice progresses independently of the NLRP3 inflammasome. Cell Death Dis. 2:e1377
-
(2011)
Cell Death Dis.
, vol.2
-
-
Menu, P.1
Pellegrin, M.2
Aubert, J.F.3
Bouzourene, K.4
Tardivel, A.5
-
116
-
-
62749144547
-
Definition and natural history of metabolic steatosis: Clinical aspects of NAFLD, NASH and cirrhosis
-
Serfaty L, Lemoine M. 2008. Definition and natural history of metabolic steatosis: clinical aspects of NAFLD, NASH and cirrhosis. Diabetes Metab. 34:634-377
-
(2008)
Diabetes Metab.
, vol.34
, pp. 634-377
-
-
Serfaty, L.1
Lemoine, M.2
-
118
-
-
0035084699
-
Nonalcoholic steatohepatitis: Association of insulin resistance andmitochondrial abnormalities
-
Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, et al. 2001. Nonalcoholic steatohepatitis: association of insulin resistance andmitochondrial abnormalities. Gastroenterology 120:1183-922
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1922
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
Rizzo, W.B.4
Contos, M.J.5
-
119
-
-
77953891627
-
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1 βin mice
-
Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, et al. 2010. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1 βin mice. Gastroenterology 139:323-34.e77
-
(2010)
Gastroenterology 139:323-34.e77
-
-
Miura, K.1
Kodama, Y.2
Inokuchi, S.3
Schnabl, B.4
Aoyama, T.5
-
120
-
-
34548272744
-
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
-
Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. 2007. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J. Hepatol. 47:571-799
-
(2007)
J. Hepatol.
, vol.47
, pp. 571-799
-
-
Rivera, C.A.1
Adegboyega, P.2
Van Rooijen, N.3
Tagalicud, A.4
Allman, M.5
Wallace, M.6
-
121
-
-
68949148889
-
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
-
Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, et al. 2009. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49:1877-877
-
(2009)
Hepatology
, vol.49
, pp. 1877-1877
-
-
Miele, L.1
Valenza, V.2
La Torre, G.3
Montalto, M.4
Cammarota, G.5
-
122
-
-
84870062861
-
Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease
-
Boaru SG, Borkham-Kamphorst E, Tihaa L, Haas U, Weiskirchen R. 2012. Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease. J. Inflamm. 9:499
-
(2012)
J. Inflamm.
, vol.9
, pp. 499
-
-
Boaru, S.G.1
Borkham-Kamphorst, E.2
Tihaa, L.3
Haas, U.4
Weiskirchen, R.5
-
123
-
-
79957576718
-
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
-
Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, et al. 2011. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145:745-577
-
(2011)
Cell
, vol.145
, pp. 745-577
-
-
Elinav, E.1
Strowig, T.2
Kau, A.L.3
Henao-Mejia, J.4
Thaiss, C.A.5
-
124
-
-
84873966954
-
Role of gut microbiota in liver diseases
-
Miyake Y, Yamamoto K. 2012. Role of gut microbiota in liver diseases. Hepatol. Res. 43:139-466
-
(2012)
Hepatol. Res.
, vol.43
, pp. 139-466
-
-
Miyake, Y.1
Yamamoto, K.2
-
125
-
-
84856957894
-
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
-
Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, et al. 2012. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482:179-855
-
(2012)
Nature
, vol.482
, pp. 179-855
-
-
Henao-Mejia, J.1
Elinav, E.2
Jin, C.3
Hao, L.4
Mehal, W.Z.5
-
126
-
-
84880036121
-
Risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel disease
-
Sourianarayanane A, Garg G, Smith TH, Butt MI, McCullough AJ, Shen B. 2013. Risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel disease. J. Crohn's Colitis 7:e279-855
-
(2013)
J. Crohn's Colitis 7:e279-855
-
-
Sourianarayanane, A.1
Garg, G.2
Smith, T.H.3
Butt, M.I.4
McCullough, A.J.5
Shen, B.6
-
127
-
-
79959573042
-
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
-
Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G. 2011. Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology 54:133-444
-
(2011)
Hepatology
, vol.54
, pp. 133-444
-
-
Csak, T.1
Ganz, M.2
Pespisa, J.3
Kodys, K.4
Dolganiuc, A.5
Szabo, G.6
-
128
-
-
80053497428
-
Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008
-
Zhu Y, Pandya BJ, Choi HK. 2011. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 63:3136-411
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 3136-3411
-
-
Zhu, Y.1
Pandya, B.J.2
Choi, H.K.3
-
129
-
-
77957688721
-
Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study
-
So A, De Meulemeester M, Pikhlak A, Yucel AE, Richard D, et al. 2010. Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: results of a multicenter, phase II, dose-ranging study. Arthritis Rheum. 62:3064-766
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 3064-3766
-
-
So, A.1
De Meulemeester, M.2
Pikhlak, A.3
Yucel, A.E.4
Richard, D.5
-
130
-
-
70349402166
-
The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: Results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study
-
Terkeltaub R, Sundy JS, Schumacher HR, Murphy F, Bookbinder S, et al. 2009. The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study. Ann. Rheum. Dis. 68:1613-177
-
(2009)
Ann. Rheum. Dis.
, vol.68
, pp. 1613-1187
-
-
Terkeltaub, R.1
Sundy, J.S.2
Schumacher, H.R.3
Murphy, F.4
Bookbinder, S.5
-
131
-
-
79957646006
-
Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: Results of a double-blind, randomised study
-
Schlesinger N, Mysler E, Lin HY, De Meulemeester M, Rovensky J, et al. 2011. Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: results of a double-blind, randomised study. Ann. Rheum. Dis. 70:1264-711
-
(2011)
Ann. Rheum. Dis.
, vol.70
, pp. 1264-1711
-
-
Schlesinger, N.1
Mysler, E.2
Lin, H.Y.3
De Meulemeester, M.4
Rovensky, J.5
-
132
-
-
58249116545
-
Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout
-
Martin WJ, Walton M, Harper J. 2009. Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. Arthritis Rheum. 60:281-899
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 281-899
-
-
Martin, W.J.1
Walton, M.2
Harper, J.3
-
133
-
-
70349379884
-
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis
-
Torres R, MacDonald L, Croll SD, Reinhardt J, Dore A, et al. 2009. Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis. Ann. Rheum. Dis. 68:1602-88
-
(2009)
Ann. Rheum. Dis.
, vol.68
, pp. 1602-1688
-
-
Torres, R.1
Macdonald, L.2
Croll, S.D.3
Reinhardt, J.4
Dore, A.5
|