Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 26, 2014, Pages 9597-9602

  Szendroedi, Julia ^a,b   Yoshimura, Toru ^c   Phielix, Esther ^a   Koliaki, Chrysi ^a   Marcucci, Mellissa ^c   Zhang, Dongyan ^c   Jelenik, Tomas ^a   Müller, Janette ^a   Herder, Christian ^a   Nowotny, Peter ^a   Shulman, Gerald I ^c   Roden, Michael ^a,b  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Insulin signaling; Lipotoxicity

Indexed keywords

ACYLCARNITINE; ADIPOCYTOKINE; ADIPONECTIN; CERAMIDE; DIACYLGLYCEROL; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE; PROTEIN KINASE B BETA; RETINOL BINDING PROTEIN 4;

ADULT; ARTICLE; CELL ADHESION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE UTILIZATION; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID OXIDATION; MALE; MUSCLE; MUSCLE BIOPSY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

INSULIN SIGNALING; LIPOTOXICITY;

ANALYSIS OF VARIANCE; BLOOD CHEMICAL ANALYSIS; CALORIMETRY, INDIRECT; DIABETES MELLITUS, TYPE 2; DIGLYCERIDES; ENZYME ACTIVATION; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN RESISTANCE; ISOENZYMES; MUSCLES; PROTEIN KINASE C;

EID: 84903691827     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409229111     Document Type: Article

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