Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Nature Immunology

Volumn 12, Issue 5, 2011, Pages 408-415

  Wen, Haitao ^a,b   Gris, Denis ^a,b   Lei, Yu ^a,b   Jha, Sushmita ^a   Zhang, Lu ^a,b   Huang, Max Tze Han ^a,b   Brickey, Willie June ^a   Ting, Jenny P Y ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INFLAMMASOME; INSULIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; OLEIC ACID; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; TUMOR NECROSIS FACTOR; UNC 51 LIKE KINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GLUCOSE TOLERANCE; HEMATOPOIETIC CELL; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; AUTOPHAGY; CARRIER PROTEINS; CASPASE 1; DIETARY FATS; ENZYME ACTIVATION; ENZYME INHIBITORS; FLOW CYTOMETRY; INFLAMMASOMES; INSULIN RESISTANCE; INTERLEUKIN-1BETA; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; OLIGOPEPTIDES; PALMITIC ACID; REACTIVE OXYGEN SPECIES; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION;

EID: 79955038882     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2022     Document Type: Article

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