Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes

Cell Metabolism

Volumn 26, Issue 1, 2017, Pages 157-170.e7

  Oral, Elif A ^a   Reilly, Shannon M ^b   Gomez, Andrew V ^b   Meral, Rasimcan ^a   Butz, Laura ^a   Ajluni, Nevin ^a   Chenevert, Thomas L ^a   Korytnaya, Evgenia ^a   Neidert, Adam H ^a   Hench, Rita ^a   Rus, Diana ^a   Horowitz, Jeffrey F ^c   Poirier, BreAnne ^b   Zhao, Peng ^b   Lehmann, Kim ^b   Jain, Mohit ^b   Yu, Ruth ^d   Liddle, Christopher ^d,e   Ahmadian, Maryam ^d   Downes, Michael ^d   Evans, Ronald M ^d   Saltiel, Alan R ^b,f   more..

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^e WESTMEAD HOSPITAL   (Australia)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

amlexanox; clinical trial; energy expenditure; fatty liver; gene expression; inflammation; obesity; protein kinase

Indexed keywords

ADIPONECTIN; AMLEXANOX; ANTIHYPERTENSIVE AGENT; BETA 3 ADRENERGIC RECEPTOR; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FIBROBLAST GROWTH FACTOR 21; FRUCTOSAMINE; GLUCOSE; HEMOGLOBIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; I KAPPA B KINASE EPSILON; INSULIN; INTERLEUKIN 4; INTERLEUKIN 6; LEUCINE ZIPPER PROTEIN; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PLACEBO; PROTEIN; REPAGLINIDE; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SULFONYLUREA; TBK1 PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; AMINOPYRIDINE DERIVATIVE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; I KAPPA B KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG RESPONSE; DRUG SAFETY; ENERGY EXPENDITURE; ENZYME INHIBITION; ERYTHEMA; FATTY LIVER; FEMALE; GENE EXPRESSION; GLUCONEOGENESIS; GLYCEMIC CONTROL; HUMAN; HUMAN TISSUE; INSULIN SENSITIVITY; MALE; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; NONALCOHOLIC FATTY LIVER; OBESITY; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RASH; SUBCUTANEOUS FAT; SUBCUTANEOUS WHITE ADIPOSE TISSUE; TREATMENT RESPONSE; ANALYSIS; ANTAGONISTS AND INHIBITORS; BLOOD; COMPLICATION; DRUG EFFECTS; ENERGY METABOLISM; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED;

AGED; AMINOPYRIDINES; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; ENERGY METABOLISM; FEMALE; GLYCATED HEMOGLOBIN A; HUMANS; I-KAPPA B KINASE; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES;

EID: 85029169452     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2017.06.006     Document Type: Article

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