Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nature

Volumn 480, Issue 7375, 2011, Pages 104-108

  Nguyen, Khoa D ^a,b   Qiu, Yifu ^b   Cui, Xiaojin ^b   Goh, Y P Sharon ^a,b   Mwangi, Julia ^b   David, Tovo ^b   Mukundan, Lata ^b   Brombacher, Frank ^c   Locksley, Richard M ^b,d   Chawla, Ajay ^b  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; INTERLEUKIN 4; LONG CHAIN FATTY ACID COENZYME A LIGASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCOUPLING PROTEIN 1;

BODY TEMPERATURE; COLD REGION; ENZYME ACTIVITY; GENE EXPRESSION; HORMONE; METABOLISM; PHYSIOLOGICAL RESPONSE; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; COLD; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME SYNTHESIS; GENE EXPRESSION; IN VITRO STUDY; LIPOLYSIS; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THERMOGENESIS; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANIMALS; BODY TEMPERATURE; CATECHOLAMINES; CELLS, CULTURED; COLD TEMPERATURE; ENERGY METABOLISM; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-4; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; STRESS, PHYSIOLOGICAL; THERMOGENESIS; U937 CELLS;

MAMMALIA; MUS;

EID: 82555186955     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10653     Document Type: Article

References (24)

1. Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359 (2004). (Pubitemid 38054374)
2. Lowell, B. B. & Spiegelman, B. M.Towardsa molecular understanding of adaptive thermogenesis. Nature 404, 652-660 (2000). (Pubitemid 30205070)
3. Tseng, Y.H., Cypess, A.M. & Kahn, C.R. Cellular bioenergeticsas atarget for obesity therapy. Nature Rev. Drug Discov. 9, 465-482 (2010).
4. Nakamura, K. & Morrison, S. F. A thermosensory pathway that controls body temperature. Nature Neurosci. 11, 62-71 (2008).
5. Morrison, S. F., Nakamura, K. & Madden, C. J. Central control of thermogenesis in mammals. Exp. Physiol. 93, 773-797 (2008). (Pubitemid 351904256)
6. Nedergaard, J., Bengtsson, T. & Cannon, B. New powers of brown fat: fighting the metabolic syndrome. Cell Metab. 13, 238-240 (2011).
7. Ellis, J. M. et al. Adipose acyl-CoA synthetase-1 directs fatty acids toward b-oxidation andisrequired for cold thermogenesis. Cell Metab. 12, 53-64 (2010).
8. Enerbäck, S. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90-94 (1997). (Pubitemid 27202655)
9. Puigserver, P. et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 (1998). (Pubitemid 28155321)
10. Cannon, B. & Nedergaard, J. Nonshivering thermogenesis and its adequate measurement in metabolic studies. J. Exp. Biol. 214, 242-253 (2011).
11. Gordon, S. Alternative activation of macrophages. Nature Rev. Immunol. 3, 23-35 (2003). (Pubitemid 37328697)
12. Odegaard, J. I. & Chawla, A. Alternative macrophage activation and metabolism. Annu. Rev. Pathol. 6, 275-297 (2011).
13. Martinez, F. O., Helming, L. & Gordon, S. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 27, 451-483 (2009).
14. Herbert, D. R. et al. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 20, 623-635 (2004). (Pubitemid 38659504)
15. Watt, M. J. et al. Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPATorHSL activity, in human skeletal muscle.Am. J. Physiol. Endocrinol. Metab. 287, E120-E127 (2004). (Pubitemid 38856291)
16. Haemmerle, G. et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312, 734-737 (2006).
17. Lass, A. et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab. 3, 309-319 (2006).
18. Flierl, M. A. et al. Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature 449, 721-725 (2007). (Pubitemid 47552095)
19. Brown, S.W.etal.Catecholaminesinamacrophagecellline.J.Neuroimmunol.135, 47-55 (2003).
20. Zhou, Q. Y., Quaife, C. J. & Palmiter, R. D. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374, 640-643 (1995).
21. 3-adrenoceptor agonist, in yellow KK mice. Life Sci. 54, 491-498 (1994).
22. Kosteli, A. et al. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J. Clin. Invest. 120, 3466-3479 (2010).
23. Odegaard, J. I. et al. Alternative M2 activation of Kupffer cells by PPARda ameliorates obesity-induced insulin resistance. Cell Metab. 7, 496-507 (2008). (Pubitemid 351729205)
24. Odegaard, J.I. etal. Macrophage-specific PPARc controls alternative activation and improves insulin resistance. Nature 447, 1116-1120 (2007). (Pubitemid 47014427)