Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

Journal of Biological Chemistry

Volumn 277, Issue 52, 2002, Pages 50230-50236

  Yu, Chunli ^a   Chen, Yan ^a   Cline, Gary W ^a   Zhang, Dongyan ^a   Zong, Haihong ^a   Wang, Yanlin ^a   Bergeron, Raynald ^a   Kim, Jason K ^a   Cushman, Samuel W ^b   Cooney, Gregory J ^d   Atcheson, Bronwyn ^d   White, Morris F ^c   Kraegen, Edward W ^d   Shulman, Gerald I ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EMULSIONS; FATTY ACIDS; GLUCOSE; GLYCEROL; LIPIDS; MUSCLE; SUBSTRATES;

PHOPHORYLATION;

INSULIN;

CERAMIDE; COENZYME A; DIACYLGLYCEROL; FATTY ACID; GLUCOSE; GLYCEROL; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LIPID EMULSION; META TYROSINE; P13 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; GLUCOSE TRANSPORT; INSULIN RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BLOCKING; SKELETAL MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; DIGLYCERIDES; FAT EMULSIONS, INTRAVENOUS; FATTY ACIDS, NONESTERIFIED; INSULIN; KINETICS; MALE; MUSCLE, SKELETAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0037184925     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M200958200     Document Type: Article

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