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Volumn 21, Issue 7, 2015, Pages 698-708

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

Author keywords

[No Author keywords available]

Indexed keywords

DACLIZUMAB;

EID: 84936892270     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3892     Document Type: Review
Times cited : (425)

References (161)
  • 1
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S.I., Greten, F.R. & Karin, M. Immunity, inflammation, and cancer. Cell 140, 883-899 (2010).
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 2
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov, R. Origin and physiological roles of inflammation. Nature 454, 428-435 (2008).
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 3
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells - A proposal for uniform nomenclature
    • Spits, H. et al. Innate lymphoid cells - a proposal for uniform nomenclature. Nat. Rev. Immunol. 13, 145-149 (2013).
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 145-149
    • Spits, H.1
  • 6
    • 84867807929 scopus 로고    scopus 로고
    • Innate lymphoid cell interactions with microbiota: Implications for intestinal health and disease
    • Sonnenberg, G.F. & Artis, D. Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity 37, 601-610 (2012).
    • (2012) Immunity , vol.37 , pp. 601-610
    • Sonnenberg, G.F.1    Artis, D.2
  • 7
    • 40049083827 scopus 로고    scopus 로고
    • Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    • Zheng, Y. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14, 282-289 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 282-289
    • Zheng, Y.1
  • 8
    • 79955030498 scopus 로고    scopus 로고
    • Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
    • Sonnenberg, G.F., Fouser, L.A. & Artis, D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat. Immunol. 12, 383-390 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 383-390
    • Sonnenberg, G.F.1    Fouser, L.A.2    Artis, D.3
  • 9
    • 40049098958 scopus 로고    scopus 로고
    • IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    • Aujla, S.J. et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14, 275-281 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 275-281
    • Aujla, S.J.1
  • 10
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • Ouyang, W., Kolls, J.K. & Zheng, Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28, 454-467 (2008).
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 11
    • 33646164439 scopus 로고    scopus 로고
    • Expanding the effector CD4 T-cell repertoire: The Th17 lineage
    • Harrington, L.E., Mangan, P.R. & Weaver, C.T. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr. Opin. Immunol. 18, 349-356 (2006).
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 349-356
    • Harrington, L.E.1    Mangan, P.R.2    Weaver, C.T.3
  • 12
    • 55149112367 scopus 로고    scopus 로고
    • The interleukin-23 axis in intestinal inflammation
    • Ahern, P.P., Izcue, A., Maloy, K.J. & Powrie, F. The interleukin-23 axis in intestinal inflammation. Immunol. Rev. 226, 147-159 (2008).
    • (2008) Immunol. Rev. , vol.226 , pp. 147-159
    • Ahern, P.P.1    Izcue, A.2    Maloy, K.J.3    Powrie, F.4
  • 13
    • 33645888708 scopus 로고    scopus 로고
    • Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    • Fallon, P.G. et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J. Exp. Med. 203, 1105-1116 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1105-1116
    • Fallon, P.G.1
  • 14
    • 55149113944 scopus 로고    scopus 로고
    • Welcome to the neighborhood: Epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites
    • Saenz, S.A., Taylor, B.C. & Artis, D. Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites. Immunol. Rev. 226, 172-190 (2008).
    • (2008) Immunol. Rev. , vol.226 , pp. 172-190
    • Saenz, S.A.1    Taylor, B.C.2    Artis, D.3
  • 15
    • 75549087056 scopus 로고    scopus 로고
    • Disease-associated functions of IL-33: The new kid in the IL-1 family
    • Liew, F.Y., Pitman, N.I. & McInnes, I.B. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat. Rev. Immunol. 10, 103-110 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 103-110
    • Liew, F.Y.1    Pitman, N.I.2    McInnes, I.B.3
  • 16
    • 34247891512 scopus 로고    scopus 로고
    • TSLP: An epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation
    • Liu, Y.J. et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu. Rev. Immunol. 25, 193-219 (2007).
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 193-219
    • Liu, Y.J.1
  • 17
    • 18244405108 scopus 로고    scopus 로고
    • IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    • Fort, M.M. et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15, 985-995 (2001).
    • (2001) Immunity , vol.15 , pp. 985-995
    • Fort, M.M.1
  • 18
    • 0016835962 scopus 로고
    • "Natural" killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell
    • Kiessling, R., Klein, E., Pross, H. & Wigzell, H. "Natural" killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell. Eur. J. Immunol. 5, 117-121 (1975).
    • (1975) Eur. J. Immunol. , vol.5 , pp. 117-121
    • Kiessling, R.1    Klein, E.2    Pross, H.3    Wigzell, H.4
  • 19
    • 0016834182 scopus 로고
    • Cytotoxic lymphocytes from normal donors. A functional marker of human non-T lymphocytes
    • Pross, H.F. & Jondal, M. Cytotoxic lymphocytes from normal donors. A functional marker of human non-T lymphocytes. Clin. Exp. Immunol. 21, 226-235 (1975).
    • (1975) Clin. Exp. Immunol. , vol.21 , pp. 226-235
    • Pross, H.F.1    Jondal, M.2
  • 20
    • 0030710079 scopus 로고    scopus 로고
    • + cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    • + cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity 7, 493-504 (1997).
    • (1997) Immunity , vol.7 , pp. 493-504
    • Mebius, R.E.1    Rennert, P.2    Weissman, I.L.3
  • 22
    • 59649099774 scopus 로고    scopus 로고
    • A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    • Cella, M. et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 457, 722-725 (2009).
    • (2009) Nature , vol.457 , pp. 722-725
    • Cella, M.1
  • 23
    • 57449118239 scopus 로고    scopus 로고
    • + cells that provide innate mucosal immune defense
    • + cells that provide innate mucosal immune defense. Immunity 29, 958-970 (2008).
    • (2008) Immunity , vol.29 , pp. 958-970
    • Satoh-Takayama, N.1
  • 24
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371-1375 (2010).
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1
  • 25
    • 78049385155 scopus 로고    scopus 로고
    • + innate lymphoid cells
    • + innate lymphoid cells. Science 330, 665-669 (2010).
    • (2010) Science , vol.330 , pp. 665-669
    • Sawa, S.1
  • 26
    • 57849131584 scopus 로고    scopus 로고
    • + natural killer-like cells
    • + natural killer-like cells. Nat. Immunol. 10, 66-74 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 66-74
    • Cupedo, T.1
  • 27
    • 78650183459 scopus 로고    scopus 로고
    • +LTi-like innate lymphoid cells by Toll-like receptor 2
    • +LTi-like innate lymphoid cells by Toll-like receptor 2. Immunity 33, 752-764 (2010).
    • (2010) Immunity , vol.33 , pp. 752-764
    • Crellin, N.K.1
  • 29
    • 75749122181 scopus 로고    scopus 로고
    • + lymphoid cells
    • + lymphoid cells. Nature 463, 540-544 (2010).
    • (2010) Nature , vol.463 , pp. 540-544
    • Moro, K.1
  • 30
    • 77954926597 scopus 로고    scopus 로고
    • Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    • Price, A.E. et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl. Acad. Sci. USA 107, 11489-11494 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 11489-11494
    • Price, A.E.1
  • 31
    • 85027948313 scopus 로고    scopus 로고
    • Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
    • Monticelli, L.A. et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol. 12, 1045-1054 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 1045-1054
    • Monticelli, L.A.1
  • 32
    • 80054889051 scopus 로고    scopus 로고
    • Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
    • Mjösberg, J.M. et al. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat. Immunol. 12, 1055-1062 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 1055-1062
    • Mjösberg, J.M.1
  • 33
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type 2 immunity
    • Neill, D.R. et al. Nuocytes represent a new innate effector leukocyte that mediates type 2 immunity. Nature 464, 1367-1370 (2010).
    • (2010) Nature , vol.464 , pp. 1367-1370
    • Neill, D.R.1
  • 34
    • 84861722864 scopus 로고    scopus 로고
    • Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells
    • Cherrier, M., Sawa, S. & Eberl, G. Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells. J. Exp. Med. 209, 729-740 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 729-740
    • Cherrier, M.1    Sawa, S.2    Eberl, G.3
  • 36
    • 84898640432 scopus 로고    scopus 로고
    • Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages
    • Klose, C.S. et al. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell 157, 340-356 (2014).
    • (2014) Cell , vol.157 , pp. 340-356
    • Klose, C.S.1
  • 37
    • 84907968021 scopus 로고    scopus 로고
    • Development, differentiation, and diversity of innate lymphoid cells
    • Diefenbach, A., Colonna, M. & Koyasu, S. Development, differentiation, and diversity of innate lymphoid cells. Immunity 41, 354-365 (2014).
    • (2014) Immunity , vol.41 , pp. 354-365
    • Diefenbach, A.1    Colonna, M.2    Koyasu, S.3
  • 38
    • 84922607138 scopus 로고    scopus 로고
    • The biology of innate lymphoid cells
    • Artis, D. & Spits, H. The biology of innate lymphoid cells. Nature 517, 293-301 (2015).
    • (2015) Nature , vol.517 , pp. 293-301
    • Artis, D.1    Spits, H.2
  • 39
    • 84925943039 scopus 로고    scopus 로고
    • NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors
    • Xu, W. et al. NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Rep. 10, 2043-2054 (2015).
    • (2015) Cell Rep. , vol.10 , pp. 2043-2054
    • Xu, W.1
  • 40
    • 84906534108 scopus 로고    scopus 로고
    • Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens
    • Geiger, T.L. et al. Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. J. Exp. Med. 211, 1723-1731 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 1723-1731
    • Geiger, T.L.1
  • 41
    • 85088493846 scopus 로고    scopus 로고
    • The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor
    • Yu, X. et al. The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. Elife doi:10.7554/eLife.0440 (2014).
    • (2014) Elife
    • Yu, X.1
  • 42
    • 84906568567 scopus 로고    scopus 로고
    • Nfil3 is required for the development of all innate lymphoid cell subsets
    • Seillet, C. et al. Nfil3 is required for the development of all innate lymphoid cell subsets. J. Exp. Med. 211, 1733-1740 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 1733-1740
    • Seillet, C.1
  • 43
    • 84896735604 scopus 로고    scopus 로고
    • NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis
    • Kobayashi, T. et al. NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis. J. Immunol. 192, 1918-1927 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 1918-1927
    • Kobayashi, T.1
  • 44
    • 84929899392 scopus 로고    scopus 로고
    • The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor
    • Seehus, C.R. et al. The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor. Nat. Immunol. 16, 599-608 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 599-608
    • Seehus, C.R.1
  • 45
    • 77956963618 scopus 로고    scopus 로고
    • Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages
    • Aliahmad, P., de la Torre, B. & Kaye, J. Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages. Nat. Immunol. 11, 945-952 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 945-952
    • Aliahmad, P.1    De La Torre, B.2    Kaye, J.3
  • 46
    • 84876762753 scopus 로고    scopus 로고
    • T cell factor 1 is required for group 2 innate lymphoid cell generation
    • Yang, Q. et al. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity 38, 694-704 (2013).
    • (2013) Immunity , vol.38 , pp. 694-704
    • Yang, Q.1
  • 47
    • 84885439404 scopus 로고    scopus 로고
    • + innate lymphocyte differentiation and protection in intestinal inflammation
    • + innate lymphocyte differentiation and protection in intestinal inflammation. J. Immunol. 191, 4383-4391 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 4383-4391
    • Mielke, L.A.1
  • 48
    • 84896396519 scopus 로고    scopus 로고
    • The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells
    • Yagi, R. et al. The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells. Immunity 40, 378-388 (2014).
    • (2014) Immunity , vol.40 , pp. 378-388
    • Yagi, R.1
  • 49
    • 84893766480 scopus 로고    scopus 로고
    • + group 3 innate lymphoid cells
    • + group 3 innate lymphoid cells. J. Exp. Med. 211, 199-208 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 199-208
    • Serafini, N.1
  • 50
    • 84918529869 scopus 로고    scopus 로고
    • + innate lymphoid cells
    • + innate lymphoid cells. Immunity 41, 988-1000 (2014).
    • (2014) Immunity , vol.41 , pp. 988-1000
    • Montaldo, E.1
  • 51
    • 85027945857 scopus 로고    scopus 로고
    • Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
    • Bernink, J.H. et al. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat. Immunol. 14, 221-229 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 221-229
    • Bernink, J.H.1
  • 52
    • 84876780238 scopus 로고    scopus 로고
    • Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells
    • Fuchs, A. et al. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. Immunity 38, 769-781 (2013).
    • (2013) Immunity , vol.38 , pp. 769-781
    • Fuchs, A.1
  • 53
    • 84867769688 scopus 로고    scopus 로고
    • The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells
    • Hoyler, T. et al. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity 37, 634-648 (2012).
    • (2012) Immunity , vol.37 , pp. 634-648
    • Hoyler, T.1
  • 54
    • 84867773093 scopus 로고    scopus 로고
    • The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells
    • Mjösberg, J. et al. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 37, 649-659 (2012).
    • (2012) Immunity , vol.37 , pp. 649-659
    • Mjösberg, J.1
  • 56
    • 84881464799 scopus 로고    scopus 로고
    • Critical role of p38 and GATA3 in natural helper cell function
    • Furusawa, J. et al. Critical role of p38 and GATA3 in natural helper cell function. J. Immunol. 191, 1818-1826 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 1818-1826
    • Furusawa, J.1
  • 57
    • 84863393407 scopus 로고    scopus 로고
    • Transcription factor RORα is critical for nuocyte development
    • Wong, S.H. et al. Transcription factor RORα is critical for nuocyte development. Nat. Immunol. 13, 229-236 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 229-236
    • Wong, S.H.1
  • 58
    • 84866519013 scopus 로고    scopus 로고
    • Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation
    • Halim, T.Y. et al. Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. Immunity 37, 463-474 (2012).
    • (2012) Immunity , vol.37 , pp. 463-474
    • Halim, T.Y.1
  • 59
    • 84923436228 scopus 로고    scopus 로고
    • Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets
    • Robinette, M.L. et al. Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat. Immunol. 16, 306-317 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 306-317
    • Robinette, M.L.1
  • 60
    • 84888000653 scopus 로고    scopus 로고
    • Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1
    • Spooner, C.J. et al. Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1. Nat. Immunol. 14, 1229-1236 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1229-1236
    • Spooner, C.J.1
  • 61
    • 84980319820 scopus 로고    scopus 로고
    • Bcl11b is essential for group 2 innate lymphoid cell development
    • in the press
    • Walker, J.A. et al. Bcl11b is essential for group 2 innate lymphoid cell development. J. Exp. Med. (in the press, 2015).
    • (2015) J. Exp. Med.
    • Walker, J.A.1
  • 62
    • 84980390670 scopus 로고    scopus 로고
    • The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
    • in the press
    • Yu, Y. et al. The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. J. Exp. Med. (in the press, 2015).
    • (2015) J. Exp. Med.
    • Yu, Y.1
  • 63
    • 84874055169 scopus 로고    scopus 로고
    • TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation
    • Kim, B.S. et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci. Transl. Med. 5, 70ra116 (2013).
    • (2013) Sci. Transl. Med. , vol.5
    • Kim, B.S.1
  • 64
    • 84876746655 scopus 로고    scopus 로고
    • Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    • Molofsky, A.B. et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med. 210, 535-549 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 535-549
    • Molofsky, A.B.1
  • 65
    • 84888346690 scopus 로고    scopus 로고
    • Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice
    • Hams, E., Locksley, R.M., McKenzie, A.N. & Fallon, P.G. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J. Immunol. 191, 5349-5353 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 5349-5353
    • Hams, E.1    Locksley, R.M.2    McKenzie, A.N.3    Fallon, P.G.4
  • 66
    • 84924969384 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
    • Brestoff, J.R. et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519, 242-246 (2015).
    • (2015) Nature , vol.519 , pp. 242-246
    • Brestoff, J.R.1
  • 67
    • 0346496018 scopus 로고    scopus 로고
    • An essential function for the nuclear receptor RORγ(t) in the generation of fetal lymphoid tissue inducer cells
    • Eberl, G. et al. An essential function for the nuclear receptor RORγ(t) in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol. 5, 64-73 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 64-73
    • Eberl, G.1
  • 68
    • 84873729246 scopus 로고    scopus 로고
    • +innate lymphoid cells
    • +innate lymphoid cells. Nature 494, 261-265 (2013).
    • (2013) Nature , vol.494 , pp. 261-265
    • Klose, C.S.1
  • 69
    • 83855160821 scopus 로고    scopus 로고
    • Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
    • Kiss, E.A. et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 334, 1561-1565 (2011).
    • (2011) Science , vol.334 , pp. 1561-1565
    • Kiss, E.A.1
  • 70
    • 84855917402 scopus 로고    scopus 로고
    • AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
    • Lee, J.S. et al. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat. Immunol. 13, 144-151 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 144-151
    • Lee, J.S.1
  • 71
    • 84856237141 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
    • Qiu, J. et al. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 36, 92-104 (2012).
    • (2012) Immunity , vol.36 , pp. 92-104
    • Qiu, J.1
  • 72
    • 78649360369 scopus 로고    scopus 로고
    • + innate lymphocytes
    • + innate lymphocytes. Immunity 33, 736-751 (2010).
    • (2010) Immunity , vol.33 , pp. 736-751
    • Vonarbourg, C.1
  • 73
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • Bouskra, D. et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 456, 507-510 (2008).
    • (2008) Nature , vol.456 , pp. 507-510
    • Bouskra, D.1
  • 74
    • 84986631150 scopus 로고    scopus 로고
    • + ILCs creates a unique microenvironment within mucosal draining lymph nodes
    • + ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nat. Commun. 6, 5862 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 5862
    • Mackley, E.C.1
  • 75
    • 84906322207 scopus 로고    scopus 로고
    • + ILC3 in lesional skin and blood of psoriasis patients
    • + ILC3 in lesional skin and blood of psoriasis patients. J. Invest. Dermatol. 134, 2351-2360 (2014).
    • (2014) J. Invest. Dermatol. , vol.134 , pp. 2351-2360
    • Teunissen, M.B.1
  • 76
    • 84867856710 scopus 로고    scopus 로고
    • + innate lymphoid cells
    • + innate lymphoid cells. Immunity 37, 674-684 (2012).
    • (2012) Immunity , vol.37 , pp. 674-684
    • Powell, N.1
  • 77
    • 84922857734 scopus 로고    scopus 로고
    • hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells
    • hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells. Nat. Immunol. 16, 161-169 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 161-169
    • Huang, Y.1
  • 80
    • 4544300682 scopus 로고    scopus 로고
    • RELMβ/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
    • Artis, D. et al. RELMβ/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc. Natl. Acad. Sci. USA 101, 13596-13600 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13596-13600
    • Artis, D.1
  • 81
    • 84892928571 scopus 로고    scopus 로고
    • Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity
    • Spencer, S.P. et al. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science 343, 432-437 (2014).
    • (2014) Science , vol.343 , pp. 432-437
    • Spencer, S.P.1
  • 82
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • Sugimoto, K. et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534-544 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 534-544
    • Sugimoto, K.1
  • 83
    • 84908075358 scopus 로고    scopus 로고
    • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen
    • Pham, T.A. et al. Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen. Cell Host Microbe 16, 504-516 (2014).
    • (2014) Cell Host Microbe , vol.16 , pp. 504-516
    • Pham, T.A.1
  • 84
    • 84907208430 scopus 로고    scopus 로고
    • Innate lymphoid cells regulate intestinal epithelial cell glycosylation
    • Goto, Y. et al. Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science 345, 1254009 (2014).
    • (2014) Science , vol.345 , pp. 1254009
    • Goto, Y.1
  • 85
    • 84908403149 scopus 로고    scopus 로고
    • Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness
    • Pickard, J.M. et al. Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness. Nature 514, 638-641 (2014).
    • (2014) Nature , vol.514 , pp. 638-641
    • Pickard, J.M.1
  • 86
    • 84872171847 scopus 로고    scopus 로고
    • Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection
    • Gladiator, A., Wangler, N., Trautwein-Weidner, K. & LeibundGut-Landmann, S. Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection. J. Immunol. 190, 521-525 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 521-525
    • Gladiator, A.1    Wangler, N.2    Trautwein-Weidner, K.3    LeibundGut-Landmann, S.4
  • 87
    • 77953495368 scopus 로고    scopus 로고
    • Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
    • Sonnenberg, G.F. et al. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J. Exp. Med. 207, 1293-1305 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1293-1305
    • Sonnenberg, G.F.1
  • 88
    • 84902996531 scopus 로고    scopus 로고
    • The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice
    • Deshmukh, H.S. et al. The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice. Nat. Med. 20, 524-530 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 524-530
    • Deshmukh, H.S.1
  • 89
    • 84890852091 scopus 로고    scopus 로고
    • IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
    • Turner, J.E. et al. IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J. Exp. Med. 210, 2951-2965 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 2951-2965
    • Turner, J.E.1
  • 90
    • 84890825282 scopus 로고    scopus 로고
    • A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis
    • Salimi, M. et al. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J. Exp. Med. 210, 2939-2950 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 2939-2950
    • Salimi, M.1
  • 91
    • 44049100259 scopus 로고    scopus 로고
    • Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone
    • Scandella, E. et al. Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nat. Immunol. 9, 667-675 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 667-675
    • Scandella, E.1
  • 92
    • 84859497086 scopus 로고    scopus 로고
    • Interleukin-22 drives endogenous thymic regeneration in mice
    • Dudakov, J.A. et al. Interleukin-22 drives endogenous thymic regeneration in mice. Science 336, 91-95 (2012).
    • (2012) Science , vol.336 , pp. 91-95
    • Dudakov, J.A.1
  • 93
    • 84876561418 scopus 로고    scopus 로고
    • IL-22-producing RORgammat-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis
    • Matsumoto, A. et al. IL-22-producing RORgammat-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis. PLoS ONE 8, e62853 (2013).
    • (2013) PLoS ONE , vol.8
    • Matsumoto, A.1
  • 94
    • 84867658823 scopus 로고    scopus 로고
    • IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection
    • Kumar, P., Thakar, M.S., Ouyang, W. & Malarkannan, S. IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. Mucosal Immunol. 6, 69-82 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 69-82
    • Kumar, P.1    Thakar, M.S.2    Ouyang, W.3    Malarkannan, S.4
  • 95
    • 77956190936 scopus 로고    scopus 로고
    • + natural killer cells in the intestinal mucosa of patients with Crohn's disease
    • + natural killer cells in the intestinal mucosa of patients with Crohn's disease. Gastroenterology 139, 882-892 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 882-892
    • Takayama, T.1
  • 96
    • 84861796578 scopus 로고    scopus 로고
    • + natural killer cells in subclinical gut inflammation in ankylosing spondylitis
    • + natural killer cells in subclinical gut inflammation in ankylosing spondylitis. Arthritis Rheum. 64, 1869-1878 (2012).
    • (2012) Arthritis Rheum. , vol.64 , pp. 1869-1878
    • Ciccia, F.1
  • 97
    • 79952986650 scopus 로고    scopus 로고
    • + innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    • + innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat. Immunol. 12, 320-326 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 320-326
    • Sawa, S.1
  • 98
    • 84865401664 scopus 로고    scopus 로고
    • Interleukin-22 protects intestinal stem cells from immunemediated tissue damage and regulates sensitivity to graft versus host disease
    • Hanash, A.M. et al. Interleukin-22 protects intestinal stem cells from immunemediated tissue damage and regulates sensitivity to graft versus host disease. Immunity 37, 339-350 (2012).
    • (2012) Immunity , vol.37 , pp. 339-350
    • Hanash, A.M.1
  • 99
    • 84881530486 scopus 로고    scopus 로고
    • Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation
    • Mielke, L.A. et al. Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation. J. Exp. Med. 210, 1117-1124 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 1117-1124
    • Mielke, L.A.1
  • 100
    • 84905111578 scopus 로고    scopus 로고
    • Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease
    • Munneke, J.M. et al. Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease. Blood 124, 812-821 (2014).
    • (2014) Blood , vol.124 , pp. 812-821
    • Munneke, J.M.1
  • 101
    • 53349120339 scopus 로고    scopus 로고
    • Commensal-dependent expression of IL-25 regulates the IL-23- IL-17 axis in the intestine
    • Zaph, C. et al. Commensal-dependent expression of IL-25 regulates the IL-23- IL-17 axis in the intestine. J. Exp. Med. 205, 2191-2198 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2191-2198
    • Zaph, C.1
  • 102
    • 84905118660 scopus 로고    scopus 로고
    • + mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
    • + mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J. Exp. Med. 211, 1571-1583 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 1571-1583
    • Longman, R.S.1
  • 103
    • 84874082076 scopus 로고    scopus 로고
    • + macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium
    • + macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunol. 6, 177-188 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 177-188
    • Manta, C.1
  • 104
    • 84924529911 scopus 로고    scopus 로고
    • IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology
    • Aychek, T. et al. IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology. Nat. Commun. 6, 6525 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6525
    • Aychek, T.1
  • 105
    • 84912074927 scopus 로고    scopus 로고
    • The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells
    • Satoh-Takayama, N. et al. The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells. Immunity 41, 776-788 (2014).
    • (2014) Immunity , vol.41 , pp. 776-788
    • Satoh-Takayama, N.1
  • 106
    • 84859911615 scopus 로고    scopus 로고
    • NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
    • Franchi, L. et al. NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat. Immunol. 13, 449-456 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 449-456
    • Franchi, L.1
  • 107
    • 84928175356 scopus 로고    scopus 로고
    • Distinct commensals induce interleukin-1β via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury
    • Seo, S.U. et al. Distinct commensals induce interleukin-1β via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury. Immunity 42, 744-755 (2015).
    • (2015) Immunity , vol.42 , pp. 744-755
    • Seo, S.U.1
  • 108
    • 84897480560 scopus 로고    scopus 로고
    • Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
    • van de Pavert, S.A. et al. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature 508, 123-127 (2014).
    • (2014) Nature , vol.508 , pp. 123-127
    • Van De Pavert, S.A.1
  • 109
    • 84906822605 scopus 로고    scopus 로고
    • Enhanced innate type 2 immune response in peripheral blood from patients with asthma
    • Bartemes, K.R., Kephart, G.M., Fox, S.J. & Kita, H. Enhanced innate type 2 immune response in peripheral blood from patients with asthma. J. Allergy Clin. Immunol. 134, 671-678 (2014).
    • (2014) J. Allergy Clin. Immunol. , vol.134 , pp. 671-678
    • Bartemes, K.R.1    Kephart, G.M.2    Fox, S.J.3    Kita, H.4
  • 110
    • 84891943376 scopus 로고    scopus 로고
    • IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis
    • Hams, E. et al. IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proc. Natl. Acad. Sci. USA 111, 367-372 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 367-372
    • Hams, E.1
  • 111
    • 79959380307 scopus 로고    scopus 로고
    • Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
    • Chang, Y.J. et al. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat. Immunol. 12, 631-638 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 631-638
    • Chang, Y.J.1
  • 112
    • 84858775590 scopus 로고    scopus 로고
    • H2 cell-type cytokines in protease allergen-induced airway inflammation
    • H2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity 36, 451-463 (2012).
    • (2012) Immunity , vol.36 , pp. 451-463
    • Halim, T.Y.1    Krauss, R.H.2    Sun, A.C.3    Takei, F.4
  • 113
    • 84863011729 scopus 로고    scopus 로고
    • hi lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs
    • hi lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol. 188, 1503-1513 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 1503-1513
    • Bartemes, K.R.1
  • 114
    • 84882750151 scopus 로고    scopus 로고
    • Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice
    • Imai, Y. et al. Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice. Proc. Natl. Acad. Sci. USA 110, 13921-13926 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 13921-13926
    • Imai, Y.1
  • 115
    • 84896849811 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation
    • Kabata, H. et al. Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation. Nat. Commun. 4, 2675 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2675
    • Kabata, H.1
  • 116
    • 84907195502 scopus 로고    scopus 로고
    • Basophils promote innate lymphoid cell responses in inflamed skin
    • Kim, B.S. et al. Basophils promote innate lymphoid cell responses in inflamed skin. J. Immunol. 193, 3717-3725 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 3717-3725
    • Kim, B.S.1
  • 117
    • 84900397775 scopus 로고    scopus 로고
    • Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation
    • Motomura, Y. et al. Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. Immunity 40, 758-771 (2014).
    • (2014) Immunity , vol.40 , pp. 758-771
    • Motomura, Y.1
  • 118
    • 84876008998 scopus 로고    scopus 로고
    • Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma
    • Barnig, C. et al. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci. Transl. Med. 5, 74ra126 (2013).
    • (2013) Sci. Transl. Med. , vol.5
    • Barnig, C.1
  • 119
    • 84896343916 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation
    • Halim, T.Y. et al. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40, 425-435 (2014).
    • (2014) Immunity , vol.40 , pp. 425-435
    • Halim, T.Y.1
  • 120
    • 84907370454 scopus 로고    scopus 로고
    • + T cells potentiates type 2 immunity and promotes parasitic helminth expulsion
    • + T cells potentiates type 2 immunity and promotes parasitic helminth expulsion. Immunity 41, 283-295 (2014).
    • (2014) Immunity , vol.41 , pp. 283-295
    • Oliphant, C.J.1
  • 121
    • 84894736115 scopus 로고    scopus 로고
    • + Th2 cell responses
    • + Th2 cell responses. J. Immunol. 192, 2442-2448 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 2442-2448
    • Mirchandani, A.S.1
  • 123
    • 84879571464 scopus 로고    scopus 로고
    • Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
    • Kirchberger, S. et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J. Exp. Med. 210, 917-931 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 917-931
    • Kirchberger, S.1
  • 124
    • 84891889644 scopus 로고    scopus 로고
    • Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
    • Kim, H.Y. et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat. Med. 20, 54-61 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 54-61
    • Kim, H.Y.1
  • 125
    • 84861801523 scopus 로고    scopus 로고
    • + innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice
    • + innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice. J. Clin. Invest. 122, 2252-2256 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 2252-2256
    • Pantelyushin, S.1
  • 126
    • 79958277385 scopus 로고    scopus 로고
    • IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
    • Geremia, A. et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J. Exp. Med. 208, 1127-1133 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1127-1133
    • Geremia, A.1
  • 127
    • 84936890053 scopus 로고    scopus 로고
    • Interleukin-6 increases production of cytokines by colonic innate lymphoid cells in mice and patients with chronic intestinal inflammation
    • Powell, N. et al. Interleukin-6 increases production of cytokines by colonic innate lymphoid cells in mice and patients with chronic intestinal inflammation. Gastroenterology doi: 10.1053/j.gastro.2015.04.017. (2015).
    • (2015) Gastroenterology
    • Powell, N.1
  • 129
    • 84923107393 scopus 로고    scopus 로고
    • Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection
    • Muñoz, M. et al. Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection. Immunity 42, 321-331 (2015).
    • (2015) Immunity , vol.42 , pp. 321-331
    • Muñoz, M.1
  • 130
    • 84868615556 scopus 로고    scopus 로고
    • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    • Huber, S. et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491, 259-263 (2012).
    • (2012) Nature , vol.491 , pp. 259-263
    • Huber, S.1
  • 131
    • 77958153282 scopus 로고    scopus 로고
    • IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46
    • Eisenring, M., vom Berg, J., Kristiansen, G., Saller, E. & Becher, B. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat. Immunol. 11, 1030-1038 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 1030-1038
    • Eisenring, M.1    Vom Berg, J.2    Kristiansen, G.3    Saller, E.4    Becher, B.5
  • 132
    • 84885572626 scopus 로고    scopus 로고
    • Type 2 innate lymphoid cells control eosinophil homeostasis
    • Nussbaum, J.C. et al. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature 502, 245-248 (2013).
    • (2013) Nature , vol.502 , pp. 245-248
    • Nussbaum, J.C.1
  • 133
    • 84920940721 scopus 로고    scopus 로고
    • Activated type 2 innate lymphoid cells regulate beige fat biogenesis
    • Lee, M.W. et al. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160, 74-87 (2015).
    • (2015) Cell , vol.160 , pp. 74-87
    • Lee, M.W.1
  • 134
    • 84925873107 scopus 로고    scopus 로고
    • Immune regulation of metabolic homeostasis in health and disease
    • Brestoff, J.R. & Artis, D. Immune regulation of metabolic homeostasis in health and disease. Cell 161, 146-160 (2015).
    • (2015) Cell , vol.161 , pp. 146-160
    • Brestoff, J.R.1    Artis, D.2
  • 135
    • 84923607143 scopus 로고    scopus 로고
    • The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells
    • Vasanthakumar, A. et al. The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. Nat. Immunol. 16, 276-285 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 276-285
    • Vasanthakumar, A.1
  • 136
    • 84890050252 scopus 로고    scopus 로고
    • A special population of regulatory T cells potentiates muscle repair
    • Burzyn, D. et al. A special population of regulatory T cells potentiates muscle repair. Cell 155, 1282-1295 (2013).
    • (2013) Cell , vol.155 , pp. 1282-1295
    • Burzyn, D.1
  • 137
    • 84906571227 scopus 로고    scopus 로고
    • The alarmin IL-33 promotes regulatory T-cell function in the intestine
    • Schiering, C. et al. The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature 513, 564-568 (2014).
    • (2014) Nature , vol.513 , pp. 564-568
    • Schiering, C.1
  • 138
    • 84866555781 scopus 로고    scopus 로고
    • + lymphocytes is associated with mucosal damage in SIV infection
    • + lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol. 5, 646-657 (2012).
    • (2012) Mucosal Immunol. , vol.5 , pp. 646-657
    • Klatt, N.R.1
  • 140
    • 84867939219 scopus 로고    scopus 로고
    • A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis
    • Kim, C.J. et al. A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis. Mucosal Immunol. 5, 670-680 (2012).
    • (2012) Mucosal Immunol. , vol.5 , pp. 670-680
    • Kim, C.J.1
  • 141
    • 84919608014 scopus 로고    scopus 로고
    • + innate lymphoid cells during acute SIV infection
    • + innate lymphoid cells during acute SIV infection. PLoS Pathog. 10, e1004551 (2014).
    • (2014) PLoS Pathog. , vol.10
    • Li, H.1
  • 142
    • 84861989207 scopus 로고    scopus 로고
    • Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
    • Sonnenberg, G.F. et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 336, 1321-1325 (2012).
    • (2012) Science , vol.336 , pp. 1321-1325
    • Sonnenberg, G.F.1
  • 143
    • 84882668842 scopus 로고    scopus 로고
    • Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora
    • Qiu, J. et al. Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 39, 386-399 (2013).
    • (2013) Immunity , vol.39 , pp. 386-399
    • Qiu, J.1
  • 144
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley, J.M. et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12, 1365-1371 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1
  • 145
    • 84928194546 scopus 로고    scopus 로고
    • Innate lymphoid cells control early colonization resistance against intestinal pathogens through ID2-dependent regulation of the microbiota
    • Guo, X. et al. Innate lymphoid cells control early colonization resistance against intestinal pathogens through ID2-dependent regulation of the microbiota. Immunity 42, 731-743 (2015).
    • (2015) Immunity , vol.42 , pp. 731-743
    • Guo, X.1
  • 146
    • 84896804302 scopus 로고    scopus 로고
    • Regulation of the adaptive immune system by innate lymphoid cells
    • Hepworth, M.R. & Sonnenberg, G.F. Regulation of the adaptive immune system by innate lymphoid cells. Curr. Opin. Immunol. 27, 75-82 (2014).
    • (2014) Curr. Opin. Immunol. , vol.27 , pp. 75-82
    • Hepworth, M.R.1    Sonnenberg, G.F.2
  • 147
    • 84897053496 scopus 로고    scopus 로고
    • Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis
    • Mortha, A. et al. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science 343, 1249288 (2014).
    • (2014) Science , vol.343 , pp. 1249288
    • Mortha, A.1
  • 148
    • 84889247024 scopus 로고    scopus 로고
    • 3 produced by innate lymphoid cells in intestinal homeostasis
    • 3 produced by innate lymphoid cells in intestinal homeostasis. Science 342, 1243-1246 (2013).
    • (2013) Science , vol.342 , pp. 1243-1246
    • Kruglov, A.A.1
  • 149
    • 48749091530 scopus 로고    scopus 로고
    • Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
    • Tsuji, M. et al. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity 29, 261-271 (2008).
    • (2008) Immunity , vol.29 , pp. 261-271
    • Tsuji, M.1
  • 150
    • 84878737123 scopus 로고    scopus 로고
    • + T-cell responses to intestinal commensal bacteria
    • + T-cell responses to intestinal commensal bacteria. Nature 498, 113-117 (2013).
    • (2013) Nature , vol.498 , pp. 113-117
    • Hepworth, M.R.1
  • 151
    • 84898679249 scopus 로고    scopus 로고
    • Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation
    • Goto, Y. et al. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 40, 594-607 (2014).
    • (2014) Immunity , vol.40 , pp. 594-607
    • Goto, Y.1
  • 153
    • 84864558396 scopus 로고    scopus 로고
    • Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis
    • Perry, J.S. et al. Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis. Sci. Transl. Med. 4, ra106 (2012).
    • (2012) Sci. Transl. Med. , vol.4
    • Perry, J.S.1
  • 154
    • 84859017988 scopus 로고    scopus 로고
    • Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    • Papp, K.A. et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N. Engl. J. Med. 366, 1181-1189 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1181-1189
    • Papp, K.A.1
  • 155
    • 84859073115 scopus 로고    scopus 로고
    • Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • Leonardi, C. et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N. Engl. J. Med. 366, 1190-1199 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1190-1199
    • Leonardi, C.1
  • 156
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study
    • Genovese, M.C. et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum. 62, 929-939 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 929-939
    • Genovese, M.C.1
  • 157
    • 33646695671 scopus 로고    scopus 로고
    • Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy
    • Bowman, E.P., Chackerian, A.A. & Cua, D.J. Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy. Curr. Opin. Infect. Dis. 19, 245-252 (2006).
    • (2006) Curr. Opin. Infect. Dis. , vol.19 , pp. 245-252
    • Bowman, E.P.1    Chackerian, A.A.2    Cua, D.J.3
  • 158
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber, W. et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61, 1693-1700 (2012).
    • (2012) Gut , vol.61 , pp. 1693-1700
    • Hueber, W.1
  • 159
    • 84875832344 scopus 로고    scopus 로고
    • Mo2083 A randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and efficacy of AMG 827 in subjects with moderate to severe Crohn's disease
    • Targan, S.R. et al. Mo2083 A randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and efficacy of AMG 827 in subjects with moderate to severe Crohn's disease. Gastroenterology 143, e26 (2014).
    • (2014) Gastroenterology , vol.143 , pp. e26
    • Targan, S.R.1
  • 160
    • 84902266081 scopus 로고    scopus 로고
    • Not all monoclonals are created equal: Lessons from failed drug trials in Crohn's disease
    • Kaser, A. Not all monoclonals are created equal: lessons from failed drug trials in Crohn's disease. Best Pract. Res. Clin. Gastroenterol. 28, 437-449 (2014).
    • (2014) Best Pract. Res. Clin. Gastroenterol. , vol.28 , pp. 437-449
    • Kaser, A.1
  • 161
    • 84875846364 scopus 로고    scopus 로고
    • Secukinumab failure in Crohn's disease: The yeast connection?
    • Colombel, J.F., Sendid, B., Jouault, T. & Poulain, D. Secukinumab failure in Crohn's disease: the yeast connection? Gut 62, 800-801 (2013).
    • (2013) Gut , vol.62 , pp. 800-801
    • Colombel, J.F.1    Sendid, B.2    Jouault, T.3    Poulain, D.4


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