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Volumn 17, Issue 6, 2017, Pages 631-662

Natural and structure-based RXR Ligand scaffolds and their functions

Author keywords

Agonists; Antagonists; Heterodimers; Ligands; Natural products; Rexinoid scaffolds; Rexinoids; RXR

Indexed keywords

13,14 DIHYDRORETINOIC ACID; CARBOXYLIC ACID; DANTRON; DOCOSAHEXAENOIC ACID; ICOSANOID; PERETINOIN; PHYTANIC ACID; RETINOIC ACID; RETINOID X RECEPTOR; RETINOL DEHYDROGENASE; UNCLASSIFIED DRUG; LIGAND;

EID: 85011072182     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026616666160617072521     Document Type: Review
Times cited : (32)

References (200)
  • 3
    • 8844262660 scopus 로고    scopus 로고
    • Principles for Modulation of the Nuclear Receptor Superfamily
    • Gronemeyer, H.; Gustafsson, J.-A.; Laudet, V. Principles for Modulation of the Nuclear Receptor Superfamily. Nat. Rev. Drug Disc., 2004, 3, 950-964.
    • (2004) Nat. Rev. Drug Disc. , vol.3 , pp. 950-964
    • Gronemeyer, H.1    Gustafsson, J.-A.2    Laudet, V.3
  • 4
    • 84892178692 scopus 로고    scopus 로고
    • Retinoic Acid Actions through Mammalian Nuclear Receptors
    • Huang, P.; Chandra, V.; Rastinejad, F. Retinoic Acid Actions through Mammalian Nuclear Receptors. Chem. Rev., 2014, 114, 233-254.
    • (2014) Chem. Rev. , vol.114 , pp. 233-254
    • Huang, P.1    Chandra, V.2    Rastinejad, F.3
  • 5
    • 0029562554 scopus 로고
    • The RXR Heterodimers and Orphan Receptors
    • Mangelsdorf, D. A.; Evans, R. M. The RXR Heterodimers and Orphan Receptors. Cell, 1995, 83, 841-850.
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.A.1    Evans, R.M.2
  • 6
  • 8
    • 1442351143 scopus 로고    scopus 로고
    • Coregulator function: A key to understanding tissue specificity of selective receptor modulators
    • Smith, C. L.; O'Malley, B. W. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr. Rev., 2004, 25, 45-71.
    • (2004) Endocr. Rev. , vol.25 , pp. 45-71
    • Smith, C.L.1    O'malley, B.W.2
  • 9
    • 84897147399 scopus 로고    scopus 로고
    • Nuclear Receptors, RXR, and the Big Bang
    • Evans, R. M.; Mangelsdorf, D. J. Nuclear Receptors, RXR, and the Big Bang. Cell, 2014, 157, 255-266.
    • (2014) Cell , vol.157 , pp. 255-266
    • Evans, R.M.1    Mangelsdorf, D.J.2
  • 10
    • 0037050017 scopus 로고    scopus 로고
    • Co-regulator recruitment and the mechanism of retinoic acid receptor synergy
    • Germain, P.; Iyer, J.; Zechel, C.; Gronemeyer, H. Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature, 2002, 415, 187-192.
    • (2002) Nature , vol.415 , pp. 187-192
    • Germain, P.1    Iyer, J.2    Zechel, C.3    Gronemeyer, H.4
  • 13
    • 0028887017 scopus 로고
    • Role of Ligand in Retinoid Signalling. 9-cis-Retinoic Acid Modulates the Oligomeric State of the Retinoid X Receptor
    • Kersten, S.; Pan, L.; Chambon, P.; Gronemeyer, H.; Noy, N. Role of Ligand in Retinoid Signalling. 9-cis-Retinoic Acid Modulates the Oligomeric State of the Retinoid X Receptor. Biochemistry, 1995, 34, 13717-13721.
    • (1995) Biochemistry , vol.34 , pp. 13717-13721
    • Kersten, S.1    Pan, L.2    Chambon, P.3    Gronemeyer, H.4    Noy, N.5
  • 14
    • 0028786255 scopus 로고
    • On the Role of Ligand in Retinoid Signalling: Positive Cooperativity in the Interactions of 9-cis-Retinoic Acid with Tetramers of the Retinoid X Receptor
    • Kersten, S.; Pan, L.; Noy, N. On the Role of Ligand in Retinoid Signalling: Positive Cooperativity in the Interactions of 9-cis-Retinoic Acid with Tetramers of the Retinoid X Receptor. Biochemistry, 1995, 34, 14263-14269.
    • (1995) Biochemistry , vol.34 , pp. 14263-14269
    • Kersten, S.1    Pan, L.2    Noy, N.3
  • 15
    • 79960121686 scopus 로고    scopus 로고
    • Structural Basis for Retinoic X Receptor Repression on the Tetramer
    • Zhang, H.; Chen, L.; Chen, J.; Jiang, H.; Shen, X. Structural Basis for Retinoic X Receptor Repression on the Tetramer. J. Biol. Chem., 2011, 286, 24593-24598.
    • (2011) J. Biol. Chem. , vol.286 , pp. 24593-24598
    • Zhang, H.1    Chen, L.2    Chen, J.3    Jiang, H.4    Shen, X.5
  • 16
    • 0034213831 scopus 로고    scopus 로고
    • Crystal structure of the human RXRa ligand-binding domain bound to its natural ligand: 9-cis-retinoic acid
    • Egea, P. F.; Mitschler, A.; Rochel, N.; Ruff, M.; Chambon, P.; Moras, D. Crystal structure of the human RXRa ligand-binding domain bound to its natural ligand: 9-cis-retinoic acid. EMBO J., 2000, 19, 2592-2601.
    • (2000) EMBO J. , vol.19 , pp. 2592-2601
    • Egea, P.F.1    Mitschler, A.2    Rochel, N.3    Ruff, M.4    Chambon, P.5    Moras, D.6
  • 17
    • 0036251738 scopus 로고    scopus 로고
    • Molecular Recognition of Agonist Ligands by RXRs
    • Egea, P. F.; Mitschler, A.; Moras, D. Molecular Recognition of Agonist Ligands by RXRs. Mol. Endocrinol., 2002, 16, 987-997.
    • (2002) Mol. Endocrinol. , vol.16 , pp. 987-997
    • Egea, P.F.1    Mitschler, A.2    Moras, D.3
  • 18
    • 0033868825 scopus 로고    scopus 로고
    • Crystal Structure of a Heterodimeric Complex of RAR and RXR Ligand-Binding Domains
    • Bourguet, W.; Vivat, V.; Wurtz, J.-M.; Chambon, P.; Gronemeyer, H.; Moras, D. Crystal Structure of a Heterodimeric Complex of RAR and RXR Ligand-Binding Domains. Mol. Cell, 2000, 5, 289-298.
    • (2000) Mol. Cell , vol.5 , pp. 289-298
    • Bourguet, W.1    Vivat, V.2    Wurtz, J.-M.3    Chambon, P.4    Gronemeyer, H.5    Moras, D.6
  • 23
    • 78049491490 scopus 로고    scopus 로고
    • Inverse Agonists and Antagonists of Retinoid Receptors
    • Conn, P. M., Ed. Academic Press: New York
    • Bourguet, W.; de Lera, A. R.; Gronemeyer, H. Inverse Agonists and Antagonists of Retinoid Receptors. In Meth. Enzymol., Conn, P. M., Ed. Academic Press: New York, 2010; Vol. 485, pp. 161-195.
    • (2010) Meth. Enzymol , vol.485 , pp. 161-195
    • Bourguet, W.1    De Lera, A.R.2    Gronemeyer, H.3
  • 26
    • 0036010727 scopus 로고    scopus 로고
    • Novel Synthetic Retinoids and Separation of the Pleiotropic Retinoidal Activities
    • Kagechika, H. Novel Synthetic Retinoids and Separation of the Pleiotropic Retinoidal Activities. Curr. Med. Chem., 2002, 9, 591-680.
    • (2002) Curr. Med. Chem. , vol.9 , pp. 591-680
    • Kagechika, H.1
  • 27
    • 24944492838 scopus 로고    scopus 로고
    • Synthetic Retinoids: Recent Developments Concerning Structure and Clinical Utility
    • Kagechika, H.; Shudo, K. Synthetic Retinoids: Recent Developments Concerning Structure and Clinical Utility. J. Med. Chem., 2005, 48, 5875-5883.
    • (2005) J. Med. Chem. , vol.48 , pp. 5875-5883
    • Kagechika, H.1    Shudo, K.2
  • 28
    • 34848862778 scopus 로고    scopus 로고
    • Design of Selective Nuclear Receptor Modulators: RAR and RXR as a Case Study
    • de Lera, A. R.; Bourguet, W.; Altucci, L.; Gronemeyer, H. Design of Selective Nuclear Receptor Modulators: RAR and RXR as a Case Study. Nature Rev. Drug. Disc., 2007, 6, 811-820.
    • (2007) Nature Rev. Drug. Disc. , vol.6 , pp. 811-820
    • De Lera, A.R.1    Bourguet, W.2    Altucci, L.3    Gronemeyer, H.4
  • 30
    • 78650499337 scopus 로고    scopus 로고
    • Retinoic acid receptor modulators: A perspective on recent advances and promises
    • Alvarez, S.; Bourguet, W.; Gronemeyer, H.; de Lera, A. R. Retinoic acid receptor modulators: a perspective on recent advances and promises. Expert Opin. Ther. Patents, 2011, 21, 55-63.
    • (2011) Expert Opin. Ther. Patents , vol.21 , pp. 55-63
    • Alvarez, S.1    Bourguet, W.2    Gronemeyer, H.3    De Lera, A.R.4
  • 31
    • 84867928062 scopus 로고    scopus 로고
    • Advances in drug design with RXR modulators
    • Vaz, B.; de Lera, A. R. Advances in drug design with RXR modulators. Exp. Op. Drug Disc., 2012, 7, 1003-1016.
    • (2012) Exp. Op. Drug Disc. , vol.7 , pp. 1003-1016
    • Vaz, B.1    De Lera, A.R.2
  • 33
    • 0036219575 scopus 로고    scopus 로고
    • Discovery and Design of Retinoic Acid Receptor and Retinoid X Receptor Class-and Subtype-Selective Synthetic Analogs of All-trans-retinoic Acid and 9-cis-Retinoic Acid
    • Dawson, M. I.; Zhang, X.-k. Discovery and Design of Retinoic Acid Receptor and Retinoid X Receptor Class-and Subtype-Selective Synthetic Analogs of All-trans-retinoic Acid and 9-cis-Retinoic Acid. Curr. Med. Chem., 2002, 9, 623-637.
    • (2002) Curr. Med. Chem. , vol.9 , pp. 623-637
    • Dawson, M.I.1    Zhang, X.-K.2
  • 34
    • 2442608526 scopus 로고    scopus 로고
    • Synthetic Retinoids and Their Nuclear Receptors
    • Dawson, M. I. Synthetic Retinoids and Their Nuclear Receptors. Curr. Med. Chem.-Anti-Cancer Agents, 2004, 4, 199-230.
    • (2004) Curr. Med. Chem.-Anti-Cancer Agents , vol.4 , pp. 199-230
    • Dawson, M.I.1
  • 35
    • 84892160516 scopus 로고    scopus 로고
    • Functions, therapeutic applications, and synthesis of retinoids and carotenoids
    • Alvarez, R.; Vaz, B.; Gronemeyer, H.; de Lera, A. R. Functions, therapeutic applications, and synthesis of retinoids and carotenoids. Chem. Rev., 2014, 114, 1-125.
    • (2014) Chem. Rev. , vol.114 , pp. 1-125
    • Alvarez, R.1    Vaz, B.2    Gronemeyer, H.3    De Lera, A.R.4
  • 36
    • 33846094038 scopus 로고    scopus 로고
    • Is 9-Cis-Retinoic Acid the Endogenous Ligand for the Retinoic Acid-X Receptor?
    • Wolf, G. Is 9-Cis-Retinoic Acid the Endogenous Ligand for the Retinoic Acid-X Receptor? Nutr. Rev., 2006, 64, 532-538.
    • (2006) Nutr. Rev. , vol.64 , pp. 532-538
    • Wolf, G.1
  • 40
    • 0027441333 scopus 로고
    • Endogenous retinoids in rat epididymal tissue and rat and human spermatozoa
    • Pappas, R. S.; Newcomer, M. E.; Ong, D. E. Endogenous retinoids in rat epididymal tissue and rat and human spermatozoa. Biol. Reprod., 1993, 48, 235-247.
    • (1993) Biol. Reprod , vol.48 , pp. 235-247
    • Pappas, R.S.1    Newcomer, M.E.2    Ong, D.E.3
  • 42
    • 83255193970 scopus 로고    scopus 로고
    • Analysis, occurrence, and function of 9-cis-retinoic acid
    • Kane, M. A. Analysis, occurrence, and function of 9-cis-retinoic acid. Biochim. Biophys. Acta (BBA) -Mol. Cell Biol. Lip., 2012, 1821, 10-20.
    • (2012) Biochim. Biophys. Acta (BBA) -Mol. Cell Biol. Lip , vol.1821 , pp. 10-20
    • Kane, M.A.1
  • 43
    • 84857756591 scopus 로고    scopus 로고
    • A sensitive and specific method for measurement of multiple retinoids in human serum with UHPLC-MS/MS
    • Arnold, S. L. M.; Amory, J. K.; Walsh, T. J.; Isoherranen, N. A sensitive and specific method for measurement of multiple retinoids in human serum with UHPLC-MS/MS. J. Lipid Res., 2012, 53, 587-598.
    • (2012) J. Lipid Res. , vol.53 , pp. 587-598
    • Arnold, S.L.M.1    Amory, J.K.2    Walsh, T.J.3    Isoherranen, N.4
  • 45
    • 0034763589 scopus 로고    scopus 로고
    • Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis-retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally
    • Ulven, S. M.; Gundersen, T. E.; Sakhi, A. K.; Glover, J. C.; Blomhoff, R. Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis-retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally. Dev. Dyn., 2001, 222, 341-353.
    • (2001) Dev. Dyn. , vol.222 , pp. 341-353
    • Ulven, S.M.1    Gundersen, T.E.2    Sakhi, A.K.3    Glover, J.C.4    Blomhoff, R.5
  • 46
    • 12244256092 scopus 로고    scopus 로고
    • Chromatographic analysis of endogenous retinoids in tissues and serum
    • Schmidt, C. K.; Brouwer, A.; Nau, H. Chromatographic analysis of endogenous retinoids in tissues and serum. Anal. Biochem., 2003, 315, 36-48.
    • (2003) Anal. Biochem. , vol.315 , pp. 36-48
    • Schmidt, C.K.1    Brouwer, A.2    Nau, H.3
  • 47
    • 0036781255 scopus 로고    scopus 로고
    • Determination of Endogenous Levels of Retinoic Acid Isomers in Type II Diabetes Mellitus Patients. Possible Correlation with HbA1c Values
    • Yamakoshi, Y.; Fukasawa, H.; Yamauchi, T.; Waki, H.; Kadowaki, T.; Shudo, K.; Kagechika, H. Determination of Endogenous Levels of Retinoic Acid Isomers in Type II Diabetes Mellitus Patients. Possible Correlation with HbA1c Values. Biol. Pharm. Bull., 2002, 25, 1268-1271.
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 1268-1271
    • Yamakoshi, Y.1    Fukasawa, H.2    Yamauchi, T.3    Waki, H.4    Kadowaki, T.5    Shudo, K.6    Kagechika, H.7
  • 48
    • 0035883991 scopus 로고    scopus 로고
    • Metabolism of a Physiological Amount of all-trans-Retinol in the Vitamin A-Deficient Rat
    • Werner, E. A.; DeLuca, H. F. Metabolism of a Physiological Amount of all-trans-Retinol in the Vitamin A-Deficient Rat. Arch. Biochem. Biophys., 2001, 393, 262-270.
    • (2001) Arch. Biochem. Biophys. , vol.393 , pp. 262-270
    • Werner, E.A.1    Deluca, H.F.2
  • 49
    • 33747520321 scopus 로고    scopus 로고
    • Method to determine 4-oxo-retinoic acids, retinoic acids and retinol in serum and cell extracts by liquid chromatography/ diode-array detection atmospheric pressure chemical ionisation tandem mass spectrometry
    • Ruhl, R. Method to determine 4-oxo-retinoic acids, retinoic acids and retinol in serum and cell extracts by liquid chromatography/ diode-array detection atmospheric pressure chemical ionisation tandem mass spectrometry. Rapid Commun. Mass Spectrom., 2006, 20, 2497-2504.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 2497-2504
    • Ruhl, R.1
  • 50
    • 33947728412 scopus 로고    scopus 로고
    • Quantitative highthroughput determination of endogenous retinoids in human plasma using triple-stage liquid chromatography/tandem mass spectrometry
    • Gundersen, T. E.; Bastani, N. E.; Blomhoff, R. Quantitative highthroughput determination of endogenous retinoids in human plasma using triple-stage liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom., 2007, 21, 1176-1186.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 1176-1186
    • Gundersen, T.E.1    Bastani, N.E.2    Blomhoff, R.3
  • 52
    • 0035377196 scopus 로고    scopus 로고
    • Biosynthesis of 9-cisretinoic acid in vivo: The roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases
    • Tryggvason, K.; Romert, A.; Eriksson, U. Biosynthesis of 9-cisretinoic acid in vivo: the roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases. J. Biol. Chem., 2001, 276, 19253-19258.
    • (2001) J. Biol. Chem. , vol.276 , pp. 19253-19258
    • Tryggvason, K.1    Romert, A.2    Eriksson, U.3
  • 54
    • 0037795409 scopus 로고    scopus 로고
    • Retinoid Activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis
    • Mic, F. A.; Molotkov, A.; Benbrook, D. M.; Duester, G. Retinoid Activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis. Proc. Natl. Acad. Sci. U. S. A., 2003, 100, 7135-7140.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 7135-7140
    • Mic, F.A.1    Molotkov, A.2    Benbrook, D.M.3    Duester, G.4
  • 57
    • 9644275410 scopus 로고    scopus 로고
    • Identification of all-trans-retinol : All-trans-13,14-dihydroretinol saturase
    • Moise, A. R.; Kuksa, V.; Imanishi, Y.; Palczewski, K. Identification of all-trans-retinol : all-trans-13,14-dihydroretinol saturase. J. Biol. Chem., 2004, 279, 50230-50242.
    • (2004) J. Biol. Chem. , vol.279 , pp. 50230-50242
    • Moise, A.R.1    Kuksa, V.2    Imanishi, Y.3    Palczewski, K.4
  • 58
    • 23044485957 scopus 로고    scopus 로고
    • Metabolism and Transactivation Activity of 13,14-Dihydroretinoic Acid
    • Moise, A. R.; Kuksa, V.; Blaner, W. S.; Baehr, W.; Palczewski, K. Metabolism and Transactivation Activity of 13,14-Dihydroretinoic Acid. J. Biol. Chem., 2005, 280, 27815-27825.
    • (2005) J. Biol. Chem. , vol.280 , pp. 27815-27825
    • Moise, A.R.1    Kuksa, V.2    Blaner, W.S.3    Baehr, W.4    Palczewski, K.5
  • 62
    • 0029981972 scopus 로고    scopus 로고
    • Oxidative and reductive metabolism of 9-cis-retinoic acid in the rat. Identification of 13,14-dihydro-9-cisretinoic acid and its taurine conjugate
    • Shirley, M. A.; Bennani, Y. L.; Boehm, M. F.; Breau, A. P.; Pathirana, C.; Ulm, E. H. Oxidative and reductive metabolism of 9-cis-retinoic acid in the rat. Identification of 13,14-dihydro-9-cisretinoic acid and its taurine conjugate. Drug Met. Disp., 1996, 24, 293-302.
    • (1996) Drug Met. Disp. , vol.24 , pp. 293-302
    • Shirley, M.A.1    Bennani, Y.L.2    Boehm, M.F.3    Breau, A.P.4    Pathirana, C.5    Ulm, E.H.6
  • 64
    • 65549160442 scopus 로고    scopus 로고
    • The endogenous retinoid metabolite (S)-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo
    • Schuchardt, J. P.; Wahlstrom, D.; Ruegg, J.; Giese, N.; Stefan, M.; Hopf, H.; Pongratz, I.; Hakansson, H.; Eichele, G.; Pettersson, K.; Nau, H. The endogenous retinoid metabolite (S)-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo. FEBS J., 2009, 276, 3043-3059.
    • (2009) FEBS J. , vol.276 , pp. 3043-3059
    • Schuchardt, J.P.1    Wahlstrom, D.2    Ruegg, J.3    Giese, N.4    Stefan, M.5    Hopf, H.6    Pongratz, I.7    Hakansson, H.8    Eichele, G.9    Pettersson, K.10    Nau, H.11
  • 66
    • 0242690337 scopus 로고    scopus 로고
    • Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor
    • Goldstein, J. T.; Dobrzyn, A.; Clagett-Dame, M.; Pike, J. W.; DeLuca, H. F. Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor. Arch. Biochem. Biophys., 2003, 420, 185-193.
    • (2003) Arch. Biochem. Biophys. , vol.420 , pp. 185-193
    • Goldstein, J.T.1    Dobrzyn, A.2    Clagett-Dame, M.3    Pike, J.W.4    Deluca, H.F.5
  • 67
    • 0026459272 scopus 로고
    • Structural and Functional Evidence for Activation of a Chick Retinoid X Receptor by Eicosanoids
    • Eager, N. S. C.; Brickell, P. M.; Snell, C.; Wood, J. N. Structural and Functional Evidence for Activation of a Chick Retinoid X Receptor by Eicosanoids. Proc. R. Soc. Lond. Ser. B: Biol. Sci., 1992, 250, 63-69.
    • (1992) Proc. R. Soc. Lond. Ser. B: Biol. Sci. , vol.250 , pp. 63-69
    • Eager, N.S.C.1    Brickell, P.M.2    Snell, C.3    Wood, J.N.4
  • 69
    • 0029664544 scopus 로고    scopus 로고
    • Phytanic acis is a retinoid X receptor ligand
    • LeMotte, P. K.; Keidek, S.; Apfel, C. M. Phytanic acis is a retinoid X receptor ligand. Eur. J. Biochem., 1996, 236, 328-333.
    • (1996) Eur. J. Biochem. , vol.236 , pp. 328-333
    • Lemotte, P.K.1    Keidek, S.2    Apfel, C.M.3
  • 70
    • 0033739281 scopus 로고    scopus 로고
    • Pristanic acid and phytanic acid: Naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor g
    • Zomer, A. W. M.; van der Burg, B.; Jansen, G. A.; Wanders, R. J. A.; Poll-The, B. T.; van der Saag, P. T. Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor g. J. Lipid Res., 2000, 41, 1801-1807.
    • (2000) J. Lipid Res. , vol.41 , pp. 1801-1807
    • Zomer, A.W.M.1    Van Der Burg, B.2    Jansen, G.A.3    Wanders, R.J.A.4    Poll-The, B.T.5    Van Der Saag, P.T.6
  • 71
    • 0029044946 scopus 로고
    • Activation of Mammalian Retinoid X Receptors by the Insect Growth Regulator Methoprene
    • Harmon, M. A.; Boehm, M. F.; Heyman, R. A.; Mangelsdorf, D. J. Activation of Mammalian Retinoid X Receptors by the Insect Growth Regulator Methoprene. Proc. Natl. Acad. Sci. U. S. A., 1995, 92, 6157-6160.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 6157-6160
    • Harmon, M.A.1    Boehm, M.F.2    Heyman, R.A.3    Mangelsdorf, D.J.4
  • 72
    • 1842858440 scopus 로고    scopus 로고
    • Effects of methoprene, its metabolites, and breakdown products on retinoid-activated pathways in transfected cell lines
    • Schoff, P. K.; Ankley, G. T. Effects of methoprene, its metabolites, and breakdown products on retinoid-activated pathways in transfected cell lines. Environ. Toxicol. Chem., 2004, 23, 1305-1310.
    • (2004) Environ. Toxicol. Chem. , vol.23 , pp. 1305-1310
    • Schoff, P.K.1    Ankley, G.T.2
  • 74
    • 84865715473 scopus 로고    scopus 로고
    • Biological role of aldoketo reductases in retinoic acid biosynthesis and signaling
    • Ruiz, F. X.; Porte, S.; Pares, X.; Farres, J. Biological role of aldoketo reductases in retinoic acid biosynthesis and signaling. Front. Pharmacol., 2012, 3, 58.
    • (2012) Front. Pharmacol. , vol.3 , pp. 58
    • Ruiz, F.X.1    Porte, S.2    Pares, X.3    Farres, J.4
  • 76
    • 35248856449 scopus 로고    scopus 로고
    • Inhibition of Balb/c 3T3 cell transformation by synthetic acyclic retinoid NIK-333; possible involvement of enhanced gap junctional intercellular communication
    • Tsujino, T.; Nagata, T.; Katoh, F.; Yamasaki, H. Inhibition of Balb/c 3T3 cell transformation by synthetic acyclic retinoid NIK-333; possible involvement of enhanced gap junctional intercellular communication. Cancer Detect. Prev., 2007, 31, 332-338.
    • (2007) Cancer Detect. Prev. , vol.31 , pp. 332-338
    • Tsujino, T.1    Nagata, T.2    Katoh, F.3    Yamasaki, H.4
  • 77
    • 84876435852 scopus 로고    scopus 로고
    • Lycopene-derived bioactive retinoic acid receptors/ retinoid-X receptors-activating metabolites may be relevant for lycopene's anti-cancer potential
    • Aydemir, G.; Kasiri, Y.; Birta, E.; Beke, G.; Garcia, A. L.; Bartok, E.-M.; Ruhl, R. Lycopene-derived bioactive retinoic acid receptors/ retinoid-X receptors-activating metabolites may be relevant for lycopene's anti-cancer potential. Mol. Nutr. Food Res., 2013, 57, 739-747.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 739-747
    • Aydemir, G.1    Kasiri, Y.2    Birta, E.3    Beke, G.4    Garcia, A.L.5    Bartok, E.-M.6    Ruhl, R.7
  • 78
    • 33845996557 scopus 로고    scopus 로고
    • Asymmetric Cleavage of b-Carotene Yields a Transcriptional Repressor of Retinoid X Receptor and Peroxisome Proliferator-Activated Receptor Responses
    • Ziouzenkova, O.; Orasanu, G.; Sukhova, G.; Lau, E.; Berger, J. P.; Tang, G.; Krinsky, N. I.; Dolnikowski, G. G.; Plutzky, J. Asymmetric Cleavage of b-Carotene Yields a Transcriptional Repressor of Retinoid X Receptor and Peroxisome Proliferator-Activated Receptor Responses. Mol. Endocrinol., 2007, 21, 77-88.
    • (2007) Mol. Endocrinol. , vol.21 , pp. 77-88
    • Ziouzenkova, O.1    Orasanu, G.2    Sukhova, G.3    Lau, E.4    Berger, J.P.5    Tang, G.6    Krinsky, N.I.7    Dolnikowski, G.G.8    Plutzky, J.9
  • 79
    • 85011059522 scopus 로고    scopus 로고
    • Selected b-apocarotenoids antagonize retinoic acid-induced transactivation of retinoic acid receptors
    • Eroglu, A.; Hruszkewycz, D.; Curley, R. W.; Harrison, E. H. Selected b-apocarotenoids antagonize retinoic acid-induced transactivation of retinoic acid receptors. FASEB J., 2010, 24, 894.
    • (2010) FASEB J. , vol.24 , pp. 894
    • Eroglu, A.1    Hruszkewycz, D.2    Curley, R.W.3    Harrison, E.H.4
  • 81
    • 84912098871 scopus 로고    scopus 로고
    • B-Apo-13-carotenone Regulates Retinoid X Receptor Transcriptional Activity through Tetramerization of the Receptor
    • Sun, J.; Narayanasamy, S.; Curley, R. W.; Harrison, E. H. b-Apo-13-carotenone Regulates Retinoid X Receptor Transcriptional Activity through Tetramerization of the Receptor. J. Biol. Chem., 2014, 289, 33118-33124.
    • (2014) J. Biol. Chem. , vol.289 , pp. 33118-33124
    • Sun, J.1    Narayanasamy, S.2    Curley, R.W.3    Harrison, E.H.4
  • 82
    • 0033855471 scopus 로고    scopus 로고
    • Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix
    • Gampe, R. T.; Montana, V. G.; Lambert, M. H.; Wisely, G. B.; Milburn, M. V.; Xu, H. E. Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix. Genes Dev., 2000, 14, 2229-2241.
    • (2000) Genes Dev. , vol.14 , pp. 2229-2241
    • Gampe, R.T.1    Montana, V.G.2    Lambert, M.H.3    Wisely, G.B.4    Milburn, M.V.5    Xu, H.E.6
  • 83
    • 77956220279 scopus 로고    scopus 로고
    • Identification of a Naturally Occurring Rexinoid, Honokiol, That Activates the Retinoid X Receptor
    • Kotani, H.; Tanabe, H.; Mizukami, H.; Makishima, M.; Inoue, M. Identification of a Naturally Occurring Rexinoid, Honokiol, That Activates the Retinoid X Receptor. J. Nat. Prod., 2010, 73, 1332-1336.
    • (2010) J. Nat. Prod. , vol.73 , pp. 1332-1336
    • Kotani, H.1    Tanabe, H.2    Mizukami, H.3    Makishima, M.4    Inoue, M.5
  • 84
    • 82255162374 scopus 로고    scopus 로고
    • Molecular Determinants of Magnolol Targeting Both RXRa and PPARg
    • Zhang, H.; Xu, X.; Chen, L.; Chen, J.; Hu, L.; Jiang, H.; Shen, X. Molecular Determinants of Magnolol Targeting Both RXRa and PPARg. PLoS One, 2011, 6, e28253.
    • (2011) Plos One , pp. 6
    • Zhang, H.1    Xu, X.2    Chen, L.3    Chen, J.4    Hu, L.5    Jiang, H.6    Shen, X.7
  • 85
    • 79952006933 scopus 로고    scopus 로고
    • Structure Basis of Bigelovin as a Selective RXR Agonist with a Distinct Binding Mode
    • Zhang, H.; Li, L.; Chen, L.; Hu, L.; Jiang, H.; Shen, X. Structure Basis of Bigelovin as a Selective RXR Agonist with a Distinct Binding Mode. J. Mol. Biol., 2011, 407, 13-20.
    • (2011) J. Mol. Biol. , vol.407 , pp. 13-20
    • Zhang, H.1    Li, L.2    Chen, L.3    Hu, L.4    Jiang, H.5    Shen, X.6
  • 86
    • 78751539633 scopus 로고    scopus 로고
    • Danthron Functions as a Retinoic X Receptor Antagonist by Stabilizing Tetramers of the Receptor
    • Zhang, H.; Zhou, R.; Li, L.; Chen, J.; Chen, L.; Li, C.; Ding, H.; Yu, L.; Hu, L.; Jiang, H.; Shen, X. Danthron Functions as a Retinoic X Receptor Antagonist by Stabilizing Tetramers of the Receptor. J. Biol. Chem., 2011, 286, 1868-1875.
    • (2011) J. Biol. Chem. , vol.286 , pp. 1868-1875
    • Zhang, H.1    Zhou, R.2    Li, L.3    Chen, J.4    Chen, L.5    Li, C.6    Ding, H.7    Yu, L.8    Hu, L.9    Jiang, H.10    Shen, X.11
  • 90
    • 0019189707 scopus 로고
    • Arotinoids: A new class of highly active retinoids
    • Loeliger, P.; Bollag, W.; Mayer, H. Arotinoids: a new class of highly active retinoids. Eur. J. Med. Chem., 1980, 15, 9-15.
    • (1980) Eur. J. Med. Chem. , vol.15 , pp. 9-15
    • Loeliger, P.1    Bollag, W.2    Mayer, H.3
  • 91
    • 54849422856 scopus 로고    scopus 로고
    • New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists
    • Alvarez, S.; Pazos-Randulfe, Y.; Khanwalkar, H.; Germain, P.; Alvarez, R.; Gronemeyer, H.; de Lera, A. R. New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists. Bioorg. Med. Chem., 2008, 16, 9719-9728.
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 9719-9728
    • Alvarez, S.1    Pazos-Randulfe, Y.2    Khanwalkar, H.3    Germain, P.4    Alvarez, R.5    Gronemeyer, H.6    De Lera, A.R.7
  • 92
    • 79955478892 scopus 로고    scopus 로고
    • Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity
    • Okitsu, T.; Sato, K.; Iwatsuka, K.; Sawada, N.; Nakagawa, K.; Okano, T.; Yamada, S.; Kakuta, H.; Wada, A. Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity. Bioorg. Med. Chem., 2011, 19, 2939-2949.
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 2939-2949
    • Okitsu, T.1    Sato, K.2    Iwatsuka, K.3    Sawada, N.4    Nakagawa, K.5    Okano, T.6    Yamada, S.7    Kakuta, H.8    Wada, A.9
  • 94
    • 0029895639 scopus 로고    scopus 로고
    • Discovery of Novel Retinoic Acid Receptor Agonists Having Potent Antiproliferative Activity in Cervical Cancer Cells
    • Zhang, L.; Nadzan, A. M.; Heyman, R. A.; Love, D. L.; Mais, D. E.; Croston, G.; Lamph, W. W.; Boehm, M. F. Discovery of Novel Retinoic Acid Receptor Agonists Having Potent Antiproliferative Activity in Cervical Cancer Cells. J. Med. Chem., 1996, 39, 2659-2663.
    • (1996) J. Med. Chem. , vol.39 , pp. 2659-2663
    • Zhang, L.1    Nadzan, A.M.2    Heyman, R.A.3    Love, D.L.4    Mais, D.E.5    Croston, G.6    Lamph, W.W.7    Boehm, M.F.8
  • 95
    • 0032489022 scopus 로고    scopus 로고
    • Synthesis and Characterization of a Highly Potent and Selective Isotopically Labeled Retinoic Acid Receptor Ligand, ALRT1550
    • Bennani, J. L.; Marron, K. S.; Mais, D. E.; Flatten, K.; Nadzan, A. M.; Boehm, M. F. Synthesis and Characterization of a Highly Potent and Selective Isotopically Labeled Retinoic Acid Receptor Ligand, ALRT1550. J. Org. Chem., 1998, 63, 543-550.
    • (1998) J. Org. Chem. , vol.63 , pp. 543-550
    • Bennani, J.L.1    Marron, K.S.2    Mais, D.E.3    Flatten, K.4    Nadzan, A.M.5    Boehm, M.F.6
  • 96
    • 0037119784 scopus 로고    scopus 로고
    • Synthesis and Characterization of a New RXR Agonist Based on the 6-tert-Butyl-1,1-dimethylindanyl Structure
    • Dominguez, B.; Vega, M. J.; Sussman, F.; de Lera, A. R. Synthesis and Characterization of a New RXR Agonist Based on the 6-tert-Butyl-1,1-dimethylindanyl Structure. Bioorg. Med. Chem. Lett., 2002, 12, 2607-2609.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 2607-2609
    • Dominguez, B.1    Vega, M.J.2    Sussman, F.3    De Lera, A.R.4
  • 104
    • 0031043055 scopus 로고    scopus 로고
    • The phantom ligand effect: Allosteric control of transcription by the retinoid X receptor
    • Schulman, I. G.; Li, C.; Schwabe, J. W.; Evans, R. M. The phantom ligand effect: allosteric control of transcription by the retinoid X receptor. Genes Dev., 1997, 11, 299-308.
    • (1997) Genes Dev. , vol.11 , pp. 299-308
    • Schulman, I.G.1    Li, C.2    Schwabe, J.W.3    Evans, R.M.4
  • 105
    • 24944439456 scopus 로고    scopus 로고
    • A New Retinoid-Like Compound That Activates Peroxisome Proliferator-Activated Receptors and Lowers Blood Glucose in Diabetic Mice
    • Deng, T.; Shan, S.; Li, Z.-B.; Wu, Z.-W.; Liao, C.-Z.; Ko, B.; Lu, X.-P.; Cheng, J.; Ning, Z.-Q. A New Retinoid-Like Compound That Activates Peroxisome Proliferator-Activated Receptors and Lowers Blood Glucose in Diabetic Mice. Biol. Pharm. Bull., 2005, 28, 1192-1196.
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 1192-1196
    • Deng, T.1    Shan, S.2    Li, Z.-B.3    Wu, Z.-W.4    Liao, C.-Z.5    Ko, B.6    Lu, X.-P.7    Cheng, J.8    Ning, Z.-Q.9
  • 106
    • 0032514549 scopus 로고    scopus 로고
    • Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor Agonists
    • Hibi, S.; Kikuchi, K.; Yoshimura, H.; Nagai, M.; Tai, K.; Hida, T. Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor Agonists. J. Med. Chem., 1998, 41, 3245-3252.
    • (1998) J. Med. Chem. , vol.41 , pp. 3245-3252
    • Hibi, S.1    Kikuchi, K.2    Yoshimura, H.3    Nagai, M.4    Tai, K.5    Hida, T.6
  • 108
    • 0041731583 scopus 로고    scopus 로고
    • Conformationally Defined Retinoic Acid Analogues. 5. Large-Scale Synthesis and Mammary Cancer Chemopreventive Activity for (2E,4E,6Z,8E)-8-(3',4'-Dihydro-1'(2'H)-naphathalen-1'ylidene)-3,7-dimethyl-2,4,6-octatienoic Acid
    • Atigadda, V. R.; Vines, K. K.; Grubbs, C. J.; Hill, D. L.; Beenken, S. L.; Bland, K. I.; Brouillette, W. J.; Muccio, D. D. Conformationally Defined Retinoic Acid Analogues. 5. Large-Scale Synthesis and Mammary Cancer Chemopreventive Activity for (2E,4E,6Z,8E)-8-(3',4'-Dihydro-1'(2'H)-naphathalen-1'ylidene)-3,7-dimethyl-2,4,6-octatienoic Acid. J. Med. Chem., 2003, 46, 3766-3769.
    • (2003) J. Med. Chem. , vol.46 , pp. 3766-3769
    • Atigadda, V.R.1    Vines, K.K.2    Grubbs, C.J.3    Hill, D.L.4    Beenken, S.L.5    Bland, K.I.6    Brouillette, W.J.7    Muccio, D.D.8
  • 111
    • 77951104122 scopus 로고    scopus 로고
    • Murine Oncogenicity and Pharmacokinetics Studies of 9-cis-UAB30, an RXR Agonist, for Breast Cancer Chemoprevention
    • Kapetanovic, I. M.; Horn, T. L.; Johnson, W. D.; Cwik, M. J.; Detrisac, C. J.; McCormick, D. L. Murine Oncogenicity and Pharmacokinetics Studies of 9-cis-UAB30, an RXR Agonist, for Breast Cancer Chemoprevention. Int. J. Toxicol., 2010, 29, 157-164.
    • (2010) Int. J. Toxicol. , vol.29 , pp. 157-164
    • Kapetanovic, I.M.1    Horn, T.L.2    Johnson, W.D.3    Cwik, M.J.4    Detrisac, C.J.5    McCormick, D.L.6
  • 115
    • 0029102106 scopus 로고
    • Conformational Effects on Retinoid Receptor Selectivity. 2. Effects of Retinoid Bridging Group on Retinoid X Receptor Activity and Selectivity
    • Dawson, M. I.; Jong, L.; Hobbs, P. D.; Cameron, J. F.; Chao, W.-r.; Pfahl, M.; Lee, M.-O.; Shroot, B.; Pfahl, M. Conformational Effects on Retinoid Receptor Selectivity. 2. Effects of Retinoid Bridging Group on Retinoid X Receptor Activity and Selectivity. J. Med. Chem., 1995, 38, 3368-3383.
    • (1995) J. Med. Chem. , vol.38 , pp. 3368-3383
    • Dawson, M.I.1    Jong, L.2    Hobbs, P.D.3    Cameron, J.F.4    Chao, W.-R.5    Pfahl, M.6    Lee, M.-O.7    Shroot, B.8    Pfahl, M.9
  • 118
    • 0029587448 scopus 로고
    • Enhancement of HL-60 Differentiation by a New Class of Retinoids with Selective Activity on Retinoid X Receptor
    • Apfel, C. M.; Kamber, M.; Klaus, M.; Mohr, P.; Keidel, S.; LeMotte, P. K. Enhancement of HL-60 Differentiation by a New Class of Retinoids with Selective Activity on Retinoid X Receptor. J. Biol. Chem., 1995, 270, 30765-30772.
    • (1995) J. Biol. Chem. , vol.270 , pp. 30765-30772
    • Apfel, C.M.1    Kamber, M.2    Klaus, M.3    Mohr, P.4    Keidel, S.5    Lemotte, P.K.6
  • 119
    • 0030049558 scopus 로고    scopus 로고
    • Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere
    • Vuligonda, V.; Lin, Y.; Chandraratna, R. A. S. Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere. Bioorg. Med. Chem. Lett., 1996, 6, 213-218.
    • (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 213-218
    • Vuligonda, V.1    Lin, Y.2    Chandraratna, R.A.S.3
  • 128
    • 67449132372 scopus 로고    scopus 로고
    • Therapeutic Potential of "Rexinoids" in Cancer Prrevention and Treatment
    • Tanaka, T.; De Luca, L. M. Therapeutic Potential of "Rexinoids" in Cancer Prrevention and Treatment. Cancer Res., 2009, 69, 4945-4947.
    • (2009) Cancer Res. , vol.69 , pp. 4945-4947
    • Tanaka, T.1    De Luca, L.M.2
  • 129
    • 0033535580 scopus 로고    scopus 로고
    • Central Hypothyroidism Associated with Retinoid X Receptor-Selective Ligands. New Engl
    • Sherman, S. I.; Gopal, J.; Haugen, B. R.; Chiu, A. C.; Whaley, K.; Nowlakha, P.; Duvic, M. Central Hypothyroidism Associated with Retinoid X Receptor-Selective Ligands. New Engl. J. Med., 1999, 340, 1075-1079.
    • (1999) J. Med. , vol.340 , pp. 1075-1079
    • Sherman, S.I.1    Gopal, J.2    Haugen, B.R.3    Chiu, A.C.4    Whaley, K.5    Nowlakha, P.6    Duvic, M.7
  • 132
    • 23144441588 scopus 로고    scopus 로고
    • Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene
    • Daiss, J. O.; Burschka, C.; Mills, J. S.; Montana, J. G.; Showell, G. A.; Fleming, I.; Gaudon, C.; Ivanova, D.; Gronemeyer, H.; Tacke, R. Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene. Organometallics, 2005, 24, 3192-3199.
    • (2005) Organometallics , vol.24 , pp. 3192-3199
    • Daiss, J.O.1    Burschka, C.2    Mills, J.S.3    Montana, J.G.4    Showell, G.A.5    Fleming, I.6    Gaudon, C.7    Ivanova, D.8    Gronemeyer, H.9    Tacke, R.10
  • 141
    • 0032580391 scopus 로고    scopus 로고
    • New Synthetic Retinoids Obtained by Palladium-Catalyzed Tandem Cyclisation-Hydride Capture Process
    • Diaz, P.; Gendre, F.; Stella, L.; Charpentier, B. New Synthetic Retinoids Obtained by Palladium-Catalyzed Tandem Cyclisation-Hydride Capture Process. Tetrahedron, 1998, 54, 4579-4590.
    • (1998) Tetrahedron , vol.54 , pp. 4579-4590
    • Diaz, P.1    Gendre, F.2    Stella, L.3    Charpentier, B.4
  • 142
    • 66249139527 scopus 로고    scopus 로고
    • Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers
    • Perez-Santin, E.; Germain, P.; Quillard, F.; Khanwalkar, H.; Rodriguez-Barrios, F.; Gronemeyer, H.; de Lera, A. R.; Bourguet, W. Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers. J. Med. Chem., 2009, 52, 3150-3158.
    • (2009) J. Med. Chem. , vol.52 , pp. 3150-3158
    • Perez-Santin, E.1    Germain, P.2    Quillard, F.3    Khanwalkar, H.4    Rodriguez-Barrios, F.5    Gronemeyer, H.6    De Lera, A.R.7    Bourguet, W.8
  • 144
    • 34249309592 scopus 로고    scopus 로고
    • RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia
    • Lagu, B.; Pio, B.; Lebedev, R.; Yang, M.; Pelton, P. D. RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia. Bioorg. Med. Chem. Lett., 2007, 17, 3497-3503.
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 3497-3503
    • Lagu, B.1    Pio, B.2    Lebedev, R.3    Yang, M.4    Pelton, P.D.5
  • 145
    • 34249304805 scopus 로고    scopus 로고
    • Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia
    • Lagu, B.; Lebedev, R.; Pio, B.; Yang, M.; Pelton, P. D. Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia. Bioorg. Med. Chem. Lett., 2007, 17, 3491-3496.
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 3491-3496
    • Lagu, B.1    Lebedev, R.2    Pio, B.3    Yang, M.4    Pelton, P.D.5
  • 148
    • 0034686419 scopus 로고    scopus 로고
    • 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic Acid and Heterocyclic-Bridged Analogues Are Novel Retinoic Acid Receptor Subtype and Retinoid X Receptor a Agonists
    • Dawson, M. I.; Jong, L.; Hobbs, P. D.; Xiao, D.; Feng, K.-C.; Chao, W.-r.; Pan, C.; Fontana, J. A.; Zhang, X.-k. 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic Acid and Heterocyclic-Bridged Analogues Are Novel Retinoic Acid Receptor Subtype and Retinoid X Receptor a Agonists. Bioorg. Med. Chem. Lett., 2000, 10, 1311-1313.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 1311-1313
    • Dawson, M.I.1    Jong, L.2    Hobbs, P.D.3    Xiao, D.4    Feng, K.-C.5    Chao, W.-R.6    Pan, C.7    Fontana, J.A.8    Zhang, X.-K.9
  • 149
    • 79954419081 scopus 로고    scopus 로고
    • Diphenylamine-based retinoid antagonists: Regulation of RAR and RXR function depending on the N-substituent
    • Ohta, K.; Kawachi, E.; Fukasawa, H.; Shudo, K.; Kagechika, H. Diphenylamine-based retinoid antagonists: Regulation of RAR and RXR function depending on the N-substituent. Bioorg. Med. Chem., 2011, 19, 2501-2507.
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 2501-2507
    • Ohta, K.1    Kawachi, E.2    Fukasawa, H.3    Shudo, K.4    Kagechika, H.5
  • 154
    • 84870992960 scopus 로고    scopus 로고
    • Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids
    • Ohta, K.; Kawachi, E.; Shudo, K.; Kagechika, H. Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids. Bioorg. Med. Chem. Lett., 2013, 23, 81-84.
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 81-84
    • Ohta, K.1    Kawachi, E.2    Shudo, K.3    Kagechika, H.4
  • 157
    • 0029795523 scopus 로고    scopus 로고
    • Synthesis and Structure-Activity Relationships of Retinoid X Receptor-Selective Diaryl Sulfide Analogs of Retinoic Acid
    • Beard, R. L.; Colon, D. F.; Song, T. K.; Daies, P. J. A.; Kochlar, D. M.; Chandraratna, R. A. S. Synthesis and Structure-Activity Relationships of Retinoid X Receptor-Selective Diaryl Sulfide Analogs of Retinoic Acid. J. Med. Chem., 1996, 39, 3556-3563.
    • (1996) J. Med. Chem. , vol.39 , pp. 3556-3563
    • Beard, R.L.1    Colon, D.F.2    Song, T.K.3    Daies, P.J.A.4    Kochlar, D.M.5    Chandraratna, R.A.S.6
  • 158
    • 0034658911 scopus 로고    scopus 로고
    • Solution-Phase Synthesis of Diaryl Selenides Using Polymer-Supported Borohydride
    • Millois, C.; Diaz, P. Solution-Phase Synthesis of Diaryl Selenides Using Polymer-Supported Borohydride. Org. Lett., 2000, 2, 1705-1708.
    • (2000) Org. Lett , vol.2 , pp. 1705-1708
    • Millois, C.1    Diaz, P.2
  • 161
    • 47649097615 scopus 로고    scopus 로고
    • The First Potent Subtype-Selective Retinoid X Receptor (RXR) Agonist Possessing a 3-Isopropoxy-4-isopropylphenylamino Moiety, NEt-3IP (RXRa/b-dual agonist)
    • Takamatsu, K.; Takano, A.; Yakushiji, N.; Morohashi, K.; Morishita, K.; Matsuura, N.; Makishima, M.; Tai, A.; Sasaki, K.; Kakuta, H. The First Potent Subtype-Selective Retinoid X Receptor (RXR) Agonist Possessing a 3-Isopropoxy-4-isopropylphenylamino Moiety, NEt-3IP (RXRa/b-dual agonist). ChemMedChem., 2008, 3, 780-787.
    • (2008) Chemmedchem. , vol.3 , pp. 780-787
    • Takamatsu, K.1    Takano, A.2    Yakushiji, N.3    Morohashi, K.4    Morishita, K.5    Matsuura, N.6    Makishima, M.7    Tai, A.8    Sasaki, K.9    Kakuta, H.10
  • 162
    • 78650207455 scopus 로고    scopus 로고
    • Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers
    • Ohsawa, F.; Morishita, K.-i.; Yamada, S.; Makishima, M.; Kakuta, H. Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers. ACS Med. Chem. Lett., 2010, 1, 521-525.
    • (2010) ACS Med. Chem. Lett. , vol.1 , pp. 521-525
    • Ohsawa, F.1    Morishita, K.-I.2    Yamada, S.3    Makishima, M.4    Kakuta, H.5
  • 163
    • 83455258276 scopus 로고    scopus 로고
    • Discovery of a Potent Retinoid X Re ceptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB
    • Nakayama, M.; Yamada, S.; Ohsawa, F.; Ohta, Y.; Kawata, K.; Makishima, M.; Kakuta, H. Discovery of a Potent Retinoid X Re ceptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB. ACS Med. Chem. Lett., 2011, 2, 896-900.
    • (2011) ACS Med. Chem. Lett. , vol.2 , pp. 896-900
    • Nakayama, M.1    Yamada, S.2    Ohsawa, F.3    Ohta, Y.4    Kawata, K.5    Makishima, M.6    Kakuta, H.7
  • 164
    • 48049114021 scopus 로고    scopus 로고
    • Reduction of Lipophilicity at the Lipophilic Domain of RXR Agonists Enables Production of Subtype Preference: RXRa-Preferential Agonist Possessing a Sulfonamide Moiety
    • Takamatsu, K.; Takano, A.; Yakushiji, N.; Morishita, K.; Matsuura, N.; Makishima, M.; Ali, H. I.; Akaho, E.; Tai, A.; Sasaki, K.; Kakuta, H. Reduction of Lipophilicity at the Lipophilic Domain of RXR Agonists Enables Production of Subtype Preference: RXRa-Preferential Agonist Possessing a Sulfonamide Moiety. ChemMedChem., 2008, 3, 454-460.
    • (2008) Chemmedchem. , vol.3 , pp. 454-460
    • Takamatsu, K.1    Takano, A.2    Yakushiji, N.3    Morishita, K.4    Matsuura, N.5    Makishima, M.6    Ali, H.I.7    Akaho, E.8    Tai, A.9    Sasaki, K.10    Kakuta, H.11
  • 169
    • 28244439306 scopus 로고    scopus 로고
    • Selective allosteric ligand activation of the retinoid X receptor heterodimers of NGFI-B and Nurr1
    • Morita, K.; Kawana, K.; Sodeyama, M.; Shimomura, I.; Kagechika, H.; Makishima, M. Selective allosteric ligand activation of the retinoid X receptor heterodimers of NGFI-B and Nurr1. Biochem. Pharmacol., 2005, 71, 98-107.
    • (2005) Biochem. Pharmacol. , vol.71 , pp. 98-107
    • Morita, K.1    Kawana, K.2    Sodeyama, M.3    Shimomura, I.4    Kagechika, H.5    Makishima, M.6
  • 171
    • 1642304065 scopus 로고    scopus 로고
    • Structural determinants of allosteric ligand activation in RXR heterodimers
    • Shulman, A. I.; Larson, C.; Mangelsdorf, D. J.; Ranganathan, R. Structural determinants of allosteric ligand activation in RXR heterodimers. Cell, 2004, 116, 417-429.
    • (2004) Cell , vol.116 , pp. 417-429
    • Shulman, A.I.1    Larson, C.2    Mangelsdorf, D.J.3    Ranganathan, R.4
  • 175
    • 0037869194 scopus 로고    scopus 로고
    • Retinoids and Cancer: Antitumoral Effects of ATRA, 9-cis-RA and the New Retinoid IIF on the HL-60 Leukemic Cell Line
    • Orlandi, M.; Mantovani, B.; Ammar, K.; Avitabile, E.; Dal Monte, P.; Bartolini, G. Retinoids and Cancer: Antitumoral Effects of ATRA, 9-cis-RA and the New Retinoid IIF on the HL-60 Leukemic Cell Line. Med. Princ. Pract., 2003, 12, 164-169.
    • (2003) Med. Princ. Pract , vol.12 , pp. 164-169
    • Orlandi, M.1    Mantovani, B.2    Ammar, K.3    Avitabile, E.4    Dal Monte, P.5    Bartolini, G.6
  • 176
    • 67449095059 scopus 로고    scopus 로고
    • Enhanced effects of PPARγ ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells
    • Papi, A.; Rocchi, P.; Ferreri, A. M.; Guerra, F.; Orlandi, M. Enhanced effects of PPARγ ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells. Oncol. Rep., 2009, 21, 1083-1089.
    • (2009) Oncol. Rep. , vol.21 , pp. 1083-1089
    • Papi, A.1    Rocchi, P.2    Ferreri, A.M.3    Guerra, F.4    Orlandi, M.5
  • 179
    • 84927619021 scopus 로고    scopus 로고
    • Synthesis and Biological Evaluation of Nitrated 7-, 8-, 9-, and 10-Hydroxyindenoisoquinolines as Potential Dual Topoisomerase I (Top1)-Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors
    • Nguyen, T. X.; Abdelmalak, M.; Marchand, C.; Agama, K.; Pommier, Y.; Cushman, M. Synthesis and Biological Evaluation of Nitrated 7-, 8-, 9-, and 10-Hydroxyindenoisoquinolines as Potential Dual Topoisomerase I (Top1)-Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors. J. Med. Chem., 2015, 58, 3188-3208.
    • (2015) J. Med. Chem. , vol.58 , pp. 3188-3208
    • Nguyen, T.X.1    Abdelmalak, M.2    Marchand, C.3    Agama, K.4    Pommier, Y.5    Cushman, M.6
  • 184
    • 84904343248 scopus 로고    scopus 로고
    • Identification of a New RXRa Antagonist Targeting the Coregulator-Binding Site
    • Chen, F.; Liu, J.; Huang, M.; Hu, M.; Su, Y.; Zhang, X.-k. Identification of a New RXRa Antagonist Targeting the Coregulator-Binding Site. ACS Med. Chem. Lett., 2014, 5, 736-741.
    • (2014) ACS Med. Chem. Lett. , vol.5 , pp. 736-741
    • Chen, F.1    Liu, J.2    Huang, M.3    Hu, M.4    Su, Y.5    Zhang, X.-K.6
  • 185
    • 77953717132 scopus 로고    scopus 로고
    • The Peptidomimetic, 1-Adamantyl-Substituted, and Flex-Het Classes of Retinoid-Derived Molecules: Their Structure-Activity Relationships and Retinoid Receptor-Independent Anticancer Activities
    • Dawson, M. I.; Fontana, J. A. The Peptidomimetic, 1-Adamantyl-Substituted, and Flex-Het Classes of Retinoid-Derived Molecules: Their Structure-Activity Relationships and Retinoid Receptor-Independent Anticancer Activities. Mini Rev. Med. Chem., 2010, 10, 455-491.
    • (2010) Mini Rev. Med. Chem. , vol.10 , pp. 455-491
    • Dawson, M.I.1    Fontana, J.A.2
  • 187
    • 23844454988 scopus 로고    scopus 로고
    • Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists
    • Benbrook, D.; Kamelle, S.; Guruswamy, S.; Lightfoot, S.; Rutledge, T.; Gould, N.; Hannafon, B.; Dunn, S. T.; Berlin, K. D. Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists. Inv. New Drugs, 2005, 23, 417-428.
    • (2005) Inv. New Drugs , vol.23 , pp. 417-428
    • Benbrook, D.1    Kamelle, S.2    Guruswamy, S.3    Lightfoot, S.4    Rutledge, T.5    Gould, N.6    Hannafon, B.7    Dunn, S.T.8    Berlin, K.D.9
  • 189
    • 0035056173 scopus 로고    scopus 로고
    • Novel Retinoidal Tropolone Derivatives. Bioisosteric Relationship of Tropolone Ring with Benzoic Acid Moiety in Retinoid Structure
    • Ebisawa, M.; Ohta, K.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Kagechika, H. Novel Retinoidal Tropolone Derivatives. Bioisosteric Relationship of Tropolone Ring with Benzoic Acid Moiety in Retinoid Structure. Chem. Pharm. Bull., 2001, 49, 501-503.
    • (2001) Chem. Pharm. Bull. , vol.49 , pp. 501-503
    • Ebisawa, M.1    Ohta, K.2    Kawachi, E.3    Fukasawa, H.4    Hashimoto, Y.5    Kagechika, H.6
  • 193
    • 44949173950 scopus 로고    scopus 로고
    • Assessment of Scaffold Hopping Efficiency by Use of Molecular Interaction Fingerprints
    • Venhorst, J.; Nunez, S.; Terpstra, J. W.; Kruse, C. G. Assessment of Scaffold Hopping Efficiency by Use of Molecular Interaction Fingerprints. J. Med. Chem., 2008, 51, 3222-3229.
    • (2008) J. Med. Chem. , vol.51 , pp. 3222-3229
    • Venhorst, J.1    Nunez, S.2    Terpstra, J.W.3    Kruse, C.G.4
  • 194
    • 0034686405 scopus 로고    scopus 로고
    • Sp2-bridged diaryl retinoids: Effects of bridgeregion substitution on retinoid X receptor (RXR) selectivity
    • Dawson, M. I.; Hobbs, P. D.; Jong, L.; Xiao, D.; Chao, W.-r.; Pan, C.; Zhang, X.-k. sp2-bridged diaryl retinoids: Effects of bridgeregion substitution on retinoid X receptor (RXR) selectivity. Bioorg. Med. Chem. Lett., 2000, 10, 1307-1310.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 1307-1310
    • Dawson, M.I.1    Hobbs, P.D.2    Jong, L.3    Xiao, D.4    Chao, W.-R.5    Pan, C.6    Zhang, X.-K.7
  • 195
    • 73349084304 scopus 로고    scopus 로고
    • The effect of antagonists on the conformational exchange of the retinoid X receptor a ligand-binding domain
    • Lu, J.; Dawson, M. I.; Hu, Q. Y.; Xia, Z.; Dambacher, J. D.; Ye, M.; Zhang, X.-K.; Li, E. The effect of antagonists on the conformational exchange of the retinoid X receptor a ligand-binding domain. Magn. Reson. Chem., 2009, 47, 1071-1080.
    • (2009) Magn. Reson. Chem , vol.47 , pp. 1071-1080
    • Lu, J.1    Dawson, M.I.2    Hu, Q.Y.3    Xia, Z.4    Dambacher, J.D.5    Ye, M.6    Zhang, X.-K.7    Li, E.8
  • 198
    • 0037066766 scopus 로고    scopus 로고
    • The Antidiabetic Agent LG100754 Sensitizes Cells to Low Concentrations of Peroxisome Proliferator-activated Receptor g Ligands
    • Forman, B. M. The Antidiabetic Agent LG100754 Sensitizes Cells to Low Concentrations of Peroxisome Proliferator-activated Receptor g Ligands. J. Biol. Chem., 2002, 277, 12503-12506.
    • (2002) J. Biol. Chem. , vol.277 , pp. 12503-12506
    • Forman, B.M.1
  • 200
    • 17844369402 scopus 로고    scopus 로고
    • 9-cis-Retinoic Acid Inhibits Androgen Receptor Activity through Activation of Retinoid X Receptor
    • Chuang, K.-H.; Lee, Y.-F.; Lin, W.-J.; Chu, C.-Y.; Altuwaijri, S.; Wan, Y.-J. Y.; Chang, C. 9-cis-Retinoic Acid Inhibits Androgen Receptor Activity through Activation of Retinoid X Receptor. Mol. Endocrinol., 2005, 19, 1200-1212.
    • (2005) Mol. Endocrinol , vol.19 , pp. 1200-1212
    • Chuang, K.-H.1    Lee, Y.-F.2    Lin, W.-J.3    Chu, C.-Y.4    Altuwaijri, S.5    Wan, Y.-J.Y.6    Chang, C.7


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