Modeling, synthesis and biological evaluation of potential Retinoid X Receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)

Journal of Medicinal Chemistry

Volumn 52, Issue 19, 2009, Pages 5950-5966

  Wagner, Carl E ^a   Jurutka, Peter W ^a   Marshall, Pamela A ^a   Groy, Thomas L ^b   Van Der Vaart, Arjan ^c   Ziller, Joseph W ^d   Furmick, Julie K ^a   Graeber, Mark E ^a   Matro, Erik ^a   Miguel, Belinda V ^a   Tran, Ivy T ^a   Kwon, Jungeun ^a   Tedeschi, Jamie N ^a   Moosavi, Shahram ^e   Danishyar, Amina ^a   Philp, Joshua S ^a   Khamees, Reina O ^e   Jackson, Jevon N ^a   Grupe, Darci K ^a   Badshah, Syed L ^b   Hart, Justin W ^a   more..

^a ARIZONA STATE UNIVERSITY   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

BEXAROTENE; RETINOID X RECEPTOR;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CUTANEOUS T CELL LYMPHOMA; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ISOMER; MOLECULAR MODEL; MUTAGENICITY;

APOPTOSIS; CELL LINE, TUMOR; HUMANS; RETINOID X RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES; TRANSCRIPTION, GENETIC;

EID: 70349645985     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900496b     Document Type: Article

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