Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IB

ACS Medicinal Chemistry Letters

Volumn 2, Issue 12, 2011, Pages 896-900

  Nakayama, Mariko ^a   Yamada, Shoya ^a   Ohsawa, Fuminori ^a   Ohta, Yui ^a   Kawata, Kohei ^a   Makishima, Makoto ^b   Kakuta, Hiroki ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b NIHON UNIVERSITY   (Japan)

Author keywords

agonists; antagonists; nuclear receptors; retinoids; RXR; Synthetic route

Indexed keywords

3 METHYL 7 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 3 PROPOXY 2 NAPHTHYL) 2,4,6 OCTATRIENOIC ACID; 6 [N ETHYL N (3 ISOBUTOXY 4 ISOPROPYLPHENYL)AMINO]NICOTINIC ACID; 6 [N ETHYL N (5 ISOBUTOXY 4 ISOPROPYL 2 STYRYLPHENYL)AMINO]NICOTINIC ACID; AMINE; ANILINE DERIVATIVE; BENZENE DERIVATIVE; ELECTROPHILE; ESTER DERIVATIVE; IODINE; PA 452; PALLADIUM; RECEPTOR BLOCKING AGENT; RETINOID X RECEPTOR AGONIST; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR ANTAGONIST; STYRENE DERIVATIVE; UNCLASSIFIED DRUG; UVI 3002;

ARTICLE; BIOTRANSFORMATION; CATALYSIS; CHEMICAL BOND; DRUG POTENCY; DRUG SYNTHESIS; IODINATION; LIGAND BINDING; PRIORITY JOURNAL; REACTION ANALYSIS; TRANSCRIPTION INITIATION;

EID: 83455258276     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200197e     Document Type: Article

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