Identification of a new RXRα antagonist targeting the coregulator-binding site

ACS Medicinal Chemistry Letters

Volumn 5, Issue 7, 2014, Pages 736-741

  Chen, Fan ^a,b   Liu, Jie ^a   Huang, Mingfeng ^a   Hu, Mengjie ^a   Su, Ying ^a,b   Zhang, Xiao Kun ^a,b  

^a XIAMEN UNIVERSITY   (China)

^b BURNHAM INSTITUTE   (United States)

Author keywords

coregulator binding site; nongenomic actions; RXR ; RXR antagonist; virtual screening

Indexed keywords

ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; NUCLEAR RECEPTOR NUR77; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN INHIBITOR; PROTEIN KINASE B; PROTEIN P85; PROTEIN P85 ALPHA SUBUNIT; RETINOIC ACID RECEPTOR GAMMA; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR ALPHA ANTAGONIST; SULINDAC; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG TARGETING; HEPG2 CELL LINE; HUMAN; IC 50; IMMUNOBLOTTING; LUNG CANCER; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION;

EID: 84904343248     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml5000405     Document Type: Article

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