Crystal structure of the heterodimeric complex of LXRα and RXRβ ligand-binding domains in a fully agonistic conformation

EMBO Journal

Volumn 22, Issue 18, 2003, Pages 4625-4633

  Svensson, Stefan ^a   Östberg, Tove ^c   Jacobsson, Micael ^a,d   Norström, Carina ^a   Stefansson, Karin ^a   Hallén, Dan ^a   Johansson, Isabel Climent ^b   Zachrisson, Kristina ^a   Ogg, Derek ^a   Jendeberg, Lena ^b  

^a BIOVITRUM AB   (Sweden)

^b Karolinska Institute ^*  (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Crystal structure; Lipid metabolism; Mutational analysis; Nuclear receptor; Transcription

Indexed keywords

CELL NUCLEUS RECEPTOR; GRIP 1 PEPTIDE; HYDROXYL GROUP; LIGAND; LIPID; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; METHOPRENE; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; OXYSTEROL; PEPTIDE; POLYUNSATURATED FATTY ACID; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; GENETIC TRANSCRIPTION; HOMEOSTASIS; INFLAMMATION; LIGAND BINDING; LIPID METABOLISM; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; RECEPTOR BINDING; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA PRIMERS; DNA-BINDING PROTEINS; ESCHERICHIA COLI; LIGANDS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS;

EID: 0141737105     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg456     Document Type: Article

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