RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3497-3503

  Lagu, Bharat ^a   Pio, Barbara ^a   Lebedev, Rimma ^a   Yang, Maria ^a   Pelton, Patricia D ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

ABCA 1; Diabetes; Dyslipidemia; HDL; LDL; LXR; RXR; Triglycerides

Indexed keywords

HETERODIMER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PIOGLITAZONE; RETINOID X RECEPTOR; RETINOID X RECEPTOR AGONIST; ROSIGLITAZONE; TO 901317; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DOSE COMPARISON; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; DYSLIPIDEMIA; IN VIVO STUDY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; DIABETES MELLITUS; DIMERIZATION; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DYSLIPIDEMIAS; HYPOGLYCEMIC AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RETINOID X RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIP;

RODENTIA;

EID: 34249309592     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.047     Document Type: Article

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