Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site

Chemistry and Biology

Volumn 21, Issue 5, 2014, Pages 596-607

  Chen, Liqun ^a,b   Wang, Zhi Gang ^a   Aleshin, Alexander E ^b   Chen, Fan ^a,b   Chen, Jiebo ^a,b   Jiang, Fuquan ^a   Alitongbieke, Gulimiran ^a   Zeng, Zhiping ^a   Ma, Yue ^a   Huang, Mingfeng ^a   Zhou, Hu ^a,b   Cadwell, Gregory ^b   Zheng, Jian Feng ^a   Huang, Pei Qiang ^a   Liddington, Robert C ^b   Zhang, Xiao Kun ^a,b   Su, Ying ^a,b  

^a XIAMEN UNIVERSITY   (China)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; K 80003; K 8002; K 8003; K 8008; K 8012; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN P85ALPHA; RETINOID X RECEPTOR ALPHA; SULINDAC; SULINDAC DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME REPRESSION; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BINDING SITE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HELA CELL LINE; HEPG2 CELL LINE; METABOLISM; NEOPLASMS; NUDE MOUSE; PATHOLOGY; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HEP G2 CELLS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; RETINOID X RECEPTOR ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP; SULINDAC; TUMOR CELLS, CULTURED;

EID: 84901425917     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.02.017     Document Type: Article

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