Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 12, 2003, Pages 7135-7140

  Mic, Felix A ^a   Molotkov, Andrei ^a   Benbrook, Doris M ^b   Duester, Gregg ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 OXORETINOIC ACID; ALITRETINOIN; LIGAND; OXIDOREDUCTASE; RETINAL DEHYDROGENASE; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BLOOD LEVEL; CATALYST; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; FEMALE; GROWTH DISORDER; ISOMERISM; LIGAND BINDING; MATERNAL SERUM; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INDUCTION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; TERATOGENICITY; TISSUE LEVEL;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; EMBRYO; FEMALE; LIGANDS; LIVER; MICE; MICE, KNOCKOUT; PREGNANCY; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; RETINOIDS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRETINOIN;

ANIMALIA;

EID: 0037795409     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1231422100     Document Type: Article

References (44)

1. Clagett-Dame, M. & DeLuca, H. F. (2002) Annu. Rev. Nutr. 22, 347-381.
2. Mangelsdorf, D. J., Ong, E. S., Dyck, J. A. & Evans, R. M. (1990) Nature 345, 224-229.
3. Petkovich, M., Brand, N. J., Krust, A. & Chambon, P. (1987) Nature 330, 444-450.
4. Giguère, V., Ong, E. S., Segui, P. & Evans, R. M. (1987) Nature 330, 624-629.
5. Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Speck, J., Kratzeisen, C., Rosenberger, M., Lovey, A. & Grippo, J. F. (1992) Nature 355, 359-361.
6. Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M. & Thaller, C. (1992) Cell 68, 397-406.
7. Allenby, G., Bocquel, M.-T., Saunders, M., Kazmer, S., Speck, J., Rosenberger, M., Lovey, A., Kastner, P., Grippo, J. F., Chambon, P. & Levin, A. A. (1993) Proc. Natl. Acad. Sci. USA 90, 30-34.
8. Urbach, J. & Rando, R. R. (1994) Biochem. J. 299, 459-465.
9. Yu, V. C., Delsert, C., Andersen, B., Holloway, J. M., Devary, O. V., Näär, A. M., Kim, S. Y., Boutin, J.-M., Glass, C. K. & Rosenfeld, M. G. (1991) Cell 67, 1251-1266.
10. Leid, M., Kastner, P., Lyons, R., Nakshatri, H., Saunders, M., Zacharewski, T., Chen, J.-Y., Staub, A., Garnier, J.-M., Mader, S. & Chambon, P. (1992) Cell 68, 377-395.
11. Zhang, X., Hoffmann, B., Tran, P. B.-V., Graupner, G. & Pfahl, M. (1992) Nature 355, 441-446.
12. Kliewer, S. A., Umesono, K., Mangelsdorf, D. J. & Evans, R. M. (1992) Nature 355, 446-449.
13. Zhang, X., Lehmann, J., Hoffmann, B., Dawson, M. I., Cameron, J., Graupner, G., Hermann, T., Tran, P. & Pfahl, M. (1992) Nature 358, 587-591.
14. Mascrez, B., Mark, M., Dierich, A., Ghyselinck, N. B., Kastner, P. & Chambon, P. (1998) Development (Cambridge, U.K.) 125, 4691-4707.
15. Horton, C. & Maden, M. (1995) Dev. Dyn. 202, 312-323.
16. Kurlandsky, S. B., Gamble, M. V., Ramakrishnan, R. & Blaner, W. S. (1995) J. Biol. Chem. 270, 17850-17857.
17. Ulven, S. M., Gundersen, T. E., Weedon, M. S., Landaas, V. O., Sakhi, A. K., Fromm, S. H., Geronimo, B. A., Moskaug, J. O. & Blomhoff, R. (2000) Dev. Biol. 220, 379-391.
18. Werner, E. A. & DeLuca, H. F. (2001) Arch. Biochem. Biophys. 393, 262-270.
19. Kurokawa, R., DiRenzo, J., Boehm, M., Sugarman, J., Gloss, B., Rosenfeld, M. G., Heyman, R. A. & Glass, C. K. (1994) Nature 371, 528-531.
20. Germain, P., Iyer, J., Zechel, C. & Gronemeyer, H. (2002) Nature 415, 187-192.
21. Allali-Hassani, A., Peralba, J. M., Martras, S., Farrés, J. & Parés, X. (1998) FEBS Lett. 426, 362-366.
22. Chai, X., Boerman, M. H. E. M., Zhai, Y. & Napoli, J. L. (1995) J. Biol. Chem. 270, 3900-3904.
23. Mertz, J. R., Shang, E. Y., Piantedosi, R., Wei, S. H., Wolgemuth, D. J. & Blaner, W. S. (1997) J. Biol. Chem. 272, 11744-11749.
24. Gagnon, I., Duester, G. & Bhat, P. V. (2002) Biochim. Biophys. Acta 1596, 156-162.
25. Montplaisir, V., Lan, N. C., Guimond, J., Savineau, C., Bhat, P. V. & Mader, S. (2002) J. Biol. Chem. 277, 17486-17492.
26. Molotkov, A., Fan, X., Deltour, L., Foglio, M. H., Martras, S., Farrés, J., Parés, X. & Duester, G. (2002) Proc. Natl. Acad. Sci. USA 99, 5337-5342.
27. Molotkov, A., Deltour, L., Foglio, M. H., Cuenca, A. E. & Duester, G. (2002) J. Biol. Chem. 277, 13804-13811.
28. Niederreither, K., Subbarayan, V., Dollé, P. & Chambon, P. (1999) Nat. Genet. 21, 444-448.
29. Mic, F. A., Haselbeck, R. J., Cuenca, A. E. & Duester, G. (2002) Development (Cambridge, U.K.) 129, 2271-2282.
30. Fan, X., Molotkov, A., Manabe, S.-I., Donmoyer, C. M., Deltour, L., Foglio, M. H., Cuenca, A. E., Blaner, W. S., Lipton, S. A. & Duester, G. (2003) Mol. Cell. Biol., in press.
31. Benbrook, D. M., Subramanian, S., Gale, J. B., Liu, S., Brown, C. W., Boehm, M. F. & Berlin, K. D. (1998) J. Med. Chem. 41, 3753-3757.
32. Zacheis, D., Dhar, A., Lu, S., Madler, M. M., Klucik, J., Brown, C. W., Liu, S., Clement, F., Subramanian, S., Weerasekare, G. M., et al. (1999) J. Med. Chem. 42, 4434-4445.
33. Guruswamy, S., Lightfoot, S., Gold, M. A., Hassan, R., Berlin, K. D., Ivey, R. T. & Benbrook, D. M. (2001) J. Natl. Cancer Inst. 93, 516-525.
34. Rossant, J., Zirngibl, R., Cado, D., Shago, M. & Giguère, V. (1991) Genes Dev. 5, 1333-1344.
35. Niederreither, K., Vermot, J., Schuhbaur, B., Chambon, P. & Dollé, P. (2002) Development (Cambridge, U.K.) 129, 3563-3574.
36. Niederreither, K., Abu-Abed, S., Schuhbaur, B., Petkovich, M., Chambon, P. & Dollé, P. (2002) Nat. Genet. 31, 84-88.
37. Kochhar, D. M., Jiang, H., Penner, J. D. & Heyman, R. A. (1995) Teratology 51, 257-265.
38. De Urquiza, A. M., Liu, S. Y., Sjöberg, M., Zetterström, R. H., Griffiths, W., Sjovall, J. & Perlmann, T. (2000) Science 290, 2140-2144.
39. Solomin, L., Johansson, C. B., Zetterström, R. H., Bissonnette, R. P., Heyman, R. A., Olson, L., Lendahl, U., Frisén, J. & Perlmann, T. (1998) Nature 395, 398-402.
40. Chawla, A., Repa, J. J., Evans, R. M. & Mangelsdorf, D. J. (2001) Science 294, 1866-1870.
41. Lehmann, J. M., Jong, L., Fanjul, A., Cameron, J. F., Lu, X. P., Haefner, P., Dawson, M. I. & Pfahl, M. (1992) Science 258, 1944-1946.
42. Pijnappel, W. W. M., Hendriks, H. F. J., Folkers, G. E., Van den Brink, C. E., Dekker, E. J., Edelenbosch, C., Van der Saag, P. T. & Durston, A. J. (1993) Nature 366, 340-344.
43. Niederreither, K., Vermot, J., Schuhbaur, B., Chambon, P. & Dollé, P. (2000) Development (Cambridge, U.K.) 127, 75-85.
44. Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P. & Dollé, P. (2001) Development (Cambridge, U.K.) 128, 1019-1031.