-
2
-
-
34848862778
-
Design of selective nuclear receptor modulators: RAR and RXR as a case study
-
DOI 10.1038/nrd2398, PII NRD2398
-
de Lera AR, Bourguet W, Altucci L, Gronemeyer H. Design of selective nuclear receptor modulators: RAR and RXR as a Case Study. Nat Rev Drug Disc 2007;6:811-20 (Pubitemid 47504872)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.10
, pp. 811-820
-
-
De Lera, A.R.1
Bourguet, W.2
Altucci, L.3
Gronemeyer, H.4
-
4
-
-
78049278719
-
Retinoid X receptors: Common heterodimerization partners with distinct functions
-
Lefebvre P, Benomar Y, Staels B. Retinoid X receptors: common heterodimerization partners with distinct functions. Trends Endocrinol Metabol 2010;21:676-83
-
(2010)
Trends Endocrinol Metabol
, vol.21
, pp. 676-683
-
-
Lefebvre, P.1
Benomar, Y.2
Staels, B.3
-
6
-
-
0029012163
-
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-a
-
Bourguet W, Ruff M, Chambon P, et al. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-a. Nature 1995;375:377-82
-
(1995)
Nature
, vol.375
, pp. 377-382
-
-
Bourguet, W.1
Ruff, M.2
Chambon, P.3
-
7
-
-
0034213831
-
Crystal structure of the human RXRα ligand-binding domain bound to its natural ligand: 9-cis retinoic acid
-
Egea PF, Mitschler A, Rochel N, et al. Crystal structure of the human RXRa ligand-binding domain bound to its natural ligand: 9-cis-retinoic acid. EMBO J 2000;19:2592-601 (Pubitemid 30323548)
-
(2000)
EMBO Journal
, vol.19
, Issue.11
, pp. 2592-2601
-
-
Egea, P.F.1
Mitschler, A.2
Rochel, N.3
Ruff, M.4
Chambon, P.5
Moras, D.6
-
8
-
-
0031892525
-
Conformational adaptation of agonists to the human nuclear receptor RARγ
-
DOI 10.1038/nsb0398-199
-
Klaholz BP, Renaud J-P, Mitschler A, et al. Conformational adaptation of agonists to the human nuclear receptor RARg. Nat Struct Mol Biol 1998;5:199-202 (Pubitemid 28113751)
-
(1998)
Nature Structural Biology
, vol.5
, Issue.3
, pp. 199-202
-
-
Klaholz, B.P.1
Renaud, J.-P.2
Mitschler, A.3
Zusi, C.4
Chambon, P.5
Gronemeyer, H.6
Moras, D.7
-
9
-
-
0025270737
-
Nuclear receptor that identifies a novel retinoic acid response pathway
-
Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 1990;345:224-9
-
(1990)
Nature
, vol.345
, pp. 224-229
-
-
Mangelsdorf, D.J.1
Ong, E.S.2
Dyck, J.A.3
Evans, R.M.4
-
10
-
-
2942621879
-
In vivo activation of PPAR target genes by RXR homodimers
-
DOI 10.1038/sj.emboj.7600209
-
Ijpenberg A, Tan NS, Gelman L, et al. In vivo activation of PPAR target genes by RXR homodimers. EMBO J 2004;23:2083-91 (Pubitemid 38737735)
-
(2004)
EMBO Journal
, vol.23
, Issue.10
, pp. 2083-2091
-
-
Ijpenberg, A.1
Tan, N.S.2
Gelman, L.3
Kersten, S.4
Seydoux, J.5
Xu, J.6
Metzger, D.7
Canaple, L.8
Chambon, P.9
Wahli, W.10
Desvergne, B.11
-
11
-
-
79960121686
-
Structural basis for retinoic X receptor repression on the tetramer
-
Zhang H, Chen L, Chen J, et al. Structural basis for retinoic X receptor repression on the tetramer. J Biol Chem 2011;286:24593-8
-
(2011)
J Biol Chem
, vol.286
, pp. 24593-24598
-
-
Zhang, H.1
Chen, L.2
Chen, J.3
-
12
-
-
0033868825
-
Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains
-
Bourguet W, Vivat V, Wurtz J-M, et al. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. Mol Cell 2000;5:289-98 (Pubitemid 30628087)
-
(2000)
Molecular Cell
, vol.5
, Issue.2
, pp. 289-298
-
-
Bourguet, W.1
Vivat, V.2
Wurtz, J.-M.3
Chambon, P.4
Gronemeyer, H.5
Moras, D.6
-
13
-
-
19944430311
-
Characterization of the interaction between RAR/RXR heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies
-
Pogenberg V, Guichou J-F, Vivat-Hannah V, et al. Characterization of the Interaction Between RAR/RXR Heterodimers and Transcriptional Coactivators Through Structural and Fluorescence Anisotropy Studies. J Biol Chem 2005;280:1625-33
-
(2005)
J Biol Chem
, vol.280
, pp. 1625-1633
-
-
Pogenberg, V.1
Guichou, J.-F.2
Vivat-Hannah, V.3
-
14
-
-
78649771898
-
The phantom effect of the rexinoid LG100754: Structural and functional insights
-
Sato Y, Ramalanjaona N, Huet T, et al. The "Phantom Effect" of the rexinoid LG100754: structural and functional insights. PLoS ONE 2010;5:e15119
-
(2010)
PLoS ONE
, vol.5
-
-
Sato, Y.1
Ramalanjaona, N.2
Huet, T.3
-
15
-
-
11144354615
-
Structure-Based Design of Potent Retinoid X Receptor α Agonists
-
DOI 10.1021/jm030565g
-
Haffner CD, Lenhard JM, Miller AB, et al. Structure-based design of potent retinoid X receptor a agonists. J Med Chem 2004;47:2010-29 (Pubitemid 38453918)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.8
, pp. 2010-2029
-
-
Haffner, C.D.1
Lenhard, J.M.2
Miller, A.B.3
McDougald, D.L.4
Dwornik, K.5
Ittoop, O.R.6
Gampe Jr., R.T.7
Xu, H.E.8
Blanchard, S.9
Montana, V.G.10
Consler, T.G.11
Bledsoe, R.K.12
Ayscue, A.13
Croom, D.14
-
16
-
-
0033681001
-
Asymmetry in the PPARg/RXRa crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
-
Gampe RT, Montana VG, Lambert MH, et al. Asymmetry in the PPARg/RXRa crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell 2000;5:545-55
-
(2000)
Mol Cell
, vol.5
, pp. 545-555
-
-
Gampe, R.T.1
Montana, V.G.2
Lambert, M.H.3
-
17
-
-
0141737105
-
Crystal structure of the heterodimeric complex of LXRα and RXRβ ligand-binding domains in a fully agonistic conformation
-
DOI 10.1093/emboj/cdg456
-
Svensson S, Ostberg T, Jacobsson M, et al. Crystal structure of the heterodimeric complex of LXRa and RXRb ligand-binding domains in a fully agonistic conformation. EMBO J 2003;22:4625-33 (Pubitemid 37162899)
-
(2003)
EMBO Journal
, vol.22
, Issue.18
, pp. 4625-4633
-
-
Svensson, S.1
Ostberg, T.2
Jacobsson, M.3
Norstrom, C.4
Stefansson, K.5
Hallen, D.6
Johansson, I.C.7
Zachrisson, K.8
Ogg, D.9
Jendeberg, L.10
-
18
-
-
10944250224
-
The nuclear xenobiotic receptor CAR: Structural determinants of constitutive activation and heterodimerization
-
DOI 10.1016/j.molcel.2004.11.036, PII S1097276504007270
-
Suino K, Peng L, Reynolds R, et al. The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Mol Cell 2004;16:893-905 (Pubitemid 40018400)
-
(2004)
Molecular Cell
, vol.16
, Issue.6
, pp. 893-905
-
-
Suino, K.1
Peng, L.2
Reynolds, R.3
Li, Y.4
Cha, J.-Y.5
Repa, J.J.6
Kliewer, S.A.7
Xu, H.E.8
-
19
-
-
84857981327
-
Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors
-
Osz J, Brélivet Y, Peluso-Iltis C, et al. Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors. Proc Natl Acad Sci USA 2012;109:E588-E94
-
(2012)
Proc Natl Acad Sci USA
, vol.109
-
-
Osz, J.1
Brélivet, Y.2
Peluso-Iltis, C.3
-
20
-
-
79955581636
-
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
-
Rochel N, Ciesielski F, Godet J, et al. Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat Struct Mol Biol 2011;18:564-70
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 564-570
-
-
Rochel, N.1
Ciesielski, F.2
Godet, J.3
-
21
-
-
56749130032
-
Structure of the intact PPARg-RXRa nuclear receptor complex on DNA
-
Chandra V, Huang P, Hamuro Y, et al. Structure of the intact PPARg-RXRa nuclear receptor complex on DNA. Nature 2008;456:350-56.
-
(2008)
Nature
, vol.456
, pp. 350-356
-
-
Chandra, V.1
Huang, P.2
Hamuro, Y.3
-
22
-
-
0037050017
-
Co-regulator recruitment and the mechanism of retinoic acid receptor synergy
-
DOI 10.1038/415187a
-
Germain P, Iyer J, Zechel C, Gronemeyer H. Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature 2002;415:187-92 (Pubitemid 34059522)
-
(2002)
Nature
, vol.415
, Issue.6868
, pp. 187-192
-
-
Germain, P.1
Iyer, J.2
Zechel, C.3
Gronemeyer, H.4
-
23
-
-
77954387100
-
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
-
le Maire A, Teyssier C, Erb C, et al. A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor. Nat Struct Mol Biol 2010;17:801-7
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 801-807
-
-
Le Maire, A.1
Teyssier, C.2
Erb, C.3
-
24
-
-
84859982562
-
Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers
-
Putcha B-DK, Wright E, Brunzelle JS, Fernandez EJ. Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers. Proc Natl Acad Sci USA 2012;109:6084-7
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 6084-6087
-
-
B-Dk, P.1
Wright, E.2
Brunzelle, J.S.3
Fernandez, E.J.4
-
25
-
-
0036251738
-
Molecular recognition of agonist ligands by RXRs
-
DOI 10.1210/me.16.5.987
-
Egea PF, Mitschler A, Moras D. Molecular recognition of agonist ligands by RXRs. Mol Endocrinol 2002;16:987-97 (Pubitemid 34478536)
-
(2002)
Molecular Endocrinology
, vol.16
, Issue.5
, pp. 987-997
-
-
Egea, P.F.1
Mitschler, A.2
Moras, D.3
-
26
-
-
73349084304
-
The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain
-
Lu J, Dawson MI, Hu QY, et al. The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain. Magn Reson Chem 2009;47:1071-80
-
(2009)
Magn Reson Chem
, vol.47
, pp. 1071-1080
-
-
Lu, J.1
Dawson, M.I.2
Hu, Q.Y.3
-
27
-
-
36849024302
-
Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function
-
DOI 10.1073/pnas.0705356104
-
Nahoum V, Pérez E, Germain P, et al. Modulators of the structural dynamics of RXR to reveal receptor function. Proc Natl Acad Sci USA 2007;104:17323-8 (Pubitemid 350219841)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.44
, pp. 17323-17328
-
-
Nahoum, V.1
Perez, E.2
Germain, P.3
Rodriguez-Barrios, F.4
Manzo, F.5
Kammerer, S.6
Lemaire, G.7
Hirsch, O.8
Royer, C.A.9
Gronemeyer, H.10
De Lera, A.R.11
Bourguet, W.12
-
28
-
-
66249139527
-
Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3- alkoxy-5 5, 8,8-tetramethyl-5,6,7, 8-tetrahydronaphthalen-2-yl)phenyl] acrylic acids and their 4-alkoxy isomers
-
Pérez-Santín E, Germain P, Quillard F, et al. Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8- tetramethyl-5,6,7, 8-tetrahydronaphthalen-2-yl)phenyl] acrylic acids and their 4-alkoxy isomers. J Med Chem 2009;52:3150-8
-
(2009)
J Med Chem
, vol.52
, pp. 3150-3158
-
-
Pérez-Santín, E.1
Germain, P.2
Quillard, F.3
-
29
-
-
33846094038
-
Is 9-cis-retinoic acid the endogenous ligand for the retinoic acid-X receptor?
-
DOI 10.1301/nr.2006.dec.532-538
-
Wolf G. Is 9-Cis-Retinoic acid the endogenous ligand for the retinoic acid-X receptor? Nutr Rev 2006;64:532-8 (Pubitemid 46057720)
-
(2006)
Nutrition Reviews
, vol.64
, Issue.12
, pp. 532-538
-
-
Wolf, G.1
-
30
-
-
33744798752
-
Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes
-
DOI 10.1101/gad.368706
-
Calléja C, Messaddeq N, Chapellier B, et al. Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. Genes Dev 2006;20:1525-38 (Pubitemid 43830658)
-
(2006)
Genes and Development
, vol.20
, Issue.11
, pp. 1525-1538
-
-
Calleja, C.1
Messaddeq, N.2
Chapellier, B.3
Yang, H.4
Krezel, W.5
Li, M.6
Metzger, D.7
Mascrez, B.8
Ohta, K.9
Kagechika, H.10
Endo, Y.11
Mark, M.12
Ghyselinck, N.B.13
Chambon, P.14
-
31
-
-
2942655572
-
Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells
-
DOI 10.1101/gad.276003
-
Wallén-Mackenzie O, Mata de Urquiza A, Petersson S, et al. Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells. Genes Dev 2003;17:3036-47 (Pubitemid 38040768)
-
(2003)
Genes and Development
, vol.17
, Issue.24
, pp. 3036-3047
-
-
Wallen-Mackenzie, A.1
De Urquiza, A.M.2
Petersson, S.3
Rodriguez, F.J.4
Friling, S.5
Wagner, J.6
Ordentlich, P.7
Lengqvist, J.8
Heyman, R.A.9
Arenas, E.10
Perlmann, T.11
-
32
-
-
73149112441
-
Activation of retinoic acid receptors by dihydroretinoids
-
Moise AR, Alvarez S, Domínguez M, et al. Activation of retinoic acid receptors by dihydroretinoids. Mol Pharmacol 2009;76:1228-37
-
(2009)
Mol Pharmacol
, vol.76
, pp. 1228-1237
-
-
Moise, A.R.1
Alvarez, S.2
Domínguez, M.3
-
33
-
-
34249977327
-
Retinaldehyde represses adipogenesis and diet-induced obesity
-
DOI 10.1038/nm1587, PII NM1587
-
Ziouzenkova O, Orasanu G, Sharlach M, et al. Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med 2007;13:695-702 (Pubitemid 46889756)
-
(2007)
Nature Medicine
, vol.13
, Issue.6
, pp. 695-702
-
-
Ziouzenkova, O.1
Orasanu, G.2
Sharlach, M.3
Akiyama, T.E.4
Berger, J.P.5
Viereck, J.6
Hamilton, J.A.7
Tang, G.8
Dolnikowski, G.G.9
Vogel, S.10
Duester, G.11
Plutzky, J.12
-
34
-
-
0034672081
-
Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain
-
DOI 10.1126/science.290.5499.2140
-
de Urquiza AM, Liu S, Sjoberg M, et al. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse. Brain Sci 2000;290:2140-4 (Pubitemid 32001593)
-
(2000)
Science
, vol.290
, Issue.5499
, pp. 2140-2144
-
-
De Urquiza, A.M.1
Liu, S.2
Sjoberg, M.3
Zetterstrom, R.H.4
Griffiths, W.5
Sjovall, J.6
Perlmann, T.7
-
36
-
-
9344249538
-
Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR
-
Kitareewan S, Burka L, Tomer B, et al. Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. Mol Cell Biol 1996;7:1153-66 (Pubitemid 26260734)
-
(1996)
Molecular Biology of the Cell
, vol.7
, Issue.8
, pp. 1153-1166
-
-
Kitareewan, S.1
Burka, L.T.2
Tomer, K.B.3
Parker, C.E.4
Deterding, L.J.5
Stevens, R.D.6
Forman, B.M.7
Mais, D.E.8
Heyman, R.A.9
McMorris, T.10
Weinberger, C.11
-
38
-
-
0033739281
-
Pristanic acid and phytanic acid: Naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor g
-
Zomer AWM, van der Burg B, Jansen GA, et al. Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor g. J Lipid Res 2000;41:1801-7
-
(2000)
J Lipid Res
, vol.41
, pp. 1801-1807
-
-
Zomer, A.W.M.1
Van Der Burg, B.2
Jansen, G.A.3
-
39
-
-
54849422856
-
New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists
-
Á lvarez S, Pazos-Randulfe Y, Khanwalkar H, et al. New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists. Bioorg Med Chem 2008;16:9719-28
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 9719-9728
-
-
Lvarez S, Á.1
Pazos-Randulfe, Y.2
Khanwalkar, H.3
-
40
-
-
79955478892
-
Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity
-
Okitsu T, Sato K, Iwatsuka K, et al. Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity. Bioorg Med Chem 2011;19:2939-49
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 2939-2949
-
-
Okitsu, T.1
Sato, K.2
Iwatsuka, K.3
-
41
-
-
0029587448
-
Enhancement of HL-60 differentiation by a new class of retinoids with selective activity on retinoid X receptor
-
DOI 10.1074/jbc.270.51.30765
-
Apfel CM, Kamber M, Klaus M, et al. Enhancement of HL-60 differentiation by a new class of retinoids with selective activity on retinoid X receptor. J Biol Chem 1995;270:30765-72 (Pubitemid 26005145)
-
(1995)
Journal of Biological Chemistry
, vol.270
, Issue.51
, pp. 30765-30772
-
-
Apfel, C.M.1
Kamber, M.2
Klaus, M.3
Mohr, P.4
Keidel, S.5
LeMotte, P.K.6
-
42
-
-
2442608526
-
Synthetic retinoids and their nuclear receptors
-
DOI 10.2174/1568011043352975
-
Dawson MI. Synthetic retinoids and their nuclear receptors. Curr Med Chem Anti Cancer Agents 2004;4:199-230 (Pubitemid 38647583)
-
(2004)
Current Medicinal Chemistry - Anti-Cancer Agents
, vol.4
, Issue.3
, pp. 199-230
-
-
Dawson, M.I.1
-
43
-
-
4344703257
-
Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid
-
DOI 10.1093/carcin/bgh122
-
Balasubramanian S, Chandraratna RAS, Eckert RL. Supression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid. Carcinogenesis 2004;25:1377-85 (Pubitemid 39162704)
-
(2004)
Carcinogenesis
, vol.25
, Issue.8
, pp. 1377-1385
-
-
Balasubramanian, S.1
Chandraratna, R.A.S.2
Eckert, R.L.3
-
44
-
-
35948982992
-
A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland
-
DOI 10.1158/1078-0432.CCR-07-1342
-
Liby K, Royce DB, Risingsong R, et al. A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland. Clin Cancer Res 2007;13:6237-43 (Pubitemid 350075086)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.20
, pp. 6237-6243
-
-
Liby, K.1
Royce, D.B.2
Risingsong, R.3
Williams, C.R.4
Wood, M.D.5
Chandraratna, R.A.6
Sporn, M.B.7
-
45
-
-
15444345866
-
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias
-
DOI 10.1021/jm970635h
-
Muccio DD, Brouillette WJ, Breitman TR, et al. Conformationally defined retinoid acid analogues. 4. Potential new agents for acute promielocytic and juvenile myelomonocytic leukemias. J Med Chem 1998;41:1679-87 (Pubitemid 28221961)
-
(1998)
Journal of Medicinal Chemistry
, vol.41
, Issue.10
, pp. 1679-1687
-
-
Muccio, D.D.1
Brouillette, W.J.2
Breitman, T.R.3
Taimi, M.4
Emanuel, P.D.5
Zhang, X.-K.6
Chen, G.-Q.7
Sani, B.P.8
Venepally, P.9
Reddy, L.10
Alam, M.11
Simpson-Herren, L.12
Hill, D.L.13
-
46
-
-
78650311702
-
A Pilot, First-in-human, pharmacokinetic study of 9cUAB30 in healthy volunteers
-
Kolesar JM, Hoel R, Pomplun M, et al. A Pilot, First-in-human, pharmacokinetic study of 9cUAB30 in healthy volunteers. Cancer Prev Res 2010;3:1565-70
-
(2010)
Cancer Prev Res
, vol.3
, pp. 1565-1570
-
-
Kolesar, J.M.1
Hoel, R.2
Pomplun, M.3
-
47
-
-
77951104122
-
Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemoprevention
-
Kapetanovic IM, Horn TL, Johnson WD, et al. Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemoprevention. Int J Toxicol 2010;29:157-64
-
(2010)
Int J Toxicol
, vol.29
, pp. 157-164
-
-
Kapetanovic, I.M.1
Horn, T.L.2
Johnson, W.D.3
-
48
-
-
0037212108
-
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid
-
DOI 10.1016/S0960-894X(02)00924-1, PII S0960894X02009241
-
Farmer LJ, Zhi L, Jeong S, et al. Retinoic acid receptor ligands based on the 6-Cyclopropyl-2,4-hexadienoic acid. Bioorg Med Chem Lett 2003;13:261-4 (Pubitemid 35441347)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.2
, pp. 261-264
-
-
Farmer, L.J.1
Zhi, L.2
Jeong, S.3
Lamph, W.W.4
Osburn, D.L.5
Croston, G.6
Flatten, K.S.7
Heyman, R.A.8
Nadzan, A.M.9
-
49
-
-
0141455873
-
Design, synthesis, and structure - Activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids
-
DOI 10.1021/jm020401k
-
Michellys PY, Ardecky RA, Chen J-H, et al. Design, synthesis and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5- dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids. J Med Chem 2003;46:4087-103 (Pubitemid 37122452)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.19
, pp. 4087-4103
-
-
Michellys, P.-Y.1
Ardecky, R.J.2
Chen, J.-H.3
D'Arrigo, J.4
Grese, T.A.5
Karanewsky, D.S.6
Leibowitz, M.D.7
Liu, S.8
Mais, D.A.9
Mapes, C.M.10
Montrose-Rafizadeh, C.11
Ogilvie, K.M.12
Reifel-Miller, A.13
Rungta, D.14
Thompson, A.W.15
Tyhonas, J.S.16
Boehm, M.F.17
-
50
-
-
30944433200
-
Biological characterization of a heterodimer-selective retinoid X receptor modulator: Potential benefits for the treatment of type 2 diabetes
-
DOI 10.1210/en.2005-0690
-
Leibowitz MD, Ardecky RJ, Boehm MF, et al. Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 2006;147:1044-53 (Pubitemid 43113025)
-
(2006)
Endocrinology
, vol.147
, Issue.2
, pp. 1044-1053
-
-
Leibowitz, M.D.1
Ardecky, R.J.2
Boehm, M.F.3
Broderick, C.L.4
Carfagna, M.A.5
Crombie, D.L.6
D'Arrigo, J.7
Etgen, G.J.8
Faul, M.M.9
Grese, T.A.10
Havel, H.11
Hein, N.I.12
Heyman, R.A.13
Jolley, D.14
Klausing, K.15
Liu, S.16
Mais, D.E.17
Mapes, C.M.18
Marschke, K.B.19
Michellys, P.-Y.20
Montrose-Rafizadeh, C.21
Ogilvie, K.M.22
Pascual, B.23
Rungta, D.24
Tyhonas, J.S.25
Urcan, M.S.26
Wardlow, M.27
Yumibe, N.28
Reifel-Miller, A.29
more..
-
51
-
-
0038454672
-
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6- trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes
-
DOI 10.1021/jm020340q
-
Michellys PY, Ardecky RA, Chen J-H, et al. Novel (2E,4E,6Z)-7-(2-Alkoxy- 3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J Med Chem 2003;46:2683-96 (Pubitemid 36702537)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.13
, pp. 2683-2696
-
-
Michellys, P.Y.1
Ardecky, R.J.2
Chen, J.H.3
Crombie, D.L.4
Etgen, G.J.5
Faul, M.M.6
Faulkner, A.L.7
Grese, T.A.8
Heyman, R.A.9
Karanewsky, D.S.10
Klausing, K.11
Leibowitz, M.D.12
Liu, S.13
Mais, D.A.14
Mapes, C.M.15
Marschke, K.B.16
Reifel-Miller, A.17
Ogilvie, K.M.18
Rungta, D.19
Thompson, A.W.20
Tyhonas, J.S.21
Boehm, M.F.22
more..
-
52
-
-
10744224797
-
Design and synthesis of fluorinated RXR modulators
-
DOI 10.1016/S0960-894X(03)00703-0
-
Gernert DL, Ajamie R, Ardecky RA, et al. Design and synthesis of fluorinated RXR modulators. Bioorg Med Chem Lett 2003;13:3191-5 (Pubitemid 37093826)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.19
, pp. 3191-3195
-
-
Gernert, D.L.1
Ajamie, R.2
Ardecky, R.A.3
Bell, M.G.4
Leibowitz, M.D.5
Mais, D.A.6
Mapes, C.M.7
Michellys, P.Y.8
Rungta, D.9
Reifel-Miller, A.10
Tyhonas, J.S.11
Yumibe, N.12
Grese, T.A.13
-
53
-
-
10744225472
-
Design, synthesis and structure-activity relationship of novel RXR-selective modulators
-
DOI 10.1016/j.bmcl.2003.12.089, PII S0960894X04000253
-
Michellys PY, D'Arrigo J, Grese TA, et al. Design, synthesis and structure-activity relationship of novel RXR-selective modulators. Bioorg Med Chem Lett 2004;14:1593-8 (Pubitemid 38299458)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.6
, pp. 1593-1598
-
-
Michellys, P.-Y.1
D'Arrigo, J.2
Grese, T.A.3
Karanewsky, D.S.4
Leibowitz, M.D.5
Mais, D.A.6
Mapes, C.M.7
Reifel-Miller, A.8
Rungta, D.9
Boehm, M.F.10
-
54
-
-
0029763777
-
Identification of the first retinoid X receptor homodimer antagonist
-
DOI 10.1021/jm960311d
-
Canan Koch SS, Dardashti LJ, Hebert JJ, et al. Identification of the first retinoid X receptor homodimer antagonist. J Med Chem 1996;39:3229-34 (Pubitemid 26322845)
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, Issue.17
, pp. 3229-3234
-
-
Koch, S.S.C.1
Dardashti, L.J.2
Hebert, J.J.3
White, S.K.4
Croston, G.E.5
Flatten, K.S.6
Heyman, R.A.7
Nadzan, A.M.8
-
55
-
-
0031043055
-
The phantom ligand effect: Allosteric control of transcription by the retinoid X receptor
-
Schulman IG, Li C, Schwabe JW, Evans RM. The phantom ligand effect: allosteric control of transcription by the retinoid X receptor. Genes Dev 1997;11:299-308 (Pubitemid 27079908)
-
(1997)
Genes and Development
, vol.11
, Issue.3
, pp. 299-308
-
-
Schulman, I.G.1
Li, C.2
Schwabe, J.W.R.3
Evans, R.M.4
-
56
-
-
0029097177
-
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells
-
Boehm MF, Zhang L, Zhi L, et al. Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J Med Chem 1995;38:3146-55
-
(1995)
J Med Chem
, vol.38
, pp. 3146-3155
-
-
Boehm, M.F.1
Zhang, L.2
Zhi, L.3
-
57
-
-
0033535580
-
Central hypothyroidism associated with retinoid X receptor-selective ligands
-
DOI 10.1056/NEJM199904083401404
-
Sherman SI, Gopal J, Haugen BR, et al. Central hypothyroidism associated with retinoid X receptor-selective ligands. N Engl J Med 1999;340:1075-9 (Pubitemid 29162512)
-
(1999)
New England Journal of Medicine
, vol.340
, Issue.14
, pp. 1075-1079
-
-
Sherman, S.I.1
Gopal, J.2
Haugen, B.R.3
Chiu, A.C.4
Whaley, K.5
Nowlakha, P.6
Duvic, M.7
-
58
-
-
70349645985
-
Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: Novel analogues of 4-[1-(3, 5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl] benzoic acid (Bexarotene)
-
Wagner CE, Jurutka PW, Marshall PA, et al. Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl) ethynyl] benzoic acid (Bexarotene). J Med Chem 2009;52:5950-66
-
(2009)
J Med Chem
, vol.52
, pp. 5950-5966
-
-
Wagner, C.E.1
Jurutka, P.W.2
Marshall, P.A.3
-
59
-
-
34447132935
-
Bexarotene-induced hypothyroidism: Bexarotene stimulates the peripheral metabolism of thyroid hormones
-
DOI 10.1210/jc.2006-2822
-
Smit JWA, Stokkel MPM, Pereira AM, et al. Bexarotene-induced hypothyroidism: bexarotene stimulates the peripheral metabolism of thyroid hormones. J Clin Endocrinol Metabol 2007;92:2496-9 (Pubitemid 47037348)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, Issue.7
, pp. 2496-2499
-
-
Smit, J.W.A.1
Stokkel, M.P.M.2
Pereira, A.M.3
Romijn, J.A.4
Visser, T.J.5
-
60
-
-
0345289652
-
The treatment of cutaneous T-cell lymphoma with a novel retinoid
-
Heald P. The treatment of cutaneous T-cell lymphoma with a novel retinoid. Clin Lymphoma 2000;1:S45-9
-
(2000)
Clin Lymphoma
, vol.1
-
-
Heald, P.1
-
61
-
-
42949179105
-
Phase III trial comparing carboplatin, paclitaxel, and bexarotene with carboplatin and paclitaxel in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT II
-
Blumenschein GR, Khuri FR, von Pawel J, et al. Phase III trial comparing carboplatin, paclitaxel, and bexarotene with carboplatin and paclitaxel in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT II. J Clin Oncol 2008;26:1879-85
-
(2008)
J Clin Oncol
, vol.26
, pp. 1879-1885
-
-
Blumenschein, G.R.1
Khuri, F.R.2
Von Pawel, J.3
-
63
-
-
0037445123
-
Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer
-
DOI 10.1200/JCO.2003.05.068
-
Esteva FJ, Glaspy J, Baidas S, et al. Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer. J Clin Oncol 2003;21:999-1006 (Pubitemid 46594127)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.6
, pp. 999-1006
-
-
Esteva, F.J.1
Glaspy, J.2
Baidas, S.3
Laufman, L.4
Hutchins, L.5
Dickler, M.6
Tripathy, D.7
Cohen, R.8
DeMichele, A.9
Yocum, R.C.10
Osborne, C.K.11
Hayes, D.F.12
Hortobagyi, G.N.13
Winer, E.14
Demetri, G.D.15
-
64
-
-
42949162662
-
Randomized phase III trial comparing bexarotene (L1069-49)/cisplatin/ vinorelbine with cisplatin/vinorelbine in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT i
-
Ramlau R, Zatloukal P, Jassem J, et al. Randomized phase III trial comparing bexarotene (L1069-49)/cisplatin/vinorelbine with cisplatin/vinorelbine in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT I. J Clin Oncol 2008;26:1886-92
-
(2008)
J Clin Oncol
, vol.26
, pp. 1886-1892
-
-
Ramlau, R.1
Zatloukal, P.2
Jassem, J.3
-
65
-
-
23144441588
-
Synthesis, crystal structure analysis, and pharmacological characterization of disila-bexarotene, a disila-analogue of the RXR-selective retinoid agonist bexarotene
-
DOI 10.1021/om040143k
-
Daiss JO, Burschka C, Mills JS, et al. Synthesis, crystal structure analysis, and pharmacological characterization of disila-bexarotene, a disila-analogue of the RXR-selective retinoid agonist bexarotene. Organometallics 2005;24:3192-9 (Pubitemid 41081649)
-
(2005)
Organometallics
, vol.24
, Issue.13
, pp. 3192-3199
-
-
Daiss, J.O.1
Burschka, C.2
Mills, J.S.3
Montana, J.G.4
Showell, G.A.5
Fleming, I.6
Gaudon, C.7
Ivanova, D.8
Gronemeyer, H.9
Tacke, R.10
-
66
-
-
67749095172
-
Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): Chemistry and biology
-
Lippert WP, Christian B, Kathrin G, et al. Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology. ChemMedChem 2009;4:1143-52
-
(2009)
ChemMedChem
, vol.4
, pp. 1143-1152
-
-
Lippert, W.P.1
Christian, B.2
Kathrin, G.3
-
67
-
-
79960678004
-
Novel silicon-containing analogues of the retinoid agonist bexarotene: Syntheses and biological effects on human pluripotent stem cells
-
Bauer JB, Lippert WP, Dorrich S, et al. Novel silicon-containing analogues of the retinoid agonist bexarotene: syntheses and biological effects on human pluripotent stem cells. ChemMedChem 2011;6:1509-17
-
(2011)
ChemMedChem
, vol.6
, pp. 1509-1517
-
-
Bauer, J.B.1
Lippert, W.P.2
Dorrich, S.3
-
68
-
-
0035943298
-
Synthesis of novel retinoid X receptor-selective retinoids
-
DOI 10.1021/jo0103064
-
Faul MM, Ratz AM, Sullivan KA, et al. Synthesis of novel retinoid X receptor-selective retinoids. J Org Chem 2001;66:5772-82 (Pubitemid 32867473)
-
(2001)
Journal of Organic Chemistry
, vol.66
, Issue.17
, pp. 5772-5782
-
-
Faul, M.M.1
Ratz, A.M.2
Sullivan, K.A.3
Trankle, W.G.4
Winneroski, L.L.5
-
69
-
-
0005016202
-
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells
-
DOI 10.1021/jm980621r
-
Canan-Koch SS, Dardashti LJ, Cesario RM, et al. Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells. J Med Chem 1999;42:742-50 (Pubitemid 29110789)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.4
, pp. 742-750
-
-
Koch, S.S.C.1
Dardashti, L.J.2
Cesario, R.M.3
Croston, G.E.4
Boehm, M.F.5
Heyman, R.A.6
Nadzan, A.M.7
-
70
-
-
6844255855
-
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers
-
DOI 10.1021/jm9704309
-
Umemiya H, Fukasawa H, Ebisawa M, et al. Regulation of retinoidal actions by diazepinylbenzoic acids. retinoid synergists activate the RXR-RAR heterodimers. J Med Chem 1997;40:4222-34 (Pubitemid 28042303)
-
(1997)
Journal of Medicinal Chemistry
, vol.40
, Issue.26
, pp. 4222-4234
-
-
Umemiya, H.1
Fukasawa, H.2
Ebisawa, M.3
Eyrolles, L.4
Kawachi, E.5
Eisenmann, G.6
Gronemeyer, H.7
Hashimoto, Y.8
Shudo, K.9
Kagechika, H.10
-
71
-
-
2442632493
-
Retinoid X receptor-antagonistic diazepinylbenzoic acids
-
Ebisawa M, Umemiya H, Ohta K, et al. Retinoid X receptor-antagonistic diazepinylbenzoic acids. Chem Pharm Bull 1999;47:1778-86 (Pubitemid 30020563)
-
(1999)
Chemical and Pharmaceutical Bulletin
, vol.47
, Issue.12
, pp. 1778-1786
-
-
Ebisawa, M.1
Umemiya, H.2
Ohta, K.3
Fukasawa, H.4
Kawachi, E.5
Christoffel, G.6
Gronemeyer, H.7
Tsuji, M.8
Hashimoto, Y.9
Shudo, K.10
Kagechika, H.11
-
72
-
-
34547531502
-
Synthesis and structure-activity relationship of novel RXR antagonists: Orally active anti-diabetic and anti-obesity agents
-
DOI 10.1016/j.bmcl.2007.06.080, PII S0960894X07007524
-
Sakaki J, Kishida M, Konishi K, et al. Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents. Bioorg Med Chem Lett 2007;17:4804-7 (Pubitemid 47187706)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.17
, pp. 4804-4807
-
-
Sakaki, J.1
Kishida, M.2
Konishi, K.3
Gunji, H.4
Toyao, A.5
Matsumoto, Y.6
Kanazawa, T.7
Uchiyama, H.8
Fukaya, H.9
Mitani, H.10
Arai, Y.11
Kimura, M.12
-
73
-
-
34547542759
-
Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure
-
DOI 10.1016/j.bmcl.2007.06.079, PII S0960894X07007512
-
Sakaki J, Konishi K, Kishida M, et al. Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure. Bioorg Med Chem Lett 2007;17:4808-11 (Pubitemid 47187705)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.17
, pp. 4808-4811
-
-
Sakaki, J.1
Konishi, K.2
Kishida, M.3
Gunji, H.4
Kanazawa, T.5
Uchiyama, H.6
Fukaya, H.7
Mitani, H.8
Kimura, M.9
-
74
-
-
79954419081
-
Diphenylamine-based retinoid antagonists: Regulation of RAR and RXR function depending on the N-substituent
-
Ohta K, Kawachi E, Fukasawa H, et al. Diphenylamine-based retinoid antagonists: regulation of RAR and RXR function depending on the N-substituent. Bioorg Med Chem 2011;19:2501-7
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 2501-2507
-
-
Ohta, K.1
Kawachi, E.2
Fukasawa, H.3
-
75
-
-
0031807177
-
Potent retinoid synergists with a diphenylamine skeleton
-
Ohta K, Tsuji M, Kawachi E, et al. Potent retinoid synergists with a diphenylamine skeleton. Biol Pharm Bull 1998;21:544-6 (Pubitemid 28259434)
-
(1998)
Biological and Pharmaceutical Bulletin
, vol.21
, Issue.5
, pp. 544-546
-
-
Ohta, K.1
Tsuji, M.2
Kawachi, E.3
Fukasawa, H.4
Hashimoto, Y.5
Shudo, K.6
Kagechika, H.7
-
76
-
-
7044260678
-
Novel retinoid X receptor (RXR) antagonists having a dicarba-closo- dodecaborane as a hydrophobic moiety
-
DOI 10.1016/j.bmcl.2004.09.035, PII S0960894X04011473
-
Ohta K, Iijima T, Kawachi E, et al. Novel retinoid X receptor (RXR) antagonists having a dicarba-closo-dodecaborane as a hydrophobic moiety. Bioorg Med Chem Lett 2004;14:5913-18 (Pubitemid 39421543)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.23
, pp. 5913-5918
-
-
Ohta, K.1
Iijima, T.2
Kawachi, E.3
Kagechika, H.4
Endo, Y.5
-
77
-
-
0036682057
-
Novel retinoid X receptor antagonists: Specific inhibition of retinoid synergism in RXR-RAR heterodimers
-
Takahashi B, Ohta K, Kawachi E, et al. Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimers. J Med Chem 2002;45:3327-9
-
(2002)
J Med Chem
, vol.45
, pp. 3327-3329
-
-
Takahashi, B.1
Ohta, K.2
Kawachi, E.3
-
78
-
-
78650207455
-
Modification at the lipophilic domain of RXR agonists differentially influences activation of RXR heterodimers
-
Ohsawa F. Morishita K-i, Yamada S, Makishima M, et al. Modification at the lipophilic domain of RXR agonists differentially influences activation of RXR heterodimers. ACS Med Chem Lett 2010;1:521-5
-
(2010)
ACS Med Chem Lett
, vol.1
, pp. 521-525
-
-
Ohsawa, F.1
K-I, M.2
Yamada, S.3
Makishima, M.4
-
79
-
-
83455258276
-
Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IB
-
Nakayama M, Yamada S, Ohsawa F, et al. Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IB. ACS Med Chem Lett 2011;2:896-900
-
(2011)
ACS Med Chem Lett
, vol.2
, pp. 896-900
-
-
Nakayama, M.1
Yamada, S.2
Ohsawa, F.3
-
80
-
-
77955654529
-
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation
-
Fujii S, Ohsawa F, Yamada S, et al. Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation. Bioorg Med Chem 2010;20:5139-42
-
(2010)
Bioorg Med Chem
, vol.20
, pp. 5139-5142
-
-
Fujii, S.1
Ohsawa, F.2
Yamada, S.3
-
81
-
-
84867950475
-
Preparation of bicyclic aromatic compounds and their use in cosmetic or dermatological compositions
-
Bernardon J-M. Preparation of bicyclic aromatic compounds and their use in cosmetic or dermatological compositions. PCT Int. Appl. WO9733881; 1997
-
(1997)
PCT Int. Appl.
-
-
Bernardon, J.-M.1
-
82
-
-
67650486116
-
Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors
-
García J, Khanwalkar H, Pereira R, et al. Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors. ChemBioChem 2009;10:1252-9
-
(2009)
ChemBioChem
, vol.10
, pp. 1252-1259
-
-
García, J.1
Khanwalkar, H.2
Pereira, R.3
-
83
-
-
64249148867
-
Highly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles
-
Pérez-Rodríguez S, Ortiz MA, Pereira R, et al. Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles. Eur J Med Chem 2009;44:2434-46
-
(2009)
Eur J Med Chem
, vol.44
, pp. 2434-2446
-
-
Pérez-Rodríguez, S.1
Ortiz, M.A.2
Pereira, R.3
-
84
-
-
34249309592
-
RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia
-
DOI 10.1016/j.bmcl.2007.01.047, PII S0960894X07000984
-
Lagu B, Pio B, Lebedev R, et al. RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia. Bioorg Med Chem Lett 2007;17:3497-503 (Pubitemid 46819007)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.12
, pp. 3497-3503
-
-
Lagu, B.1
Pio, B.2
Lebedev, R.3
Yang, M.4
Pelton, P.D.5
-
85
-
-
34249304805
-
Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia
-
DOI 10.1016/j.bmcl.2007.01.049, PII S0960894X0700100X
-
Lagu B, Lebedev R, Pio B, et al. Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia. Bioorg Med Chem Lett 2007;17:3491-6 (Pubitemid 46819008)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.12
, pp. 3491-3496
-
-
Lagu, B.1
Lebedev, R.2
Pio, B.3
Yang, M.4
Pelton, P.D.5
-
86
-
-
77956220279
-
Identification of a Naturally occurring rexinoid, honokiol, that activates the retinoid X receptor
-
Kotani H, Tanabe H, Mizukami H, et al. Identification of a Naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. J Nat Prod 2010;73:1332-6
-
(2010)
J Nat Prod
, vol.73
, pp. 1332-1336
-
-
Kotani, H.1
Tanabe, H.2
Mizukami, H.3
-
87
-
-
78751539633
-
Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor
-
Zhang H, Zhou R, Li L, et al. Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem 2011;286:1868-75
-
(2011)
J Biol Chem
, vol.286
, pp. 1868-1875
-
-
Zhang, H.1
Zhou, R.2
Li, L.3
-
88
-
-
79952006933
-
Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode
-
Zhang H, Li L, Chen L, et al. Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode. J Mol Biol 2011;407:13-20
-
(2011)
J Mol Biol
, vol.407
, pp. 13-20
-
-
Zhang, H.1
Li, L.2
Chen, L.3
-
89
-
-
33845996557
-
Asymmetric cleavage of β-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses
-
DOI 10.1210/me.2006-0225
-
Ziouzenkova O, Orasanu G, Sukhova G, et al. Asymmetric cleavage of b-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses. Mol Endocrinol 2007;21:77-88 (Pubitemid 46041692)
-
(2007)
Molecular Endocrinology
, vol.21
, Issue.1
, pp. 77-88
-
-
Ziouzenkova, O.1
Orasanu, G.2
Sukhova, G.3
Lau, E.4
Berger, J.P.5
Tang, G.6
Krinsky, N.I.7
Dolnikowski, G.G.8
Plutzky, J.9
-
90
-
-
77957899316
-
The eccentric cleavage product of b-carotene, b-apo-13-carotenone, functions as an antagonist of RXRa
-
Eroglu A, Hruszkewycz DP, Curley RW Jr, Harrison EH. The eccentric cleavage product of b-carotene, b-apo-13-carotenone, functions as an antagonist of RXRa. Arch Biochem Biophys 2010;504:11-16
-
(2010)
Arch Biochem Biophys
, vol.504
, pp. 11-16
-
-
Eroglu, A.1
Hruszkewycz, D.P.2
Curley Jr., R.W.3
Harrison, E.H.4
-
91
-
-
20044365801
-
The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis
-
DOI 10.1073/pnas.0409721102
-
Kolluri SK, Corr M, James SY, et al. The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci USA 2005;102:2525-30 (Pubitemid 40279410)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.7
, pp. 2525-2530
-
-
Kolluri, S.K.1
Corr, M.2
James, S.Y.3
Bernasconi, M.4
Lu, D.5
Liu, W.6
Cottam, H.B.7
Leoni, L.M.8
Carson, D.A.9
Zhang, X.-K.10
-
92
-
-
77953283014
-
NSAID sulindac and its analog bind RXR ± and nhibit RXR ±-dependent AKT signaling
-
Zhou H, Liu W, Su Y, et al. NSAID sulindac and its analog bind RXR ± and nhibit RXR ±-dependent AKT signaling. Cancer Cell 2010;17:560-73
-
(2010)
Cancer Cell
, vol.17
, pp. 560-573
-
-
Zhou, H.1
Liu, W.2
Su, Y.3
-
93
-
-
44949173950
-
Assessment of scaffold hopping efficiency by use of molecular interaction fingerprints
-
DOI 10.1021/jm8001058
-
Venhorst J, N-uñez S, Terpstra JW, Kruse CG. Assessment of scaffold hopping efficiency by use of molecular interaction fingerprints. J Med Chem 2008;51:3222-9 (Pubitemid 351821881)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.11
, pp. 3222-3229
-
-
Venhorst, J.1
Nunez, S.2
Terpstra, J.W.3
Kruse, C.G.4
-
94
-
-
67749114627
-
Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor g Ligand 1-Di(1H-indol-3-yl)methyl-4- trifluoromethylbenzene
-
Dawson MI, Ye M, Cao X, et al. Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor g Ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene. ChemMedChem 2009;4:1106-19
-
(2009)
ChemMedChem
, vol.4
, pp. 1106-1119
-
-
Dawson, M.I.1
Ye, M.2
Cao, X.3
-
95
-
-
64249099170
-
Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors
-
le Maire A, Grimaldi M, Roecklin D, et al. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO Rep 2009;10:367-73
-
(2009)
EMBO Rep
, vol.10
, pp. 367-373
-
-
Le Maire, A.1
Grimaldi, M.2
Roecklin, D.3
-
96
-
-
33751533155
-
The pharmacology and classification of the nuclear receptor superfamily RETINOID X RECEPTORS (RXRs)
-
Germain P, Chambon P, Eichele G, et al. The pharmacology and classification of the nuclear receptor superfamily. RETINOID X RECEPTORS (RXRs). Pharmacol Rev 2006;58:760-72
-
(2006)
Pharmacol Rev
, vol.58
, pp. 760-772
-
-
Germain, P.1
Chambon, P.2
Eichele, G.3
-
97
-
-
47649097615
-
The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety NEt-3IP (RXRa/b-dual agonist)
-
Takamatsu K, Takano A, Yakushiji N, et al. The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRa/b-dual agonist). ChemMedChem 2008;3:780-7
-
(2008)
ChemMedChem
, vol.3
, pp. 780-787
-
-
Takamatsu, K.1
Takano, A.2
Yakushiji, N.3
-
98
-
-
48049114021
-
Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRa-preferential agonist possessing a sulfonamide moiety
-
Takamatsu K, Takano A, Yakushiji N, et al. Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRa-preferential agonist possessing a sulfonamide moiety. ChemMedChem 2008;3:454-60
-
(2008)
ChemMedChem
, vol.3
, pp. 454-460
-
-
Takamatsu, K.1
Takano, A.2
Yakushiji, N.3
-
99
-
-
58849150709
-
Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity
-
Morishita K, Yakushiji N, Ohsawa F, et al. Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity. Bioorg Med Chem Lett 2009;19:1001-3
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 1001-1003
-
-
Morishita, K.1
Yakushiji, N.2
Ohsawa, F.3
-
100
-
-
84861031956
-
RXR partial agonist CBt-PMN exerts therapeutic effects on type 2 diabetes without the side effects of RXR full agonists
-
Kakuta H, Yakushiji N, Shinozaki R, et al. RXR partial agonist CBt-PMN exerts therapeutic effects on type 2 diabetes without the side effects of RXR full agonists. ACS Med Chem Lett 2012;3:427-32
-
(2012)
ACS Med Chem Lett
, vol.3
, pp. 427-432
-
-
Kakuta, H.1
Yakushiji, N.2
Shinozaki, R.3
-
101
-
-
85047685428
-
Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes
-
DOI 10.1172/JCI200112864
-
Yamauchi T, Waki H, Kamon J, et al. Inhibition of RXR and PPARg ameliorates diet-induced obesity and type 2 diabetes. J Clin Inv 2001;108:1001-13 (Pubitemid 32946074)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.7
, pp. 1001-1013
-
-
Yamauchi, T.1
Waki, H.2
Kamon, J.3
Murakami, K.4
Motojima, K.5
Komeda, K.6
Miki, H.7
Kubota, N.8
Terauchi, Y.9
Tsuchida, A.10
Tsuboyama-Kasaoka, N.11
Yamauchi, N.12
Ide, T.13
Hori, W.14
Kato, S.15
Fukayama, M.16
Akanuma, Y.17
Ezaki, O.18
Itai, A.19
Nagai, R.20
Kimura, S.21
Tobe, K.22
Kagechika, H.23
Shudo, K.24
Kadowaki, T.25
more..
-
102
-
-
34848834842
-
RAR and RXR modulation in cancer and metabolic disease
-
DOI 10.1038/nrd2397, PII NRD2397
-
Altucci L, Leibowitz MD, Ogilvie KM, et al. RAR and RXR modulation in cancer and Metabolic disease. Nat Rev Drug Disc 2007;6:793-810 (Pubitemid 47504871)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.10
, pp. 793-810
-
-
Altucci, L.1
Leibowitz, M.D.2
Ogilvie, K.M.3
De Lera, A.R.4
Gronemeyer, H.5
-
103
-
-
34247526984
-
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
-
DOI 10.1038/nrc2129, PII NRC2129
-
Liby KT, Yore MM, Sporn MB. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat Rev Cancer 2007;7:357-69 (Pubitemid 46652485)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.5
, pp. 357-369
-
-
Liby, K.T.1
Yore, M.M.2
Sporn, M.B.3
-
104
-
-
84862777666
-
ApoE-directed therapeutics rapidly clear b-amyloid and reverse deficits in AD mouse models
-
Cramer PE, Cirrito JR, Wesson DW, et al. ApoE-directed therapeutics rapidly clear b-amyloid and reverse deficits in AD mouse models. Science 2012;335:1503-6
-
(2012)
Science
, vol.335
, pp. 1503-1506
-
-
Cramer, P.E.1
Cirrito, J.R.2
Wesson, D.W.3
-
105
-
-
17444442152
-
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
-
DOI 10.1038/386407a0
-
Mukherjee R, Davies PJA, Crombie DL, et al. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 1997;386:407-10 (Pubitemid 27154482)
-
(1997)
Nature
, vol.386
, Issue.6623
, pp. 407-410
-
-
Mukherjee, R.1
Davies, P.J.A.2
Crombie, D.L.3
Bischoff, E.D.4
Cesario, R.M.5
Jow, L.6
Hamann, L.G.7
Boehm, M.F.8
Mondon, C.E.9
Nadzan, A.M.10
Paterniti Jr., J.R.11
Heyman, R.A.12
-
106
-
-
84855613853
-
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial
-
Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 2012;69:29-38
-
(2012)
Arch Neurol
, vol.69
, pp. 29-38
-
-
Craft, S.1
Baker, L.D.2
Montine, T.J.3
|