Synthesis and Biological Evaluation of Nitrated 7-, 8-, 9-, and 10-Hydroxyindenoisoquinolines as Potential Dual Topoisomerase i (Top1)-Tyrosyl-DNA Phosphodiesterase i (TDP1) Inhibitors

Journal of Medicinal Chemistry

Volumn 58, Issue 7, 2015, Pages 3188-3208

  Nguyen, Trung Xuan ^a   Abdelmalak, Monica ^b   Marchand, Christophe ^b   Agama, Keli ^b   Pommier, Yves ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 (HYDROXY) 6 (3 MORPHOLINOPROPYL) 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11(6H) DIONE; 6 [3 (1H IMIDAZOL 1 YL)PROPYL] 7 HYDROXY 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11(6H) DIONE; 6 [3 (1H IMIDAZOL 1 YL)PROPYL] 9 (BENZYLOXY) 8 METHOXY 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11(6H) DIONE; 6 [3 (1H IMIDAZOL 1 YL)PROPYL] 9 HYDROXY 8 METHOXY 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11(6H) DIONE HYDROBROMIDE; 7 HYDROXY 6 (3 MORPHOLINOPROPYL) 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11(6H) DIONE; 8 (BENZYLOXY) 9 METHOXY 6 (3 MORPHOLINOPROPYL) 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11[6H] DIONE; 8 (HYDROXY) 6 (3 MORPHOLINOPROPYL) 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11(6H) DIONE; 8 HYDROXY 9 METHOXY 6 (3 MORPHOLINOPROPYL) 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11(6H) DIONE HYDROBROMIDE; 9 (BENZYLOXY) 6 (3 BROMOPROPYL) 8 METHOXY 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11(6H) DIONE; 9 HYDROXY 8 METHOXY 6 (3 MORPHOLINOPROPYL) 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11(6H) DIONE; 9(BENZYLOXY) 8 METHOXY 6 (3 MORPHOLINOPROPYL) 3 NITRO 5H INDENO[1,2 C]ISOQUINOLINE 5,11[6H] DIONEI; ALKALOID; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CIS 3 [4 (BENZYLOXY) 3 METHOXYPHENYL] N (3 BROMOPROPYL) 4 CARBOXY 3 ,4 DIHYDRO 7 NITRO 1(2H) ISOQUINOLINE; DNA TOPOISOMERASE; ISOQUINOLINE DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG; DNA TOPOISOMERASE INHIBITOR; INDENE DERIVATIVE; NITRIC ACID DERIVATIVE; NORINDENOISOQUINOLINE; PHOSPHODIESTERASE; TOP1 PROTEIN, HUMAN; TYROSYL-DNA PHOSPHODIESTERASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; DEBENZYLATION; DNA CLEAVAGE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; MOLECULAR MODEL; NITRATION; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DOSE RESPONSE; GENETICS; METABOLISM; PRECLINICAL STUDY; PROCEDURES; SYNTHESIS;

CAMPTOTHECIN; CHEMISTRY TECHNIQUES, SYNTHETIC; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; INDENES; ISOQUINOLINES; NITRATES; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

EID: 84927619021     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00136     Document Type: Article

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