Modification at the lipophilic domain of RXR agonists differentially influences activation of RXR heterodimers

ACS Medicinal Chemistry Letters

Volumn 1, Issue 9, 2010, Pages 521-525

  Ohsawa, Fuminori ^a,b   Morishita, Ken Ichi ^a   Yamada, Shoya ^a   Makishima, Makoto ^c   Kakuta, Hiroki ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

heterodimer activation; LXR; permissive heterodimers; PPAR; reporter gene assay; RXR agonists

Indexed keywords

6 [ETHYL (3 ISOPROPOXY 4 ISOPROPYLPHENYL)AMINO]NICOTINIC ACID; BENZYLOXY DERIVATIVE; CYCLOPROPYLMETHOXY DERIVATIVE; HETERODIMER; LIVER X RECEPTOR AGONIST; N PROPOXY DERIVATIVE; NICOTINIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

EID: 78650207455     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100184k     Document Type: Article

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