메뉴 건너뛰기




Volumn 17, Issue 24, 2003, Pages 3036-3047

Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells

Author keywords

Dopamine neurons; Neuronal survival; Nuclear receptor; Orphan receptor; Retinoid X receptor

Indexed keywords

DIMER; LIGAND; NUCLEAR RECEPTOR RELATED FACTOR 1; RETINOID X RECEPTOR;

EID: 2942655572     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.276003     Document Type: Article
Times cited : (122)

References (64)
  • 1
    • 0037144591 scopus 로고    scopus 로고
    • Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1
    • Aarnisalo, P., Kim, C.H., Lee, J.W., and Perlmann, T. 2002. Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1. J. Biol. Chem. 277: 35118-35123.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35118-35123
    • Aarnisalo, P.1    Kim, C.H.2    Lee, J.W.3    Perlmann, T.4
  • 3
    • 0034957480 scopus 로고    scopus 로고
    • Nuclear hormone receptors and gene expression
    • Aranda, A. and Pascual, A. 2001. Nuclear hormone receptors and gene expression. Physiol. Rev. 81: 1269-1304.
    • (2001) Physiol. Rev. , vol.81 , pp. 1269-1304
    • Aranda, A.1    Pascual, A.2
  • 4
    • 0026523529 scopus 로고
    • The hydrolysis of natural phosphatidylethanolamines by phospholipase A2 from rat serum: A degree of selectivity is shown for docosahexaenoate release
    • Baker, R.R. and Chang, H.Y. 1992. The hydrolysis of natural phosphatidylethanolamines by phospholipase A2 from rat serum: A degree of selectivity is shown for docosahexaenoate release. Biochim. Biophys. Acta 1125: 56-61.
    • (1992) Biochim. Biophys. Acta , vol.1125 , pp. 56-61
    • Baker, R.R.1    Chang, H.Y.2
  • 7
    • 0030960780 scopus 로고    scopus 로고
    • Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
    • Botling, J., Castro, D.S., Oberg, F., Nilsson, K., and Perlmann, T. 1997. Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation. J. Biol. Chem. 272: 9443-9449.
    • (1997) J. Biol. Chem. , vol.272 , pp. 9443-9449
    • Botling, J.1    Castro, D.S.2    Oberg, F.3    Nilsson, K.4    Perlmann, T.5
  • 8
    • 0032736041 scopus 로고    scopus 로고
    • Apoptosis in primary cultures of E14 rat ventral mesencephala: Time course of dopaminergic cell death and implications for neural transplantation
    • Branton, R.L. and Clarke, D.J. 1999. Apoptosis in primary cultures of E14 rat ventral mesencephala: Time course of dopaminergic cell death and implications for neural transplantation. Exp. Neurol. 160: 88-98.
    • (1999) Exp. Neurol. , vol.160 , pp. 88-98
    • Branton, R.L.1    Clarke, D.J.2
  • 11
    • 0031805754 scopus 로고    scopus 로고
    • Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
    • Castillo, S.O., Baffi, J.S., Palkovits, M., Goldstein, D.S., Kopin, I.J., Witta, J., Magnuson, M.A., and Nikodem, V.M. 1998. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol. Cell. Neurosci. 11: 36-46.
    • (1998) Mol. Cell. Neurosci. , vol.11 , pp. 36-46
    • Castillo, S.O.1    Baffi, J.S.2    Palkovits, M.3    Goldstein, D.S.4    Kopin, I.J.5    Witta, J.6    Magnuson, M.A.7    Nikodem, V.M.8
  • 12
    • 0035900751 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and morphological differentiation by Nurr1 and retinoids in dopamine MN9D cells
    • Castro, D.S., Hermanson, E., Joseph, B., Wallen, A., Aarnisalo, P., Heller, A., and Perlmann, T. 2001. Induction of cell cycle arrest and morphological differentiation by Nurr1 and retinoids in dopamine MN9D cells. J. Biol. Chem. 276: 43277-43284.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43277-43284
    • Castro, D.S.1    Hermanson, E.2    Joseph, B.3    Wallen, A.4    Aarnisalo, P.5    Heller, A.6    Perlmann, T.7
  • 13
    • 0032584919 scopus 로고    scopus 로고
    • Nurr1 mRNA expression in neonatal and adult rat brain following kainic acid-induced seizure activity
    • Crispino, M., Tocco, G., Feldman, J.D., Herschman, H.R., and Baudry, M. 1998. Nurr1 mRNA expression in neonatal and adult rat brain following kainic acid-induced seizure activity. Brain Res. Mol. Brain Res. 59: 178-188.
    • (1998) Brain Res. Mol. Brain Res. , vol.59 , pp. 178-188
    • Crispino, M.1    Tocco, G.2    Feldman, J.D.3    Herschman, H.R.4    Baudry, M.5
  • 14
    • 0028009121 scopus 로고
    • Developmental expression of murine retinoid X receptor (RXR) genes
    • Dolle, P., Fraulob, V., Kastner, P., and Chambon, P. 1994. Developmental expression of murine retinoid X receptor (RXR) genes. Mech. Dev. 45: 91-104.
    • (1994) Mech. Dev. , vol.45 , pp. 91-104
    • Dolle, P.1    Fraulob, V.2    Kastner, P.3    Chambon, P.4
  • 15
    • 0036071823 scopus 로고    scopus 로고
    • Dopamine neurons heterozygous for the Nurr1-null allele have reduced survival in vitro
    • Eells, J.B., Yeung, S.K., and Nikodem, V.M. 2002. Dopamine neurons heterozygous for the Nurr1-null allele have reduced survival in vitro. Neurosci. Res. Comm. 30: 173-183.
    • (2002) Neurosci. Res. Comm. , vol.30 , pp. 173-183
    • Eells, J.B.1    Yeung, S.K.2    Nikodem, V.M.3
  • 16
    • 0029002298 scopus 로고
    • Unique response pathways are established by allosteric interactions among nuclear hormone receptors
    • Forman, B.M., Umesono, K., Chen, J., and Evans, R.M. 1995. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81: 541-550.
    • (1995) Cell , vol.81 , pp. 541-550
    • Forman, B.M.1    Umesono, K.2    Chen, J.3    Evans, R.M.4
  • 17
    • 0037050017 scopus 로고    scopus 로고
    • Coregulator recruitment and the mechanism of retinoic acid receptor synergy
    • Germain, P., Iyer, J., Zechel, C., and Gronemeyer, H. 2002. Coregulator recruitment and the mechanism of retinoic acid receptor synergy. Nature 415: 187-192.
    • (2002) Nature , vol.415 , pp. 187-192
    • Germain, P.1    Iyer, J.2    Zechel, C.3    Gronemeyer, H.4
  • 18
    • 0033305499 scopus 로고    scopus 로고
    • Orphan nuclear receptors: From gene to function
    • Giguère, V. 1999. Orphan nuclear receptors: From gene to function. Endocr. Rev. 20: 689-725.
    • (1999) Endocr. Rev. , vol.20 , pp. 689-725
    • Giguère, V.1
  • 19
    • 0031778101 scopus 로고    scopus 로고
    • Intraamniotic ethyl docosahexaenoate administration protects fetal rat brain from ischemic stress
    • Glozman, S., Green, P., and Yavin, E. 1998. Intraamniotic ethyl docosahexaenoate administration protects fetal rat brain from ischemic stress. J. Neurochem. 70: 2484-2491.
    • (1998) J. Neurochem. , vol.70 , pp. 2484-2491
    • Glozman, S.1    Green, P.2    Yavin, E.3
  • 21
    • 0029976536 scopus 로고    scopus 로고
    • Global ischemia induces immediate-early genes encoding zinc finger transcription factors
    • Honkaniemi, J. and Sharp, F.R. 1996. Global ischemia induces immediate-early genes encoding zinc finger transcription factors. J. Cereb. Blood Flow Metab. 16: 557-565.
    • (1996) J. Cereb. Blood Flow Metab. , vol.16 , pp. 557-565
    • Honkaniemi, J.1    Sharp, F.R.2
  • 22
    • 0032949438 scopus 로고    scopus 로고
    • Prolonged expression of zinc finger immediate-early gene mRNAs and decreased protein synthesis following kainic acid induced seizures
    • -. 1999. Prolonged expression of zinc finger immediate-early gene mRNAs and decreased protein synthesis following kainic acid induced seizures. Eur. J. Neurosci. 11: 10-17.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 10-17
  • 23
    • 0028920237 scopus 로고
    • Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo
    • Horton, C. and Maden, M. 1995. Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo. Dev. Dyn. 202: 312-323.
    • (1995) Dev. Dyn. , vol.202 , pp. 312-323
    • Horton, C.1    Maden, M.2
  • 25
    • 0032966607 scopus 로고    scopus 로고
    • Specification of dopaminergic and serotonergic neurons in the vertebrate CNS
    • Hynes, M. and Rosenthal, A. 1999. Specification of dopaminergic and serotonergic neurons in the vertebrate CNS. Curr. Op. Neurobiol. 9: 26-36.
    • (1999) Curr. Op. Neurobiol. , vol.9 , pp. 26-36
    • Hynes, M.1    Rosenthal, A.2
  • 26
    • 0033784155 scopus 로고    scopus 로고
    • Early and delayed induction of immediate early gene expression in a novel focal cerebral ischemia model in the rat
    • Johansson, I.M., Wester, P., Hakova, M., Gu, W., Seckl, J.R., and Olsson, T. 2000. Early and delayed induction of immediate early gene expression in a novel focal cerebral ischemia model in the rat. Eur. J. Neurosci. 12: 3615-3625.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 3615-3625
    • Johansson, I.M.1    Wester, P.2    Hakova, M.3    Gu, W.4    Seckl, J.R.5    Olsson, T.6
  • 29
    • 0027074637 scopus 로고
    • Identification of a new brain-specific transcription factor, NURR1
    • Law, S.W., Conneely, O.M., DeMayo, F.J., and O'Malley, B.W. 1992. Identification of a new brain-specific transcription factor, NURR1. Mol. Endocrinol. 6: 2129-2135.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 2129-2135
    • Law, S.W.1    Conneely, O.M.2    DeMayo, F.J.3    O'Malley, B.W.4
  • 31
    • 0032692692 scopus 로고    scopus 로고
    • Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury
    • Le, W.-D., Conneely, O.M., He, Y., Jankovic, J., and Appel, S.H. 1999b. Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury. J. Neurochem. 73: 2218-2221.
    • (1999) J. Neurochem. , vol.73 , pp. 2218-2221
    • Le, W.-D.1    Conneely, O.M.2    He, Y.3    Jankovic, J.4    Appel, S.H.5
  • 34
    • 0029664544 scopus 로고    scopus 로고
    • Phytanic acid is a retinoid X receptor ligand
    • Lemotte, P.K., Keidel, S., and Apfel, C.M. 1996. Phytanic acid is a retinoid X receptor ligand. Eur. J. Biochem. 236: 328-333.
    • (1996) Eur. J. Biochem. , vol.236 , pp. 328-333
    • Lemotte, P.K.1    Keidel, S.2    Apfel, C.M.3
  • 36
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin, L.F., Doherty, D.H., Lile, J.D., Bektesh, S., and Collins, F. 1993. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260: 1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 38
    • 0031027183 scopus 로고    scopus 로고
    • Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis
    • Lu, H.C., Eichele, G., and Thaller, C. 1997. Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis. Development 124: 195-203.
    • (1997) Development , vol.124 , pp. 195-203
    • Lu, H.C.1    Eichele, G.2    Thaller, C.3
  • 39
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf, D.J. and Evans, R.M. 1995. The RXR heterodimers and orphan receptors. Cell 83: 841-850.
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 40
    • 0025270737 scopus 로고
    • Nuclear receptor that identifies a novel retinoic acid response pathway
    • Mangelsdorf, D.J., Ong, E.S., Dyck, J.A., and Evans, R.M. 1990. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345: 224-229.
    • (1990) Nature , vol.345 , pp. 224-229
    • Mangelsdorf, D.J.1    Ong, E.S.2    Dyck, J.A.3    Evans, R.M.4
  • 42
    • 0032217312 scopus 로고    scopus 로고
    • The RXRα ligand-dependent activation function 2 (AF-2) is important for mouse development
    • Mascrez, B., Mark, M., Dierich, A., Ghyselinck, N.B., Kastner, P., and Chambon, P. 1998. The RXRα ligand-dependent activation function 2 (AF-2) is important for mouse development. Development 125: 4691-4707.
    • (1998) Development , vol.125 , pp. 4691-4707
    • Mascrez, B.1    Mark, M.2    Dierich, A.3    Ghyselinck, N.B.4    Kastner, P.5    Chambon, P.6
  • 43
    • 0033539490 scopus 로고    scopus 로고
    • Feedback-inducible nuclear-receptor-driven reporter gene expression in transgenic mice
    • Mata de Urquiza, A., Solomin, L., and Perlmann, T. 1999. Feedback-inducible nuclear-receptor-driven reporter gene expression in transgenic mice. Proc. Natl. Acad. Sci. 96: 13270-13275.
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 13270-13275
    • Mata De Urquiza, A.1    Solomin, L.2    Perlmann, T.3
  • 45
    • 0028040008 scopus 로고
    • Differential expression of the immediate early genes c-fos, c-jun, junB, and NGFI-B in the rat brain following transient forebrain ischemia
    • Neumann-Haefelin, T., Wiessner, C., Vogel, P., Back, T., and Hossmann, K.A. 1994. Differential expression of the immediate early genes c-fos, c-jun, junB, and NGFI-B in the rat brain following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 14: 206-216.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 206-216
    • Neumann-Haefelin, T.1    Wiessner, C.2    Vogel, P.3    Back, T.4    Hossmann, K.A.5
  • 46
    • 0024147741 scopus 로고
    • The essentiality of n - 3 fatty acids for the development and function of the retina and brain
    • Neuringer, M., Anderson, G.J., and Connor, W.E. 1988. The essentiality of n - 3 fatty acids for the development and function of the retina and brain. Annu. Rev. Nutr. 8: 517-541.
    • (1988) Annu. Rev. Nutr. , vol.8 , pp. 517-541
    • Neuringer, M.1    Anderson, G.J.2    Connor, W.E.3
  • 47
    • 0028946634 scopus 로고
    • A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
    • Perlmann, T. and Jansson, L. 1995. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes & Dev. 9: 769-782.
    • (1995) Genes & Dev. , vol.9 , pp. 769-782
    • Perlmann, T.1    Jansson, L.2
  • 48
    • 0027237598 scopus 로고
    • Determinants for selective RAR and TR recognition of direct repeat HREs
    • Perlmann, T., Rangarajan, P.N., Umesono, K., and Evans, R.M. 1993. Determinants for selective RAR and TR recognition of direct repeat HREs. Genes & Dev. 7: 1411-1422.
    • (1993) Genes & Dev. , vol.7 , pp. 1411-1422
    • Perlmann, T.1    Rangarajan, P.N.2    Umesono, K.3    Evans, R.M.4
  • 50
    • 0034761025 scopus 로고    scopus 로고
    • Effect of GDNF on neuroblast proliferation and photoreceptor survival: Additive protection with docosahexaenoic acid
    • Politi, L.E., Rotstein, N.P., and Carri, N.G. 2001. Effect of GDNF on neuroblast proliferation and photoreceptor survival: Additive protection with docosahexaenoic acid. Invest. Ophthalmol. Vis. Sci. 42: 3008-3015.
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 3008-3015
    • Politi, L.E.1    Rotstein, N.P.2    Carri, N.G.3
  • 52
    • 0028811341 scopus 로고
    • Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonic carcinoma cell differentiation by an RA receptor α (RAR α)-, RAR β-, or RAR γ-selective ligands in combination with a retinoid X receptor-selective ligand
    • Roy, B., Taneja, R., and Chambon, P. 1995. Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonic carcinoma cell differentiation by an RA receptor α (RAR α)-, RAR β-, or RAR γ-selective ligands in combination with a retinoid X receptor-selective ligand. Mol. Cell. Biol. 15: 6481-6487.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6481-6487
    • Roy, B.1    Taneja, R.2    Chambon, P.3
  • 53
    • 0032584085 scopus 로고    scopus 로고
    • Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    • Saucedo-Cardenas, O., Quintana-Hau, J.D., Le, W.D., Smidt, M.P., Cox, J.J., De Mayo, F., Burbach, J.P., and Conneely, O.M. 1998. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. 95: 4013-4018.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 4013-4018
    • Saucedo-Cardenas, O.1    Quintana-Hau, J.D.2    Le, W.D.3    Smidt, M.P.4    Cox, J.J.5    De Mayo, F.6    Burbach, J.P.7    Conneely, O.M.8
  • 54
    • 0032555724 scopus 로고    scopus 로고
    • Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons
    • Sockanathan, S. and Jessell, T.M. 1998. Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell 94: 503-514.
    • (1998) Cell , vol.94 , pp. 503-514
    • Sockanathan, S.1    Jessell, T.M.2
  • 57
    • 0034763589 scopus 로고    scopus 로고
    • Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are superelevated experimentally
    • Ulven, S.M., Gundersen, T.E., Sakhi, A.K., Glover, J.C., and Blomhoff, R. 2001. Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are superelevated experimentally. Dev. Dyn. 222: 341-353.
    • (2001) Dev. Dyn. , vol.222 , pp. 341-353
    • Ulven, S.M.1    Gundersen, T.E.2    Sakhi, A.K.3    Glover, J.C.4    Blomhoff, R.5
  • 59
  • 60
    • 0027305861 scopus 로고
    • The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction
    • Wilson, T.E., Fahrner, T.J., and Milbrandt, J. 1993. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol. Cell. Biol. 13: 5794-5804.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5794-5804
    • Wilson, T.E.1    Fahrner, T.J.2    Milbrandt, J.3
  • 61
    • 0029857001 scopus 로고    scopus 로고
    • Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1 and Nor1
    • Zetterström, R.H., Solomin, L., Mitsiadis, T., Olson, L., and Perlmann, T. 1996a. Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1 and Nor1. Mol. Endocrinol. 10: 1656-1666.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 1656-1666
    • Zetterström, R.H.1    Solomin, L.2    Mitsiadis, T.3    Olson, L.4    Perlmann, T.5
  • 62
    • 0000190727 scopus 로고    scopus 로고
    • Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system
    • Zetterström, R.H., Williams, R., Perlmann, T., and Olson, L. 1996b. Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Mol. Brain Res. 41: 111-120.
    • (1996) Mol. Brain Res. , vol.41 , pp. 111-120
    • Zetterström, R.H.1    Williams, R.2    Perlmann, T.3    Olson, L.4
  • 64
    • 0033047696 scopus 로고    scopus 로고
    • Role of retinoids in the CNS: Differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid
    • Zetterström, R.H., Lindqvist, E., Mata de Urquiza, A., Tomac, A., Eriksson, U., Perlmann, T., and Olson, L. 1999. Role of retinoids in the CNS: Differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid. Eur. J. Neurosci. 11: 407-416.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 407-416
    • Zetterström, R.H.1    Lindqvist, E.2    Mata De Urquiza, A.3    Tomac, A.4    Eriksson, U.5    Perlmann, T.6    Olson, L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.