Syntheses and structure-activity relationships of novel retinoid X receptor agonists

Journal of Medicinal Chemistry

Volumn 41, Issue 17, 1998, Pages 3245-3252

  Hibi, Shigeki ^a   Kikuchi, Kouichi ^a   Yoshimura, Hiroyuki ^a   Nagai, Mitsuo ^a   Tai, Kenji ^a   Hida, Takayuki ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 [1 (1 METHYLETHYL) 1,2,3,4 TETRAHYDROQUINOLIN 6 YL] 6 FLUORO 3 METHYLNONA 2,4,6 TRIENOIC ACID; ALITRETINOIN; BEXAROTENE; FLUORINE; RADIOLIGAND; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID DERIVATIVE; RETINOID X RECEPTOR; RO 13 6307; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN COS1; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; GENE EXPRESSION REGULATION; HYDROPHOBICITY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION;

ANIMALS; CELL LINE; COS CELLS; CRICETINAE; DRUG DESIGN; HUMANS; KINETICS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; QUINOLONES; RECEPTORS, RETINOIC ACID; RECOMBINANT PROTEINS; RETINOID X RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRETINOIN;

EID: 0032514549     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980058c     Document Type: Article

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