메뉴 건너뛰기




Volumn 17, Issue 6, 2010, Pages 560-573

NSAID Sulindac and Its Analog Bind RXRα and Inhibit RXRα-Dependent AKT Signaling

Author keywords

CELLCYCLE; CHEMBIO

Indexed keywords

K 80003; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN P85 ALPHA; RETINOID X RECEPTOR ALPHA; SULINDAC; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 77953283014     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2010.04.023     Document Type: Article
Times cited : (114)

References (50)
  • 1
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: A double-edged sword
    • Aggarwal B.B. Signalling pathways of the TNF superfamily: A double-edged sword. Nat. Rev. Immunol. 3 (2003) 745-756
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 2
    • 0035749803 scopus 로고    scopus 로고
    • The promise of retinoids to fight against cancer
    • Altucci L., and Gronemeyer H. The promise of retinoids to fight against cancer. Nat. Rev. Cancer 1 (2001) 181-193
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 181-193
    • Altucci, L.1    Gronemeyer, H.2
  • 3
    • 25444495618 scopus 로고    scopus 로고
    • Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor
    • Altucci L., Rossin A., Hirsch O., Nebbioso A., Vitoux D., Wilhelm E., Guidez F., De Simone M., Schiavone E.M., Grimwade D., et al. Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor. Cancer Res. 65 (2005) 8754-8765
    • (2005) Cancer Res. , vol.65 , pp. 8754-8765
    • Altucci, L.1    Rossin, A.2    Hirsch, O.3    Nebbioso, A.4    Vitoux, D.5    Wilhelm, E.6    Guidez, F.7    De Simone, M.8    Schiavone, E.M.9    Grimwade, D.10
  • 4
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill F. Tumour necrosis factor and cancer. Nat. Rev. Cancer 9 (2009) 361-371
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 5
    • 0033868825 scopus 로고    scopus 로고
    • Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains
    • Bourguet W., Vivat V., Wurtz J.M., Chambon P., Gronemeyer H., and Moras D. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. Mol. Cell 5 (2000) 289-298
    • (2000) Mol. Cell , vol.5 , pp. 289-298
    • Bourguet, W.1    Vivat, V.2    Wurtz, J.M.3    Chambon, P.4    Gronemeyer, H.5    Moras, D.6
  • 6
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 7
    • 7644221712 scopus 로고    scopus 로고
    • Retinoid X receptor regulates Nur77/TR3-dependent apoptosis by modulating its nuclear export and mitochondrial targeting
    • Cao X., Liu W., Lin F., Li H., Kolluri S.K., Lin B., Han Y.-H., Dawson M.I., and Zhang X.-k. Retinoid X receptor regulates Nur77/TR3-dependent apoptosis by modulating its nuclear export and mitochondrial targeting. Mol. Cell. Biol. 24 (2004) 9705-9725
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 9705-9725
    • Cao, X.1    Liu, W.2    Lin, F.3    Li, H.4    Kolluri, S.K.5    Lin, B.6    Han, Y.-H.7    Dawson, M.I.8    Zhang, X.-k.9
  • 8
    • 0036219575 scopus 로고    scopus 로고
    • Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid
    • Dawson M.I., and Zhang X.-K. Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid. Curr. Med. Chem. 9 (2002) 623-637
    • (2002) Curr. Med. Chem. , vol.9 , pp. 623-637
    • Dawson, M.I.1    Zhang, X.-K.2
  • 9
    • 0018953871 scopus 로고
    • Kinetics of the tissue distributions of sulindac and metabolites. Relevance to sites and rates of bioactivation
    • Duggan D.E., Hooke K.F., and Hwang S.S. Kinetics of the tissue distributions of sulindac and metabolites. Relevance to sites and rates of bioactivation. Drug Metab. Dispos. 8 (1980) 241-246
    • (1980) Drug Metab. Dispos. , vol.8 , pp. 241-246
    • Duggan, D.E.1    Hooke, K.F.2    Hwang, S.S.3
  • 10
    • 6044274282 scopus 로고    scopus 로고
    • Coxibs and cardiovascular disease
    • Fitzgerald G.A. Coxibs and cardiovascular disease. N. Engl. J. Med. 351 (2004) 1709-1711
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1709-1711
    • Fitzgerald, G.A.1
  • 11
    • 0035004021 scopus 로고    scopus 로고
    • Changes in expression and subcellular localization of nuclear retinoic acid receptors in human endometrial epithelium during the menstrual cycle
    • Fukunaka K., Saito T., Wataba K., Ashihara K., Ito E., and Kudo R. Changes in expression and subcellular localization of nuclear retinoic acid receptors in human endometrial epithelium during the menstrual cycle. Mol. Hum. Reprod. 7 (2001) 437-446
    • (2001) Mol. Hum. Reprod. , vol.7 , pp. 437-446
    • Fukunaka, K.1    Saito, T.2    Wataba, K.3    Ashihara, K.4    Ito, E.5    Kudo, R.6
  • 12
    • 18144387309 scopus 로고    scopus 로고
    • Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation
    • Ghose R., Zimmerman T.L., Thevananther S., and Karpen S.J. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl. Recept. 2 (2004) 4
    • (2004) Nucl. Recept. , vol.2 , pp. 4
    • Ghose, R.1    Zimmerman, T.L.2    Thevananther, S.3    Karpen, S.J.4
  • 13
    • 33745238704 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors
    • Grosch S., Maier T.J., Schiffmann S., and Geisslinger G. Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. J. Natl. Cancer Inst. 98 (2006) 736-747
    • (2006) J. Natl. Cancer Inst. , vol.98 , pp. 736-747
    • Grosch, S.1    Maier, T.J.2    Schiffmann, S.3    Geisslinger, G.4
  • 14
    • 0034980582 scopus 로고    scopus 로고
    • Sulindac and its derivatives: A novel class of anticancer agents
    • Haanen C. Sulindac and its derivatives: A novel class of anticancer agents. Curr. Opin. Investig. Drugs 2 (2001) 677-683
    • (2001) Curr. Opin. Investig. Drugs , vol.2 , pp. 677-683
    • Haanen, C.1
  • 16
    • 11244262332 scopus 로고    scopus 로고
    • Regulation of STAT signalling by proteolytic processing
    • Hendry L., and John S. Regulation of STAT signalling by proteolytic processing. Eur. J. Biochem. 271 (2004) 4613-4620
    • (2004) Eur. J. Biochem. , vol.271 , pp. 4613-4620
    • Hendry, L.1    John, S.2
  • 17
    • 0037102446 scopus 로고    scopus 로고
    • Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor-alpha allele in the prostate epithelium
    • Huang J., Powell W.C., Khodavirdi A.C., Wu J., Makita T., Cardiff R.D., Cohen M.B., Sucov H.M., and Roy-Burman P. Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor-alpha allele in the prostate epithelium. Cancer Res. 62 (2002) 4812-4819
    • (2002) Cancer Res. , vol.62 , pp. 4812-4819
    • Huang, J.1    Powell, W.C.2    Khodavirdi, A.C.3    Wu, J.4    Makita, T.5    Cardiff, R.D.6    Cohen, M.B.7    Sucov, H.M.8    Roy-Burman, P.9
  • 19
    • 42649119825 scopus 로고    scopus 로고
    • The SH3 domain-a family of versatile peptide- and protein-recognition module
    • Kaneko T., Li L., and Li S.S. The SH3 domain-a family of versatile peptide- and protein-recognition module. Front. Biosci. 13 (2008) 4938-4952
    • (2008) Front. Biosci. , vol.13 , pp. 4938-4952
    • Kaneko, T.1    Li, L.2    Li, S.S.3
  • 20
    • 0029584593 scopus 로고
    • Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life?
    • Kastner P., Mark M., and Chambon P. Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life?. Cell 83 (1995) 859-869
    • (1995) Cell , vol.83 , pp. 859-869
    • Kastner, P.1    Mark, M.2    Chambon, P.3
  • 21
    • 0033780029 scopus 로고    scopus 로고
    • Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B
    • Katagiri Y., Takeda K., Yu Z.X., Ferrans V.J., Ozato K., and Guroff G. Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B. Nat. Cell Biol. 2 (2000) 435-440
    • (2000) Nat. Cell Biol. , vol.2 , pp. 435-440
    • Katagiri, Y.1    Takeda, K.2    Yu, Z.X.3    Ferrans, V.J.4    Ozato, K.5    Guroff, G.6
  • 25
    • 0034682890 scopus 로고    scopus 로고
    • Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3
    • Li H., Kolluri S.K., Gu J., Dawson M.I., Cao X., Hobbs P.D., Lin B., Chen G., Lu J., Lin F., et al. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science 289 (2000) 1159-1164
    • (2000) Science , vol.289 , pp. 1159-1164
    • Li, H.1    Kolluri, S.K.2    Gu, J.3    Dawson, M.I.4    Cao, X.5    Hobbs, P.D.6    Lin, B.7    Chen, G.8    Lu, J.9    Lin, F.10
  • 26
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 27
    • 0035091032 scopus 로고    scopus 로고
    • RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations
    • Li M., Chiba H., Warot X., Messaddeq N., Gerard C., Chambon P., and Metzger D. RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. Development 128 (2001) 675-688
    • (2001) Development , vol.128 , pp. 675-688
    • Li, M.1    Chiba, H.2    Warot, X.3    Messaddeq, N.4    Gerard, C.5    Chambon, P.6    Metzger, D.7
  • 28
    • 1342306819 scopus 로고    scopus 로고
    • Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3
    • Lin B., Kolluri S., Lin F., Liu W., Han Y.H., Cao X., Dawson M.I., Reed J.C., and Zhang X.K. Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3. Cell 116 (2004) 527-540
    • (2004) Cell , vol.116 , pp. 527-540
    • Lin, B.1    Kolluri, S.2    Lin, F.3    Liu, W.4    Han, Y.H.5    Cao, X.6    Dawson, M.I.7    Reed, J.C.8    Zhang, X.K.9
  • 29
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf D.J., and Evans R.M. The RXR heterodimers and orphan receptors. Cell 83 (1995) 841-850
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 31
    • 0032509203 scopus 로고    scopus 로고
    • Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor-alpha by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action
    • Nagaya T., Murata Y., Yamaguchi S., Nomura Y., Ohmori S., Fujieda M., Katunuma N., Yen P.M., Chin W.W., and Seo H. Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor-alpha by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action. J. Biol. Chem. 273 (1998) 33166-33173
    • (1998) J. Biol. Chem. , vol.273 , pp. 33166-33173
    • Nagaya, T.1    Murata, Y.2    Yamaguchi, S.3    Nomura, Y.4    Ohmori, S.5    Fujieda, M.6    Katunuma, N.7    Yen, P.M.8    Chin, W.W.9    Seo, H.10
  • 32
    • 0033522391 scopus 로고    scopus 로고
    • Conformation of the Bax C-terminus regulates subcellular location and cell death
    • Nechushtan A., Smith C.L., Hsu Y.T., and Youle R.J. Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J. 18 (1999) 2330-2341
    • (1999) EMBO J. , vol.18 , pp. 2330-2341
    • Nechushtan, A.1    Smith, C.L.2    Hsu, Y.T.3    Youle, R.J.4
  • 34
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes O.N., Mayo L.D., Gustin J.A., Pfeffer S.R., Pfeffer L.M., and Donner D.B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401 (1999) 82-85
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 35
    • 0035831556 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells
    • Panka D.J., Mano T., Suhara T., Walsh K., and Mier J.W. Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells. J. Biol. Chem. 276 (2001) 6893-6896
    • (2001) J. Biol. Chem. , vol.276 , pp. 6893-6896
    • Panka, D.J.1    Mano, T.2    Suhara, T.3    Walsh, K.4    Mier, J.W.5
  • 37
    • 49049106608 scopus 로고    scopus 로고
    • Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity
    • Pincheira R., Castro A.F., Ozes O.N., Idumalla P.S., and Donner D.B. Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity. J. Immunol. 181 (2008) 1288-1298
    • (2008) J. Immunol. , vol.181 , pp. 1288-1298
    • Pincheira, R.1    Castro, A.F.2    Ozes, O.N.3    Idumalla, P.S.4    Donner, D.B.5
  • 40
    • 0037138743 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues
    • Thun M.J., Henley S.J., and Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues. J. Natl. Cancer Inst. 94 (2002) 252-266
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 252-266
    • Thun, M.J.1    Henley, S.J.2    Patrono, C.3
  • 41
    • 8644282859 scopus 로고    scopus 로고
    • Combination of retinoic acid and tumor necrosis factor overcomes the maturation block in a variety of retinoic acid-resistant acute promyelocytic leukemia cells
    • Witcher M., Shiu H.Y., Guo Q., and Miller Jr. W.H. Combination of retinoic acid and tumor necrosis factor overcomes the maturation block in a variety of retinoic acid-resistant acute promyelocytic leukemia cells. Blood 104 (2004) 3335-3342
    • (2004) Blood , vol.104 , pp. 3335-3342
    • Witcher, M.1    Shiu, H.Y.2    Guo, Q.3    Miller Jr., W.H.4
  • 42
    • 0033578879 scopus 로고    scopus 로고
    • Sulindac inhibits activation of the NF-kappaB pathway
    • Yamamoto Y., Yin M.J., Lin K.M., and Gaynor R.B. Sulindac inhibits activation of the NF-kappaB pathway. J. Biol. Chem. 274 (1999) 27307-27314
    • (1999) J. Biol. Chem. , vol.274 , pp. 27307-27314
    • Yamamoto, Y.1    Yin, M.J.2    Lin, K.M.3    Gaynor, R.B.4
  • 43
    • 0033535555 scopus 로고    scopus 로고
    • Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
    • Ye Y., Lukinova N., and Fortini M.E. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature 398 (1999) 525-529
    • (1999) Nature , vol.398 , pp. 525-529
    • Ye, Y.1    Lukinova, N.2    Fortini, M.E.3
  • 45
    • 0034602188 scopus 로고    scopus 로고
    • Role of BAX in the apoptotic response to anticancer agents
    • Zhang L., Yu J., Park B.H., Kinzler K.W., and Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science 290 (2000) 989-992
    • (2000) Science , vol.290 , pp. 989-992
    • Zhang, L.1    Yu, J.2    Park, B.H.3    Kinzler, K.W.4    Vogelstein, B.5
  • 47
    • 0026536522 scopus 로고
    • Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors
    • Zhang X.K., Hoffmann B., Tran P.B., Graupner G., and Pfahl M. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 355 (1992) 441-446
    • (1992) Nature , vol.355 , pp. 441-446
    • Zhang, X.K.1    Hoffmann, B.2    Tran, P.B.3    Graupner, G.4    Pfahl, M.5
  • 48
    • 0141976407 scopus 로고    scopus 로고
    • Aberration in the expression of the retinoid receptor, RXRalpha, in prostate cancer
    • Zhong C., Yang S., Huang J., Cohen M.B., and Roy-Burman P. Aberration in the expression of the retinoid receptor, RXRalpha, in prostate cancer. Cancer Biol. Ther. 2 (2003) 179-184
    • (2003) Cancer Biol. Ther. , vol.2 , pp. 179-184
    • Zhong, C.1    Yang, S.2    Huang, J.3    Cohen, M.B.4    Roy-Burman, P.5
  • 50
    • 33744957050 scopus 로고    scopus 로고
    • Nuclear export of retinoid X receptor-alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260
    • Zimmerman T.L., Thevananther S., Ghose R., Burns A.R., and Karpen S.J. Nuclear export of retinoid X receptor-alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260. J. Biol. Chem. 281 (2006) 15434-15440
    • (2006) J. Biol. Chem. , vol.281 , pp. 15434-15440
    • Zimmerman, T.L.1    Thevananther, S.2    Ghose, R.3    Burns, A.R.4    Karpen, S.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.