Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 1868-1875

  Zhang, Haitao ^a   Zhou, Rong ^b   Li, Li ^a   Chen, Jing ^a   Chen, Lili ^a   Li, Chenjing ^a   Ding, Hong ^a   Yu, Liang ^a   Hu, Lihong ^a   Jiang, Hualiang ^a   Shen, Xu ^a,b,c  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COREPRESSORS; DRUG DISCOVERY; IN-VIVO; INSULIN SENSITIVITY; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; LIGAND BINDING DOMAIN; METABOLIC SYNDROMES; NEW MECHANISMS; RECEPTOR ANTAGONISTS; RESPONSE ELEMENTS; STRUCTURAL BASIS; TETRAMERIC STRUCTURES; TETRAMERS; THERAPEUTIC APPLICATION; TRADITIONAL CHINESE MEDICINE;

LIGANDS; MEDICINE; OLIGOMERS;

CRYSTAL STRUCTURE;

DANTRON; GLUCOSE; INSULIN; RETINOID X RECEPTOR ALPHA;

ARTICLE; BINDING AFFINITY; CHINESE MEDICINE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG TARGETING; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; ISOTHERMAL TITRATION CALORIMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTHRAQUINONES; DRUGS, CHINESE HERBAL; HEK293 CELLS; HUMANS; MALE; MICE; MUTAGENS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RESPONSE ELEMENTS; RETINOID X RECEPTOR ALPHA; RHEUM;

MUS; RHEUM X HYBRIDUM;

EID: 78751539633     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.166215     Document Type: Article

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