Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity

Journal of Medicinal Chemistry

Volumn 57, Issue 12, 2014, Pages 5370-5380

  Atigadda, Venkatram R ^a   Xia, Gang ^a   Desphande, Anil ^a   Boerma, Leeann J ^b   Lobo Ruppert, Susan ^c   Grubbs, Clinton J ^c   Smith, Craig D ^a   Brouillette, Wayne J ^a   Muccio, Donald D ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 (3',4' DIHYDRO 1'(2'H)NAPHTHALEN 1' YLIDENE) ,7 DIMETHYL 2,4,6 OCTATRIENOIC ACID DERIVATIVE; BEXAROTENE; METHYL GROUP; RETINOID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; FEMALE; HYPERLIPIDEMIA; LIGAND BINDING; LIPOGENESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BINDING SITES; CELL LINE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CRYSTALLOGRAPHY, X-RAY; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; HYPERLIPIDEMIAS; MAMMARY NEOPLASMS, EXPERIMENTAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; RATS; RETINOID X RECEPTOR ALPHA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES; TRANSCRIPTIONAL ACTIVATION;

EID: 84903552701     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5004792     Document Type: Article

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