Retinoids and cancer: Antitumoral effects of ATRA, 9-cis RA and the new retinoid IIF on the HL-60 leukemic cell line

Medical Principles and Practice

Volumn 12, Issue 3, 2003, Pages 164-169

  Orlandi, M ^a   Mantovani, B ^a   Ammar, K ^a   Avitabile, E ^a   Dal Monte, P ^a   Bartolini, G ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Cancer; HL 60; IIF; Leukemia; Retinoids

Indexed keywords

5 HYDROXIDE O HYDROPHENANTHRENE; ALITRETINOIN; DNA FRAGMENT; PROTEIN BCL 2; RETINOIC ACID; RETINOIC ACID DERIVATIVE; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CELL STRUCTURE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PROTEIN ANALYSIS; TRANSCRIPTION INITIATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HL-60 CELLS; HUMANS; PHENANTHRENES; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, RETINOIC ACID; TRANSCRIPTION, GENETIC; TRETINOIN;

EID: 0037869194     PISSN: 10117571     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070753     Document Type: Article

References (26)

1. Chomienne C, Balitrand N, Ballerini P, Castaigne S, de Thé H, Degos L: All-trans retinoic acid modulates the retinoic acid receptor alpha in promyelocytic cells. J Clin Invest 1991;88:2150-2154.
2. Warrell RP: Pathogenesis and management of acute promyelocytic leukaemia. Annu Rev Med 1996;47:555-565.
3. Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM: Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature 1992;355:446-452.
4. Giguere V, Ong ES, Segui P, Evans RM: Identification of a receptor for morphogen retinoic acid. Nature 1987;330:624-629.
5. Martin SJ, Bradley JG, Cotter TG: HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis. Clin Exp Immunol 1990:79:448-453.
6. Ammar K: Derivatives of Phenanthrene for Medicinal Use and a Process for Their Preparation. International patent application. WO 00/17143. World Intellectual Property Organization, 2000.
7. Denizot F, Lang R: Rapid colorimetric assay for cell growth and survival: Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986;89:271-277.
8. Breitman TR: Growth and differentiation of human myeloid leukaemia cell line HL-60. Methods Enzymol 1990;190:118-130.
9. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
10. Smith MA, Parkinson DR, Cheson BD, Friedman MA: Retinoids in cancer therapy. J Clin Oncol 1992;10:839-864.
11. Muindi J, Frankel SR, Miller WH Jr, Jakubowski A, Scheinberg DA, Young CW, Dmitrovsky E, Warrell RP Jr: Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: Implications for relapse and retinoid resistance in patients with acute promyelocytic leukaemia. Blood 1992;79:299-303.
12. Delva L, Cornic M, Balitrand N, Guidez F, Micléa JM, Delmer A, Teillet F, Fenaux P, Castaigne S, Degos L, Chomienne C: Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukaemia: Study of in vitro ATRA sensitivity and cellular retinoic acid binding protein levels in leukaemic cells. Blood 1993;82:2175-2181.
13. Zhou DC, Hallam SJ, Lee SJ, Klein RS, Wiernik PH, Tallman MS, Gallagher RE: Constitutive expression of cellular retinoic acid binding protein II and lack of correlation with sensitivity to all-trans retinoic acid in acute promyelocytic leukaemia cells. Cancer Res 1998;58:5770-5776.
14. Miller WH Jr, Jakubowski A, Tong WP, Miller VA, Rigas JR, Benedetti F, Gill GM, Truglia JA, Ulm E, Shirley M: 9-cis retinoic acid induces complete remission but does not reverse clinically acquired retinoid resistance in acute promyelocytic leukemia. Blood 1995;85:3021-3027.
15. Warrell RP Jr, He LZ, Richon V, Calleja E, Pandolfi PP: Therapeutic targeting of transcription in acute promyelocytic leukaemia by use of an inhibitor of histone deacetylase. J Natl Cancer Inst 1998;90:1621-1625.
16. Vadhat L, Maslak P, Miller WH Jr, Eardley A, Heller G, Scheinberg DA, Warrell RP Jr: Early mortality and the 'retinoic acid syndrome' in acute promyelocytic leukemia: Impact of leukocytosis, low-dose chemotherapy, PMN/RAR-alpha isoform, and CD13 expression in patients treated with all-trans retinoic acid. Blood 1994;84:3843-3849.
17. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ: Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993;75:229-240.
18. Zamzami N, Susin SA, Marchetti P, Hirsch T, Gòmez-Monterrey I, Castedo M, Kroemer G: Mitochondrial control of nuclear apoptosis. J Exp Med 1996;183:1533-1544.
19. Leek RD, Kaklamanis L, Pezzella F, Gatter KC, Harris AL: bcl-2 in normal human breast and carcinoma, association with estrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer 1994;69:135-139.
20. Chan WK, Poulsom R, Lu QJ, Patel K, Gregory K, Fisher CJ, Hanby AM: Bcl-2 expression in invasive mammary carcinoma: Correlation with apoptosis, hormone receptors and p53 expression. J Pathol 1993;169(suppl):138-140.
21. Del Bufalo D, Biroccio A, Leonetti C, Zupi G: Bcl-2 overexpression enhances the metastatic potential of a human breast cancer line. FASEB J 1997;11:947-953.
22. Furuya Y, Krajewski S, Epstein JI, Reed JC, Isaacs JT: Expression of bcl-2 and the progression of human and rodent prostatic cancers. Clin Cancer Res 1996;2:389-398.
23. Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C: 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992;68:397-406.
24. Minucci S, Zand DJ, Dey A, Marks MS, Nagata T, Grippo JF, Ozato K: Dominant negative retinoid X receptor β inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells. Mol Cell Biol 1994;14:360-372.
25. Mangelsdorf DJ: Vitamin A receptors. Nutr Rev 1994;52:S32-S44.
26. Nagy L, Thomàzy VA, Shipley GL, Fésus L, Lamph W, Heyman RA, Chandraratna RAS, Davies PJ: Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. Mol Cell Biol 1995;15:3540-3551.